Xiaomi messes up with HyperOS 2.0: a key update canceled

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There is no good news today regarding HyperOS 2.0. Xiaomi has canceled one of the most anticipated features of the operating system. The function has been seen by the beta versions for months, and was due to land on stable software shortly via an update. Today we finally know that this won’t happen. The company itself has come out to give explanations, something that does not usually happen after canceling a novelty before making it official. The curious thing is that it was something so long awaited by users, that the fact of not finally seeing it in HyperOS 2.0 is causing some complaints. What has Xiaomi canceled? It may seem like a small thing, but it is a simple animation and a small change of style for multitasking. Yes, we are talking about the interface recent appsthe one that appears when you want to navigate between the apps you already had open. For months, it has been expected that HyperOS 2.0 change the traditional way for a much more sophisticated one. In essence, the idea is go from multitasking with a rectangle aesthetic to one with overlapping pages in the style iOS. Goodbye to the most anticipated change Xiaomi has confirmed that HyperOS 2.0 will finally not adopt multitasking design that has been showing up in the beta phase. This considerably modified the aesthetics, implemented several very careful animations and, in general, The dynamics of changing apps greatly improved from this part of the system. On the right, the usual interface. On the left, the one that Xiaomi has canceled for HyperOS 2.0. Why isn’t the new multitasking coming? The HyperOS 2.0 development team has said that This new design consumes a lot of resourcesand therefore prefers to continue with the usual formula to preserve fluidity. Since the beginning of development, the company has focused efforts on improving performanceand this decision is a good example of that. Of course, the most powerful mobile phones in the catalog They could accommodate this new interface without performance problems, but things can change when the raw power drops in level in the mid-range and entry range. Xiaomi’s solution, beyond dividing the update by ranges, has been remove the novelty and make it not present in HyperOS 2.0. Which Xiaomi phones can update to HyperOS 2.0? This bad news aside, there are other good things to say about HyperOS 2.0 Global. The deployment of the operating system is being fast and quite constant, allowing several dozen mobile phones to have been updated in countries such as Spain and other regions such as Latin America. Here you have a list with the models that should already be receiving the OTA. Xiaomi MIX Flip Xiaomi 14 Xiaomi 14 Ultra Xiaomi 14T Xiaomi 14T Pro Xiaomi 13 Xiaomi 13 Pro Xiaomi 13 Ultra Xiaomi 13T Xiaomi 13T Pro Xiaomi 12 Xiaomi 12 Pro Xiaomi 12T Xiaomi 12T Pro Xiaomi Mi 11 Xiaomi Mi 11 Ultra Xiaomi 11 Lite 5G NE Redmi Note 13 Redmi Note 13 5G Redmi Note 13 Pro Redmi Note 13 Pro 5G Redmi Note 13 Pro+ 5G Redmi 13 Redmi 13C Redmi 13C 5G Redmi Note 12S Redmi Note 12 Redmi Note 12 5G Redmi Note 12 Pro 5G Redmi Note 12 Pro+ 5G Redmi 12 Redmi 12 5G LITTLE F6 LITTLE F6 Pro POCO X6 POCO X6 Pro LITTLE M6 POCO M6 Pro LITTLE F5 POCO F5 Pro LITTLE C75 LITTLE C65 POCO X5 Pro 5G LITTLE F4 GT POCO X4 GT Is your mobile not on the list? You may simply not have received the update yet. Luckily, there is a system to check this that is quite accurate. It’s about the app HyperOS Downloaderwhich not only tells you if your Xiaomi is compatible with HyperOS 2.0, but also tells you when it will update.

Mahomes on apparent help from referees: “They are doing their best”

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The general perception among NFL fans is that Patrick Mahomes is being excessively protected by refereesbut the Kansas City Chiefs star quarterback said this Wednesday that he disagrees. It’s not common for a quarterback to talk to the media about officiating, but the topic of the apparent help that Mahomes and the Chiefs have been receiving from the referees has grown exaggeratedly throughout this season. A reporter asked Mahomes on Wednesday if he felt he had extra protection from officers. “I don’t agree with that,” said Mahomes, who was recently father for the third time. “At the end of the day, the officials are doing their best to run the games as fairly and appropriately as they can.” Texans accused referee protection for Mahomes The most recent controversy arose on Saturday during the Chiefs’ victory over the Texans in their divisional round matchup. The officials penalized Houston twice for personal fouls on Mahomes. Both markings were very debatable and both helped Kansas City sustain those offensive drives and finish them in points. The Chiefs won 23-14. One of those punishments was tagged against linebacker Will Anderson Jr.defensive star of the Texans, who at the end of the game told the press: “We knew it was going to be us against the referees before the game started.” Markings like that have been repeated throughout this season and the previous one.. The San Francisco 49ers ended the last Super Bowl very frustrated when the officials did not call a single penalty of holding against the Chiefs, who won the game in overtime. “All you can do is go out and play the game you love as hard as you can and accept the results,” added Mahomes, who this Sunday will open his seventh consecutive AFC Championship Game (they have won four of them), all in their stadium, when they received the Buffalo Bills. Elaborating on the subject of referees, the three-time Super Bowl MVP said: “We have new referees every year, we have new circumstances, and you can never really know because every play is different and that’s what makes the game so special. NFL. I feel like I’ve just continued playing the sport and just try to win, and whatever has to happen happens.” Keep reading:– Super Bowl LIX is in sight: date and times for the long-awaited conference finals– Chiefs’ victory against Texans with Taylor Swift present sets an audience record– The Rams came very close to giving the big shake in the snow against Philadelphia

list of mobile phones and tablets compatible with the update

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Let’s tell you What are the Samsung devices that are going to be updated? to One UI 7the next version of your customization layer. The update will not reach everyone at the same time, but rather it will be released in batches, reaching the high-end first and then going down, but everyone on the list will receive it. In total, between mobile phones and tablets, the figure is expected to reach 50 device models different. Here is the list, and if your mobile or tablet is on it, that means that you will surely receive the update with the improvements. Samsung devices that will receive One UI 7 Here is the complete list of Samsung devices that will receive the update to One UI 7, both mobile phones and tablets. The order goes by ranges, putting the high ranges at the beginning of the list and then going down to the lower ones. Then at the end there are also the tablets. In Xataka Basics | Slow Samsung Galaxy: what settings to change in One UI to speed up the performance of your mobile

These are the autonomous communities that maintain the discounts

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Yesterday, January 22, 2025, the Government failed to carry out the Omnibus Decree that contemplated the pension increasethe extension of the MOVES III Plan and its aid to the electric car or the public transport subsidywith free or discounted multi-trip passes and tickets. The latter has had a direct consequence among those who use public transport daily because they have seen how the same transport passes that were discounted yesterday have now returned to their official prices before the discount. Óscar Puente, Minister of Transport, assured yesterday that public transport passes acquired before the refusal was given Omnibus Decree of the Government will maintain the advantages until the end of the first quarter (when said subscriptions had to be renewed) since the user had the “acquired right” with the purchase of the titles. However, those who had not obtained the titles before yesterday’s vote will not have these purchase aids. Aid that also affects regional titles. In the latter case, the transport subsidy is maintained if the town councils or autonomous communities responsible for them undertake to extend their contribution. Some of them have already confirmed that this will be the case. The autonomous communities that will maintain aid for public transport in 2025 Just a few days ago, with the first hours of 2025, the Government confirmed that it was extending aid to public transport until June 30, 2025. A measure that It would cost us 1.6 billion euros and that came with another promise: a single public transport ticket for all of Spain starting in the second half of the year. Aid for public transport, however, reached citizens through two sources. In those of state ownership (such as free quarterly subscriptions for Media Distancia with predefined origin and destination, the 50% reduction in the price of Avant multi-trip tickets or the free state-managed bus lines), the aid has been completely eliminated as it does not have the support of the Congress of Deputies. However, passes and multi-trip tickets of municipal or regional extension within the same autonomous community had double funding in the aid. The responsible organizations that wanted to benefit from the aid had the obligation to offer these multi-trip passes and tickets with at least a 50% discount. In order to apply this discount, the regional government was obliged to commit to a minimum aid of 20% of the original price and the State would support with the remaining 30% until reaching that minimum 50% reduction. Without the contribution of the State and the extension of aid, the autonomous communities and town councils have three options: Eliminate aid for public transport Maintain your minimum contribution of 20% or the one you have been applying until now Assume the State’s part and maintain the 50% discount, accepting that the entire final amount has to come from its coffers. In this context, some autonomous communities have already confirmed that they will maintain their aid to public transport in one way or another: Community of Madrid: It will maintain the 60% discount that its users already enjoyed. The regional government matched the State contribution and, therefore, the reduction in the final price was 60%. Government spokespersons in the region have confirmed that They will maintain the aid “for the moment” and therefore the prices They are still the ones you find in this link.Catalonia: At least temporarily, aid for public transport in Catalonia is maintained. It has been confirmed by Metropolitan Transport Authority (ATM) who claim that prices are maintained at a 50% discount “until the Ministry of Transport and Sustainable Mobility officially publishes or communicates” the withdrawal of its 30% state aid. From then on, the ATMs of Barcelona, ​​Lleida, Tarragona and Girona will maintain the 20% aid that corresponded to them until now but the state contribution will be lost. the Basque Country: As stated EFEaid for public transport in the Basque Country will also remain at a 50% discount until the Government of Spain confirms the withdrawal of its part of the aid. At this time, 20% of Basque aid is provided, 10% by the Autonomous Community and the remaining 10% by the provincial councils and town councils. Regarding the application in each City Council, in Bilbao the 50% discounts are maintained on the barik card and in temporary titles until February 20. After this date, if the State does not maintain its 30% aid, the reduction will be 20%. In San Sebastián it has been confirmed that the 50% discounts are maintained although no date has been specified and in Vitoria they will be maintained, at least, until January 31, according to Basque Chronicle. Valencian Community: According to The Sixththe Generalitat Valenciana is studying to what extent it can maintain transport aid, which, for the moment, will continue to receive a 50% discount until next December 31. Andalusia: As stated Seville newspaperthe Junta de Andalucía will maintain, at least, the 20% discount on the price of passes and multi-trip tickets that it already supported with its funds. This discount is active throughout the Autonomous Community and, therefore, also in the Metro services of Seville, Málaga and Granada.Galicia: Pick up ABC that the Xunta de Galicia will also maintain transport aid at 50% until the end of January. From then on, the aid will be reduced to 20% corresponding to the section provided by the autonomous communities.Asturias: The Principality of Asturias has confirmed in X that the CONECTA card is used throughout the Autonomous Community will continue to maintain exactly the same current rates. The card can be recharged monthly up to a maximum of 30 euros (unused money is returned) and with it you can take trips that are divided into zones. Prices can be consulted at this link.Castile and León: Pick up EFE that the Junta de Castilla y León has confirmed that it will maintain public transport subsidies that depend on the regional contribution. Thus, the Avant service will maintain a 20% discount and metropolitan transport a 20% discount. Rural transport will … Read more

They could be from the new Glyph rear of their next mobile, the Phone (3)

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Just yesterday the British manufacturer returned to the fray with the Pokémon which will be linked to some of the mobile phones that it plans to launch this year. There are several possibilities and everything seems to indicate that they would be the Phone (3) and the (3a), and if anything has to modify or change Nothing is the back, precisely what seems to be drawn in some sketches that the British company has shared. If there is a manufacturer that likes to play with mystery with its imminent launches, this would be Nothing, and since it began its journey as a new mobile manufacturer, started posting images of insects to give clues about your next Phone (2) or the same Phone (2a) from last year. In that game he now finds himself publishing five images from his Instagram account in which you can see a series of sketches that draw part of the design concepts of some of the mobiles which he plans to launch this year. They can look like pieces of a puzzle or simply loose concepts that throw ideas about the change that must occur on the back of your mobile. And it is precisely that he received a lot of criticism with the Nothing Phone (2) when it was launched, since the back was very similar to Phone (1). These criticisms led me to play with another “Glyph” in the design of the next Telephone (2a) that he launched last year in Spain, so it is possible that those sketches made with erratic linesbut that draw shapes, be they part of the back of the next Phone (3) or (3a). Nothing’s sketches nothing The Free Android Of them there is an image that does not fit into the rest or in some way it cannot be related, and that is that they look like two boxes with an oval shadow that do not make it clear what they are referring to; which could be part of the rear with which it can move away from the design of previous mobile phones and thus powerfully draw attention again as it has done with many of its technological products. Be that as it may, mystery once again surrounds a Nothing Phone (3) mobile that was anticipated by Carl Pei himself at the beginning of the year in an email that he sent to his employees to make it clear that this year his commitment is going to be greater. In fact, he announced that Nothing was looking for capital to invest in the technology necessary to bring generative artificial intelligence to its new premium; and even more so when this time it wants to elevate the mobile phone category to catch up with those from Samsung, Apple and others. All five images are available from your account at instagram.

Win as if Mahomes and Allen were Trent Dilfer

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The New England Patriots of Tom Brady and Bill Belichick They had two decades of relevance in the NFL. Six Super Bowl titles won between 2002 and 2019 comprise the greatest dynasty of the 21st century in American sports in a period in which their ability to adapt and survive explain their success even more than the enormous greatness they showed. Those Patriots did it in every way, first based on defense, running game and a functional Brady plus, in the middle reinventing the position and use of the tight ends, for example, and finishing a little as they had started, with the defensive marking the differences in the superbowl of 2019. Along the way they adapted better than anyone to rule changes, mutations in patterns regarding the offensive game and an evolution of the sport that they always stayed ahead of. The Patriots dynasty emerged during the pocket passer sublimation period (Peyton Manning) and ended up surviving in a last dance at the dawn of the Mahomes of life. In a quarterback-centric league, Brady won rings by throwing 4 touchdown passes in the final and 0 touchdown passes in the final. Brady lifted Lombardi, throwing for 466 yards and passing for 145. Last week, Josh Allen and Mahomes They combined for 304 passing yards, one throwing touchdown, and 34 rushing yards (and two rushing touchdowns). Numbers that, if they had been signed by either of the two alone, would not be in the top 10 of best performances by both in the playoffs. This says a lot more about the teams that train Andy Reid and Sean McDermott that of the two quarterbacks, who in addition to their historical talent, have now mastered the craft of winning football games no matter how, always knowing what the team needs. Mahomes has been at it for two seasons. Allen, with the best support of his career, has understood it this season. The Chiefs and the Bills played two games as perfect as we can imagine in terms of the NFL It is known as situational football. The two AFC finalists had 0 turnovers and only five penalties between them for 39 yards. The Chiefs have gone 8 consecutive games without a turnover, an all-time NFL record. buffalo It is the team with the best average turnover ratio in the league (+1.4). Kansas is in the top 10 and also with a positive ratio. In the last eight games, the Chiefs They have caused 11 turnovers and have not committed any. Bill Belichick, the best coach in history, always used to repeat that the first step to winning a game in the NFL is not losing it. All in all, McDermott and Spagnoulo’s (defensive coordinator) game plans for Sunday night will begin and almost end with containing the Chiefs’ No. 15 and the Chiefs’ No. 17. Bills. At this point in life, confusing them with extracurricular coverage is practically impossible. His level of anticipation, reading and composure even surpasses his physical ability. Both Allen and Mahomes are two of the quarterbacks who penalize the blitz the most. Their ability to execute quickly is incredible and so is the escapism they display. But both defensive playcallers will have to do it and take the risks. The Chiefs are the fourth team that has launched the most blitzes this season in the NFL (31.7%) and are the fifth team that has achieved the highest percentage of successful pressures (26.1%). In the divisional round they recorded eight sacks and more than half of the dropbacks put pressure on CJ Stround. On 12 of 17 blitzes, they were successful in generating pressure. Buffalo also took its chances against Lamar Jackson despite being one of the teams that least sends extra men to bother the passer. The sixth-fewest team in 2024 (19.1%) went for Lamar on 48% of pass plays, the fifth-most in the NBA era. McDermott as a coach, and the most since November 2021. The success in these calculated risk actions was key, since they had a 60% success rate in generating pressure, well above the 25% they achieved when they only sent the four men on the defensive line. On Sunday night all the focus will be on Mahomes and Allen. For the first time in their careers, their teams can surely win a game if these two men, who have already secured their presence in the Hall of Famethey sign a stat line from a random Trent Dilfer. Or they can even win with the line Tom Brady had in his first and last Super Bowl. It’s cool that these guys can be Superman, but it’s still unfair to always ask for it. Even Patrick.

Christopher Nolan signs a Marvel star for ‘The Odyssey’

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The Odyssey (The Odyssey) will be the new movie Christopher Nolan. The Oscar-winning director will tackle an epic project that is very different from his previous titles with the firm intention of offering a new unparalleled show. The British takes on one of the most important fables in the history of humanity. And for this they have just signed a new star who comes from the Marvel Cinematic Universe. As reported deadlineChristopher Nolan adds to Jon Bernthal to The Odyssey. The actor is known worldwide for his sensational The Punisher. The character debuted in the series Daredevil from Netflix, but it was so popular that it had its own project shortly after with two more than adequate seasons. Now, he’s about to return in the new series Daredevil: Born Again. Outside of Marvel, Jon Bernthal He has a successful filmography. Highlights his supporting role in the multi-award-winning series The Bearwhich in 2024 earned him the Emmy for Best Guest Actor in a Comedy Series. Also appeared in The Walking Dead giving life to Shane Walsh. Not to mention movies like The Wolf of Wall Street, Fury either Hitman. Without a doubt, Christopher Nolan has acquired one of the most consistent and talented actors on the current scene. Cast and release date The Odyssey With the signing of Jon Bernthal, Christopher Nolan continues to expand a cast of absolute luxury for The Odyssey. In the movie they will be Matt Damon, Tom Holland, Zendaya, Robert Pattinson, Anne Hathaway, Lupita Nyong’o and Charlize Theron. All of them will give life to the journey of Odysseuswritten by Homer in the 8th century BC The story tells of the journey back home to the king of Ithaca. A journey across the seas that lasted ten long years after the Trojan War. On his way, the hero must face numerous obstacles that the gods put in front of him, overcoming them thanks to his incredible bravery and cunning. Furthermore, at home, his wife Penelope and his son Telemachus They must face her constant suitors, since the king is believed to be dead. The Odyssey will be released in theaters on July 17, 2026 and will be the most expensive film of his career Christopher Nolan. The film will begin filming next month. It is known that they will use revolutionary IMAX technology with which the director aspires to go a new step further. The project will be produced by Universal Pictures, as well as Oppenheimer.

Today’s horoscope for Gemini for January 23, 2025

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Everything indicates that you will take key steps in your daily life, optimizing your performance and strengthening your professional position. With your constant effort, disciplined approach, and the support of influential figures who value your work, a promotion is close at hand. Love horoscope for Gemini You want an easy life and you make compromises with your partner, giving rise to their desires. However, by doing that, you forget some of your own needs that you don’t like to do. There comes a time when instead of suffering resentment, you make a stop, which ends up benefiting the relationship. Money horoscope for Gemini Don’t waste your time on small projects. Your business instincts are well-honed today, so use them to focus on what’s important. Make the investments you need and the benefits will soon come to you. Buy yourself something, because these favorable circumstances are truly something to celebrate. Sex horoscope for Gemini Lots of action indicates that your lover is crazy about your passionate lovemaking and is regularly being taken to the heights of ecstasy. He will show his appreciation by responding with intense desire. It’s an even greater reward for your lover to know that he or she won’t always have to make the first move.

A UK nuclear submarine caught a Russian ship in front of the nation’s undersea cables. It’s the second time in three months

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If yesterday Taiwan was the nation that suffered a new cut of submarine cablestoday the tension moves to Europe, to be more exact, to British waters. A few hours ago it was known, through the UK governmentabout events that occurred last fall with a mysterious Russian ship called Yantar. The problem is that it has reappeared in the vicinity of the nation’s underwater communication channels, and this time it has been “escorted” by a Royal Navy nuclear submarine. Recent raids. The UK has raised its voice about what appears to be a growing threat of aggression from Russia following the recent Yantar spy ship raid in British waters for the second time in just three months, which has been interpreted as an attempt by the Kremlin to evaluate the country’s defense capabilities. According to British Defense Secretary John Healey, a nuclear submarine and two Royal Navy ships were deployed for two days to monitor the activity of the Yantar, described as a vessel designed for intelligence gathering and mapping of critical underwater infrastructureincluding telecommunications and power cables connecting the UK to mainland Europe. This incursion, furthermore, occurs in that context of growing concern over the security of key infrastructure in Europe that we have been talking about, and at a time when Western intelligence services have warned about Russia’s intention to use sabotage as a tool of pressure after the war in Ukraine. The Yantar and its history. The Yantar had previously been detected in November 2024when it was observed to remain over areas of strategic submarine infrastructure of the United Kingdom. On that occasion, Healey authorized a Royal Navy nuclear submarine to surface near the Russian ship, sending a clear message that its movements were being closely monitored. During the raid, The Yantar was also escorted by the Russian frigate Admiral Golovko and the tanker Vyazmawho left the area after the British response. Russian ship capabilities. The Yantar, operated by the Main Directorate of Deep Sea Research of the Russian Navy and “officially” a project 22010 oceanographic research vessel, is a ship specifically designed for the collection of information on underwater infrastructure. It is equipped with autonomous submersibles capable of operating at depths of up to 5,500 metersallowing you to identify, map and even manipulate submarine cables essential for Europe’s connectivity and energy supply. In this regard, and although its capabilities could allow acts of sabotage, security experts, such as Justin Crump of the intelligence firm Sibylline, point out that the main purpose of the vessel appears to be aimed at collecting sensitive information for future strategic operations, rather than direct action. Concern about Russian sabotage. There is no doubt that Yantar’s activities have generated concern in the United Kingdom and throughout Europe, especially after recent incidents in the Baltic Sea, where underwater energy and telecommunications cables were found cut in what have been suspected to be deliberate acts. of sabotage, unconfirmed acts and that, as we told yesterdayofficial investigations point to other types of problems derived from inexperience. Be that as it may, what is certain is that NATO has responded by intensifying its presence in the region with operation Baltic Sentrydeploying warships, air patrols and drones to protect critical underwater infrastructure. What the United Kingdom says. After what happened for the second time, the British Defense Secretary has emphasized that Russia represents the most immediate and significant threat to the United Kingdomand has reiterated the country’s commitment to taking firm measures to protect its national security. As part of this strategy, Royal Navy rules of engagement have been updated to allow closer monitoring of Russian vessels suspected of hostile activities. In fact, the most recent incursion of the Yantar into British waters caused HMS Somerset and HMS Tyne will escort the Russian ship until its departure for Dutch watersensuring that he did not remain in the area for prolonged periods. What does seem crystal clear is that the return of the Yantaring into British waters highlights the growing Russian threat to the UK’s critical infrastructure and the need for constant surveillance and a determined response. Image | Royal Navy In Xataka | The investigations into the cut submarine cables in the Baltic have taken a turn: it was not Russia, it was inexperience In Xataka | If China once again displays itself against Taiwan in the next two years, it will find a surprise: the US army

We are wrong about the origin of sunburn

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We all know that if we spend a lot of time exposed to the sun without protection we will burn The skin becomes red, hot and inflamed and hurts with a simple touch. Then it peels off and for days we can barely touch each other. That’s clear, we don’t need science to explain it to us because practically all of us have experienced it at some point. However, we were wrong about the origin of those sunburn. We have always thought it was due to DNA damage. That’s what the textbooks say. Now, however, an international team of scientists has shown that, in reality, they are the RNA damage those that give rise to that unpleasant effect. These researchers, coming from the University of Copenhagen and Nanyang Technological Universityin Singapore, they carried out their experiments both in mice as in human skin cell cultures. This is very important, since not everything that is studied in mice can be extrapolated to humans, but cell cultures can help understand the effects on our species. With both types of experiments they observed that the response to RNA damage is much faster. At least, it is the one that seems to be closely related to sunburn. It may seem that this does not give us any interesting information. What does it matter if it’s DNA or RNA? Sunburns hurt just the same! And yes, that’s true, but this seemingly trivial fact It can help us a lot in the future. DNA or RNA? DNA is the instruction book of an organism. It contains all the information about who we are and what we need to stay alive. Our DNA contains the instructions to synthesize insulin when glucose builds up in the blood or to help us sleep through melatonin when night falls. They also include data about the color of our eyes or the way our hair grows. Everything we are is in DNA. All our cells have the same DNA, but not all DNA is used in all cells. For example, the gene with the instructions to synthesize insulin is in the cells of the eye, but it is not necessary there. It will never be used. Yes, it is necessary in the cells of the pancreas, since it is the organ that is responsible for synthesizing it. It is used there. This use of a specific gene is what is known as gene expression. The gene turns on where and when it is needed. In this case, in the cells of the pancreas (where), when glucose accumulates in the blood (when). Differences between DNA and RNA. Credit: Sponk (Wikimedia Commons) We already know what DNA is. Something more or less immutable. It can undergo mutations, but it remains more or less fixed throughout our lives. On the other side we have RNA. This is another nucleic acid. DNA is deoxyribonucleic acid and RNA is ribonucleic acid. It differs in the presence of a different sugar within the molecule: ribose In the case of RNA and deoxyribose in the case of DNA. There are many types of RNA: transfer RNA, ribosomal RNA, messenger RNA… Each one has a function, but in this case we are going to focus on the messenger, since it is the one mentioned in the study of sunburn. We have already seen that DNA is used only when and where it is necessary. This use consists of using the information contained in a gene to build a protein, which will carry out the desired function. These proteins are synthesized in cellular organelles called ribosomes. But there is a problem. Ribosomes are unable to read DNA. said very roughly speaking, It is a language they do not understand. They understand the language of messenger RNA. Therefore, when a gene is to be expressed, its information is transcribed into messenger RNA. Like when we translated a page from an instruction book that was in English into Spanish so that our grandmother knew how to use the washing machine. That is the function of messenger RNA. With this well learned, we can move on to the next thing. What does all this have to do with sunburn? Sunburn is caused by exposure to the Sun’s radiation. Specifically, ultraviolet raysespecially type B (UVB). This generates DNA damage, it is totally true. In fact, these DNA damages can accumulate and eventually lead to a melanoma. None of that has changed. However, we usually think that sunburns are that first warning that DNA has been damaged and, in reality, it turns out that it has not. It is the messenger RNA the one who gets upset. How UVB affects ZAK signaling pathways to cause sunburn symptoms. (Lind et al., Molecular Cell, 2025) After reading the literature and carrying out several experiments, the authors of the study that has just been published thought that sunburn could be related to a protein called ZAK-alpha. This is involved in the response to something known as ribotoxic stress. That is, when a failure is detected in the messenger RNA, this protein starts the immune system to attack the cells in which this damage is found, so that the altered messenger RNA not translated on the ribosome. If that happened, you would get failed proteins and could be dangerous. This immune system response also launches an inflammatory response. The skin turns red, becomes hot, swells… What does it sound like to you? Indeed, sunburn! This entire cascade of reactions to ultraviolet radiation was detected in human skin cell cultures. But what would happen in a living organism? The scientists tried to genetically modify a group of mice so that the gene with the instructions for synthesizing the ZAK-alpha protein was not present. If there was no ZAK alpha, when the mice were exposed to ultraviolet B radiation They did not experience burns. On the other hand, with ZAK-alpha intact they did. What is the use of knowing all this? The authors of the research believe that this new … Read more

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