capable

non-alcoholic beer capable of getting drunk

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Friday. Eight in the afternoon. You are on a terrace in the center with your friends and you want to have a drink a couple of rods (maybe a couple of cupping) to take advantage of the sun of a retreating summer, but the mere idea of the Hangover of the next morning and having alcohol ruin a good part of your weekend puts you back, so you end up ordering a ‘without’ beer. Another one. But… What if there was an IPA or a ‘without’ liquor capable of giving you a touch of euphoria and disinhibition, all without a single drop of alcohol, hangovers or the risk of ending up developing an addiction? That is the curious promise that a British laboratory has launched. What has happened? That at a delicate moment for the alcohol industry, marked by the demand drop in key markets, a generational change clear in the consumption of drinks and a growing interest For ‘without’ beers or wines, there are those who already want to go several steps further and reach the ‘holy grail’ of the drink. Which? Neither more nor less than squaring the circle: liquors and beers that are alcohol-free but capable of intoxicating. Or at least to give those who consume them that point of disinhibition and euphoria that is sought in the bottles. Who is behind? The key name in that race is David Nutta neuroscientist with extensive research experience who has spent decades exploring how drugs, addiction and anxiety affect the brain. Nutt recognize that the drink offers certain advantages on a social level, but hopes that people can enjoy their drinks in a safer and healthier way, avoiding risks such as addiction, cirrhosis or aggressive behavior. Convinced that it can be achieved, years ago he co-founded GABA Labsa firm that starts from an ambitious promise: “Give social drinkers what they want from alcohol without the alcohol.” The team is working to bring a patented molecule called Alcarellean odorless, tasteless, colorless compound that acts as “an ingredient designed to promote socialization and relaxation.” Its purpose, clarify from Bloomberg, is to amplify the effects of gamma-aminobutyric acid, a neurotransmitter that transmits chemical messages to nerve cells to tell the brain to relax. The company has also proposed another ambitious goal: that your creation surpasses traditional alcohol without being addictive. Not only that. In the interviews that Nutt usually talks about effects similar to those of spirits without the hangover the next day. And how are they doing? In your website GABA Labs specifies that its goal is for Alcarelle and derived products to be available in the US starting in 2028, although in an interview granted a few months ago to Bloomberg Nutt confessed that he hopes the compound will be commercially available before the end of 2027. Last January Independent influenced on the same schedule: the idea is that Alcarelle completes its FDA tests this year and can be exploited in 2027. Since it was founded almost a decade ago, GABA Lab has been searching for molecules capable of acting on GABA receptors of the brain to achieve the desired results (and avoid the unwanted ones), which has led them to develop dozens of different options. “It’s about testing and refining,” the scientist acknowledges. Right now the laboratory has three ‘finalist’ molecules and hopes to soon opt for the most promising to advance its research and development. Your work is already generating a huge expectation. Statista chart. Have they released anything yet? Yes. To check the results of GABA you won’t have to wait that long. In 2021, the company launched a drink in small quantities in the United Kingdom and some time later in the United States. Your name: I felt. The brew does not include still the molecule that GABA is pursuing, but it is made with natural ingredients that aim to offer a preview of Nutt’s plans. Its creators they present it as an alternative for customers “tired of choosing between alcohol or non-alcoholic who are looking for a functional beverage that enhances their social connection.” A different ‘without’ beer? That’s the latest promise from the Nutt team. In 2025 the EFE agency echoed of the launch of a ‘without’ beer capable of generating in those who drink it a disinhibition similar to that of the traditional drink. Your business name: Gabyr. “It provides the same effects that people look for in a drink, relaxation, sociability, but with a much lower impact than alcohol,” claims the co-founder of the laboratory from Hemel Hempsetad, on the outskirts of London, which is where the drink is manufactured, according to the agency. The team is also already working on a whiskey and a wine. Why is it important? For several reasons. First, because of what it promises. Although at the moment it is basically about that (promises and declarations of intent), in your interviews Nutt insists that his goal is ambitious: he is pursuing a range of ‘without’ drinks that offer what many social drinkers look for in their drinks: disinhibition and a touch of euphoria. Everything, he insists, with an alternative not addictive neither hangovers. It is drunk and in theory the effects arrive after 20 minutes. That of course leaves some interesting questions raised in different areas. How to deal with it at a regulatory level? How would it influence driving? And how could authorities monitor its use? with breathalyzers? Does it have side effects? In an interview with BloombergKenneth Sher, a professor at the University of Missouri, admits that it is difficult for him to imagine a substitute for alcohol “based exclusively on GABA.” Another academic, Jim Cook, is also wary of possible side effects, such as drowsiness or memory loss. Is there more? Yes. Behind Nutt’s proposal there is more than just scientific interest. The lucrative alcohol industry has experienced important changes over the last decades, and although the trend it’s not the same (not even equally intense) in all markets, there are certain patterns … Read more

A simple router is a machine capable of identifying humans with almost 100% accuracy. Or so these researchers say

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Using WiFi networks as a technology to track people is a twist in the script that not all of us saw coming. He Karlsruher Institute for Technologyone of the strongest research institutions in Germany, assures close to 100% accuracy when recognizing people without any type of camera and using it. What exactly happened. The KIT (Karlsruhe Institute of Technology) team published a paper with a promising headline: “Ordinary WiFi can identify people with almost perfect accuracy”. And this is achieved thanks to something that routers have been doing for recent years: beamforming feedback information. How the hell does this work?. To understand what it is about beamforming You must first understand how the devices emit signals. routers. In their first generations, routers emitted in all directions, just like a light bulb emits light in that way. With the most modern versions of WiFi, the way the signal is transmitted has improved. Routers began to concentrate the signal towards where the receiving device is, like a flashlight instead of a light bulb. Beanformig. That is called beamformingto form a concentrated beam and received by another device. But to aim well, the router needs to know where to point, and it is the connected devices themselves—your cell phone, your laptop—that send that information to the router continuously. Basically, they are constantly telling the router “hey, I’m here.” That message is the BFI, beamforming feedback information. And what is this for?. Now you know that your router sends information to your gadgets and that your gadgets send information to the router. When the devices send information to the router, they describe how the signal arrives, and interference along the way is recorded. Among them, human beings. Our body partially absorbs WiFi waves, reflects them, deflects them and alters how they reach the mobile phone or router. The researchers used that signal data to train models of artificial intelligencein order to detect patterns that would allow humans to be detected. They fed the system with thousands of examples associated with different people until the model learned to detect those wave changes associated with human presence. The system is not capable of visually recognizing anything in the environment, but it manages to have information about when a human is present in the environment. The caution. According to the researchers, “this technology turns each router into a potential means of surveillance.” “If you regularly pass by a café that operates a WiFi network, you could be identified there without realizing it and be recognized later, for example, by public authorities or companies.” The reality? It would be necessary for cybercriminals to develop a system identical or similar to that of the KIT to achieve a human video surveillance system through WiFi signals. The nuance. Under laboratory conditions, with 197 participants and in controlled environments, the system was close to 100% accuracy. But in the real world, it would be necessary to train a new model with data from hundreds of people in different spaces. The model is not a ready-to-deploy technology or a real threat – nor is it intended to be applied – but the research reveals how simple a priori data sets can be trained as a surveillance tool. In Xataka | There is a booming job in the era of artificial intelligence: cybersecurity expert

The United Kingdom has a laser capable of shooting down drones flying at 650 km/h. And each shot is the same as two beers.

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For some time now, armies have pursued an idea: weapons that fire energy instead of projectiles. Already in the Cold War was experienced with systems capable of concentrating heat at a distance, although technical limitations relegated them to tests and prototypes for years. Today, with advances in electrical generation and beam control, that ambition has begun to emerge from the laboratory, although it still entailed challenges that for a long time seemed impossible to solve. The UK seems to have solved the most important one. From the laboratory to real combat. He DragonFire program marks a turning point in the evolution of directed energy weapons, and it does so by going from technological demonstrator to embedded operating system. The United Kingdom has decided to accelerate its deployment until 2027integrating it into Type 45 destroyers and becoming the first European country from NATO in deploying a functional naval laser. There is no doubt, the movement is not only technological, but also doctrinal, because it implies changing the way in which air defense at sea is conceived, integrating new layers that do not depend on traditional ammunition. Two beers for the price of a shot. The key element of DragonFire is not only its accuracy, but rather its economy. Each shot costs just about 10 pounds (just over 11 euros) in electricity, just a couple of “pints” in a pub compared to the hundreds of thousands that a conventional interceptor missile can cost, which completely alters the balance between attack and defense. we had seen it in Ukraine and now in Iran. In a scenario where cheap drones are launched by the dozens or hundreds, responding with expensive missiles had become unsustainable, while a laser allows the pace to be maintained. without depleting critical resources. This difference makes the laser an especially attractive tool in modern conflicts where saturation is more important than sophistication. Extreme precision and new capabilities. The system has proven capable of hitting targets the size of a coin a kilometer away, maintaining the beam on moving targets until causing structural failure. More: its architecture combines multiple fiber lasers in a single high-quality beam, guided by electro-optical sensors and continuous tracking systems. Furthermore, its sustained firing capability eliminates one of the main limitations of conventional weapons: need to rechargeallowing you to take on multiple threats consecutively in a matter of seconds. The response to swarms. The rise of cheap drones and swarm attacks has put in check to traditional defense systems, designed to intercept more limited and higher value threats. DragonFire positions itself as the direct response to that change, offering an effective solution against small, fast and numerous targets without compromising missile arsenals intended for strategic threats. In this context, the laser does not replace existing systems, but rather complements themreinforcing short-range defense and freeing up resources for more complex scenarios. From sea to air and land. Beyond its naval deployment, the program aims for broader integration in ground and aerial platformswhich infers a structural change in modern weaponry. Let us think that the possibility of standardizing this type of technology in vehicles, ships or even combat fighters opens the door to a new generation of systems where energy progressively replaces to physical ammunition. Analysts recalled by Army Recognition that although there are still limitations (such as the need for line of sight, electrical power and thermal management), the advancement of DragonFire indicates that that concept before fantastic of “infinite ammunition” has ceased to be a theoretical idea and has become an operational reality in development. Image | UK Ministry of Defense In Xataka | Spain has built a laser that shields the backbone of its Navy: the A400M is now ready for combat In Xataka | China has achieved something hard to believe: reducing the production of laser weapons and parts for electric cars to one second

an interoceanic corridor capable of connecting the Pacific with the Atlantic in seven hours

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If you are in the Atlantic and want to reach the Pacific (or vice versa), the only viable option from the point of view of time and distance is pay the fee and cross the 80 kilometers of the Panama Canal. The options of surrounding the northern or southern part of the continent are directly unfeasible, whether due to distance, climate, geopolitics or danger. But Panama is not the only country that has a privileged location from a logistical point of view: there is Colombia, Costa Rica, Honduras, Guatemala, Nicaragua or Mexico. In fact, a few years ago Nicaragua already tried his own channel without success. Now it is Mexico that has put an ambitious project on the table: the Interoceanic Corridor of the Isthmus of Tehuantepec (CIIT). Of course, it is not an artificial waterway that unites the two oceans, but rather a combination of ports and railways to connect both coasts of the North American country. A “dry canal”. The Interoceanic Corridor of the Isthmus of Tehuantepec is a multimodal infrastructure project that combines three railway lines, which exceed 1,200 kilometers of tracks (including branches) with two ports, the from Coatzacoalcos (Veracruz) and Salina Cruz (Oaxaca). The idea of ​​passage is the following: the containers disembark at a port, cross the territory by train and are re-embarked on the other side, all of this in less than seven hours. Your goal is transport 1.4 million containers a year. The three railway lines of the Interoceanic Corridor of the Isthmus of Tehuantepec Why is it important. The Mexican government itself refers This project is considered to be of great importance for the economic development of the country for three reasons: the improvement of its railway and port infrastructure, promoting the transfer of goods and also becoming a competitor to the Panama Canal. It will be especially interesting for those boats that do not fit in the canal, such as post-Panamax and Ultra Large ships. The corridor is also a blessing for the nearshoring at a time when the American market (and its president) is inviting companies to leave China in favor of localizations closer ones like Mexico: being able to move goods from the Pacific to the Atlantic and vice versa is a real boost. Finally, this infrastructure will contribute to the development of the region: crosses 79 municipalities46 from Oaxaca and 33 from Veracruz. The infrastructure, in detail. The system is articulated in three axes: Line Z, from Coatzacoalcos to Salina Cruz, 214 km. The FA Line, from Coatzacoalcos to Palenque, 308 km. Line K, from Ixtepec to Ciudad Hidalgo, 476 km. As for ports, although Coatzacoalcos on the Atlantic and Salina Cruz on the Pacific are the main nodes, Dos Bocas and Puerto Chiapas are complementary. Furthermore, it carries the industrial impulse under its arm: the project includes the construction of 14 industrial parks along the corridor forming different clusters. The government provides logistics infrastructure and access to suppliesthus tax benefits to promote companies to establish themselves. The roadmap. The Government of Mexico formalized the CIIT roadmap for the period 2025–2030. Regarding the railway lines, the Z has been operating since December 2023, the FA line since September 2024 and the one that is still under construction is the K line. However, its completion is planned by June 2026. As for the ports, the project contemplates the modernization of all of them to reinforce their capacity and increase their depth, essential to allow the docking of larger and more ships. The objective of the Mexican government is that the Corridor operate at 100% by mid-2026. Bottom line: In theory, it’s just around the corner. Yes, but. The real success of the Corridor depends on the railways, ports, roads and industrial parks functioning as a single perfectly assembled and optimized system. At the moment, ports, trains and industrial estates are going at different paces. Currently, the Corridor is partially operational and the difference between installed capacity and real demand is abysmal: according to the 2024 Railway Statistical Yearbook of the Railway Transport Regulatory Agencythe railroad moved 111,000 tons of agricultural cargo and 1,000 tons of industrial cargo, well below what is expected for a competitor to the Panama Canal. In addition, it has handicaps compared to its neighbor’s structure: having to unload, load into a wagon and reload is a structural disadvantage compared to a direct transfer. The project brings with it challenges such as environmental threats not only derived from the seismic conditions of the Isthmus and high rainfall, but also the risk of deforestation, endangered species or water stress derived from industrial activity. Finally, insecurity and the lack of qualified labor can also cause a dent in its real impact in Mexico. In Xataka | Saudi Arabia’s impossible bridge to join Africa and Asia: a 32-kilometer megastructure over the Red Sea In Xataka | The Mayan Train has become a nightmare for Mexico: what seemed like a great plan has run into justice Cover | face islam and Alex Pagliuca

It is capable of compressing space and time

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15 meters deep, in a basement of Zhejiang University, China has installed a machine the size of a building capable of doing something hitherto impossible for a laboratory: reproducing in hours what nature takes centuries to build. Or destroy. Its name is CHIEF1900 and it can rotate at extreme speeds or generate a gravitational force a thousand times greater than that of the Earth, which for example serves to simulate an earthquake and its effects. Context. For a geology professional, analyzing a portion of land means deciphering the history of the planet in layers: each stratum is a record of millions of years. The problem is that nature writes it slowly. Reproducing this phenomenon in a laboratory has been one of the great challenges of experimental physics for decades. Hypergravity centrifuges are the tool that comes closest to that goal. These machines are capable of rotating at extreme speeds, generating forces hundreds or thousands of times greater than Earth’s gravity. When rotating, the arms generate outward pressure on everything inside the machine. The faster it is, the greater the force. The result is a controlled hypergravity field that compresses time and distance. What China has achieved. Zhejiang University (Hangzhou) has completed the construction of the most powerful hypergravity centrifuge in the world: it will have a total capacity of 1,900g·ton, that is, it can apply 1,900G to a one-tonne sample. The CHIEF1900 will surpass the record that China had established a few months before (September 2025), with the CHIEF1300. This power makes it possible to replicate land deformations on a kilometer scale, simulate the transport of pollutants over millennia, evaluate the resistance of a dam to an earthquake or generate thousands of new material samples. As a reference, with the CHIEF1300 they have already been able to reproduce the pressure of the seabed at a depth of 2,000 meters to evaluate the extraction of methane hydrates, or simulate how a 20-meter tsunami affects the seabed. Why is it important. To natural disasters such as earthquakes or tsunamis we have to add other consequences of human activity such as the breaking of dams, contamination of aquifers or deformation of the soil under high-speed infrastructure or the melting of glaciers. Predicting how these phenomena will behave requires information that is not available since obtaining them in real conditions is either impossible or would take decades. Dan Wilson, deputy director of the Center for Geotechnical Modeling at the University of California, explains for Popular Mechanics that this will be one of the four largest dynamic centrifuges in the world, that is, it can simulate active earthquakes using hypergravity. Chen Yunmin, chief scientist of the project, sums it up accurately: It aims to create experimental environments spanning from milliseconds to tens of thousands of years, and from the atomic to the kilometer scale. How they have done it. To build a machine with such performance, Zhejiang University brought together a multidisciplinary team that brings together personnel specialized in civil engineering, thermodynamics or automation. Among the technical challenges they faced was heat: at high rotation speeds, the centrifuge reaches such temperatures that the stability of the system is compromised. The solution was a cooling system that combines vacuum, forced ventilation and glacial coolant. The fact that the installation is buried has an explanation: it minimizes external vibrations, which could contaminate the experiments to be carried out. Pending subjects. Although the installation dates back to the end of 2025 and Popular Mechanics mentions which is already operational, no scientific results from CHIEF1900 are yet available. At an operational level, these scale models reproduce the loads well but not always all the size effects: certain material behaviors do not scale linearly under hypergravity, which requires caution in the interpretation of results. To minimize this risk, it is common for the data obtained to be compared with that of other similar facilities around the world. In Xataka | China has taken a silent step in the new space race: the world’s first system to measure time on the Moon In Xataka | It’s not a telescope, it’s a time machine: what James Webb reveals to us about “deep space” Cover | Peter Herrmann and Arthur Wang Xinhua

The US is launching a missile capable of burying the Tomahawk on Iran. And the big question is where are you doing it from?

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The image of an American precision strike has been linked to silhouettes taking off from the sea or from the air. However, in recent years the Army has invested billions in recovering a capability that seemed secondary: hitting very, very far… from the mainland. In that bet may lie one of the greatest transformations of modern military power. A debut that changes theater. USA has premiered in combat the so-called Precision Strike Missileits new tactical ballistic missile, within the operation against Iran. It is not a minor evolution of the former ATACMSit is rather a leap in scope and concept. With more than 500 kilometers radius (and room to grow towards 650 and even 1,000) practically doubles the depth of ground fire available until now. As in many other “premieres”, it is not symbolic, it is doctrinal. A missile to bury the Tomahawk. The PrSM flies at speeds greater than Mach 3 in the terminal phase, allowing it to arrive earlier and better penetrate hardened targets. Forehead to Tomahawkslower and subsonic, the new system greatly reduces the enemy’s reaction time and complicates interception. Additionally, two missiles fit in a single HIMARS launcher pod, meaning that double the punch per vehicle. Of course, it does not replace the Tomahawk in strategic range, but in regional scenarios it can be left in the background due to speed, survivability and response capacity against time-sensitive targets. A PrSM capsule seen in front of a US Army M142 during an exercise in Australia. The M142 carries a 227 mm rocket with six projectiles. The Persian Gulf as a platform. At this point, geography explains a good part of the movement. The Gulf has a medium width of just 250 kilometerswith American allies aligned on the western bank and Iran occupying the eastern one. With a range of 500 kilometers, a land battery located anywhere on the Arab side can cover wide swathes from Iranian territory without the need to penetrate its airspace. That makes the missile a perfect tool to support an air campaign without exposing fighters or depending exclusively on ships. A test launch of a PrSM The key question: from where? The most decisive fact remains unknown. No has been confirmed Which Gulf country has authorized the use of its soil to launch these missiles. This mystery is not technical, it is rather political. The reason? Allowing a US land battery to fire on Iran automatically makes that territory in possible objective of retaliation. Many States in the region have historically preferred discreetly support to Washington while avoiding public exposure. Put another way, the exact location of the launch determines what capital takes on the direct risk. Hunting sensitive targets. Short-range ballistic missiles are especially effective against radars, mobile launchers and air defense nodes. Plus: they can be maintained on permanent alert and strike within minutes when a target arises. In a conflict where neutralizing anti-aircraft systems is key to sustaining air superiority, the PrSM provides a ground suppression capability which until now relied heavily on aviation and naval missiles. Beyond Iran. If you also want the premiere of the PrSM send a signal to other scenarios, especially the Pacific. Its planned evolution includes anti-ship versions capable of attacking moving targets and variants with greater range that will touch the threshold of medium-range missiles. It we have counted before. The US Army wants regain prominence in long-range warfare, traditionally dominated by the Air Force and Navy. Iran, in that sense, has been the first real test bed. Cost, volume and future. It is the “but” of any ballistic missile. Each projectile can exceed a million and a half dollars, although the price has been dropping as production increases. The goal is to reach up to 400 units annuallywhich will expand the available inventory and facilitate its sustained use. With future versions that could exceed the 1,000 kilometers rangethe PrSM does not seem just a substitute for the ATACMS. It is the first stone of a terrestrial architecture that seeks to project deep power from solid ground. What is really at stake. In short, the real twist is not that the United States has launched a new missile in a war, but that it has from the ground and against Iran. If he Tomahawk has symbolized precision warfare from the sea, the PrSM aims to represent the return of the tactical ballistic missile as a flexible instrument of regional pressure. And while it is not known with certainty from what ground ally is taking off, the political dimension of that launch will continue to be as relevant as the technical one. Image | CENTCOM, Australian Army, US Army In Xataka | If the question is how much of Europe is within range of Iran’s missiles, the answer is simple: a fairly large In Xataka | The arrival of the B-2s to Iran can only mean one thing: the search for the greatest threat to the United States has begun

RAM memory already represents 35% of the cost of a PC. The only solution that HP finds: capable equipment

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The PC industry – like many others – is facing a perfect storm that is completely altering manufacturing costs. As revealed by Karen Parkhill, CFO of HP, RAM memory has increased its prices so much that its specific weight in the cost of a PC is now almost unsustainable. Bad business. 35% of what your PC costs you is RAM. According to the directive, RAM memory has gone from representing an acceptable 15–18% of the bill of materials for your PCs and laptops to representing a suffocating 35%. The change is drastic, and has occurred in just one fiscal quarter. Things will get worse. This increase is due to the fact that according to HP, memory costs have doubled sequentially and have grown by 100% in a few months. Not only that: the company’s forecast is pessimistic, and they expect prices to rise as 2026 progresses. From more expensive PCs… The direct consequence for users is inevitable: the prices of PCs and laptops are going to rise. Analysts are already warning of increases of between 15% and 20% in the RRP of these devices, and in fact HP has already begun to make changes to its price tags precisely to protect its profit margins in the face of the massive increase in the price of critical components such as DRAM memory and NAND chips in SSD units. …to capable PCs. But the price is not the only thing that will change. To keep the equipment “affordable”, HP is adopting another strategy that we had already seen in mobile phones: that of “cut specifications.” This means that we will see more low- and mid-range configurations with less RAM than one would expect in 2026. The measure is clearly intended to save costs at the sacrifice of performance. At the moment they are saving the ballot. At HP they are diversifying their suppliers and cutting back on specifications and extras to compensate for the extra cost of chips. The company is even using AI systems to optimize its planning processes and has halved the time it takes to qualify new materials for agile component changes. The demand for HP PCs is still there: its personal systems division grew 11% in revenue. The company warns, however, that this trend could fall: high prices could cause sales to slow down. Damn data centers. The big culprit of everything is AI, of course, which is causing most of the production of DRAM memory chips and NAND chips to be destined for the AI ​​accelerators of NVIDIA and other manufacturers and, of course, for the gigantic data centers that are being planned everywhere. In addition, the industry is focusing on HBM memories, which are much more powerful for AI applications but which cause the production of “traditional” memories to suffer. Hello, 8 GB of RAM in 2026. For many years it seemed that 8 GB of RAM had become the de facto standard in our laptops and many PCs, but a couple of years ago we clearly made the leap to 16 GB. This crisis threatens to take us back to the past and see many “affordable” computers with 8 GB of RAM. Can we survive with this memory? Most likely yes… if our use of the equipment is relatively modest. The 16 GB really helps a lot now that we have become accustomed to opening a lot of browser tabs and applications in an era where these consume more and more memory. 8 GB seemed like a thing of the past, but we fear that we will have to learn to live with that type of configuration again. In Xataka | If you were thinking about setting up a NAS to create your own cloud, we have bad news: AI has other plans

There are people capable of testing positive in a breathalyzer test without having drunk a drop of alcohol. And we already know why

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Although it may seem crazy, failing a breathalyzer test after drinking only water and a plate of pasta is possible. And while explaining it that way to a police officer may raise questions about a poor excuse, The truth is that it is a medical reality for those who suffer from the known self-fermentation syndrome. The investigation. Until now we attributed this problem to yeast, but a team of researchers from UC San Diego and Massachusetts General Hospital has identified specific strains of Escherichia coli and Klebsiella pneumoniae as those responsible for generate intoxicating levels of ethanol in the intestineopening the door to treatments as surprising as fecal transplantation. That is, there are bacteria that can literally make us drunk without drinking a drop of alcohol. The metabolic storm. To reach this conclusion, the study analyzed to 22 patients diagnosed with this metabolic problem, comparing them with 21 healthy relatives. In this case, the results were quite compelling, because fecal samples from patients in the midst of the outbreak were capable of endogenously producing ethanol at alarming levels. In order to know much more, These samples were cultured and an ethanol concentration of up to 136 mg/dl was observed.. To put it in context, in many countries the legal limit for driving around 50 mg/dl in bloodso these patients without drinking would be doubling the level of alcohol permitted while driving. An alcohol factory. The novelty of this study is that it shifts the focus from yeast to bacteria, since genomic analyzes showed a massive enrichment of genes related to mixed acid fermentation. But we must not fall for the statement that these bacteria are ‘bad’, but rather that the ecosystem is broken to give rise to this problem. And what is the trigger? The antibiotics. And the use of these drugs can sweep away the balanced flora, allowing opportunistic pathogens to take control of the intestine and begin to metabolize sugars into alcohol. The treatment. Logically, this is a serious problem, not because of the fact of testing positive in the alcohol test, but because of the toxicity that the body faces. That is why the objective right now is on the treatment that now has the focus on a fecal microbiota transplant. For this study, the donor of his fecal microbiota was a personal trainer with enviable intestinal health. And the result was incredible, since the patient with this problem saw these problems disappear permanently, and his ability to “self-produce” alcohol disappeared after repopulating his intestine with the healthy bacteria of another person. Beyond getting drunk. As we have said before, it may seem ideal to have a feeling of intoxication without having to spend a single euro on a drink, but the reality is that this problem also leads to non-alcoholic fatty liver disease. And constantly producing alcohol can cause very serious liver damage. But on the social issue, this endogenous overproduction of ethanol has led people to lose their driving license or face labor problems unfairly. All for a problem that may seem like the perfect excuse, but is actually a major medical problem. Images | Lawrence Krowdeed In Xataka | There is an age at which we should stop drinking alcohol forever. Neuroscience is clear why

They have found a bacteria capable of increasing your risk

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We often think of the health of our mouth as something completely isolated that has no more significance than the odious cavities that we get. forced to go to the dentist or the bad breath. However, science has been warning for years that the mouth is the gateway to much more complex systems, such as the possibility that a bacteria from our gums travel to the breast tissue and may accelerate tumor growth. An unwanted traveler. The protagonist of this new discovery is the bacteria Fusobacterium nucleatum, an old acquaintance of dentists. We are talking about an opportunistic bacteria that thrives in dental plaque and is one of the main culprits of periodontitis, which is undoubtedly one of the most recognized gum diseases. What the team led by Dipalo Sharma has recently demonstrated is that this bacteria does not stay still on the gumsbut it has the ability to travel through the body to the breast tissue or even also is already linked to colon cancer. Its effect. The study In this case, he used mice to simulate two different scenarios in order to see how this very common bacteria behaved. The first of them was to inject the bacteria into the breasts of healthy mice, where precancerous inflammatory lesions began to be seen. In the case of injecting into existing tumors is where the alarms go off, since in these mice the presence of the bacteria tripled the size of the cancer and caused lung metastases in 100% of the cases observed. How he does it. It’s the million-dollar question: how does a bacteria from the mouth know that it has to go to the chest and how does it manage to do so much damage? Science has found an explanation at a molecular level that begins with inflammation of the gums in periodontal disease, since this causes the bacteria to enter the bloodstream. Once in the stream, the bacteria begins to travel and takes advantage of a very specific protein, called Fap2, which acts like a key that searches for a specific lock: a sugar called Gal-GalNAc, which turns out to be very abundant on the surface of breast cancer cells. Creating a shield. Once the bacteria adheres to the tissue thanks to this specificity, it begins to colonize, but it also has the ability to suppress the cells in charge of our defense. And specifically those that defend us from cancer cells that bypass the body’s checkpoints. Furthermore, it induces direct DNA damage and preferentially colonizes cells that have mutations in the BRCA1 gene, exacerbating the risk in genetically predisposed people. Dental hygiene. The result of this research leads us to a very clear question: does not brushing your teeth cause cancer? Logically not. In the field of health, causality is not as simple as ‘do this and that happens’, but rather it works as an accumulation of risks that increase the chances of generating a problem such as cancer. A risk factor. In this case, science suggests that having periodontitis, due to poor hygiene sustained over time, is associated with an increase of around 22% in the risk of suffering from breast cancer. And it is not the first time that dental disease is a risk factor of this type. A well documented case is in the relationship between deep dental caries and bacterial endocarditisan infection of the inner lining of the heart. That is why the recommendation here is always to maintain good oral hygiene and always treat cavities as soon as possible when they appear. Images | Caroline L.M. In Xataka | AI is no longer a promise in breast cancer: the largest clinical trial confirms that it detects more and reduces the burden on the radiologist

Agentic AI was the new race for Big Tech and Meta was far behind. It has bought the company most capable of recovering

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Meta has closed the purchase of manusa Singapore-based artificial intelligence startup, for more than $2 billion. Throughout this year, Meta has reinforced its AI operations by acquiring several companies focused on different specialties. In July bought Play AIfocused on voice with AI. In August acquired WaveFormsan audio-focused startup. And in September was done with Rivosa company specialized in the design of semiconductors and RISC-V chips. Manus’s is already the fourth major purchase this year, and it is his hope not to be diluted in the race to dominate AI when all this time he has focused his efforts on Llama and his open weights approach. Why it is important. The Agentic AI (agents capable of performing complex tasks with minimal human supervision) has long become the new battlefield for big technology companies. Although companies like Microsoft or OpenAI had sufficient resources to develop in this field, Meta needed to strengthen its position in this segment if it did not want to be left behind. Manus came to reach 100 million dollars in annual recurring revenue just eight months after its launch, which offers Meta a product that generates money right away, something not very common in this sector. What does Manus do? The startup rose to fame in March with a video demo that went viral, showing how its AI agent was able to produce detailed research reports, build custom web pages, filter job candidates, plan vacations, and analyze investment portfolios. All using AI models developed by companies such as Anthropic and Alibaba. At the time, Manus even claimed to surpass OpenAI’s Deep Research. Currently, the company has around 100 employees, mainly in Singapore, offers subscriptions of $20 to $200 per month and already has a user base of millions. Initial success. Manus emerged a few months after the debut of DeepSeekthe Chinese model that shook the foundations of the industry due to its capabilities supposedly developed with less computing power than its American rivals. Just like account WSJ, the startup secured a $75 million funding round led by Benchmark in April, which valued the company at $500 million. Among its investors are firms such as Tencent, ZhenFund or HSG. Untying ties in China. The parent company behind Manus, Butterfly Effect, was founded in 2022 in Beijing by two Chinese entrepreneurs, including its CEO Xiao Hong, known as ‘Red’. Although most of its researchers and engineers were located in China, Manus launched outside the country because it used American AI models that are not available there. Shortly after securing its investment with Benchmark, the company officially moved its headquarters to Singapore. According to account WSJ, Manus has ruled out developing a version for the Chinese market. Goal declared to Nikkei Asia that, following the acquisition, Manus will have no ties to Chinese investors and will no longer operate in China. All existing investors have been excluded from the operation, according to they count from Bloomberg. What’s coming now? Meta plans to keep Manus running independently while integrating its agents into Facebook, Instagram and WhatsApp, platforms where Meta AI is available. According to WSJManus CEO Xiao Hong will report directly to Javier Olivan, Meta’s chief operating officer. “Joining Meta allows us to build on a stronger, more sustainable foundation without changing how Manus works or how decisions are made,” Xiao stated in the official announcement. No return guarantees. Mark Zuckerberg continues his mission to prove that AI can deliver tangible returns. Goal plans to spend $600 billion in American infrastructure over the next three years, much of it related to AI. Just like assures Bloomberg, it is an amount that causes some skepticism in some investors, since there are no guarantees that this expense will generate significant income soon. Cover image | TechCrunch In Xataka | NVIDIA has paid $20 billion to “license” Groq’s technology. He actually bought it

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