results

Bandai Namco has presented its financial results and there is an anime that has given them more money than ‘One Piece’ and ‘Dragon Ball’

by

Neither ‘Dragon Ball’ nor ‘One Piece’. The anime that has given the most money to Bandai Namco in its last fiscal year will be a whopping 47 years old in 2026, and it is not associated with fantastic adventures for all audiences, but with plastic models that have little to do with pirate ships and the nonsense of the Monkey King. In fact, for a time it was considered a mere niche for collectors. The annual results that the company made public on May 13 reveal a figure that rearranges the ranking in a surprising way. The top. ‘dragon ball‘ and ‘One Piece‘are the most commercial franchises in Japanese entertainment; an idea that seems to have settled in the heads of fans with implacable firmness. However, the Bandai Namco’s latest financial results They deny it: ‘Mobile Suit Gundam‘ is the company’s most profitable intellectual property, with 254.3 billion yen in total group sales. ‘One Piece’ registered 139.3 billion and ‘Dragon Ball’, 138.0 billion. That is, there is a distance of 115 billion yen between Gundam and its most direct competitor in Bandai Namco, a figure that is approximately equivalent to 730 million euros. The nuance. Important and significant: Bandai owns ‘Gundam’ directly. ‘Dragon Ball’, ‘One Piece’ or ‘Naruto’, on the other hand, are intellectual properties that the company exploits under license: the complete rights belong to their authors, publishers and studios. Therefore, although the benefits for Bandai Namco from the licenses are astronomical, they do not fall one hundred percent on the company, as is the case to a greater extent with ‘Gundam’. That is, we do not have to read this Bandai ranking as an absolute list of global popularity. What is this due to? surprise? In 2022 Bandai Namco released ‘Mobile Suit Gundam: The Witch from Mercury’ (you can watch it on Crunchyroll), first ‘Gundam’ with a female protagonist. As confirmed then by the president of Bandai, Masaru Kawaguchi, the gunpla (name given to the models of the series) of the Gundam Aerial broke the initial sales record in the history of the franchise. Fiscal year 2023 ended that year with 131.3 billion yen for ‘Gundam’, the highest historical figure up to that time. SEED arrives. The next step was ‘Gundam SEED Freedom’ in 2024: film-sequel to a cult 2002 series of the franchise. You can see it on Netflix (and the series on Crunchyroll), and grossed 5.38 billion yen at the Japanese box office, becoming the franchise’s most popular film in its more than four-decade history. The 2025 financial year closed with ‘Gundam’ earning 153.5 billion yen, still below ‘Dragon Ball’ that year but already establishing the trend. The trigger: ‘GQuuuuuuX’. The final leap came with ‘Mobile Suit Gundam GQuuuuuuX’. The bizarrely named series was co-produced by Sunrise (the historical studio of ‘Gundam’) and Khara, the studio of Hideaki Anno who made ‘Neon Genesis Evangelion’, and which made a previous film version on January 17, 2025. Result:more than 3 billion yen at the box office and 1.8 million viewersthe second highest-grossing film in the history of the franchise, only surpassed by the aforementioned ‘SEED Freedom’. The world premiere of the series on Prime Video definitely impacted the numbers: only in the first quarter of fiscal year 2o25 ‘Gundam’ creceived 81.2% compared to the same period of the previous year. The power of synergy. Unlike other companies like Disney, which usually focus on a main launch (series, movie) around which secondary businesses sprout (merchandisingvideo games), Bandai Namco has been applying for years what they themselves call “IP synergy”: a model that coordinates releases of anime, video games, merchandisingphysical events, collectible cards, all supported with the same strength. ‘Gundam’ is the latest and most perfect example of that strategy. In this way, for example, in fiscal year 2026 the ‘GQuuuuuuX’ series, the expansion of the model lines, Premium Bandai launches and the Gundam Next Future Pavilion at the 2025 Osaka World Expo, an event for which Bandai is responsible for much of the growth. Bandai Namco believes that its toy and model arm, which has grown 12.9%, is the leader of all the company’s business segments. Another primary difference with the company’s North American and European counterparts. In Xataka | The 26 best anime of all time and where to watch them

The most opaque business in Silicon Valley has just published its best results. This is exactly what Palantir sells

by

Palantir has published some quarterly results that have surprised even its most optimistic analysts: revenues of $1.63 billion in the first quarter, 85% more than a year before. The company has also raised its annual forecast to almost 7,660 million. These are numbers that place Palantir in another league. And yet, many people don’t know exactly what they do. That is not an accident when it comes to this company, with such a specific type of activity. The context. Palantir has been building data analysis software for more than twenty years for governments and institutions that prefer not to make the headlines: the CIA, the FBI, the Pentagon, the United States immigration services… The company was founded in 2003 by Peter Thiel, the investor who also put money into Facebook and which today orbits in the power constellation. Trumpian, and by Alex Karp, its CEO, a notably eccentric figure with a PhD in Social Theory from Frankfurt. The combination of American intelligence money (In-Q-Tel, the CIA’s venture capital fund, was one of its first investors) and German university campus philosophy perfectly defines the moral ambiguity in which the company lives. In detailand. Palantir’s business has two legs. The first, and the one that is growing the most, is the American government: 687 million dollars in this quarter alone, 84% more than the previous year. The second leg is the commercial business with private companies, which has grown even faster (133%) to 595 million. But to understand how Palantir makes money you have to understand what it sells: Palantir Gotham It is its star product for governments and defense. It integrates dispersed data sources (satellite images, interceptions, movement logs, social networks, intelligence databases, etc.) and turns them into a coherent map that an analyst can interrogate. That is, it transforms oceans of noise into manageable information environments on which to make decisions. The screenshot that heads this article is an example. Palantir Foundry It is the business version. It does the same thing but for large companies: it unites data from different departments, cleans the information and allows automated workflows to be built on it. Maven AI It is their most recent and most controversial product. It is a command and control system that analyzes battlefield data and identifies targets in real time. The Pentagon is in the process of making it an official program of the American army, which would guarantee succulent long-term contracts. Between the lines. CEO Alex Karp This week he addressed his shareholders to explain to them that “the United States remains the constant core of the business. And that business is exploding.” Palantir’s rise is directly linked to increased defense spending, escalating geopolitical conflicts, and the growing use of AI in military contexts. In other words: when the world becomes more dangerous, Palantir makes more. Its business model is, to some extent, a barometer of global tension. Yes, but. Palantir Stock fell 1.5% in the aftermarket despite the good results, and they have accumulated a drop of around 18% so far this year. Investors have two questions without clear answers. The first: is 85% growth sustainable? The second, the most uncomfortable: what happens if the administration changes, if defense priorities change or if Congress tightens spending? A company whose main engine is a single client (the US government) has a concentration of risk that does not appear in the metrics they boast about. The money trail. The perennial debate about Palantir is not the financial one but the ethical one. The company has been at the center of some controversies for its work with ICE (the American immigration service) in identifying undocumented people, and for the role that its tools have played in military operations in different parts of the world. Karp does not shy away from these questions: he openly argues that the West needs companies willing to do this work, and that those who refuse simply leave the field open to others. It is an argument that its investors accept without many questions. And the results, for now, prove them right. In Xataka | AI is crucial for the US military. So he’s naming OpenAI and Palantir leaders as lieutenant generals Featured image | Palantir, Xataka with Mockuuups Studio

If anyone was waiting for the AI ​​bubble to burst, NVIDIA’s results have a message: sit tight

by

NVIDIA just published your results of the fourth quarter of its last fiscal year and has left Wall Street speechless. Revenues of $68.1 billion, a net profit that almost doubles that of the same period of the previous year, and a forecast for the following quarter that has far exceeded analysts’ expectations. And all this in a turbulent context where more efficient models and other alternatives are beginning to appear. The crash of DeepSeek is far away, and the demand for chips does not slow down. We tell you the numbers in detail. In case your position was not clear. Only a handful of companies in history have exceeded $100 billion in annual profit. Alphabet, Microsoft and Apple are in that club. NVIDIA has just joined them, with $120 billion in profits in the last twelve months, according to the report. The difference is speed: just three years ago, its annual profit was 4.4 billion. We can say with certainty that no technology company has ever grown so quickly on that scale. AI, and more AI. The engine that has driven these profits is its data center business, which generated $62.3 billion in the quarter, 71% more than a year ago. Within that segment, if we focus on their Blackwell chips, they have gone from entering 32.6 billion to 51.3 billion, while the networks (NVLink, Spectrum-X and InfiniBand) grow from 3,000 to 11,000 million. Gross margin is 75%, and earnings per share nearly double to $1.76 in GAAP terms (which is the official rulebook that companies follow to demonstrate transparent accounting). What Jensen Huang says. “Without computing, there is no way to generate tokens. Without tokens, there is no way to grow revenue.”, counted directly the CEO of NVIDIA in the meeting with investors. Their thesis is that in the new AI economy, computing power directly equates to revenue for their customers. That is why the large cloud service providers (Google, Amazon, Microsoft, Meta) continue increasing your capex budgetswhich together will exceed 500,000 million dollars in 2026 to build AI data centers. And NVIDIA is the main beneficiary of that expense. What DeepSeek has not broken, but accelerated. At the beginning of 2025, the emergence of the Chinese DeepSeek model generated an unprecedented tremor in the markets, leaving a simple question in our minds: if AI becomes more efficient, why do we need so many chips? The answer from NVIDIA’s results is that efficiency does not reduce infrastructure demand, it multiplies it. Every improvement in inference efficiency lowers the cost per token, encouraging more companies to deploy more AI applications, which in turn requires more compute. It’s like Jevons’ paradox, but applied to AI: efficiency expands the market instead of contracting it. Agentic AI as the next catalyst. On the same call with investors and analysts, Huang stood out that “enterprise adoption of agents is skyrocketing.” AI agentsthese systems that make decisions and execute tasks autonomously, require many more inference cycles than chatbots. They are the next step in the AI ​​value chain, and NVIDIA is once again in a privileged position. Colette Kress, CFO of the company, confirmed In addition, the first samples of Vera Rubin, the next generation of chips that will arrive later this year, have already been sent. China and the competition. Not everything is green. NVIDIA acknowledged that its forecast for the next quarter ($78 billion) does not include computing revenue in China. The company has generated just about $60 million from H20 chips since the Trump administration reapproved some sales in August 2025, according to SEC filings, and has yet to earn revenue from the most recently approved H200. Regulatory uncertainty with Beijing remains a small China in Huang’s shoe. In parallel, competitors such as AMD, Broadcom or Google’s own custom chips (TPUs) are gaining ground. But the NVIDIA CEO remains focused on his vision. And according to pointed at the meeting: “Every company depends on software, and all software will depend on AI.” As long as this is fulfilled, everything indicates that NVIDIA will continue selling the blades and picks. Cover image | NVIDIA In Xataka | NVIDIA was founded by three engineers, but only Jensen Huang remains CEO: “I wish I had kept some shares”

A company has filled a neighborhood with sidewalk outlets to charge electric cars. Their results are contradictory

by

In 2022, a German company called Rheinmetall proposed a new charging solution: put outlets on the sidewalks. Trying to find solutions for those who wanted to jump to an electric or plug-in hybrid car but did not have a garage, the company proposed a system to charge on the same street, without having to go to an electric station. Three years later: we have the results. A pilot test. After receiving approval from the authorities, the company began a pilot in 2024 in central Cologne and Lindenthala residential neighborhood of the city characterized by its low and individual houses. Neighborhood where, by the way, you will find the status of the local soccer team. The idea is simple, you park on the sidewalk and on the ground, on the curb, you find a plug hidden in a cover. You scan a code printed on it and connect the car with your own charging cable for AC use. As if it were any other charging point, both ends are joined and when the payment is completed, it is passed through the use of a mobile application. The results. In general terms, the results have been good. According to the company, a total of 2,800 charging cycles were carried out in the pilot test in one year. On average, the cars recharged 18 kWh, which in the city means more than 100 kilometers of autonomy for an electric car and between 80 and 100 kilometers on the highway (depending on its efficiency). They point out that each day the plug has been used an average of twice a day and that its availability has been 99%, so there have hardly been any breakdowns. The figure is good if we compare it with the European and Spanish average. In our country, public outlets They are only used 1.5 times a day and, on average, each charger is only busy between 30 and 120 minutes a day in Europe. Customer opinion. The company has conducted a survey of users who have offered their point of view to the system. It included the score given by the drivers (five points maximum) and some notes, complaints or recommendations made by customers. In total, the system has obtained 4.38 points out of five. But, above all, they have received very positive evaluations among customers over 60 years old, who value the simplicity of the system. In addition, they highlight that the plugs have not been damaged by water and that vandalism or uncivil acts (such as not picking up pet excrement) have not been found to have been a problem when recharging. A curious solution is that the cover that hides the plug has been designed to open with a small push of the charging cable, allowing the customer to lift said cover without having to touch it with their hand. Good idea, with some cracks. They point out in forumelectriccars that one of the main problems with this type of charging points is the cost of the plug. Each one of them, which has refrigeration and air conditioning to improve charging, costs 5,000 euros, so it is a bad idea compared to a traditional home charger. Furthermore, if you want to get the most out of the system, it would be necessary to reserve space for these charging points on the street, so there is no difference with any other public charging point unless the street is filled with plugs. That is, as happens with public outlets that are not located at a gas station, the parking space is reduced to reserve spaces that are not always occupied. Other proposals. Public charging is one of the great challenges that the electric car represents. One of its advantages is to leave the house with a charged car or, at least, take advantage of its parking lot to fill its batteries since alternating current is slow and most of the time a car is stopped. The most obvious proposal is the electric stations, with a huge number of high-power plugs available. another is fill shopping and leisure centers with chargerssince a visit to fully recharge the battery can take days or weeks (depending on daily trips) without plugging in our car. With an average of 50 kilometers per day, a car that drives 500 kilometers of autonomy in the city has 10 days to go without plugging the car back in, just three days a month. But if we want to bring public charging to the city streets, Portugal, United Kingdom either Netherlands have been experimenting with public outlets on streetlights. The system is as simple as including sockets on the curbs but with the difference that the socket comes from a street lamp and does not require installation on the ground. The paradox of slow recharging. The problem with this type of recharge is that slow charging takes hours and hours with the car plugged in. If a socket charges our car at 7.4 kW of power, it will be necessary to spend about 10 hours to completely fill the battery of a 60 kWh vehicle, a small size that is on the border between those who want the car for an urban environment and those who want to dare to travel with him. Those refills They are interesting if the price is low But they require that, to get the most out of it, we have to leave the car parked there for an entire working day or an entire night. The system, therefore, is certainly inefficient in terms of servicing more than one car. To charge at this power, the data says that most electric car drivers charge at home. Outside of it, the customer usually chooses to recharge at higher powers. For example, a 50 kW plug can now fully charge a car in less than three hours, which is the time we spend watching a movie at the cinema. And on a trip, the most practical thing is usually to look for … Read more

Productivity had become an obsession. Until leisure has started to give better results at work

by

The constant pressure to perform to the maximum has marked work life for a long time, leaving rest almost forgotten. A recent study shows how reserving well-planned leisure time changes the perception of daily routines and contributes to improved performance at work. Experts have verified that organize free time actively through crafts or other forms of abstraction brings improvements to creativity and motivation in your work tasks. This finding questions the belief that only by working non-stop can we achieve good work results. Let the brain create things. A group of researchers from the University of East Anglia in the United Kingdom and Erasmus University Rotterdam in the Netherlands investigated on the effects of creative craft-based entertainment during employees’ leisure time. The result of the experiment was not an improvement in the morale and motivation of the employees who participated in the study, but rather it contributed to these employees offering a more creative response in solving the problems that arose at work. Improvements in daily work life. The workers who participated in the study felt that, by exercising new manual skills, they better appreciated the processes of their crafts, making them gain value. The curious thing is that the change was bigger in the workplace than in his personal life, even though it was his leisure time. “We were surprised to see that crafts had a greater impact at work than in personal life. We expected similar benefits in both areas,” explains Professor George Michaelides, from UEA Norwich Business School. Curiously, the group that noticed this improvement the most was the one formed by the most senior employeesthose over 61 years of age. The explanation for this phenomenon is found in cognitive aptitude, a brain condition that is activated during learning processes. Gymnastics for the brain. Just as they collect the studies of Professors Gilkey and Kilts, of the schools of medicine and business at Emory University, carry out various creative activities that require a motor and cognitive combinationlike playing the guitar, juggling or learning a new language, helps expand the neural system and makes it more communicative. That is, the development of new skills through crafts was improving the “physical fitness” of the employees’ cognitive system, and the results were more visible in those more prone to cognitive decline and memory deterioration due to age. Keep “fit“Cognitive aptitude improves performance in decision making and problem solving, as well as in the generation of new ideas. The capacity for abstraction. One of the keys to the use of crafts or pleasurable leisure activities is that they act as a natural stress reducer and depressive symptoms. “Hobbies are already known to be good for well-being. But our study shows that hobbies not only make you happier, they can also help you feel more fulfilled and creative at work. This goes beyond simply relaxing or having fun (like watching Netflix non-stop) and turns hobbies into something that helps people grow,” says Dr. Paraskevas Petrou, the lead author of the study. Beyond the cognitive improvement derived from the development of the neural system, a study from Cardiff University found that the use of crafts or repetitive activities, how to knitinduces the brain into a state of full attention that increases abstract thinking activity by up to 25%, which contributes to the generation of new ideas and improves problem solving. In Xataka | Feeling overwhelmed at work is normal, but it is not ideal: six techniques to avoid it and be much more productive Image | Unsplash (Elena Mozhvilo)

Researchers removed Instagram and TikTok from 300 young people to see if their anxiety decreased. The results speak for themselves

by

The debate about whether social networks are the new tobacco for the mental health of the generation Z It’s been on for years. There are many young people who They can’t go without watching TikTok completing the streak with their friends, uploading stories of what they eat to Instagram or simply away from the cell phone. And this is something that can be tremendously harmful. What we knew. Until now we could make one of them, and parents undoubtedly remember this message when they spend many hours in front of the phone. Even companies offer the tools to be able to limit the amount of time that we spend in an app and it even applies limits to us. With numbers. But now science has shed light on this problem with a published study in JAMA Network Open that provides concrete data. The premise was simple: ask a group of young adults (ages 18 to 24) to reduce their consumption of social networks this week. Once done, we wanted to see if the symptoms of anxiety, depression or insomnia were reduced. And it is precisely the excessive use of social networks is related to depressionsince it generates social isolation, low self-esteem, cyberbullying or even physical disorders due to the effects of blue light from the screen. So… Does giving up the cell phone also improve the quality of life of young people? The study. To do so, they not only focused on what users said they did with their mobile phones, since lying can be very easy in this case. What they did was passively record what was done with the phone through the ‘digital phenotyping‘. In total, there were 373 participants in this study, of which only 295 were able to complete the intervention, which was completely voluntary. They only had to reduce consumption for one week of the main social networks: Facebook, Instagram, Snapchat, TikTok and X. The results. Simply put, the results showed significant clinical improvement across key areas after just seven days. The data indicated that depression symptoms were reduced by 24.8%, anxiety by 16.1% and sleep problems fell by 14.5%. Interestingly, the study found that the effects were much more pronounced in those participants who already had symptoms of moderate or severe depression at the start of the experiment. Don’t let go of your cell phone. A priori, one might think that when a young person automatically leaves social networks aside, their cell phone will be of absolutely no use to them. But nothing could be further from the truth. He digital phenotyping revealed that although social media use fell from about 2 hours a day to just 30 minutes, total screen time increased slightly by 4.5% and participants spent 6.3% more time at home. In this way, users replaced the infinite scrolling of TikTok with other digital activities such as messaging, browsing the internet or even playing games. However, despite still being glued to the screen, mental health improved. This reinforces a theory that is gaining weight among experts: the problem is not the screen itself, but how we use it. The study points out that objective use time has a weak association with mental health, since what is really harmful is “problematic use”, such as negative social comparison or emotional addiction to platforms. Easier apps to leave. We can all have more ‘affection’ for a specific social network, which is surely more difficult to stop using. In this case, it was seen that it was easier for users to reduce the time they spent on TikTok or X. But Instagram or Snapchat were the “hard bones” to beat. Specifically, 67.8% of Instagram users and 48.8% of Snapchat users failed to comply with the reduction and continued to use them significantly during the detox process. It is not a treatment. Although the percentages sound like a victory, it is necessary to maintain the usual scientific skepticism. Dr. John Torous, co-author of the study, warns in statements collected for him New York Times that reducing networks “would certainly not be your first or only form of treatment (for mental health problems),” although it is worth experimenting with. This focuses on the fact that the study has some limitations such as the lack of a reference control group and it was not seen how long the detoxification process from social networks lasted. But what did not improve was loneliness, since eliminating these social networks in people can have the opposite effect by also cutting the connection link that unites them with other people. Images | Panos Sakalakis Vitaly Gariev In Xataka | Social networks were once a place to tell our lives. Now the trend is different: “zero posts”

Science wants to put ‘microrobots’ into our bodies to medicate us. They have already given good results

by

One of the great problems of modern medicine in the treatment of different human ailments is the “killing flies with cannon” approach. This means that when we have a headache and we take paracetamol, this medicine is distributed throughout the body and not only where it needs to take effect. But this is something that may end up changing thanks to microrobots. The importance. That the medication ‘walks’ throughout the body seems completely irrelevant as long as it has its analgesic effect, but the reality is that it is the responsible for many side effects that are generated. For example, taking a simple ibuprofen to relieve pain or reduce inflammation seems like a wonderful thing. But the fact that it has a general effect on the body also causes the blocking of mucus production in the stomach, which can lead to one of its most ‘famous’ side effects, such as the generation of stomach ulcers when abused. And when we talk about the much more serious side effects, it can cause many clinical trials of new drugs to have to be stopped because of this. But simply with a system that makes the medication act in a specific place in the body, this problem could be alleviated (in part). A new advance. A team of researchers from ETH Zurich has published in the magazine Science a solution that brings us a little closer to the setting of the movie Amazing Journey: a platform of magnetic microrobots ready for clinical use that are capable of traveling through blood vessels and releasing their cargo into the affected tissue. Bradley J. Nelson, co-author of the study and professor of robotics at ETH Zurich, says this is just the beginning: “We’re just the tip of the iceberg. I think surgeons are going to look at this and I’m sure they’ll have a lot of ideas about how to use it.” A simple grain of sand. In this case we are not talking about a metal robot with gears, but rather a capsule of approximately 1.69 mm in diameter that is designed to dissolve inside the body. We can rest assured that we will not have thousands of grains of metal sand in our bloodstream. But to get here, the engineering behind it is not at all simple. One of the challenges, logically, is that its application would be viable within the human body. To do this, the team had to balance three key factors such as: biocompatibility, drug loading capacity and magnetic control. The result was a spherical gelatin matrix that has three components: Iron oxide nanoparticles to respond to magnetic fields. Tantalum: a dense metal that can be ‘seen’ through radiology techniques in order to follow its path through the body. The medication you want to apply. How it moves. In addition to the capsule, what is important is how it moves until it reaches the target where it must act. For this, an electromagnetic navigation system called Navion is used. To do this, coils are placed around the patient’s head to generate a magnetic field around it that allows the capsule to move. In this way, a surgeon, for example, will be able to control the capsule almost as if it were a remote-controlled car to be able to reach the desired action point. To do this, there are different ways of moving through the vessels: by rolling, by dragging or by navigating the blood flow itself. A suicide mission. Once this microrobot reaches its destination, the doctor will be able to activate the final phase. Using high-frequency alternating magnetic fields, the iron nanoparticles inside will heat up, which will cause the gelatin matrix to melt in a matter of 40 seconds, releasing the drug at once. In their tests, they managed to transport rtPA (a powerful drug to dissolve thrombi) to a clot in a vascular model, managing to restore blood flow in less than 20 minutes. When will it reach the hospitals? Although the system is quite promising, it will take time to reach patients. The researcher himself points out that clinical trials could begin within three to five years. In addition to thrombi, applications are being considered to treat aneurysms, arteriovenous malformations and very aggressive types of brain cancer. It’s not the first time. The medicine every time tends more towards personalization of treatments. In cancer we already see it with use of therapies such as CAR-T which focuses on training the immune system to specifically attack a person’s tumor cells and not healthy cells. A completely targeted therapy like the one proposed in this system, but in this case it is applied in the daily clinic (although it has a very high cost). The same happens with the immunotherapy with the use of antibodies. In this case, science looks for those particles that are unique to tumor cells and that are not present in healthy cells. In this way, drug weapons can be created that directly attack cancer cells. In Xataka | The rarest element on Earth aims to cure cancer. And Europe is already accelerating its production

The most unexpected treatment against cancer is LED light, and it is giving good results

by

Currently there are many research groups that have a very clear objective: find a cancer treatment that is effective, specific and above all safe. Something that can be really complex because of everything that cancer hides behind it, but science continues to give us good news. The last one comes from the University of Texas and the University of Porto which have developed a technique based on tin oxide nanoflakes (SnOx) and LEDs that allows cancer cells to be destroyed with precision. The current problem. The therapy par excellence today in the fight against cancer, without a doubt It’s chemotherapy and radiotherapy. The first of these has numerous problems that have been tried to be corrected, such as low specificity, that is, it attacks both cancer cells like the healthy ones. And this ultimately produces many side effects that can cause you to not continue with the treatment. This makes the goal of science to seek specificity and for the treatment to attack only cancer cells. This is something that is being tried to achieve with immunotherapy and techniques like CAR-T which ultimately is part of personalized medicine for each patient and which offers a very specific selection of the type of cell to destroy. But science has not stopped here. The discovery. One of the techniques that appears to be promising is photothermal therapy (PTT). The concept in this case is quite simple to understand: inject nanomaterials into a tumor and then heat them using light. This logically causes a localized increase in temperature, which selectively destroys the cancer cells that have been marked before. The problem until now was materials and light. Many photothermal therapies require high-powered lasers, which are expensive and can damage surrounding tissue. Now, a team of researchers from the University of Texas at Austin and the University of Porto have found the key to changing the rules of the game. A secret ingredient. The team has developed a new photothermal agent called nanoflakes that are made of tin oxide. After all, they are tiny sheets with a thickness of less than 20 nanometers and what is really ingenious is how they were manufactured. The really ingenious thing is how they made them. They started from a cheap and abundant material such as tin disulfide, which ironically is useless for photothermal therapy. In this way, through a ‘green’ and scalable process called electrochemical exfoliation with oxidation, which only uses aqueous media, they managed to transform the inactive tin disulfide into tin oxide that was already ready to fight cancer. And the light came. Once this material was available, all that was left was to expose it to the LED irradiation low-cost that emit infrared light at 810 nm. In this case we are talking about radiation that is very safe and does not damage healthy skin as can occur with radiotherapy, and it is also extremely cheap and accessible to everyone (even developing countries). Results. To test the effectiveness, researchers have tested cells in culture. The first thing they saw was that this treatment had no effect on healthy cells, that is, it did not destroy them. But the best comes when applying it to cancer cells results in a great reduction in the different colonies. Specifically, in skin cancer there was a 92% reduction in the viability of tumor cells, while in colorectal cancer this percentage dropped to 50%, but still maintained good results. And all thanks to an increase in temperature from 37 °C to 50 °C in 30 minutes that killed cancer cells. The future. This study not only presents a more efficient material, but validates its use with safer and more economical light sources. The researchers themselves point to the potential of LED systems for applications such as skin cancer treatment, which could theoretically be self-administered at home. This would be a great advantage for patients and would reduce the burden on health systems, although there is still a lot of research ahead to see if this therapy can be viable in a range that will surely not be less than 10 years. Images | National Cancer Institute Logan Voss In Xataka | Colon cancers are increasing alarmingly among young people. We have a suspect: sedentary lifestyle

“Guided missiles” are revolutionizing cancer treatment. And they are already giving results

by

Chemotherapy marked a great revolution in the treatment of different cancers despite its many problems in the nonspecificity of the ‘attack’ that caused healthy cells to also be affected by its effects. Although attempts have been made to increasingly specific chemotherapiesthe reality is that the next natural step in the evolution of the treatment It is immunotherapy, which is a field that continues to advance, giving us more and more joy in the fight against cancer. But there is a revolution that wants to go much further, and it is nothing more than taking all the good things that immunotherapy has with the high potency of chemotherapy. And this ‘cocktail’ has a name: immunoconjugates (ADC). The current problem. Traditional chemotherapies have been seen as a really aggressive treatment that generates a large number of side effects by attacking absolutely everything they encounter. This forces us to rethink the strategy. For this, it has been thought in immunotherapy Basically what it does is ‘wake up’ our natural defenses so that it can attack the tumor with its own tools. Something that It is personalized for each individual. by extracting, for example, their T lymphocytes to ‘reprogram’ them and make them fight against the tumor, which is nothing more than their own cells. But the next step requires this specificity with greater potency than the stimulated immune system can provide. And this forces us to look for new therapies that have a similar mechanism, although it goes further in the way of applying the drug to the target cells. And this is where we are in the fight against cancer. The goal of treatment. Precisely the future focuses on personalized treatments for each of the patients who have cancer in their body, without having to generalize with a drug for one type of tumor. This is achieved with treatments that are considered ‘remote-controlled missiles’ or ‘Trojan horses’ that promise greater specificity when attacking a tumor cell and leaving the body’s healthy cells ‘calm’. But always taking into account the particular characteristics of a person’s tumor. This is what is achieved with ADCs which are designed like a missile with lethal precision. Its mission is to deliver an explosive charge of chemotherapy into the tumor cell, largely ignoring healthy cells, and the results are promising in the early phases of research, demonstrating its great potential to cure more patients in the early stages. That’s how they work. The technology behind ADCs (Antibody-Drug Conjugates) is as elegant as it is powerful. It is made up of three key parts: The antibody that acts as the guidance system. A monoclonal antibody designed in a laboratory to search and fit like a key in a lock to specific proteins, a kind of “antennae” (receptors), which are found massively on the surface of tumor cells. And the point is that each tumor cell has different ‘antennas’ and that is why it is important to find the most suitable antibody. The payload, which we can assume is our ‘warhead’ which is a very powerful chemotherapy molecule and so toxic that it often cannot be administered in normal chemotherapy mode due to the large effects it has. So, here we are combining chemotherapy with immunotherapy. The linker. A mechanism that binds the antibody and the cargo so that it can travel ‘comfortably’ through the blood until it reaches its target tissue. The process is pure military strategy: the ADC travels through the body, the antibody detects its target (the cancer cell), anchors to it and the cell, deceived, absorbs it. Once inside, the linker breaks and releases the chemotherapy, annihilating the malignant cell from within and without affecting the ‘neighbors’. A before and after. At the congress of the European Society of Medical Oncology (ESMO 2025) without a doubt this treatment has been on the lips of many experts. And it is logical seeing the good results that have been reported in this regard. You just have to see a recent study published in the prestigious magazine New England Journal of Medicine that confirms that this ADC such as trastuzumab deruxtecan is more effective than conventional chemotherapy in cases of metastatic HER2+ breast cancer, showing improvements from 7 to almost 10 months without tumor progression. Another treatment, sacituzumab govitecan, also has shown important results before him triple negative breast cancerwhich is one of the most aggressive and could have the worst prognosis. The result is also very promising: an improvement in survival and quality of life. The hidden side. Like all cutting-edge technology, ADCs are not without challenges. They are not harmless. One of the geniuses behind these studies, the Spanish Javier Cortés pointed out to the side effects that could occur, mainly diarrhea and lowered defense. This made him have to point out that “in general, Trojan horses give a toxicity that, in relation to traditional chemotherapy, is usually somewhat better.” But there is also another front ahead: in some patients with this treatment the tumor continues to grow. The investigation now focuses on understanding it: The tumor cell receptors may mutate and are not the appropriate target, the chemo release mechanism within the cell may fail, or the tumor may simply be resistant to that particular chemo. The future. What is being targeted right now is the possibility of mixing ADCs with immunotherapy or even combining several ADCs with each other. But where things get more interesting is the possibility of loading these ‘Trojan horses’ with radioligands, that is, rradioactive dioisotopes to apply radiotherapy very selective on cancer cells. In this way, a wide range of possibilities open up for the treatment of cancer. Images | Angiola Harry National Cancer Institute In Xataka | Colon cancers are increasing alarmingly among young people. We have a suspect: sedentary lifestyle

Microsoft has put co -pilot in Excel. And you have also notified that you do not use it if you need the results to be correct

by

Artificial intelligence has finally landed In one of the most famous spreadsheets in the world: Excel. But he hasn’t done it as many imagined. Talk to the program in natural language and automatically solve everything for us? Only in part. Copilot’s shortcuts allow to summarize, classify and order databut they do not turn Excel into a agent able to take control of a project from beginning to end. In addition, the novelty comes with clear limits: the function can make mistakes. Microsoft is testing co -pilot as a native function within the Excel calculation engine. The idea is simple: write an instruction in natural language within the sheet and obtain a result that is placed directly in the grid, with the same behavior as any Excel exit. Integration allows you to continue working with defined ranges, tables and names without changing the structure of the file, and the results are updated when the data changes, without resorting to scripts or external accessories. Copilot is landing in Microsoft Excel As we see, it is a useful function, but with clear limitations. At the moment we cannot ask in natural language things such as “fuses the books of the subsidiaries, make everything to euros to the official change, eliminate duplicates and enter me a quarterly consolidated balance with comparative graphics.” Copilot, for now, plays in another land: Understand instructions in natural languageYes, but it does it within Excel and always about the data you have on the sheet itself. Accepted that Copilot is not an automatic pilot, it is worth exploring what it is practical. Microsoft points to four daily fronts that are resolved without abandoning the sheet: Rain of ideas without leaving the sheet. Ask for a list of concepts, titles or keywords from a brief description. If we need it, we can ask that you rewrite a text in a lighter or more formal tone and leave the result ready to polish. Summaries that go to the point. Point out a wide range and request a short text with trends, peaks and falls. This is useful when a table must be converted into an understandable paragraph for a report. Direct classification in the grid. Deliver a column with comments, tickets or survey responses. We can ask that you return labels such as “positive/neutral/negative” and a brief category. Everything would turn to new columns to continue working. Lists and tables on the fly. From a description, which proposes a table with the columns that we indicate (task, responsible, date, state). It is a basis for organizing without wasting time mocking. ⠀In the official noteCatherine Pidgeon (Excel team) offers a very clear example of what Copilot can do today. Imagine a sheet with a column full of opinions about a new coffee maker in the office. Some value flavor, others complain about noise or deposit size. Copilot can read that column and return, right next to us, a table with two fields: the feeling of each comment (positive, neutral or negative) and a category Cut that helps you group (“taste”, “noise”, “capacity”). In minutes we would go from a messy list to something analyzable. There we decided: filter for the most frequent problems, count a category or prepare a summary. And how is it used in practice? Exactly like any other Excel function: writing the sign equal to the beginning of a cell and then the name of the function. In this case, Simply put = co -pilot () and add inside the instruction in natural language or the range of data that we want to use as a context. There are no tricks or hidden menus, it is invoked as invoked a = sum () or un = search (), which makes learning minimal and experience is familiar from the first moment. It is time to put the caution on the table. Copilot works within the book itself: it does not access the web or documents of the company, and its results must be reviewed and validated before including them in reports or business decisions. Microsoft is clear about it: it is not appropriate for high -risk scenarios (with legal, regulatory or compliance implications). There are also operational limits: the function has quotas of use (up to 100 calls every ten minutes and 300 per hour). Microsoft is clear about it: it is not appropriate for high -risk scenarios. What we are seeing should not surprise us either. Artificial intelligence has advanced by giant steps, but still has a weak point: it can be wrong. These inaccuracies are usually called “hallucinations”And, although technology improves with each generation, the companies that develop it warn that It is not convenient to re -one hundred percent. It is almost a courtesy reminder that we have already normalized: every time we open a chatbot as COPILOT, Chatgpt either GeminiWe find a warning that reminds us that what we read can contain errors. Will the day come when these failures disappear? There is no clear answer. Even paying for the most advanced versions, the fastest or most expensive, absolute security does not exist. That is the reflection that also applies in Excel: Copilot is useful and opens possibilities, but never replaces the tranquility it gives for oneself that the numbers walk. Copilot does not reach everyone yet. Microsoft is gradually display They are on the beta channel, both in Windows and Mac. The company ensures that in the coming months it will also be available in the Excel Web version through the Frontier program. Nothing must be done to activate it: the function appears on the sheet when the requirements are met, and its use is completely optional. Images | Microsoft | WIRESTOCK In Xataka | If the question is whether there is an AI bubble, Sam Altman has just answered. One with which he is winning

Log In

Forgot password?

Forgot password?

Enter your account data and we will send you a link to reset your password.

Your password reset link appears to be invalid or expired.

Log in

Privacy Policy

Add to Collection

No Collections

Here you'll find all collections you've created before.