The problem with microrobots is that they don’t have a “brain.” The solution has been to use Einstein’s relativity to guide them

Making robots the size of a piece of human hair is already a reality, but it faces a big problem: they are too small to bring a “brain” on board. And it is logical, since on a microscopic scale there is no space to insert a microchip, batteries or navigation systems, so in a few words we can talk about “dumb robots” that only react to basic stimuli. But here the Einstein’s relativity has given a small solution. The solution. One of the functions of these small robots is precisely in be able to navigate the bloodstream to react to different stimuli. But the big question here is how they can navigate a bloodstream without colliding with each other. Something that was on the mind of a team of researchers from the University of Pennsylvania what have you seen that the key is not in making robots smarter, but in manipulating the “spacetime” through which they move. To understand this thread, you have to think about how gravity works according to the theory of general relativity. Here Einstein taught us that planets do not revolve around the sun because an invisible force pulls them, but because the mass of the Sun curves the fabric of spacetime, as with the Earth, which follows the easiest path through that curved space. To biology. Here the researchers wanted to apply this same mathematical principle to microrobotics, introducing the concept of “artificial spacetimes”. And since microscopic robots move in response to light, the scientists designed light fields projected onto a Petri dish that mimic the curvature of spacetime. In this way, the variations in light they faced acted like “artificial gravity.” In this way, the robot does not need to know where it is or where it is going. It simply turns on and moves forward, since it is the light pattern that “pushes” it to curve its path to avoid obstacles or find the exit from a maze, exactly like a ray of light curves when passing near a massive object in the cosmos. It seems like magic. In the experiment proposed by the researchers, different two-dimensional light labyrinths are projected. In this virtual scenario, they created dark areas that mathematically act as “black holes”, since when the microrobot approaches these areas, the equations that govern your response to light They are formally identical to those of the path of light falling through an extreme gravitational field. In this way, when the microrobot approaches these areas, the equations that govern its response to light are formally identical to those of the path of light falling through an extreme gravitational field. From here, using mapping, scientists managed to get these robots to ‘patrol’ specific areas, avoid obstacles and group together at an exact point. And the most interesting thing is that all this happens without a single processing chip on board the robot, since the “calculation” falls entirely on the geometry of the projected environment. A future doctor. The implications of this advance will now allow microrobots to be freed from the need to have a computer system inside them, which means they can be manufactured cheaply and even made even smaller. From here opens the door to very important medical applicationssince millions of these “reactive robots” can be injected into the human body. The objective here is to use external fields such as magnetic fields that act as a curved spacetime that allows them to move through our circulatory system to release a drug, clean arteries or perform biopsies at the cellular level. Images | Ruben Sukatendel In Xataka | Robots have a problem that no one has solved in decades: they get lost. A Spanish engineer believes she has found the key

Science wants to put ‘microrobots’ into our bodies to medicate us. They have already given good results

One of the great problems of modern medicine in the treatment of different human ailments is the “killing flies with cannon” approach. This means that when we have a headache and we take paracetamol, this medicine is distributed throughout the body and not only where it needs to take effect. But this is something that may end up changing thanks to microrobots. The importance. That the medication ‘walks’ throughout the body seems completely irrelevant as long as it has its analgesic effect, but the reality is that it is the responsible for many side effects that are generated. For example, taking a simple ibuprofen to relieve pain or reduce inflammation seems like a wonderful thing. But the fact that it has a general effect on the body also causes the blocking of mucus production in the stomach, which can lead to one of its most ‘famous’ side effects, such as the generation of stomach ulcers when abused. And when we talk about the much more serious side effects, it can cause many clinical trials of new drugs to have to be stopped because of this. But simply with a system that makes the medication act in a specific place in the body, this problem could be alleviated (in part). A new advance. A team of researchers from ETH Zurich has published in the magazine Science a solution that brings us a little closer to the setting of the movie Amazing Journey: a platform of magnetic microrobots ready for clinical use that are capable of traveling through blood vessels and releasing their cargo into the affected tissue. Bradley J. Nelson, co-author of the study and professor of robotics at ETH Zurich, says this is just the beginning: “We’re just the tip of the iceberg. I think surgeons are going to look at this and I’m sure they’ll have a lot of ideas about how to use it.” A simple grain of sand. In this case we are not talking about a metal robot with gears, but rather a capsule of approximately 1.69 mm in diameter that is designed to dissolve inside the body. We can rest assured that we will not have thousands of grains of metal sand in our bloodstream. But to get here, the engineering behind it is not at all simple. One of the challenges, logically, is that its application would be viable within the human body. To do this, the team had to balance three key factors such as: biocompatibility, drug loading capacity and magnetic control. The result was a spherical gelatin matrix that has three components: Iron oxide nanoparticles to respond to magnetic fields. Tantalum: a dense metal that can be ‘seen’ through radiology techniques in order to follow its path through the body. The medication you want to apply. How it moves. In addition to the capsule, what is important is how it moves until it reaches the target where it must act. For this, an electromagnetic navigation system called Navion is used. To do this, coils are placed around the patient’s head to generate a magnetic field around it that allows the capsule to move. In this way, a surgeon, for example, will be able to control the capsule almost as if it were a remote-controlled car to be able to reach the desired action point. To do this, there are different ways of moving through the vessels: by rolling, by dragging or by navigating the blood flow itself. A suicide mission. Once this microrobot reaches its destination, the doctor will be able to activate the final phase. Using high-frequency alternating magnetic fields, the iron nanoparticles inside will heat up, which will cause the gelatin matrix to melt in a matter of 40 seconds, releasing the drug at once. In their tests, they managed to transport rtPA (a powerful drug to dissolve thrombi) to a clot in a vascular model, managing to restore blood flow in less than 20 minutes. When will it reach the hospitals? Although the system is quite promising, it will take time to reach patients. The researcher himself points out that clinical trials could begin within three to five years. In addition to thrombi, applications are being considered to treat aneurysms, arteriovenous malformations and very aggressive types of brain cancer. It’s not the first time. The medicine every time tends more towards personalization of treatments. In cancer we already see it with use of therapies such as CAR-T which focuses on training the immune system to specifically attack a person’s tumor cells and not healthy cells. A completely targeted therapy like the one proposed in this system, but in this case it is applied in the daily clinic (although it has a very high cost). The same happens with the immunotherapy with the use of antibodies. In this case, science looks for those particles that are unique to tumor cells and that are not present in healthy cells. In this way, drug weapons can be created that directly attack cancer cells. In Xataka | The rarest element on Earth aims to cure cancer. And Europe is already accelerating its production

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