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In the last 20 years, colorectal cancer has doubled among young people and we didn’t know why. Now we have a track

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In the last 20 years, the incidence of colorectal cancer has doubled in young adults and that has fired all alarms. Above all, because while this type of tumor shoots, we have no idea why. Now, a study headed by Spanish researchers has found a suspect: it is called colibactin and a bacterial toxin produced by some strains of Escherichia coli. The colorectal epidemic. The term is “epidemic”, yes. As Manuel Anse explainedthe alarm jumped in the US in the late 2000s: while colorectal cancer decreased in people over 70, growth rates in children under 50 grew at a rate of 1.5%. In Europe, the data suggests that it has arrived to grow to the rhythm of 8% Between twenty -year -old. It was a huge public health problem. But, above all, it was a mystery. What could be behind all this? The first track. In 2020, a research team from the Netherlands discovered that certain strains of Escherichia coli They produced colibactin and that toxin could produce cancer mutations In the children’s DNA. It was an interesting, promising way; But there were too many conditional in the idea. Those conditionals are those who have tried to eliminate the investigation that It has just been published in Nature. What have they done? They have analyzed the DNA of almost a thousand tumors of this type of 11 different countries (and three continents). Not only that: they have examined varieties, typologies and demographic features. And what they have found is more than interesting. To begin with, there are two genetic brands related to the toxin in question that are 3.3 times more common in tumors of young people (compared to those of people over 70 years old). To continue, “they are especially prevalent in countries with a high incidence of colorectal cancer in young people.” What does this mean? “Mutational firms are a kind of historical record in the genome; they point out that exposure to colibactin in early stages of life promotes colorectal cancer of early appearance,” Ludmil Alexandrov explainedfrom the University of California in San Diego. Everything seems to indicate that the harmful effects of this toxin begin soon (in the first 10 years of life). That is, “if someone acquires one of these driving mutations at 10 years, decades could be advanced in the development of colorectal cancer and suffering from age 40 instead of 60, “explained Alexandrov. It is great news. No, it’s excellent news. Insufficient, preliminary and still precarious: but if we are clear, it is that to contain the epidemic we must understand where it comes from. And, for now, it seems that it comes from the modern world. “In the most industrialized countries there is an increase in cases of infection with this strain of Escherichia coliwhich leads us to think about changes in lifestyle “, Díaz Gay says in the country. How can we use it in our favor? We do not know, but we will discover it. Image | JC Gellidon | National Cancer Institute In Xataka | We have found a cure for more aggressive colon cancer: this is how the drug is referred to

We knew that Holy Week was going to be complicated. What we didn’t know is that a polar dough was going to complicate it even more

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That Holy Week was going to be complicated, we already knew it. What we did not suspect is that, taking advantage of the absence of high pressures, they were going to strain on the whole peninsula A series of polar masses That not only They are going to erase all trace from Borrasca Olivierbut the country’s temperatures will collapse. What comes from Greenland. As Victor Gonzalez explainedin the next few hours “a very cold air tongue in medium-high layers will take off from the immediate vicinity of Greenland” and “will cause a sharp change of time.” It is logical, the storm that now affected us (Olivier) came from the Canary Islands with a southern air upstage that contributed to soften temperatures. Polar mass It will move The storm (which will still leave showers and storms) and will knock the thermometers. So what can we expect from Holy Week? Aemet He has just published An update about the time of the week that begins. Monday 14: The models expect rainfall (locally strong and occasionally with a storm) in Galicia that “will be extended by the rest of the Atlantic aspect weak or moderate.” In the Mediterranean, we are likely to meet intense stormy showers and wind gusts. In addition, temperatures will fall throughout the country (except in the Cantabrian, where they will rise). Tuesday 15 and Wednesday 16: The rains of the Atlantic facade was a front that preceded the entrance of a polar mass that will collapse temperatures. The snow level, in fact, will remain between 900 and 1,200 in much of the northwest. Generalized rain is expected in much of the country. Thursday 17 and Saturday 19: PAt the end of the week, the situation will tend to stabilize. However, everything seems to indicate that a new storm in Galicia will begin to enter and gradually will spread through the northwestern third of the Peninsula. Sunday 20 and Monday 21: Although the uncertainty is high, it is “probable that rainfall continues throughout the northern part of the Peninsula, in the Balearic Islands and in part of the east. It is not ruled out that some of these showers can be very intense. There are no changes on the horizon? The truth is not. Atmospheric circulation does not show great changes and that not only guarantees us a few unusually fresh days, but also makes front and storms continue. It doesn’t hurt to remember that The monthly forecast of the ECMWF is bet “For an extremely rainy April in the southwest quadrant and peninsular downtown area, with wet anomalies of up to 50 l/m2 compared to the average in Western Andalusia, Sierra de Gredos and locally in the community of Madrid.” That is, although It is not clear what will happenwe better get used to the rains. Spring continues to delay. Image | ANDCMWF In Xataka | Time at Holy Week 2025: The best websites and apps to know what time you will have on your vacation

In 1643, Descartes created one of the most important theorems of geometry. We knew he was right, but we didn’t know why. Until now

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In 1643, René Descartes wrote a letter to Princess Isabel del Palatinado in which she simplified a classic problem of Western geometry and offered a solution: the so -called ‘Descartes theorem’; that, according to the famous problem that Frederick Soddy published in 1936 in Natureit can be summarized as “the sum of the squares of the four curvatures is half the square of its sum in figures.” Basically, he found a relationship between the radios of four mutually tangent circles. The problem is that the French philosopher did not explain the reasoning behind that relationship and, in fact, he never managed to find a general formula for more than four circles. His intuition is that this solution existed, but was not able to find it. That has brought mathematicians since then. A couple of years ago Daniel Mathews and Orion Zymaris, from the Australian University of Monash, They decided to try With a radically new approach. What if we use tools of theoretical physics? That was the question that was asked: As Héctor Farrés explainedinstead of pulling the tools of conventional geometry, they began to play with ‘thorn’ (a type of objects of theoretical physics that need a 720 degree turn to return to their natural position). “We use a version of thorn developed by Roger Penrose and Wolfgang Rindler, which applied to the theory of relativity,” The authors said. In this way they achieved ‘re-conceptualize’ circles as algebraic entities that can suffer from geometric transformations. That was the key to obtaining a general formula to be able to describe increasingly complex groups of mutually tangent circles. Why is it interesting? To start because it solves a historical problem of geometry. But, above all, because it does it again and with many ramifications. When Andrew Wiles He managed to demonstrate Fermat’s last theoremthere was some disappointment for the use of modern mathematical tools. In that case it was understandable: part of the grace of the problem was to find the demonstration that Fermat himself said he had discovered (but never wrote). With Descartes’s theorem is different. There was nothing to look for, just a solution to develop. And doing so shows all the potential of mathematics to destroy the limitations that lead us to grip for centuries. In the end, As Arthur C. Clarke said“When a distinguished but elderly scientist says that something is possible, it is almost certain that he is right. When he states that something is impossible, it is almost certain that he is wrong. Image | Frans Hals | Jacob Rus In Xataka | The “Matrix” fillet was always real: philosophical and metaphysical reflections on metovers

We already knew that Spanish wine was on its way to collapse. What we didn’t know was that drought was going to accelerate it so much

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At this point of 2025, say that Spanish wine is on its way to disaster It cannot surprise Nobody. However, it is inevitable that, reading phrases like that, let’s think it is exaggerating. Soon we examine the data, we see that the coup can become huge. Two news that is better understood together. The first is from July 25, 2024: The earliest harvest Within Jerez’s framework since there are historical records. That is to say, For more than 130 years. As the winemakers themselves said, They saw that “In July the grape was already at its optimal point (the 10.5º Baumé demanded) and that if we expected more I was going to lose weight and deteriorate.” The second news is a couple of months later: the production of wine from the United Kingdom has doubled in a very short time and, in fact, the surface planted with vines has increased 75% in the last five years. This is very rare in a place where (despite have vineyards from Roman times and produce commercially since the 60s) the vines have never been good for cold and bad weather. Both news are the beam and the underside of a huge problem: the huge impact that climate change in the main wine regions of Europe has. And, especially, in Spain. A global problem that affects us especially. Traditionally, there are two planetary areas indicated for the cultivation of the vine: the one between the 30th and 50th parallels of the northern hemisphere and that located between the 30th and 40th in the south. The problem is that, like The National Institute for Agronomic Research predicted In France, around 2100 those areas will be completely blurred with the double “very warm” days of the historical average. According to a study published in Nature Reviews Earth & Environment In March 2024up to 70% of the current wine -producing regions could face a substantial risk to lose their suitability for viticulture. In that drawer we are. In Spain, as defends happiness in Herralde, researcher at the Institute for Agrifood Research and Technology of Catalonia, towards the end of the century “the water deficit could reach 200 liters per square meter.” That is, in many wine areas “half of the rainwater that is now available in a year may be missing.” Things are changing. “I have gone from harvesting to do it in a short sleeve and always looking at the sky. My father does not remember in all his youth or a hail storm and now they come to us in September shattering the harvest and even in spring, sweeping that of that year And the next one, because it takes all the yolks “, explained in Rioja2 Berta Valgañónfarmer and producer of the denomination of qualified origin Rioja. And when we say that “time is crazy” we are not entirely aware of what it implies. As Olivia García pointed out “In winter it does not snow, (…) in February it is hot and the plants begin to sprout before but the risk of frosts extends to May (…). In spring it hardly rains and summer is totally dry.” The result is that, when “the harvest arrives so hot that the level of sugar and acidity becomes totally unbalanced.” It is not uncommon. “In a reference period from 1972 to 2005 we have found that, for example, in the Penedès region the increase in average annual temperatures has already reached two and a half degrees,” explained of Herralde in the country. Estimates are terrifying. At the end of 2022, the Reading University published a report where it was concluded that “a fifth of the United Kingdom could have adequate climatic conditions to cultivate Chardonnay grapes in 2050”. But instead, “according to A study conducted over 15 years In vineyards from different areas of the world, 90% of current cultivation areas will not be suitable within a few years. “ To this we must add the problem of water. Not only is water missing at very important specific moments, but As Jordi Pastor defendedmost winemakers already grow with an amount of water lower than optimal. As with the olive tree, the agricultural strategy is to migrate production towards irrigation and, in fact, while 20 years ago the percentages of irrigated vine Today I already touched 50%. And yet, the situation is very complicated … With the available data of the denominations of Catalan origin, we can say that sprouting and flowering are being advanced around 11 days compared to half a century ago. But in addition, “the main cycles of the vineyard (sprouting, flowering, curd, envre and harvest) are faster, those phases are shorter.” Is What we saw too Within the framework of Jerez and In the rest of wine areas from Spain, Greece, Italy or southern California. France, much less affected, too He has seen him The ears to the wolf. … that goes beyond the future. This April, Freixenet presented an ERTE for 615 workers for drought. As they explainedit was an “exercise of responsibility” to “guarantee the operability of the business” in the face of grapes due to the lack of rain. Regardless of the details of that specific case, the truth is that the labor, financial and industrial ramifications The problem is here. And he will not go anywhere. How do we do the wine? “Spain will be a little suitable place to make wine, which means that wine production will not become impossible, but it will be increasingly difficult according to the degree of global warming,” defended Sébastien Zitoresearcher at the Institute of Vineyard Sciences and Burgundy Wine. He is right. Therefore, the world of wine Work already in a hurry for looking for solutions. And the truth is that the struggle to maintain profitability is not the only problem. After all, this environmental pressure also attacks the personality itself of the wines. Can Spanish wines survive while being themselves on the way? Image | Trent Erwin | Climate Resanalyzer In … Read more

Everything you didn’t know about supermodel Helena Christensen, who turns 56

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The 90s were one of the best times for models. Cindy Crawford Claudia Schiffer or Naomi Campbell became great references in the general panorama, and the most prestigious brands fought over them. It was also the case of Helena Christensena Danish supermodel (December 25, 1968, Copenhagen) who swept all the catwalks from Chanel, Dior, Yves Saint Laurent and a long etcetera; and continues to do so today. On the occasion of his 56th birthdaywe collected some surprising facts about her. © Getty Images Of miss to supermodel Both Helena and her family knew that she had potential as a model, which is why she decided to sign up with just 16 years old to a beauty pageantfrom which she emerged with the title of Miss Copenhagen. After a few years, the model entered a competition again, this time on a large scale, and which awarded her the designation of Miss Denmark at 18 years old. It was from here, when the big brands discovered her and began to feature her in their shows. © Getty Images She was one of the first generation of Victoria’s Secret Angels. Along with other models such as Tyra BanksHelena Christensen had the opportunity to be part of the first generation of angels. He was present in the brand from 1996 to 1998, and walked in ’96 and ’97, before the show was broadcast on television. His time at the firm was brief but intense, so much so that, even though 26 years have passed, Christensen is still a true Victoria’s Secret icon. In 2020, she posed again for the lingerie brand. © helenachristensen Photography, his other great passion Unlike many models, Helena Christensen has also always liked being behind the cameras. In 1999, he co-founded the magazine Nylonwhich published its last issue in 2017 and of which it was also photographer and editor. Apart from this, she has participated with numerous magazines to create their cover photos, becoming a renowned photographer and supermodel. © Getty Images From not parading in 10 years to reappearing at the tribute to Gianni Versace Helena Christensen retired from the catwalks for a few years to dedicate herself to her son, but what we didn’t know is that she would return in the way she did. In 2007, a parade in honor to the designer and founder of Versace, Gianni Versacein which she and the models Carla Bruni, Naomi Campbell, Claudia Schiffer and Cindy Crawford They starred in the emblematic photo moment. Dressed in similar pieces but with different silhouettes, this show went down in the history of the Italian house as one of the most successful. © Getty Images Although she was born in Denmark, she is half Peruvian His father was Danish and his mother was Peruvian, but he lived his entire childhood living with his family in Copenhagen. It wasn’t until 2023 when obtained Peruvian nationality to help his nephew, Oliver Sonne, get it. Sonne wanted to be a candidate for the Peruvian team, and to do so he had to have nationality, so Helena requested it. © Getty Images Still present on international catwalks Who said that at a certain age you can no longer parade? Helena Christensen is proof that the talent goes beyond age. The model walked in show of Elie Saab The 1001 Seasons of Elie Saab on November 13, 2024. There, she wore this spectacular dress embroidered with rhinestones and with a semi-transparent cape that shows that what once was, always will be. © Getty Images She has a son with actor Norman Reedus. In 1999, their first and only child was born, Mingus Lucien Reedus; which is the result of his relationship with the actor Norman Reedusknown for starring in series such as The Walking Dead. The love relationship began in 1998 and a year later they had their son. It was not until 2003 when they decided to end their courtship, but they get along very welland on social networks they continue to show us photos of both on significant occasions, such as Father’s Day or their son’s graduation. © Getty Images Participated in the Dior 60th anniversary show Christian Dior has always been one of the most important Haute Couture brands and, as such, its 60th anniversary In 2007 it had to be up to par. With the designer John Galliano and the Versailles Palace As a space, models such as Helena Christensen, Gisele Bündchen or Naomi Campbell wore spectacular designs that definitely marked a before and after for the brand. © Getty Images What did Gianni Versace say about Helena Christensen? With measurements of 89-61-88 and a height of 1.78 meters, the model has been one of the most sought-after in the industry. Her green eyes and the beauty of the Danish and Peruvian mix have made her reach the top. The proof of this is that great designers like Gianni Versace They have come to affirm that Christensen’s body was the most beautiful in the world. © Getty Images She was one of the supermodels of the 90s Although it is not so present on catwalks now, it was one of the most influential supermodels in the 90s. Houses like Chanel, Dior, Versace and Yves Saint Laurent wanted to have her wear their designs. Furthermore, his legacy as muse of renowned photographers and her impact on popular culture established her as one of the most prominent figures in the industry. © Getty Images © Getty Images Red carpet vs. street style We are used to seeing her on catwalks or on red carpets, always like a brush and with a makeup and a look of 10. But is the real Helena Christensen like this in her daily life? The answer is obvious, and it is that you can never look the same as on a red carpet. As we see in the second photo, the supermodel adopts a much more relaxed style in her daily life, opting for looser pieces. On the other hand, on … Read more

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