years

A paleontologist discovered a frozen bison for 50,000 years. Then he stewed him to eat it with vegetables

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Almost half a century ago, in the middle of the Summer of 1979the American paleontologist Dale Guthrie received one of those calls that accelerate the pulse of any fossil lover like him. Some miners had found close to Fairbanks, in Alaska, which seemed to be part of the body of a bison of the ice age. At least that was what suggested the confusing knead of hooves, legs and skin that had peeked between the mud while the operators were looking for gold. Years after that call (and after intense work through) Guthrie and his colleagues celebrated the one who has probably been one of the most delusional banquets in the history of humanity: a stew with flesh of 55,000 years. What the hell is this? Something such that Walter Roman and his family have to think about the summer of 1979, when they discovered in a mine north of Fairbanks (Alaska) something that little or nothing had to do with the gold they were looking for. While working in the area they realized that something appeared between the frozen land: the remains of what seemed like a Ancient ancient creature of tens of thousands of years. They were so surprised that they warned of the finding and the news ended up arriving at Guthriepaleontologist at the University of Alaska Fairbanks (UAF). Something better than gold. Guthrie had to drive about an hour On gravel roads to get to the Roman mine, but the effort was worth it. Once there he observed what they looked like muscle tissues, bones and black hair, the remains of an ancient semi -soured steparia creature between the ice. “Roman’s finding was a novelty for both. He had found an authentic mummy, an exceptional event,” I would report Years later Guthrie in one of his books. The body had peeked thanks to the force of the hose with which the miners worked, powerful enough to remove part of the frozen mud, but not to completely release the body. Seeing him Guthrie decided to finish the task to prevent the meat from breaking down. With you, the Bison Priscus. The paleontologist concluded that what he had before him was a Bison Priscusan exceptionally well -preserved steparium bison if you take into account that tens of thousands of years had lived. Unfortunately, not everything was good news. Ice accumulations prevented removing the body quickly. And the summer heat played against him. To get out of trouble Guthrie took A decision Worthy of King Solomon: he waited for a large part of the body to appear, cut what could be preserved in one of the powerful freezers of the UAF and then excavated the rest of the body that was still embedded in the icy mud, which included the head and neck of the animal. When he had all the pieces he assembled them with the help of a specialized taxidermist. Not just that. As it details An article Published in 1986 in the Magazine of the University of Alaska (UA), the researchers were responsible for preserving the bones, hairs, insects, wood fragments and plants … any fragment that would be hidden among the ice, however insignificant, to rebuild the last instant of the life of the bison. For that same reason, the geology of the area analyzed in detail, in addition to the orientation and position in which the body was. Once the work was completed they baptized the animal ‘Blue Babe’. Why ‘Blue Babe’? For a double wink. The first, to the coloration that acquired the body for the chemical reactions that occurred during the excavation. The body was covered with a layer of Vivianita that, when exposed to the air, acquired a bluish hue. The second is a reference to American folklore: Blue Babe It is the name of the blue ox that accompanies Paul Bunyan, a popular US and Canada figure, a strong and large lumberjack. A bloody story. So far the funniest part. What Guthrie and his colleagues discovered (in the excavation His wife also participatedMary Lee) when examining the body was much less enjoyable. On the back they found brands of claws and teeth that led them to conclude that Blue Babe was killed by a Panthera Leoatrxan extinct and related feline with the African lions. The beast opened the side of the bison, killing and leaving exposed vertebrae, ribs and muscles that later were responsible for devouring other carnivores. A first radiocarbon dating of a skin fragment led them to think that this event occurred some 36,000 yearsalthough subsequent studies have proven that they fell short and traced it to 50,000 years. Much more than a fossil. He Panthera Leoatrx And the rest of the beasts who participated in the bloodthirsty Festin were not the only ones who put the vote at the coast of Blue Babe. When examining the body the scientists found out something else, that the bison died towards autumn or winter, which favored the body to cool quickly and ended up freezing before their 50,000 -year -old dream. Your state of conservation It was so extraordinarily good That the paleontologists found blood coagulated in the skin, bone marrow, fat … and something else: they found that the muscle tissue that the lion and rest of the beasts had not realized had a color and texture very similar to that of fresh meat. So, why treat it the same? “A small part of the neck”. “All of us who worked on this had heard the stories of the Russians who excavated things like bison and mammoths at the north end and were frozen enough to eat them,” He came to confess Guthrie in statements collected by Obscure atlas. “So we said: ‘Do you know what we can make’ prepare a meal with this bison ‘.” No sooner said than done. The paleontologist and his colleagues decided to try a piece of one of the best preserved parts of Blue Babe, the neck. The banquet was held in … Read more

Printers have been a terrible product for 30 years. The fault is Nash’s balance

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Let’s go back to 1949. A young mathematician named John Nash Find an original idea for your thesis at Princeton University. Game theory already existed thanks to the previous works (1944) by John Von Neumann and Oskar Morgenstern, but the von Neumann model focused on zero -sum games (one player wins, the other loses). Nash had a spark of genius in proposing that in any game there should be at least one point where no player could improve his situation by changing his strategy unilaterally. Formalized that idea in a short two -page article (‘Equilibrium Points in N-Person Games‘) In January 1950, and with it revolutionized history. Including printers. Is the printer the worst technological product in history? And is that the printers is an almost manual example to apply the call Nash balance. These types of products have been following – at least, to a large extent – the economic model of the machin and blades: you sell cheap the first, but face the second. Consumers know that when we buy an ink printer, the price will be economical, almost ridiculous. But we also have assumed that ink and cartridges for those printers will be very expensive. And if they are not, what will end up being is Ink subscription… either to the printers themselves. Not only that: in the last 30-40 years we have seen how printers have become-probably- The worst technological product in history. It is no longer only that printers can get stuck or work erratically. The real problem is terrifying form in which manufacturers have protected their business, preventing in all possible ways that users can for example use Compatible cartridges and tonniers of third parties. Nash’s balance explains very well why manufacturers do what they do. Imagine two great manufacturers such as HP and Canon with two options: Expensive and blocked cartridges (current model) Cheap and open cartridges (which allow competition and lower prices) Given this situation, HP and Canon managers know that three types of market situations can be found: If both keep expensive and blocked cartridges: they earn a lot If one “opens” its cartridges and lowers prices and the other remains closed: the one that opens loses income and the one that is still closed earns more … or the opposite. Whatever happens, one will end up winning a lot and the other losing a lot. If both open: there is strong competition again, but both win less Given that scenario, manufacturers make an inevitable business decision: they close their cartridge technology and sell it face Because that’s what gives more benefits to everyone. Nash’s balance is fully fulfilled here: it describes a stable point for each player (company) but does not ensure that the result is the best for the whole. Collectively and from the social point of view, the optimal would be to open the technology and lower prices: companies would earn less, but the market would be larger and fair. Reality, as we know, is very different. But maybe that reality can change. We need a “Tesla printer” The printer user has therefore 30 years constant bleeding which translates into an exaggerated expense in cartridges and also in an erosion of time and productivity. What has happened with printers is something extraordinary: We have normalized that printers are almost more a problem than a solution. The Open Printer, a striking printer project “Open Source” and is based on the use of HP cartridges but accepts compatible third -party cartridges. Source: The Open Printer. And that is why we have a panorama in which there is a great opportunity for a revolution in the printers market. This segment is hungry for an ethical disruptive: the manufacturer who abandons the current Nash balance can change everything here. It is a mature field in which an innovative based on transparency and reliability could not only capture the market, but even redefine it. What the market needs is a kind of “Tesla printer”. And we refer to a printer that causes in this segment what Tesla managed to provoke in the car industry: a machine that has a great design, a reliable operation and that is also designed to last. But above all, that offers an alternative to current printers and their dictatorial philosophy with cartridges. Here are some projects underway. The project The Open Printerfrom the Parisian startup Open Tooks, is intended as A repair ink printer, Open Sourceand that focuses its operation on reparable cartridges. Its creators claim that this printer is created “with standard mechanical components and with modular parts”, which theoretically simplifies its assembly, modification and repair. Source: The Open Printer. In fact, the Open Printer works with a small Raspberry Pi W plate as an operations center. There are no proprietary firmware or cartridges with DRM. It is designed to use HP63 cartridges (HP 302 in Europe) both in black and in color but they serve both those of HP and third parties. And not only can you print on AAR or A4 folios, but even in 27 mm paper rolls. There are no details about its price or availability for the moment, but the idea will not be launched directly, and will first be launched as a collective financing project. We know for previous failures (and frauds) that such financing models It has its risksbut in this case that option seems reasonable and we only have to wait for the best of the project. That may not be the only launch in this regard, and in fact There is an even more interesting rumor. Frameworkthe company that has conquered us with its repairable laptops, seems to be considering the idea of ​​creating its own printer (modular and repairable? We expect that!). This is how at least a recent message indicates in X in which they commented on how “one of you must have sabotaged the office printer and has forced us to manufacture one. It is not possible that HP is selling printers that broken.” … Read more

125,000 years ago the Neanderthals ate bones to survive. Today we discovered that they were right

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In the police comedy Brooklyn 99during a party the detective Charles Boyle meets the gastronomic writer Vivian Ludley, with whom he talks about the last meal on earth. The policeman, in a clamor for his love of French food, chooses El Hortelano: a tiny French bird that eats a single bite, with skin, viscera and bones. “A challenge to God”, They call it. Vivian replies that the practice is illegal, But he confesses that he had academic permission to try one: “The peak was very crispy,” he recalls with fascination. The scene may seem eccentric, but opens a question that is not less: what is in the bones that makes them so valuable – at the same time so controversial – in the history of food? Western oblivion. For centuries, the bones were a natural part of the human diet. The neardentals They came to ride “Fats of fat” in places like Neumark-Nord (Germany), where 125,000 years ago they broke bones of deer, horses and cattle to extract marrow and heat fragments with water until obtainable lipids. It was not a whim: it was survival, a way to avoid the so -called starvation of the rabbit, caused by eating too much lean protein without sufficient fat. Later, many cultures continued with practice. In sub -Saharan Africa, for example, rural communities even chew long bones as part of the daily diet. In Asia it is common to eat flags and fins of fried fish until they are crispy. And in Europe, popular cuisine always turned to the thorns of canned sardines and anchovies, softened by sterilization. However, speaking today of what bones are as such, this practice of consuming them disappeared. Most meat reaches the clean, boneless plate, ready to avoid discomforts. The bone has been relegated to the secondary paper of the broth. As Chef Jennifer McLAGAN explains: “We no longer see bones as useful. People consider them a discomfort, something to get rid of.” But that perception begins to crack through The search for “superfood”and the bones are on the table again. What is inside the bones? The short response would be essential nutrients. But I will not be so simplistic, the bones are mainly formed by calcium and phosphorusin addition to containing iron, magnesium and potassium. In protein terms, up to a 25 and 33% of the content of an animal It corresponds to collagen, a key structural protein for bones, skin and joints. In my case, I discovered it by accident. After an injury doing crossfitthe traumatologist told me about the importance of collagen To recover fabrics. Beyond prescribing supplements – which also opened the door to the veal bone broths, rich in natural collagen. It was my first conscious contact with this part of the animal we usually throw without thinking. Science behind. In a National Geographic report describe how bones They are one of the denser tissues in nutrients: they provide collagen, fat marrow and minerals. But science clarifies. An article, Posted in Frontiers in Nutritionpoints out that the benefits are modest: some trials show minor improvements in skin and joints, although with methodological limitations. A meta -analysis in Orthopec Reviews It points positive effects on bone and articulating health, but insists on the need for broader and standardized studies. In addition, we are not designed to bite hard bones: they can splinter, damage teeth or pierce the digestive tract. And large animals bones tend to accumulate heavy metals such as lead or cadmium, which advise against consuming them in excess or un controlled dust, According to Healthline. The heat and pressure of the long broths allow to extract collagen and minerals safely, and some studies They suggest a certain benefit when ingesting collagen peptides. However, the reviews of the studies consulted coincide: Quality trials are missing, with standardized protocols and clear clinical markers. A new trend? The interest in bones does not happen in a vacuum. A couple of months ago, the “Carnivorous Diet” for Babies: families that offer ribs or cord to their children as part of the Baby-Led Weaning. Health and expert authorities They coincide in which to introduce meat from six months is recommended by its iron and zinc. But they warn that a strictly carnivorous diet in babies lacks fiber and vitamin C, essential nutrients for development. At the same time, startups in Europe and Asia experiment with powdered bone -based products: breads, sausages, patches or nuggets that incorporate calcium and collagen without bothering the consumer. According to National Geographicthe initial results are positive: when the bone appears as an invisible ingredient, acceptance is high. Collagen is more present. Korean cosmetics and social networks They have converted To the collagen in a global phenomenon, associated not only to joint or bone health, but above all to beauty and anti -aging. From facial creams to soluble coffee powders, the promise is to erase wrinkles, combat sagging and rejuvenate the skin. However, skeptical voices such as that of the surgeon Afshin mosahebi Remember that scientific evidence It is limited and that, by ingesting it, the collagen does not reach the dermis: it decomposes in amino acids like any other protein. The bone broth is a nutritious and comforting classic, but Not a guaranteed age. The real secret to aging well is still in basic habits: do not smoke, protect from the sun, maintain a balanced diet and sleep enough. An unexpected return. Of the “fat factories” Neanderthals to Korean cosmetics, bones have accompanied humanity in multiple forms. Today they return to the scene between broths and collagen powders. The difference is that, this time, they do not arrive as a resource of survival, but as a market as a product: what was previously thrown, is now sold as a trend. Image | Freepik Xataka | Boomers trust pills and supplement, generation Z in “functional snacks”: two ways to look for the same

Thousands of people have been drinking apple vinegar for years before eating to lose weight. The fault has an erroneous study

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A couple of months ago, the last viral trend of social networks was taken on an empty stomach in the morning recently raised: the “morning sucks.” There were all kinds: apple vinegar, of grass Or even A tablespoon coconut oil. Everyone promises the same: flat bellies, express detox and accelerated metabolism. Under the appearance of natural remedy, the illusion of a quick solution was really sold. In particular, apple vinegar stands out as the biggest protagonist, since a study endorsed it, but it was a misinterpretation. The origin of the myth. We have always heard that phrase of “speaking people understand”, although quite simplistic it is that misunderstandings are the order of the day and in science they are usually given. To get to the origin of that study, the tracking takes you to a study published in BMJ Nutrition, Prevention & Health. This research became popular to ensure that apple vinegar helped lose weight. However, According to Sciencedailythat study has been retracted after detecting inconsistencies in data and serious errors in statistical analysis. In science, a retraction is an exceptional mechanism: it means recognizing that the results are not reliable and, therefore, that the study should no longer be cited as evidence. It is a guarantee of self -correction, but it is late when the finding has already traveled media and viral videos. The viralization of myth. The networks did the rest. Under hashtags like #guthealth or #morningritual, vinegar It settled In morning routines with other “shots” that promise express benefits: ginger, turmeric, teas detox. As we detail in Xatakathis phenomenon is understood in the framework of the culture of immediacy: we live at a time when rapid and visible results are sought. A morning drink fits perfectly with that promise of instant change. The problem is that neither vinegar nor any of these mixtures fulfill what they promise. And in some cases They can have adverse effects: Excessive consumption of fasting vinegar can irritate the stomach and esophagus, damage tooth enamel and cause digestive discomfort. More studies. Beyond the retracting study, there are research that has analyzed the effect of vinegar on metabolic health, although scientific evidence remains low. A systematic review, Posted in Pubmed Central in 2021evaluated clinical trials on this product. According to this work, vinegar can have modest effects on the reduction of blood glucose and total cholesterol. But the same review warns: there is no solid evidence that it causes clinically relevant weight losses. In other words: vinegar is not a burning, much less a magical solution to lose weight. The mirage of detox. The rise of these “morning shots” also relies on the language of the detox. However, experts Remember that Detoxification does not work like this: the body already has organs such as the liver and the kidneys that fulfill that function continuously. Chupitos do not “clean” the organism, but they do perpetuate the idea that there are miraculous shortcuts to compensate for excesses. An even greater paradigm. The history of apple vinegar is, in the background, a lesson on how health myths are built in the digital age. A study with methodological errors, amplified on social networks, became a global ritual. And although today we know that there was no evidence behind, the practice was already installed in millions of morning routines. The lesson is clear: easy solutions are rarely, and health is not built with shortcuts. Image | Freepik and Pexels Xataka | There are people taking a “sucking” apple vinegar in the morning. Science has an opinion about it

For years summer is synonymous with gastronomic parties. In Galicia, hoteliers believe they are unfair competition

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If you travel to Galicia in summer it is likely that in addition to beaches, seafood and tourists In search of the best cove in which to plant your umbrella, find something else: Gastronomic parties. There are tens. To hundreds. From entrance spring to Autumn well advanced It is possible to meet throughout of the region quotes dedicated to percebe, Carneiro Ao spongrazors, Albariño or hamburgers, between a long long etc. They are so many and so many people move in Ribadeo (In the province of Lugo) local hoteliers and merchants They have said enough. The reason: where others see a mass celebration they have detected something else, one “unfair competition”. In a place in Galicia … Ribadeo is a small town of the Eastern Mariña (Lugo Province) of somewhat less than 10,000 inhabitants. However, in summer thousands of tourists attracted for their heritage, landscape, gastronomy, environment and especially their great jewel: The beach of the cathedralsone of the great natural monument of the Peninsular North. The INE calculates that only between June and August were housed in the hotels of the municipality 28,200 travelersthousands of potential clients for shops, coffee shops and restaurants in the town. Local trade … and something else. The fact is that in Ribadeo (as in many other villas in Spain) there are not only stores and bars. Throughout the year and especially in summer, fairs, markets, gastronomic parties are held … events organized in the most central streets and squares and that capture the interest of neighbors and visitors. The large dating calendar serves for the people to be more attractive, but the local merchant association (Acisa Ribadeo) He just lifes his voice to alert that not everything is positive. In his opinion also represents a “unfair competition” For businesses that work throughout the year, not only in summer. “Without Control” celebrations. The matter is serious enough for the organization to have been treated as a great point of the day in a Extraordinary Assembly held this week. Has even dedicated A reportunanimously ratified and in which he exposes why (in his opinion) the celebration “without control” of this kind of quotes undermines its profitability. “It includes the arguments for which Acis emphasize. “Acisa is not against the celebration of these markets and events, what we reject is that they be held without control, on the poorly appropriate dates and with excessive durations,” claims The Association Manager, Jesús Pérez. “In recent months, events with little planning have been held, without transparency with respect to the promoters or the purposes to which the benefits are dedicated, becoming scheduled every little time and in the middle of high season. This implies direct and unfair competition for local trade and hospitality and a deterioration of the ribadeo image.” Why’s that? Acisa complaint That kind of specific quotes “take advantage of the work that takes place throughout the year” to boost the people and capture visits. And they also do so by taking advantage of the high season and “the best locations” of the town in exchange for “minimum or null taxes for the benefits they get.” “The rates that pay for occupying public roads are in many cases symbolic, ridiculous or non -existent,” Crows. In summary, merchants and hoteliers feel that the fairs stand up during the high season while they are responsible for serving, paying rent and taxes and generating employment in the town throughout the year. “In addition they do not always comply with the basic regulations, such as the issuance of purchase tickets, nor are they subject to health, labor or fiscal controls. They do not generate employment in the municipality and use municipal services such as works, hooks of light or cleanliness, which we pay all ribadenses,” Pérez argueswho also clarifies that these celebrations “do not contribute anything new” to customers. “The products and services they offer can be found in local businesses with higher quality.” The debate, served. That in general (not only in ribadeo) the markets, festivals and gastronomic parties They attract people It is difficult to discuss. The key to Acisa is when and how they are celebrated. And especially the impact they have on small businesses entrenched in the town. Hence they speak of a “direct unfair competition” for entrepreneurs who do assume fixed expenses, taxes and “normative obligations” that, denounce, “are not always assumed by the organizers” of that kind of appointments. “They seek to place themselves in the moments of greater tourist influx in ribadeo, taking advantage of the previous effort and investment made by the sector to attract visitors to the town,” insists The collective. Moreover, in its report it warns that “in many cases” specific events “lack clear planning” and transparency, which can compromise “the tourist image” of Ribadeo. “Prioritize improvised and very poor quality activities compared to the value of trade and local hospitality.” What do they suggest then? In Your report Acisa demands “order, regulate and compatible” these events with the “legitimate interests” of the merchants and hoteliers of the town. They even speak directly of limiting authorizations to “protect the local economic fabric”, restricting permits for those appointments that enter direct competition with local businesses or extend for too many days or repeatedly in the same year. Aware that fairs, festivals and markets help to boost the town, even suggests rethink the calendar of the celebrations. What in practice translates into organizing them “preferably” outside the high season or dates in which the flow of customers, such as Holy Week, summer or Christmas months, “when local trade and hospitality already make an extraordinary effort to meet the demand.” “We don’t need them”. “Ribadeo does not need this type of event in high season. We consider that they can be held promptly in low season following the premises collected by the report prepared by Acisa,” its president concludesCarmen Cruzado. The group leaves out the bag, yes, the events of a solidarity and non -profit nature and those with a limited duration, a … Read more

24 years ago, the earth was symmetrical. Now the northern hemisphere is “unequivocally” darker than the southern hemisphere

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NASA’s last 24 years of satellite data reveal an “unequivocal” trend: the earth has lost its balance, and now the northern hemisphere reflects less light than the southern hemisphere. How is that? Until a few years ago, our planet maintained an almost perfect symmetry in regard to its albedo: its reflectivity from the perspective of an observer in the earth’s orbit. Despite its obvious differences (the north dominated by terrestrial masses and the south by oceans), both hemispheres reflected practically the same amount of sunlight to outer space. Now that doesn’t happen anymore. The northern hemisphere is absorbing more solar energy than the southern hemisphere, breaking the balance that had been maintained for a long time. In figures. The new study, published in Proceedings of the National Academy of Sciencesquantifies this divergence at 0.34 wm – 2 per decade. It is a statistically significant value that points to a deep change in the energy engine of our planet. And why? The study, led by Norman Loeb, from the NASA Langley Research Center, points to a combination of factors; The first one, somewhat paradoxical. According to Loeb, the main engine of the growing asymmetry is the aerosols, the tiny particles suspended in the atmosphere against which we have been fighting for some time. Thanks to environmental protection measures, fine particle pollution has decreased significantly in Europe, the United States and China in recent years. Less contamination means a cleaner air and, therefore, less particles that reflect sunlight. The result is that more radiation reaches the surface and is absorbed. In the southern hemisphere it has happened just the opposite. Mass events, such as Australian forest fires of 2019-2020 or the eruption of the Hunga Tonga volcano in 2022, injected huge amounts of aerosols into the atmosphere, temporarily increasing the reflectivity. There is something else. To the aerosols we must add the change in the Albedo of the surface itself. The northern hemisphere is losing snow and sea ice at an accelerated pace, in this case because of global warming. If white and bright surfaces (which reflect the light) are replaced by water and dark terrain (that absorb it), the hemisphere is further darkened. Clouds are missing. What has most bewildered scientists is the role of clouds. For a long time it was theorized that clouds would act as a natural compensatory mechanism for this phenomenon: if a hemisphere darkened by external factors, atmospheric circulation would adjust cloudiness to reflect more light and restore balance. However, the data shows that this is not what is happening. The study concludes that the contribution of clouds to the difference in reflectivity between hemispheres is surprisingly small. The reason is complex: it seems that the changes in the clouds of the tropics are being canceled with the changes in the highest latitudes, questioning one of the fundamental hypotheses on the self -regulation of the earth’s climate. A problem. That a hemisphere hotly gets more than the other is not a simple academic curiosity. The Earth’s energy balance is the engine that drives atmospheric and oceanic circulation; that is, our climate and our weather patterns. This imbalance is already having consequences. The northern hemisphere not only heats up faster than the south, but is also seeing an increase in rainfall in tropical latitudes. If the intertopical convergence zone, the land rain belt, moves north, the consequences will be hard for billions of people.

29 years ago we clone to the Dolly sheep. Thanks to this, today we are one step closer to solving the fertility crisis

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Imagine a future in which the infertility caused by the lack of ovules or sperm is no longer an insurmountable obstacle. A future where two men can have a biological child together, or where A woman who has lost her ability to produce ovules For age or for a cancer treatment may have offspring with its own genetics. This future, which until now belonged to science fiction, is a little closer thanks to a revolutionary advance that has been published in Nature. Biology This advance, which seems like a science fiction, has been made by the team of researchers at Oregon Health & Science University, led by Dr. Shoukhrat Mitalipov. In this case they have managed to develop an experimental technique that forces a skin cell (somatic) to reduce your number of chromosomes in half. It is, in essence, the most crucial and complicated step in the creation of a gamete (an ovule or a sperm). A process they have called mitomeiosis. To be able to understand it, you have to know that all the cells of our body have in total 46 chromosomes in its nucleus. But there is an exception: sperm and gametes that They have 23 chromosomes. A very important number so that when an ovule and sperm merge, they have a total of 46 chromosomes. That is why it is revolutionary that they have managed to get a skin cell to have 23 chromosomes to be an ideal candidate to give offspring. The trick. The natural process to create these haploid cells (with 23 chromosomes) is called meiosis. A very complex type of cell division that has been investigating for a long time. This made it replicate in a laboratory, which is known as in vitro gametogenesis (IVG) was one of the greatest challenges of biology. Something that now reminds us of what we already saw with the Dolly sheep in the cloning process. OHSU’s team addressed the problem in an ingenious way. Using a technique similar to cloning, called nuclear somatic cell transfer (SCNT). A technique that is complex, but can be summarized in three different steps: The first thing is to take a donated human ovule and extract the genetic material. In this way, the ovule maintained all its cytoplasm with the organelles, which ultimately is like the machinery that the cell has to produce energy and carry out many processes such as meiosis. Once done, a skin cell is taken (a diploid cell with 46 chromosomes in a 2N state) and is extracted the nucleus inside. Now it only remains to introduce the core of the skin cell into the ovule that has been emptied. The result. In this case it was amazing, since the ovule cytoplasm could ‘deceive’ the skin’s core, forcing it prematurely into a state similar to the metaphase of the Meiosis. This caused its 46 chromosomes to be organized in a spindle ready to divide, despite having skipped the DNA duplication phase in the cell cycle that is before the division of the genetic material. The problem. However, here they met a wall. In nature, the entrance of the ‘active’ sperm to complete its division, being mediated by a large number of zinc. But in this case, when they tried to fertilize the SCNT ovules with sperm, the vast majority (almost 77%) remained ‘arrested’ without reacting. The natural signal was not enough for this artificial construction. The solution in this case went to develop an artificial ‘starter’ key. After sperm fertilization, they applied an assisted activation protocol an electrical pulse by electroporation to simulate the calcium entry caused by sperm to its entrance, followed by a treatment with a chemical inhibitor called Roscovitin. And it is something that ended up working. Forced activation made the modified ovules leave their arrest and complete the division. The 46 chromosomes of the cell were separated, leaving an average of 23 chromosomes within the fertilized ovum (now a zigoto) and expelling a small polar body from the rest, having achieved the long -awaited ploidy reduction that was the objective of this experiment. Progress. The embryos resulting from this experiment containing chromosomes of the skin and sperm cell, beginning to divide and even some reached the blastocyst phase (an early development of about 5-6 days), with a success rate of 8.8%. This shows that genomes can integrate and work together. It’s just a test. The authors who are still a long way forward, since for now it is a “proof of concept” by not being a perfect replica of natural meiosis. In this case, segregation is random unlike meiosis, where it is ensured that each daughter cell receives a copy of each of the 23 types of original chromosomes. In this project the separation of homologous chromosomes (the paternal and maternal) was completely random. This generates aneuploid embryos that are incompatible with life. In addition, it also lacks ‘cross -rise’ or crossovera vital mechanism in meiosis where paternal and maternal chromosomes exchange fragments creating genetic diversity. This is something that is not present in this process and that takes away a lot of variability. The future. Despite the limitations of this study, work is a fundamental milestone. It aligns with other laboratories such as the Japanese Katsuhiko Hayashi that in 2023 managed to create functional ovules From male mice skin cells, with which healthy offspring were born. In the long term, the implications of these studies give hope to those women who suffer from infertility due to lack of functional gametes and who want to have offspring with their own genetics. The same happens in same -sex couples that also open the door for a couple of men (using a skin cell to create an ovule) or women (creating sperm) can have biologically related son between both members of the couple. Although we cannot also forget that right now there is a fertility crisis that causes that in Spain, for example, there is reduced birth rate. This is also conditioned that it is … Read more

A green elixir distilled by nuns 400 years ago is the best example

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In the seventeenth century, a apothecary entrusted the French Benedictines of Notre-Dame du Calvaire a secret formula made with sage, rosemary, honey and piperite mint. Four centuries later, the nuns of Bozy-La-Forêt They continue to distill His famous “Emerald Water” as a soothing and energizing lotion. A symbol of how “natural” has always accompanied health care, long before social networks They would make him a trend. The self -care is fashionable. In Spain, eight out of ten people consider that self -care is key to maintaining good health, According to the Association for Health Self -care (ANEFP). And this perception does not remain in theory: it is promoting a market in full expansion. This is the case of the Italian company ABOCA, which has billed more than 50 million euros in Spain with natural health products for common problems such as coughing, reflux or irritations, According to El Confidencial. At the same time, supplement fever and nutricheastics It has been installed in supermarkets, pharmacies and social networks. 75% of Spaniards has consumed Some supplement: from collagen to enriched vitamins or coffees. The difference is that older people trust capsules and anti -aging protocols, while young people seek the same in “functional” snacks or drinks. ANDThe self -care is no longer marginal. The I radiography of self -care in Spain (2025), prepared by ANEFPoffers a clear photograph: 85.3% believe that self -care can improve healthcare. 8 out of 10 see it fundamental to preserve health. Only 1 in 3 associate it directly with disease prevention. 42.5% recognize that lack of knowledge is the main barrier to practice it. The conclusion is evident: there is interest and disposition, but health education is still for a responsible self -care. Natural yes, but regulated. Not everything that is sold as “natural” has the same base. Natural health products act for physical or support mechanisms (for example, create a barrier against acidity), and have European regulation (Regulation 2017/745) which guarantees your safety and efficacy. As the EU regulations rememberevery health product must carry the CE marking, which ensures that it meets safety, health and environmental protection requirements. The key, Experts warnIt is not to confuse natural with harmless: any substance, plant or synthetic, has real effects on the body. But is homeopathy? It should be clarified: natural health products and homeopathy are not the same. The former have European regulation, clinical studies and verifiable mechanisms of action. Instead, homeopathy is based on extreme dilutions without scientific evidence beyond the placebo effect. In Spain, the Spanish Agency for Medicines and Health Products (AEMPS) has registered more than 1,100 homeopathic products. Despite this, citizen trust It collapses: In 2020 only 17.2% of respondents claimed to believe a lot or much in this type of treatment compared to the more than 50% that said otherwise. The business, which came to move dozens of millions, is in decline. And experts They coincide: Confusing “natural” with homeopathy is a mistake that can undermine the credibility of responsible self -care. A cultural change. More than a fashion, self -care reflects a deep cultural change. As we have already written in Xatakaprevention, aesthetics and emotional well -being are mixed in a new culture that promises energy, youth or health control, but also reveals obsessions and social pressures. Social networks have accelerated this phenomenon and have become shop windows, where self -care appears both as part of the daily routine as in the form of viral tendency. Mental health adds another layer: with high levels of stress and anxiety, many resort to self -care as a personal strategy, although 42.5% recognize the lack of knowledge as the main barrier, According to ANEFP. To this are added social inequalities that condition habits, As investigations of the Clinical Medicine Magazine point out. What seemed before an eccentricity – a lotion of nuns or a functional shake – today is part of a new culture of health that combines science, tradition and marketing, and reflects the contemporary aspiration of control not only how much we livebut how we do it. Between tradition and future. From the discreet distillation of Emerald water in a French convent to viral supplements in social networks, self -care has traveled a long way. Today, it represents a solid, regulated and growing market, but also a cultural phenomenon that reflects our obsessions: living more, living better or simply feeling that we have control of our health. What is clear is that self -care is no longer a marginal practice. It is an industry that combines tradition, science and marketing, and that forces us to ask ourselves not only how we want to take care of ourselves, but with what criteria. Image | Photo by Logan Gutierrez ON Unspash and Photo by Mariana Rascão ON Unspash Xataka | An open microphone in China has reminded us of the great dream of the elites of Russia: living forever

Ten years ago, this man introduced radical changes in ‘Dungeons & Dragons’. Thanks to them, it is now a millionaire fever

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‘Dungoons & Dragons’ is the Role game par excellenceand his reign has not turned off the least since 1974, when his most primitive version, still very little affordable because of his rules system, He saw the light. He still had decades ahead and much to evolve to become the accessible entertainment that moves millions of devotees from fantasy of all the world that is today. In the Comic-with Malaga We have had the opportunity to listen to Jeremy Crawford, one of the architects of the fifth edition of the game. It is considered the most modern and affordable: its way of simplifying the classic rules without losing all the richness and complexity that had made ‘D&D This was told by Crawford, a recognized game enthusiast who is also a precise analyst of everything that is attractive to the franchise. The fifth edition broke sales records from its departure, with 3 million copies sold (“It is the first edition of D&D whose sales have not stopped increasing”), But what factors contributed to this unprecedented success? A good part of this is attributed to the explosion of online retransmissions of items, As we count at the time: “Thanks to the fundamental role of Dimension 20 And many other live games programs, now just enter YouTube, Twitch or other services to see how the game is. You can see how fun it is. You can see that it is not as intimidating as it might seem by the extensive regulation “ An important part of this growth is also due to the “analog” part of that diffusion: players shared their enthusiasm for the game with friends and family, inviting them to try it. This made, despite having half a century old, the game was new to many people: “Much of what happened is that you started telling your friends. You started inviting your family,” says Crawford. This emotional connection contributed to the sustained increase in sales, a phenomenon that unusual in previous editions, which normally experienced a decrease after launch. Recommended readings However, all this does not start from the void. There are some previous and foundational elements that had to study before getting to work. Crawford told us that his team “not only studied the previous editions, but that we immerse ourselves in the books that inspired the original games (Elric’s novels, ‘The Lord of the Rings0, HP Lovecraft and Conan stories …) to understand firsthand on what the original D&D creators were based.” Much of that material was “included in the list of readings that Gary Gygax provided in the first edition of the Dungeon Master guide” To this is added that Crawford feels “a deep love for ancient mythology and world history.” This personal interest, together with their trips through Europe and the reading of ancient books about occultism and history, constitutes “a large part of my inspiration when working in any fantastic world.” The objective is to understand “how people thought in the past and then transfer that to the worlds we create, the adventures we design, and incorporate part of that inspiration.” This approach guarantees a large range of options for players, by “resorting to as many sources of inspiration as possible.” Finally, Crawford detailed some steps that had followed to determine which elements of ‘d & d’ conserve and which to let them evolve during the design of the fifth edition: one of the things is “play a lot. There is nothing to play your own game as a designer. And in the case of ‘D & D’, also being the Dungeon Master. “And there is the key to the contagious enthusiasm that Crawford communicated to the audience. Crawford told the public that “any of you who is a game director in ‘D&D’ or other role -playing game, is a game designer. Because being a game designer means creating experiences for other people to enjoy, which is exactly what a master’s degree does.” And he concluded: “Every time someone asks me: ‘What should I do to be a game designer?’ I often say that you have to be a game director, because it is experienced in real time how people respond to what one has created. And also how people usually do what they want in response to what one has created” And that was a bit the summary of what Crawford injected to the fifth edition: all the attendees were designers of the game because to start, the designers of the game were also players. That was the key to an impulse for ‘Dungoons & Dragons’ in its fifth edition and today survives. Header | Gian-Luca Riner in Unspash In Xataka | To play Dungoons & Dragons you just needed ball, paper and dice. Now a course of 2,000 dollars wants to teach you better

Spanish elites have been practicing the noble art of endogamy 3200 years

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There was a copistería in front of the Faculty of Sciences that had hung on the wall, one after another, all the ons of one of the wildest engineering in the entire Spanish university system. I used to look at them while waiting. And I know it may seem boring, but there was nothing more fascinating than seeing how the people of the cloister were changing, but the surnames did not. Yes, yes. It is an exaggeration, an easy stereotype. But it is also true. And not only in college: Endogamy is one of those recurrent phenomena of the social life of our country. A long history. As They explained a few years ago Professor Javier Barnes and economist Fernando Faces, “that in Spain the rules of the game for the contests and awards of contracts are based on norms of a century and a half ago, of 1870, it gives us an idea of ​​how much we need to renew ourselves.” It is not a bug, it is a feature. It is a well -known anthropological technology to reinforce the power of a group of people. And that is why not only affects The municipalities, Companies or the university: endogamy came to provoke The extinction of the Habsburg Dynasty Branch. What we did not know is that it was something so old. When was innovamy invented? We do not know, but we are close to discovering it. After analyzing 24 buried individuals In the Zaragoza necropolis of the Castellets II, an international team of specialists has found a possible response to all this. And it is that up to two thirds of the individuals were related to each other. But there were not only parents and children, there were kinships of fifth and sixth grade. That means that Mequinenza’s mound was used as a mausoleum of an extensive family, as a kind of central funeral node of a dense filiation structure. It is the first direct evidence of inbreeding practices at the end of the era of bronze in the peninsular. What does this mean? That the peninsular of that time were discovering the most basic version of Endogamy: leaders who consolidate their status marrying each other. “Such levels of consanguinity had not registered in previous periods of the Iberian Prehistory,” The researchers say. The big change. Metals have always been metals. “Prehistory is the period of the history of humanity from our origins to the appearance of the first bureaucratic states,” Archaeologist Rodrigo Villalobos explained. And what we are seeing in Mequinenza is how these states begin to take shape. This allows us to know things about Endogamy, of course. Nothing new in ethnographic terms, but something key that affects us today. Endogamy is still alive because it is an extremely effective method to ensure the stability of social structures. It has associated costs, but They are long -term costs. In the medium term, they are usually more than assumable. But beyond: the interesting thing is that, like supports the investigationendogamic practices are practical sensitive “Legal systems and administrative practices”. It is not an irreformable curse. This leads us to a deeper question: do we really want to change it? Image | Meressa Chartrand In Xataka | 8,000 years ago, 3,000 before the invention of the first toilet, we already had intestinal parasites

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