Science Archives - Page 23 of 23

Getting an infusion with olive leaves sounds very good and healthy. Science has much more doubts about it

January 25, 2025 by usatoday24

Olive oil is a fundamental ingredient In the Mediterranean diet. Spain is one of the great producers That, for years, he focused on being a large world producer of consumer oil, Leaving Italy The high ranges. That changed a few months agobut of course: in addition to olive or olives, we have to talk about by -products, Like the bone or the leaves. With them, we can make infusions, buy bread with embedded leaves and in the herbalists and brands Its multiple benefits are cited. But science is not done alone, and researchers have tested these properties of olive leaf infusions. Oleuropein. All those supposed benefits of the infusions of the olive leaf come from the hand of an antioxidant called oleuropein. This is the majority phenolic component of the pulp of green olives and is the one that gives a certain bitter taste in extra virgin olive oils. It turns out that it is also a main component of the olive leaves. In 2011 a study and it was stated that this antioxidant could show antifibrotic and anti -inflammatory effects. The interesting thing is that the oleuropein concentration depends on the color of the leaf: the greener, the more oleuropein it contains, so the leaves collected in spring have higher levels compared to those collected at another time of the year. The studies. These properties such as antioxidant have led us to consume the infusion sheets, but … are they really safe and healthy? In The Conversation we can see two recent studies. One of them, of 2022, combined data from 12 experimental studies in which 819 people participated, concluding that the olive leaf extract (managed in capsules with dose of between 500 milligrams and 5 grams during periods of six to six 48 weeks) improved heart disease risk factors and reducing blood pressure. Data. In people with high blood pressure, the effects were greater. In a study More recent, from 2024, data from other experimental studies with a sample of 703 participants were again studied. The doses were this time between 250 and 1,000 mg -very minors -, administered in capsules or incorporated into the PAN. Some of the participants had high and overweight blood pressure, but others were in healthy parameters. Significant benefits were observed in blood glucose control and a reduction in blood pressure, but when all data crossed, no significant effects were appreciated and it was indicated that it was necessary to continue investigating. Safe levels. In these cases, we are talking about an “the olive leaf can improve the hypotensive effect, since, as we say, it is not a certainty and we must continue to investigate. But something that studies seem to coincide is that, a daily supplementation of this extract, with a dose of a gram per day, has no adverse effects or contraindications. What is indicated in others studies It would be good for pregnant and infant women to avoid consumption, since effectiveness and safety have not been proven during this phase. Toxicity. It is interesting, however, that some cases of aggressiveness have been reported after excessive consumption. It is suspected that a high dose, 85 mg/kg of body weight, is toxic, causing an event similar to that of an excess of dopamine, taking a 67 -year -old woman to aggressive behavior. This woman took 5.5 grams of dry olive leaf per day to treat hay fever, experiencing changes in mood and the aforementioned aggressive behavior after intake. Researchers think that the culprit is hydroxythritic, a component of the olive leaf extract that has a structure similar to dopamine, altering levels. It is still an isolated case, but there it is. Head. Therefore, that olive leaf is sold to make infusions is not negative, because the effects as an antioxidant in our body are there, but the usual thing is important: to have head and common sense so as not to self -medicate with chemical drugs … or with natural remedies with remedies . Are they healthy? Yes, in small doses, but of course they do not replace medicines and treatments made by professionals. And, if they love each other Take as a complementit can be infused, but also in smoothies or as a salad and bread complement. Images | Júlio Reis, Bea.miau In Xataka | During centuries Galicia was a thriving land of olive groves with unique varieties in the world. What changed it is still a mystery

The atlas of side effects (positive and negative) of Ozempic discovered | Health and well-being

January 23, 2025 by usatoday24

All medications have side effects, just take a look at any leaflet to see this. But there are not many cases in which these amount to the main effect. This is what happened a few years ago with GLP-1 agonists, medications used for decades to treat type 2 diabetes that began to demonstrate weight-loss effects. After several reformulations, new commercial brands, such as Ozempic and Wegovy, became an effective way to end obesity. But science is proving that there are many other side effects that could become major ones. GLP-1 is a molecular Swiss army knife, a kind of all-purpose drug. They affect our bodies in ways we still don’t fully understand. But today we are closer to listing. A team of scientists from the University of Washington School of Medicine has published the first detailed atlas of the side effects of these drugs. They have found benefits for cognitive and behavioral health, while revealing an increased risk of developing pancreatitis and kidney conditions. “Until now we had seen anecdotes and reports here and there. “Some people saying that it can affect this or that,” explained its main author, the clinical epidemiologist, in the presentation of the study. Ziyad Al-Aly, from the John J. Cochran Veterans Hospital. “But no one, no one had thoroughly investigated the effectiveness and risks of GLP-1 and all the ways it can affect health.” The study was published this Monday in the journal Nature Medicineshowcase of the best world science. More information “We did an analysis that comprehensively mapped the associations between GLP-1 and 175 potential health effects,” Al-Aly notes. The benefits, beyond weight loss, included a lower risk of substance use disorders and a reduction in suicidal ideation, schizophrenia, and other psychotic disorders. They also observed a reduction in cognitive disorders, such as Alzheimer’s and dementia. And finally, a reduction in the risk of clotting disorders, including stroke. “We found that these drugs have a wide range of beneficial effects, but all this does not come without risks,” warns the expert. The study confirms that, in some cases, they can cause gastrointestinal problems, such as nausea and vomiting. This is quite common and has already been documented in some patients. An increased risk of gastroparesis or stomach paralysis in rare cases and an increased risk of low blood pressure have also been seen. The analysis also notes that the drug may increase the risk of sleep problems and headaches, kidney stones, and drug-induced kidney inflammation. For these reasons, the authors recommend that, when evaluating this treatment, it should always be done under medical supervision and after an individualized analysis. “It is an observational study, although it has a large database and has been carried out for a long time,” he explains. Christopher Moralesan endocrinologist at the Virgen Macarena University Hospital in Seville, who was not involved in the study. The study does not demonstrate, therefore, that the medication is the cause of the listed effects. But these are consistent enough (risk reduction between 10 and 20%) and the database large enough (almost two million patients over three years) to think there is a direct relationship. “With Big Data you can scrape these results in very large databases and this is positive. But we must remember that here we can only verify association, not causality.” The objective of this research, in the words of its own authors, was not to analyze a specific effect and demonstrate causality, but to build an atlas of the association of risks and benefits of this relatively new medicine. “It’s like when Christopher Columbus arrived in America, and he thought about mapping it to get his bearings,” explains Al-Aly. “This is what we are doing, drawing a landscape of benefits and risks.” This opens the door to the possibility that in the future, after many reformulations and research, we can talk about an Ozempic for dementia, alcoholism or Alzheimer’s. There is still a long way to go, but this study has drawn a first map to locate the path. And there are many companies willing to embark on this adventure. There is currently a scientific and commercial race to find the next revolutionary use of GLP-1 agonists. Everyone has in mind the case of Novo Nordisk, the Danish laboratory that presented Ozempic in 2018, and which today has a stock market capitalization of 382,000 million dollars, which makes it the largest company in Europe. This has enormous business and economic implications, but from the scientific world, the question is different. How does an anti-diabetes drug have so many and varied effects? “Medicines don’t work surgically. They are designed to do one thing, but the reality is that this is almost never the case,” reflects Al-Aly. “Biology is complex and multiple, and if you touch one thing you will create a network of various effects.” GLP-1 acts on the intestine, but also on the brain, affecting areas that are involved in impulse control and reward signaling. This would explain why they help mitigate addiction problems. These medications would also affect the blood vessels, and in doing so have a potential effect on the heart. There is research that suggests that they also reduce inflammation, including that of the brain, which could explain their protective effect against neurodegenerative diseases. “But there is also another simpler theory that can explain all these positive health effects,” explains Al-Aly. Obesity is considered a disease in itself, but also the gateway to many others. It is the fifth risk factor for death in the world and every year 2.8 million adults die as a result of this condition. “When we treat obesity, it is normal that this affects other diseases, since it is the mother of them all,” summarizes Al-Aly. The expert has not yet decided, with the available scientific evidence, on which of these two theories has more force. The first would mean that we are talking about a miracle drug with multiple uses. The second would be less profitable for companies, would fill … Read more

Tell me what bacteria live in your intestine and I will tell you who your friends are | Health and well-being

January 23, 2025 by usatoday24

Mencius, a Chinese philosopher, wrote a handful of centuries ago that “friendship is one mind in two bodies.” Modern science could add another element: friendship is also a microbiota in two bodies. A study has found that the more people interact, the more similar the composition of the microorganisms living in their intestines becomes, even if they do not live in the same household. The investigation, recently published in the magazine Naturealso ensures that an individual’s microbiome is determined not only by their closest social contacts, but also by the connections of these contacts. That is, the friends of your friends. To know the details of this investigation you have to take a trip to the western heart of the Honduran jungle. It was in this Caribbean country where scientists from Yale University worked for ten years until they recruited a group of 1,787 adults, spread across 18 isolated villages, to donate a sample of their feces. All participants had a traditional diet and practically did not consume antibiotics or other medications. Nicholas Christakis, lead author of the study, explains that they were “very lucky that the participants were helpful and engaged.” The scientists needed to be able to trace each of the volunteers’ contacts with certainty, something that would have been much more complicated to do in cities like Madrid or Barcelona. The towns of Honduras, in this case, were perfect. More information Before continuing to advance with the results of this research, it is worth explaining what the microbiota is and why it is important. Francisco Guarner, director of the Digestive System Research Unit at the Vall d’Hebron General Hospital in Barcelona, has a definition: “It is the bacteria communityviruses and fungi that colonize the digestive tract. We could think of it as another organ of the human body, a set of biological capacities that help the survival of an individual.” Although this organ It lives within us, it functions under its own rules and hierarchies. It is organized in its own way and it is not easy to manipulate it. “It is essential for the digestion of food. It provides us with many enzymes and metabolic pathways that humans do not have,” adds the expert. Thanks to the microbiota we can, for example, digest fiber. They are also essential for the development of a balanced immune system. For decades, science has explored the composition of the microbiota to understand how it is generated in each person. Mireia Vallés Colomer, director of the Microbiome Research Group at Pompeu Fabra University, details that vertical transmission had been, until now, the most likely explanation. “We receive these microorganisms, in large part, from our mothers, through childbirth and breastfeeding. We also share bacteria that our grandmother passed to our mother,” he details. However, the new study ventures that the microbiota changes throughout life, and that those largely responsible for these changes are our social contacts. A horizontal transmission. “We were very surprised by the reach of microbes that networks of people share. In fact, we can predict who your friends are based on how similar the microbes in your stool are to theirs,” says Christakis. Data suggests that people living in the same house share up to 14% of the microbial strains in their intestines. While those who do not live together, but usually spend time together, share 10%. The research has also been able to determine that individuals who live in the same town, but who do not usually interact too frequently, share only 4%. There is, the authors say, a chain of transmission because friends of friends share more strains than would be expected by mere chance. The transmission method There is a question that continues to swirl around this research and that is to understand how strains are transmitted bacteria from one microbiota to the other. “We do not have a conclusive answer about how this transmission occurs,” says Vallés. And he adds: “What is hypothesized is that what reaches the intestine has to pass through the mouth. “Many bacteria in the microbiome don’t tolerate direct contact with oxygen for very long, so close contact is needed, but we don’t know exactly what that looks like.” Guarner, however, details that “the fecal-oral route “It seems to be the most important transmission vector.” That is to say, although we clean ourselves and more or less control our hygiene, in some previous studies it has been detected that the bacteria that are typically found in the intestine also appear on the hands. This is how they then reach the mouth. Some of the bacteria manage to survive this journey from the intestine because they travel in the form of spores, similar to those of fungi. “With this transmission mechanism it does not have to be extremely direct contact, it can be through a towel or clothing,” details Guarner. There is no need to be alarmed. This transfer of microorganisms It is what, in some way, keeps us alive. So much so, that new lines of research on the relationship between microbiota and health suggest that a healthy and fit community of microorganisms has an impact on several aspects of our well-being. Some researchers are trying to establish a direct relationship between the microbiota and non-communicable diseasessuch as cardiovascular diseases, diabetes and even depression. Guarner explains: “This is still a bit speculative, but normally what happens is that these types of diseases are associated with a poor microbiome.” Vallés contributes that “it has been observed that people with the so-called ‘modern diseases’ suffer an alteration in the composition of their microbiome.” But it is not that there is a particular bacteria responsible for these diseases, but rather it is the loss of diversity in general that worsens the state of health. In this case, the research opens the door to continue analyzing whether these non-communicable diseases, in fact, do have a transmissibility factor. And if an entire community of people has a weakened microbiota, these diseases could proliferate more easily … Read more

Johann Hari, journalist: “The idea that obesity is a sin is deeply rooted in our culture” | Health and well-being

January 23, 2025 by usatoday24

A couple of days after starting to take Ozempicsays the journalist and writer Johann Hari (Glasgow, 46 years old), he woke up with a strange sensation, unknown to him: he was not hungry. He got out of bed and went out to have breakfast at the bar, the usual breakfast, a chicken sandwich with mayonnaise. He took a couple of bites and couldn’t finish it. It was full. The medicine, belonging to that generation of drugs that have revolutionized The fight against obesity by imitating the effect of a hormone (GLP-1) that tells us when we are full, was restoring a lost perception: that of satiety. Hari tells this and other anecdotes about his experience with these medications in his new book Lose weight at any price. How Ozempic and other drugs are going to revolutionize our diet and our physical and mental health (Península), which reaches bookstores today. In these pages, the journalist, who has been overweight since he was young, embarks on a journey, accompanied by obesity experts and scientists who have participated in the development of the new drugs, for the benefits and risks of these treatments, the uncertainties that surround them and the uncertain scenarios that open in the field of health and beyond it. The journalist attends EL PAÍS by videoconference from London. More information Ask. He has spoken to many scientists. What has impressed you the most about what they have told you? Answer. Which obesity it really does you. Since I was seven years old I knew that being overweight is not good for your health, but I was surprised by the evidence of how serious it is. If you are obese, you are much more likely to suffer a heart attack, stroke, dementia and cancer. If you are obese by the time you are 18, you are 70% more likely to develop type 2 diabetes. And diabetes is the leading preventable cause of blindness in the UK and limb amputation in the US. Q. He assures that these anti-obesity drugs are destined to be the defining medicine of our time, like birth control pills or Prozac at other times in the last century, for example. Why do you say it? R. Because obesity is the biggest cause of death in the Western world. And now we have a medicine that, if you take it, reverses it and puts an end to it. It’s amazing. So all of us who are overweight or obese have a choice, but we have to compare the risks of remaining obese with the risks of these medications and think about it a lot. (These drugs) They are going to have enormous effects. Q. How can they change our lives and our culture? R. The change is enormous. Jefferies Financial, which is a financial consulting firm, made a report for American airlines saying that they may have to spend much less money on jet fuel, because it costs more money to fly with heavier people and that is going to be a much smaller population. Also in Los Angeles there has been an increase in demand for jewelers to change and adjust wedding rings because people have lost so much weight that the rings no longer fit on their fingers. Approximately 20% of Americans have already tried these medications. This is huge. This is an astonishing scientific advance that will profoundly change society for better and worse. “The foods we eat are undermining our ability to feel full” Q. Regarding this negative part, he exposes some issues that the consumption of these medications entails, such as the risk of losing the culture of body positive or what would happen if people with eating disorders access these drugs that help them lose weight. Have you found answers to these questions? R. The invention of these drugs is like the discovery of fire. Fire is a great tool if I use it to heat my house, but it is terrible if I use it to burn my house down. And in the same way, when something as powerful as this is discovered, it will have great positive effects and great negative effects. If you are overweight or obese and start taking these medications, for example, you are 20% less likely to have a heart attack or stroke in the next 18 months. But you also mentioned something that worries me a lot: when you take these medications, you eat much less; and that’s good if you’re obese like me, but people with an eating disorderanorexia for example, if you are thin and start taking these medications, you can kill yourself with them. Therefore, one of the things we must do is regulate these medications very strictly. Q. The book also delves into what makes ultra-processed foods so addictive. Do they cause a kind of short circuit in our brain systems? R. If you look at a photograph of a beach in Spain in 1979, the year I was born, everyone is very thin and you wonder: where are the obese people? So, obesity was very low. Modern humans have been around for 300,000 years, but obesity was extremely rare. And basically, during my lifetime, it exploded. What happened? We know the answer: Obesity skyrockets everywhere people make a change, when they go from eating mostly fresh foods they prepared that day to eating primarily processed and ultra-processed foodsThat is, food is made up of chemicals in factories in a process that is not even called cooking, it is called making food. This new type of food affects us in very different ways. The foods we eat are undermining our ability to feel full and what these new medications do is restore the feeling of satiety. Q. And what about the industry’s responsibility in this context? R. Need regulate the food industry to prevent children from being exposed to these foods that make them sick and undermine their ability to feel full. I’m talking about a long-term solution and we … Read more

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