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Ozempic’s great challenge is the rebound effect. Science already has two promising solutions to avoid it

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The rise of medications such as Ozempic, wegovy o Mounjaru has completely transformed the clinical and social landscape of the weight lossmaking many people do not hesitate to ask their family doctor to prescribe it in order to lose weight and also regulate blood sugar. The results during treatment are undeniable, but the big question it raises about medical consultations is what exactly happens when the medication is stopped. What we know. One of the most feared points of this type of treatment is the ‘rebound effect’ which causes that, at the time of stopping the treatment and if eating habits have not been adjusted, a large weight gain will be seen. This is something that causes many people to see that this treatment only gives a few months of ‘thinness’, but science is now trying to avoid this effect. The rebound. An exhaustive analysis published in The BMJ finally put exact figures on this phenomenon so that you can speak appropriately to patients. And what has been seen after analyzing 9,300 participants is that patients recover an average of 0.4 kilos per month after stopping treatment. At this rate, the return to the initial weight before starting therapy occurs in just 1.7 years. But this is also accompanied by a loss of cardiovascular shield at 1.4 years. The solution. one of them it involves taking a pill daily known as orforglipronwhich is nothing more than a non-peptide GLP-1 receptor agonistwhich means that it can be taken orally and not through subcutaneous injections. The idea here is to use the injectable treatment, which is more powerful, for the first few weeks and then transition to this daily pill to consolidate the results without the rebound effect. This not only greatly improves patient comfort, but facilitates mass production by not relying on problematic ‘pens’ containing semaglutide, and helps maintain satiety signaling at the brain level without the invasive impact of the needle. A bacteria. The second line of research points to the intestinal microbiome, by analyzing supplementation with the bacteria Akkermansia muciniphila MucT pasteurized as a tool to avoid the rebound effect after a low-calorie diet. A bacteria that is long known in the field of nutrition for its role in the integrity of the intestinal barrier. After doing the analysisit was seen that the group of patients who received the bacterial supplement recorded a weight recovery of only 13.6%, compared to 32.9% in the control group. But beyond the scale, it has been seen that this bacteria shows a notable preservation of insulin sensitivity, a crucial factor to avoid the development of type 2 diabetes and keep lipid metabolism under control. The future. We are undoubtedly at the beginning of a paradigm shift, since the medical narrative is moving from the short-term “war against kilos” to chronic and sustainable management. But logically, for this to reach the market, we must wait (and not a little) for better results and above all for it to be tested in humans. Images | stefamerpik in Magnific In Xataka | We thought Ozempic was only for weight loss. Science is seeing that it can end alcoholism

why the great battle of mobile cameras is in size and not in megapixels

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How difficult can it be? know if the camera of one mobile phone is better than that of another. An example as a riddle, let’s see if you can see, at a glance, which camera is better. They are the two main cameras of two different phones: 50 megapixel sensor with f/1.7 aperture and one-inch size. 3.2 µm pixels and OIS stabilization. 200 megapixel sensor with f/1.7 aperture and 1/1.4 inch size. 0.56 µm pixels and OIS stabilization. Since a large number always attracts attention, a first glance could tell us that the camera with 200 megapixels is better than the one with 50 megapixels. Is that so? Well, not in this case, since the top camera (which corresponds to a Xiaomi 17 Ultra) It’s much better than the one below (from a Redmi Note 15 Pro+). That is something we could know from the size of the sensor and the pixels, which is exactly what we are going to explain in this article. A camera with more megapixels is not necessarily better Cameras are increasingly a claim by manufacturers when it comes to selling mobile phones. This is nothing new, since we have been seeing different races between them for years: first they were to offer more megapixels and then, to have a greater number of cameras. As we have seen in the example above, even cheap phones already have sensors with 200 megapixels. But, Does that mean the camera is better? In order to answer this question, we are going to explain what a megapixel is. A megapixel (also called ‘MP’ or ‘mpx’ on mobile devices) is equivalent to one million pixels and is an element that is not used to measure the quality of a sensor or an image, but its resolution. In short, the higher the number of megapixels, the larger the image size will be. This is very useful because it allows you to take large photographs and later make a digital crop to have an enlarged image. It is a very interesting solution for mobile phones that do not have a telephoto sensor (like the iPhone 17efor example), but it is not a factor that will determine the quality of the photograph. I understand this, now let’s talk about a key concept in photography: light. The more light a camera captures, the better the image quality and the less noise it will have. This is where pixel size comes in: the larger they are, the more light they are able to collect. What’s happening? That you cannot fit a huge number of megapixels into a small sensor because, in that case, each pixel receives less light. That is exactly the opposite of what we are looking for in photography, but it is a problem that is diluted if the sensor is larger. Why is sensor size so important? If the camera sensor is larger, the pixel and megapixel size will be larger. so they will capture more light. In fact, this is another detail that we can see in the example cameras that we used at the beginning of the article, since they tell us the size of their pixels measured in micrometers (or µm). The larger these are, the more light they will capture. Precisely based on this, manufacturers use a technique called ‘Pixel Binning’. Explained very simply, it is a process by which pixels join adjacent ones, thus forming larger pixels (and therefore, capable of capturing more light). There the number of megapixels (and therefore the resolution) is reduced in exchange for gaining more light. At this point, the question may arise in our mind as to why manufacturers don’t introduce larger sensors in phones. The answer, if we ignore the cost of these, is that you not only have to mount them: they have to be placed on the mobile so that it can take advantage of them 100%. And that takes up a lot of space on a device that seeks to be (relatively) thin. And where is the size of a sensor most noticeable? Well when we go to take a photo and there is little light. These large sensors offer more natural results at night and when lighting is poor, all without the need for overly aggressive software processing. It also performs very well with the contrast between dark and brightly lit areas, in addition to achieving a natural blur effect without having to resort to Portrait mode (or what is usually called ‘bokeh). How can I find out the size of a camera sensor? Sensor size is expressed in inches, usually as a fraction: for example, 1/1.95″. The smaller that fraction (closer to 1), the larger the sensor. A 1/1.3″ sensor is larger than a 1/1.95″ sensor. Megapixels are easy to sell because they are a large number and easy to compare in a store. Sensor size is harder to communicate, harder to manufacture, and harder to make profitable in the mid-range. That’s why manufacturers highlight it when they have it and omit it when they don’t.. Now you know which column to look at. Two mobile phones with one-inch sensors In recent months we have been seeing mobile phones with very good photographic sections and the vast majority of them (if not all) have one-inch sensors. It is true that we have mobile phones with an outstanding photographic section that barely have a sensor like this, like the Vivo X300 Ultra (main camera sensor measures 1/1.12 inch), he Vivo X300 Pro (1/1.28 inch) or the OPPO X9 Ultra (also 1/1.12 inch). There are many aspects that come into play when talking about mobile photography. and not all of them are physical (the processor and software also have a lot to say). Now, we have two good examples with one-inch sensors that we are going to see right below. Xiaomi 17 Ultra We have used it as an example because the Xiaomi 17 Ultra is one of the best cameras we have seen on mobile phones … Read more

China and Nvidia star in the “great technological divorce” of 2026. A bureaucratic hell that is erasing it from the market

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Talking about Nvidia is talking about artificial intelligence glue. The GPU giant has invested millions financing cocompanies like OpenAI or Anthropicbut along the way has not forgotten startups or to make purchases for strengthen your position in the market. The problem is that it is missing out on a potential $50 billion market: China. Because Nvidia is eager to enter China, but it is trapped between bureaucracy, the Trump Government, Xi Jinping’s Government, and the smuggling of its graphics cards. The great divorce. In a very short time, Nvidia has gone from dominating the Chinese GPU market for artificial intelligence to losing it completely. The restrictions of the Trump Administration and the intensification of the trade war between the powers left Nvidia out of the game. Either it would adapt its GPUs and create less capable versions of those it sold in the West or it would not be able to sell in China. For a time, Nvidia was selling the H20 to adapt to the new rules, but it is something that has taken its toll. As AI needs demanded more powerful GPUs and own chinese industry with Huawei, Cambricon and Moore Threads was developed, Nvidia was being left out of the game. Official quota. In the middle of last year, Nvidia CEO Jensen Huang pressed Donald Trump to see reason: it was better for Nvidia to be able to enter China both to make money and to slow the accelerated development of the domestic industry, one that Western restrictions had given wings to. In the end, the US gave in previous tariffs of 25% and one condition: all GPU orders from Chinese companies to Nvidia would be reviewed one by one. There is a problem: the US body in charge of reviewing these export licenses has decreased by 20% in recent months, which is causing delays of months when it comes to fulfilling an order. From when a Chinese company asks for Nvidia GPUs until they are given an answer, the ‘chinese dragons‘They have already released some product. The result? Huang points out that Nvidia has gone from being a leader in China to have a 0% quotapainting the situation as a true drama and pointing directly to the strategies of both China and, above all, the United States as the cause of his company falling into the offside of the large Asian market. Furthermore, it is China itself that encourages its companies to, to the extent possible, use Chinese hardware that they is developing at accelerated rates. “Official” fee. But the fact that Huang claims that his market share in China is 0% does not mean that there are no GPUs for AI in China because it seems that there are H100, H200 and even B200 due to something very simple: smuggling. Despite the proprietary technological solutions they are developing, it is evident that a large part of the AI ​​industry is built with Nvidia GPUs and that implies that the tools are very well optimized for them. There are several occasions in which Nvidia AI chip smuggling networks have been reported, with modest seizures on occasions (just tens of millions of dollars) and somewhat larger seizures on others (hundreds of millions in a few months). Chinese companies obtain these chips through indirect routes from Hong Kong and Singapore and, although Nvidia tries to trace the origin, the clandestine flow and opaque chains make the task complex. trapped. Someone is lining their pockets and that someone is not Nvidia. And the problem is that Huang’s pressure had an effect, but the solution they gave him is not as agile as the market needs. Returning to the issue of bureaucracythe United States Office of Industry and Security, which is responsible for reviewing these export licenses, reduced its workforce by 19% in 2024. Specifically, those who develop standards linked to the semiconductor industry and review licenses have decreased by 20%. The result is an average of 76 days to resolve export requests, something that is extending so far this year and which is disastrous news for both Nvidia and others deeply involved in the AI ​​segment, such as AMD. From China, things are not much better, since companies must make it very clear why they need Nvidia AI chips and cannot meet their objectives using national alternatives. Jensen, almost excluded. In any case, it is evident that Huang does not like to be missing the AI ​​party in China, in the same way that he is going to miss the new trip of Donald Trump and other executives to a summit between Trump and Xi Jingping that will be held between the 13th and 15th of this month. Or so it seemed. This is an event in which conversations will focus on agriculture and commercial aviation, so a priori Jensen didn’t have much in mind. But of course, alongside Trump are CEOs like Elon Musk, Cristiano Amon or Tim Cook, among others. And, although it seemed that he was not invited, as we see in South China Morning PostIn a message from Trump on his social network, it was confirmed that Huang will finally accompany him on the trip. In the end, it’s about money. Jensen Huang doesn’t want China to have the best chips because He wants to save those for the United States.but it is a very large market in which Nvidia can offer chips strategically: it makes money while making companies opt for its product instead of that of the Chinese companies themselves. In Xataka | Nvidia’s superpower is not having money, it is making everyone work for it: Foxconn is the latest to join

End-to-end encryption is a great idea and that’s why it’s almost impossible to understand why Instagram removes it. Almost

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In an era where many users may be concerned about their privacy and looking to ensure their conversations are as secure as possible, Meta has made a curious move. On May 8, as planned, instagram removed end-to-end encryption in direct messages. The big question now is no longer how to communicate safely but something deeper: what interest Meta may have in those conversations. And AI leads the first suspicions. In short. Although it may seem contradictory, Meta is a company that has shown some concern about allowing the user to have secure private conversations. WhatsApp has been using end-to-end encryption for years and, although It took longer to arrive than desiredFaceBook and Instagram also implemented it for direct messages years ago. Simply put, end-to-end encryption (E2EE) is a technology that ensures that only the sender and receiver can read chats. There are applications that implemented it by default (WhatsApp), but on Instagram it wasn’t like that. It is the user who had to activate it and, if done, automatically and transparently for the user, the device blocks the message using a unique key that prevents anyone other than the recipient from accessing the conversation. It’s over. Download your messages. As we say, it has been on their support blog where Meta has confirmed that end-to-end encrypted messages are no longer available on Instagram. Since last May 8, in fact, and if you have a chat that was protected in this way, a message will appear with instructions to download the messages and keep them safe in case you want to do so. Pressure. The end of this security feature has not been accompanied by a reason why Meta abandons this feature, but it is clear that the company has not done it simply for the sake of it. A few weeks ago, when the company’s plans were announced, a Meta spokesperson told Guardian that “very few people were choosing to send end-to-end encrypted messages.” That was the main reason they cited for stopping service, but you don’t have to scratch the surface too hard to find shadier reasons. For example, different police agencies (Interpol, the United Kingdom National Crime Agency or the FBI) ​​have been pressuring FaceBook to grant them access to encrypted messages. Because of course, this technology is very useful for all of us who value privacy, but it also gives wings to those who want to use it for much darker purposes. There are organizations that have criticized the implementation in apps like Instagram because they point out that, although it is useful, if the company does not implement adequate security measures, it can intensify acts of child sexual exploitationterrorism or giving rise to violent extremism. In fact, the UK government has been searching that Signal, Telegram, WhatsApp or iMessage open or end with that end-to-end encryption. And Apple has had a media battle against the FBI for that very reason. The suspicion. But of course, for a company that has been promoting the discourse since 2019 that encryption in its applications was the way to follow to protect users, this movement seems strange and there are already those who point to more practical reasons for Meta than, simply, to please governments. Those reasons are the ability to train AI. Because if there is no encryption, there is nothing hidden. And, although there is no human reading (although it seems increasingly evident that behind the AI there are humans labeling what our video devices and voice see and hear), having access to the conversations of millions of users allows the algorithms to continue training with the aim of offer advertising more personalized (something that Meta has become very aggressive about in recent months) or chatbots that can continue drinking the Internet. It’s not such a crazy theory.. WhatsApp. “Anyone who wants to keep messaging with end-to-end encryption can go to WhatsApp,” is Meta’s own recommendation and something they said both in statements to The Guardian and on their support page. Because for their communication app they do continue to aggressively push that argument of “express yourself freely with end-to-end encryption”, “show yourself as you are, speak freely” and “no one else has access, not even WhatsApp”. Seeing that the company maintains this encryption on WhatsApp, but not on an Instagram that is increasingly a bazaar, makes the opinion that they withdraw end-to-end encryption based solely on government pressure lose some weight. In any case, as Meta itself says, if you want privacy in your conversations… you will have to go to WhatsApp. Or to any other app with end-to-end encryption. In Xataka | Meta will pay $1.4 billion to Texas for violating the privacy of its users. Used facial recognition without permission

How Albert Camus, the great symbol of the philosophy of the absurd, had the most absurd of deaths

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There are times when the line between tragedy, irony, absurdity and cruelty is so fine that it is almost impossible to appreciate it. It happened on the afternoon of January 4, 1960 in the Route Nationale 5 of France, near the town of Villeblevinin Burgundy, when a luxury car left the road and crashed into a plane tree. The impact was so violent that it immediately killed one of its occupants, the famous writer Albert Camus. That’s the tragic part of the story. The ironic (or cruel, who knows) thing is that this absurd death silenced a writer who had stood out precisely for its depth when analyzing the meaninglessness of the human condition. A fateful change of plans They say that Albert Camus he didn’t like them cars or speed. True or not, the reality is that his initial idea to return to Paris after spending the Christmas holidays in Lourmarin was to take a train. Even came to buy the ticket, which according to some versions he had in his pocket at the time of his death. If he finally chose to travel by road it was because Michel Gallimardhis friend and editor, convinced him to return with him and his family aboard his brand new Facel Vegaa French luxury car brand that fell in love, inter aliato Pablo Picasso, Ava Gardner or James Dean. That change of itinerary (now we know) was a blunder. On the afternoon of January 4, 1960, while driving through Burgundy, Gallimard’s Facel Vega FV3B suffered a puncture that caused it to lurch, according to a reconstruction published at the time by the magazine L’Automobile and rescued in 1961 by Atlantic. What exactly happened? The left rear tire is believed to have burst. The tire slid on the asphalt. The right front wheel went into a ditch. And the car went to the side. The Facel Vega ended up hitting a tree. The impact was so strong that the vehicle spun and suffered a second collision against another of the plane trees that flanked the road. The scene, which the drivers of National Route Number 5 soon approached, gives an idea of ​​the violence of the accident: the engine and gearbox were thrown and the chassis ended up twisted. As for the people who were traveling on board, they all suffered the impact, but not to the same extent. Gallimard’s wife and daughter were bleeding after being thrown from the back of the car, although they were well enough to call the family pet. The driver was unconscious, so he had to be taken to the hospital, where despite all attempts to save his life (he was even transferred from Villeneuve-la-Guyard to Paris) he died days later. The worst off was Camus, who was traveling as a passenger in the right front seat. After the first crash and lurch, the Facel Vega was bounced and hit a second log, which hit the door located right next to the writer. It is believed that he died instantly. When the reporters began to arrive at the scene, after learning that this was not just another accident, but the accident that had deprived French literature of one of its great promises, they found a destroyed dashboard that left two figures to remember: the clock, whose hands marked 1:54; and a speedometer stuck at 145 km/hwhich raises the question to what extent speed played a key role in the tire blowout. “Unforeseen and absurd” Although Camus was only 46 years old (he had turned two months earlier) he was already a celebrity inside and outside France, both for the scope of his literary work and his prestige as an intellectual, activist and philosopher. As if that weren’t enough a few years earlier, in 1957had become the second youngest writer to win the Nobel Prize in Literature. This great fame explains why French public radio interrupted its musical programming to break the news, which ended up reaching media outlets around the world. The Korean newspaper The Chosun Daily dedicated multiple pages and in Spain the news was picked up by, among others, the newspaper ABCwhose correspondent I remembered that the blow had been so violent that the car was broken into three pieces. The chronicle the firm Federico García-Requena, correspondent in Paris, who chose a headline that went beyond simply informative: “The death, unforeseen and absurd, of Albert Camus.” The term ‘unforeseen’ is obvious, but to understand the term ‘absurd’ (beyond the fact that all deaths on the asphalt are absurd) it is necessary to know more about Camus’ philosophical legacy. If he explored something in his work, both from narrative fiction (‘The Stranger’) and from the philosophical essay (‘The Myth of Sisyphus’), it is the absurdity, the absolute meaninglessness of human existence. Although for the writer of Algerian origin, assuming that maxim is not equivalent to adopting a defeatist attitude. On the contrary: “This essay considers the absurdity, taken until now as a conclusion, as a starting point“, ‘The Myth of Sisyphus’ startsperhaps the work in which he deepens his vision of existence the most. “All that can be said is that this world, in itself, is not reasonable. But what is absurd is the confrontation of that irrational and that unbridled desire for clarity whose call resonates in the depths of man,” Camus exposes on the following pages. “The absurd is born from this confrontation between the human call and the unreasonable silence of the world. This is what must not be forgotten. This is what must be clung to, since the entire consequence of a life can be born from it.” Faced with this suffocating reality, Camus reminds us that embracing the absurd is not equivalent to resignation. On the contrary. “This rebellion gives life its value. Extended throughout an entire existence, it restores its greatness. For a man without blinders there is no more beautiful spectacle than that of intelligence in struggle with a reality that surpasses it. The spectacle of human pride … Read more

from futuristic city to the great logistical shortcut that eludes Hormuz

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In 1869, when it was inaugurated the Suez Canala long caravan of boats crossed for the first time an artificial pass that changed trade routes millennia in a matter of days, not months. What seemed like an almost utopian work ended up demonstrating that, when a strategic route is transformed, the entire balance of world trade can revolve around it. The map changes with a closure. He closure of the strait of Hormuz during the war with Iran has shown to what extent a relatively small strip of water can disrupt global trade. In fact, the Gulf Countries have been forced to improvise alternative routes to maintain the flow of goods and energy. Saudi Arabia, although less affected than other neighbors, has had to quickly reconfigure your logistics network. The result is that this kind of global shock has accelerated decisions that had been on the table for years and has changed strategic priorities. Neom comes down to earth. Yes, the futuristic megaproject and increasingly utopian of Neom, conceived as a fantastic vision with developments like The Lineit seems that it has entered a much more pragmatic phase. As we have been saying, the extra costs and the economic pressure have forced us to cut back on ambitions and focus on projects that generate tangible value. And in that turn, the neom port and the industrial city by Oxagon They have gained prominence. As? The logic has shifted towards what can be built, financed and operationalized within a realistic economic framework. The great shortcut: avoiding Hormuz from the Red Sea. The war has given immediate meaning to this reconversion. counted the financial times this morning that the port of Neom is positioning itself as an alternative door which connects Europe, Africa and the Gulf without passing through Hormuz. From that perspective, goods travel from Europe to the Mediterranean, cross Egypt and reach the Red Sea to redeploy to the Gulf by sea and land. This route, already in use by several European countries, has become more relevant as the strait was blocked. Neom Under construction… but already operational. Although the project is still in development, the port is already working and shows signs of activity growing. In fact, satellite images they have captured traffic of trucks and operations at the site, while infrastructure such as automated cranes, container terminals and sustainable energy systems are completed. The ambition is to turn it into an electrical porthighly automated and prepared for large vessels. All of this currently places it as an emerging piece within the Saudi logistics network. The turn to the west: the economy moves towards the Red Sea. Because the crisis has accelerated a structural change in Saudi Arabia. The economic weight, traditionally concentrated on the Gulf coast, begins to shift towards the red sea. Infrastructure such as the east-west pipeline and the port of Yanbu have gained importancewhile exports increase from that facade. The problem: that although the movement reduces vulnerability to Iran, it also introduces new risks in other areas. Beyond Neom: a network of routes to resist. Yes, because the momentum is not limited to a single project. Apparently, the Times said that Saudi Arabia and its neighbors are already developing logistics corridors, combining ports, roads and future rail connections. Multimodal routes connecting the Gulf with the Red Sea and other markets are also being integrated. The objective seems clear: create redundancy in supply chains to avoid depending on a single strategic step. From science fiction to real geopolitics. In this context, the scenario that is being glimpsed indicates that Neom stops being just a futuristic and hyperbolic symbol and becomes a whole a strategic tool. The war has acted as a catalyst, transforming an ambitious and possibly utopian vision into a practical solution for an immediate problem. There is no doubt, the project was not originally designed to avoid Hormuz by any means, but now it fits perfectly into that role. And in that change it is summarized the new reality: When routes fail, it is possible that even the most futuristic ideas may end up being necessary. Image | NEOM In Xataka | NEOM may have failed, but Saudi Arabia still has crazy things in its hat: a huge artificial lake at 2,600 meters In Xataka | While NEOM builds ski slopes in the desert, Dubai is going in the opposite direction: attracting tourism without going bankrupt

Unintentionally, the war in Iran has dynamited the great oil cartel

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The energy earthquake that caused the Third Gulf War has just claimed an unexpected victim: the unity of the oil cartel. As of May 1, the United Arab Emirates (UAE) will no longer be part of OPEC and its OPEC+ alliance. As reported by the state news agency WAMin Abu Dhabi consider that it is time to prioritize their “national interest.” After spending almost six decades making “great sacrifices”, the Emirati Government considers that stage over and prefers to fly alone, guided by its own “strategic and economic vision” far from the limits of the group. The context could not be more volatile. The Strait of Hormuz—through which a fifth of the world’s crude oil normally transits— is submerged in operational chaos due to Iranian threats and attacks, in addition to the US blockade of Iranian ports. As explained Reutersin this scenario of suffocation, the Emirates has decided that its energy future needs to maneuver without the ties of Vienna. The beginning of the end of quotas. The impact of this exit is tectonic for the oil market. As analyst Saul Kavonic warns in the BBCthis breakup could be “the beginning of the end for OPEC.” With the departure of Emirates, the cartel loses approximately 15% of its total capacity and one of its most rigorous members, leaving the organization weakened and with only 11 core members. The key to this divorce lies in production, since the Emirati authorities had been complaining for some time that the cartel’s quotas unfairly limited their exports. As detailed by Robin Mills, analyst consulted by the cnnOPEC kept the Emirates restricted to a production of 3.2 million barrels per day, when the country has invested aggressively to reach a real capacity close to 5 million. The Emirates “have been eager to pump more oil for some time,” notes David Oxley of Capital Economics in the same medium. The economic consequences are already being felt. The World Bank, which classifies this crisis as the largest supply loss on record, predicts a 25% increase in energy prices. Brent crude oil has experienced extreme volatility, fluctuating between $104 and $119 per barrel since the start of hostilities. Looking ahead, Jorge León, from Rystad Energy, explains in Guardian that Saudi Arabia will be left alone to shoulder the heavy burden of stabilizing the market, which predicts much greater volatility in the long term. The Arab fracture. Beyond barrels and dollars, the departure of the UAE is a direct symptom of a deep geopolitical fracture accelerated by the war. Emirates feels abandoned. The disappointment of the Gulf: As highlighted Al Jazeerathe decision comes shortly after harsh statements by Anwar Gargash, diplomatic advisor to the Emirati president. Gargash openly criticized the “historically weak” response of Arab countries and the Gulf Cooperation Council (GCC) to the Iranian attacks. According to Euronewsthe Emirates have had to absorb much of the impacts of missiles and drones, feeling that their OPEC allies have not provided them with political or military support. Direct tension with Riyadh: The departure has not been agreed with the de facto leader of the cartel. UAE Energy Minister Suhail Mohamed al-Mazrouei confirmed to Reuters who made this “political” decision without consulting Saudi Arabia. The relationship between both powers has been deteriorating for months due to economic competition and recent military disagreements, such as the collapse of their coalition in Yemen in December. An unexpected triumph in Washington. Curiously, this regional fracture represents a diplomatic victory for the American president. Donald Trump had been accusing OPEC of “scam the world” manipulating prices, while the United States paid for the military defense of the Gulf. The departure of the group’s third largest producer weakens exactly the structure that Trump had criticized so much. Towards a “new energy era”. Paradoxically, the flood of Emirati oil will not reach the markets tomorrow morning. As long as the Strait of Hormuz remains blocked by war, the impact on global supply will be limited in the short term because ships simply cannot leave. However, the message is sent. When the waters of the Persian Gulf calm, the world will find itself with a market flooded with Emirati crude oil, operating freely. The Emirates has decided to embrace a “new energy era”, the geopolitical map of the Middle East is being redrawn in the heat of the bombs, and OPEC, as we knew it, seems to be one of its first major collateral victims. Image | Emiel Molenaar Xataka | By blocking the Strait of Hormuz blockade, the US is dragging an unpredictable actor into the war: China

There are people reselling tickets to the World Cup final for 2.3 million dollars. Great news for FIFA

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It is still too early to know if the 2026 World Cup will be a success, a failure or will be added without pain or glory to the extensive chronicle of FIFA. What we can say at this point is that enjoying the tournament in situ it won’t come cheap. Especially if you aspire to see the final, which will be played on July 19 at MetLife Stadium in New Jersey. The cost of your tickets it takes months embroiled in controversy, but the debate has soured after some positions have come to light resale market for the price of a 200 m2 apartment in the center of Madrid. All with the veiled pleasure of FIFA. What has happened? That although there is still more than a month until the opening match, the World Cup in North America (to be played between Mexico, Canada and the USA) is already earning the dubious honor of being the most expensive of history. The fans screamed in the sky last decemberwhen the first tickets were launched, but the rates that were offered then seem like a ‘bargain’ when compared to those that are now being achieved in the purchase and sale market. In this secondary trade, channeled through FIFA, there are passes that are offered for the same What does a 200 m2 apartment in Madrid cost? Does it sell so expensive? Yes. The news has advanced it the Associated Press (AP) agency, but it comes with taking a look at the buying and selling platform of tickets hosted on the FIFA website to verify it. If we look for available passes for the final on July 19, we will see that there are people reselling them for more than two million dollars. To be precise, there are at least four seats on sale in the lower stand (behind the goal) for a whopping $2,299,998.85. Not all tickets cost the same, but resale prices are generally not affordable for everyone. The cheapest seats, 3rd category, are offered for $10,900. If you want a position with better views and more comfort, you can add a few thousand more to that figure and purchase higher category passes for $16,100, $33,800, $43,200 or even $207,000. The prize goes to the entries of 2.3 million and 991,500, which is what a seller asks for seats located in the front area. On Wednesday FIFA itself put up for sale a new block of tickets on its direct sales platform, where it was possible to find seats for the final by $10,990. Who controls these rates? Direct sale tickets are launched by FIFA itself, but things change when we talk about the secondary market. There, in the so-called “Resale/Exchange Market” the federation does not control prices, although it does take a considerable part of the business. For each transaction you pocket a commission which is divided into two parts. One, 15%, is applied to whoever purchases the ticket. Another, of the same value, is borne by whoever detaches from the entry for resale. As they explain in Guardianthat means that if one of the tickets that cost 2.3 million is finally sold, FIFA would deposit $690,000 into its account. But… How is that possible? In other editions of the World Cup, the resale price of tickets was limited at face value, but this time FIFA has changed the approach. The reason? First, adapt to the market of the host countries, especially the United States, which is the one will host more games of the tournament. Secondly, FIFA hopes that by channeling the buying and selling itself, the use of portals such as StubHub will be discouraged. “FIFA has established a ticketing and secondary market model that reflects standard ticket market practices for major sporting and entertainment events in host countries,” alleges in a statement cited by the Associated Press. “Resale facilitation fees are aligned with industry standards in the North American sports and entertainment sectors.” Is it an isolated controversy? The controversy has now arisen due to the prices that are being reached in resale, but the truth is that the cost of the tickets has been a matter of discussion since the first phase of sale, activated in December 2025. The focus has been on both the prices themselves and the system applied by FIFA in the sale, the ‘variable pricing’similar to dynamic rates. Consumer organizations like the OCU have already raised their voices for that same reason. For reference, in December tickets for the final were already being sold for prices ranging from 4,185 and 8,680 dollars. And this despite the initial promise to offer them for 60 dollars in the group stage. “They only exist as ridiculous green splotches on the edge of seating maps, little more than mirages of inclusion,” ironizes Bryan Armen, from Guardian. Does it only happen with tickets? No. The tickets are so expensive because, FIFA allegesare one of their main sources of income. However, passes to matches are not the only thing that is valued at a gold price. In recent days, another controversy has arisen around the celebration of the World Cup in the US that revolves around something that has little to do with sport: public transportation. The New Jersey rail operator has decided that those who want to buy round-trip tickets to travel from Manhattan to MetLife and watch the July 19 final there will have to pay 150 dollars. It is almost 11 times more than what the same service costs on a normal day, when it is around $12.9. Images | FIFA and Wikipedia In Xataka | Mexico City is already noticing the economic effect of the World Cup: it is losing homes and gaining Airbnb apartments

Who is Johny Srouji and why this great unknown has just become the second most powerful person at Apple

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For those who have been following Apple for a long time, Johny Srouji is no stranger. For the rest of the world yes, but after the appointment of John Ternus as CEO of Applethis Israeli engineer has become the second most powerful person in the company. The question is obvious: who is Johny Srouji? Who is Srouji and why does he matter?. Born in Haifa, Israel, in 1964 to a middle-class Christian Arab family, Srouji studied computer science at the Israel Institute of Technology (Technion) and graduated Summa Cum Laude in both his engineering and master’s degrees. He worked at Intel and IBM before Apple hired him in 2008 with a very clear assignment: to design the company’s first chips. He did much more than that. The revolution made chip. That first chip designed by Srouji was the Apple A4, which debuted in 2010 in the original iPad and the iPhone 4. From there, Srouji forged one of the most prestigious hardware careers in the recent history of the technology industry. The A7 of 2013 was the first SoC in using 64-bit architecture, and then there would come the revolution of the Apple M1 with which the company definitively got rid of dependence on Intel in its Macs. But his work goes beyond. His official title until now was senior vice president of hardware technologies, but it did not reflect the real scope of his work. Srouji not only led the chip design. Also that of batteries, cameras, storage controllers, sensors, displays, cellular modems and other critical components of the entire family of Apple devices. Almost everything that makes these products work the way they do is largely due to the work of Srouji and his team. With the new position, his responsibility expands and he will now control the entire cycle: not only the hardware itself, but also the physical design. It’s a colossal challenge, but if anyone seems prepared to take it on, it’s Srouji. He was about to leave. In December 2025 Bloombeg reported that Srouji had informed Tim Cook that he was seriously considering leave Apple in the near future. Two days later, Srouji himself published a message to his team denying the newsbut the damage was done. For Apple to lose Srouji would have been a disaster, and it is very likely that this new position is in part Apple’s response to that alarm signal. Textbook talent retention, but raised to maximum power. New position, new structure. In it internal communication that Srouji has sent to team employees, the engineer detailed how he will organize the division into five areas: Hardware engineering: led by Tom Marieb, an Intel veteran who joined Apple in 2019. Siilicio: it will be directed by Sri Santhanam, a manager with a long career at Apple Advanced Technologies: Supervised by Zongjian Chen Platform architecture: led by Tim Millet Program management: will be managed by Donny Nordhues In that message, Srouji acknowledges that this “represents a significant change” but believes it will work thanks to the entire team. It seems that you are very clear about how you want to work with your team. A fusion with a lot of historical sense. The reunification of hardware engineering and the hardware technologies division under the same leader is not entirely new. It is the structure that Apple had for years under the direction of Bob Mansfield, former head of hardware. until 2013 and? then he took charge of the failed Project TitanApple’s car. That’s when those two areas were divided, something that allowed both Ternus and Srouji to progress in their domains, but also caused some structural tensions between teams that had to collaborate. Bringing them back together is a clear commitment to strengthening that collaboration. The great cover-up of Ternus’s appointment. It is normal that the vast majority of headlines go to Ternus, who will decide the future of the company from now on, but Apple is above all a hardware company. That Srouji now becomes his leader makes this engineer a person with enormous power within the company. The change is promising in terms of promoting that facet of the product that both he and Ternus dominate, and without a doubt interesting times await us at Apple. Image | Apple In Xataka | John Ternus, vice president of Apple: “The iPhone Air had been in development for years, but we had to say ‘no’ until now”

Science has managed to turn off the extra chromosome of Down syndrome. It has also opened the great ethical debate on gene editing

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In the complex genetic map that surrounds the known down syndromethe problem is not that there is a lack of information in our cells, but that there is an excess. The presence of a third copy of chromosome 21 It unbalances the entire cellular system that ends up generating an entire clinic that today did not have any type of cure. But thanks to clinical advances and revolutionary gene therapies, we have found a way to turn off this gene that is extra in the cells of people with Down. A natural switch. To understand this advance, we must look at how nature itself resolves its own genetic imbalances. And, for those who do not know, in human beings sex is determined by two types of chromosomes: X and Y. If you are a woman, you will have XX chromosomes, and if you are a man, you will have XY. The problem, boiling it down to its most basic, is that always one of the ‘X’ genes must be silenced so that the genetic load is compensated in humans. And this is something that is done thanks to the gene XIST which encodes an RNA molecule that covers the chromosome and alters its chromatin, silencing de facto their genes. Something that has been developed by nature itself in order to maintain the species, and then the question is obligatory: why not use this natural switch to silence the chromosomes that generate diseases as important as Down syndrome? It’s not something new. The idea of ​​using this “switch” to be able to alter the gene expression of the chromosomes that we have in excess is not new, since in 2013 the researcher Jeanne Lawrence demonstrated for the first time that this RNA could induce the silencing of the extra chromosome 21 in human cells that were in culture in a laboratory. Later, in 2020, it was applied to neural stem cells, but the historical problem has always been the same: the very low efficiency when integrating this gene into the affected cells.. A new milestone. This has changed radically, as a team at Beth Israel Deaconess Medical Center in Boston has published a new article in PNAS with a solution to eradicate this bottleneck thanks to the tool CRISPR/Cas9. This system can be visualized as simple scissors that specifically cut into our DNA to eliminate something that was left over or altered. The problem is that it was not very efficient at integrating new genetic material, and to overcome this, scientists have developed a modified version of CRISPR/Cas9 that boosts the success rate of the integration of the XIST gene which will silence the third chromosome 21. Good results. Here we recognize how XIST has been integrated into 20-40% of cell lines that have trisomy 21. Furthermore, the method reliably affects only the extra copy of chromosome 21 without silencing other genes that can cause other diseases. There are problems. Despite the enthusiasm, the technique is far from being applied in humans, since one of the biggest challenges of CRISPR is the mutations off-target, That is, it acts on other genetic points that are its marked objectives. And this occurs when these ‘scissors’ cut a sequence of DNA that closely resembles its target, but which in reality is not. In this way, an error off-target It could trigger severe cellular problems or even cancer. Recent studies show that experimentation on embryos with these techniques often results in mosaicism with edited and unedited cells, as well as incomplete edits. This means that right now we have to work on having greater specificity in the genetic objectives of the therapy so that the consequences of using it are not much greater than the fact of curing a disease. Ethical shock. The controversy is served with genetic therapies in general, since right now one of the lines that are open is to eliminate this extra chromosome directly in a human embryo before implementing it in a woman so that she is not born with this disease. This is where bioethicists they point because experimenting with human embryos damages their physical integrity and poses irreversible risks for future generations. Furthermore, they underline the urgency of distinguishing between the use of CRISPR for purely therapeutic purposes, such as treating symptoms, and its use for “genetic improvement” or the selection of embryos that are much more advanced or genetically perfect. This is also added to the fact that genetic editing in embryos for reproductive purposes is currently prohibited in most countries. Images | Sangharsh Lohakare In Xataka | The surprising thing is not that we have sequenced the DNA of a Neanderthal from 11,000 years ago: it is what it has revealed

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