The atlas of side effects (positive and negative) of Ozempic discovered | Health and well-being

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All medications have side effects, just take a look at any leaflet to see this. But there are not many cases in which these amount to the main effect. This is what happened a few years ago with GLP-1 agonists, medications used for decades to treat type 2 diabetes that began to demonstrate weight-loss effects. After several reformulations, new commercial brands, such as Ozempic and Wegovy, became an effective way to end obesity. But science is proving that there are many other side effects that could become major ones. GLP-1 is a molecular Swiss army knife, a kind of all-purpose drug. They affect our bodies in ways we still don’t fully understand. But today we are closer to listing. A team of scientists from the University of Washington School of Medicine has published the first detailed atlas of the side effects of these drugs. They have found benefits for cognitive and behavioral health, while revealing an increased risk of developing pancreatitis and kidney conditions. “Until now we had seen anecdotes and reports here and there. “Some people saying that it can affect this or that,” explained its main author, the clinical epidemiologist, in the presentation of the study. Ziyad Al-Aly, from the John J. Cochran Veterans Hospital. “But no one, no one had thoroughly investigated the effectiveness and risks of GLP-1 and all the ways it can affect health.” The study was published this Monday in the journal Nature Medicineshowcase of the best world science. More information “We did an analysis that comprehensively mapped the associations between GLP-1 and 175 potential health effects,” Al-Aly notes. The benefits, beyond weight loss, included a lower risk of substance use disorders and a reduction in suicidal ideation, schizophrenia, and other psychotic disorders. They also observed a reduction in cognitive disorders, such as Alzheimer’s and dementia. And finally, a reduction in the risk of clotting disorders, including stroke. “We found that these drugs have a wide range of beneficial effects, but all this does not come without risks,” warns the expert. The study confirms that, in some cases, they can cause gastrointestinal problems, such as nausea and vomiting. This is quite common and has already been documented in some patients. An increased risk of gastroparesis or stomach paralysis in rare cases and an increased risk of low blood pressure have also been seen. The analysis also notes that the drug may increase the risk of sleep problems and headaches, kidney stones, and drug-induced kidney inflammation. For these reasons, the authors recommend that, when evaluating this treatment, it should always be done under medical supervision and after an individualized analysis. “It is an observational study, although it has a large database and has been carried out for a long time,” he explains. Christopher Moralesan endocrinologist at the Virgen Macarena University Hospital in Seville, who was not involved in the study. The study does not demonstrate, therefore, that the medication is the cause of the listed effects. But these are consistent enough (risk reduction between 10 and 20%) and the database large enough (almost two million patients over three years) to think there is a direct relationship. “With Big Data you can scrape these results in very large databases and this is positive. But we must remember that here we can only verify association, not causality.” The objective of this research, in the words of its own authors, was not to analyze a specific effect and demonstrate causality, but to build an atlas of the association of risks and benefits of this relatively new medicine. “It’s like when Christopher Columbus arrived in America, and he thought about mapping it to get his bearings,” explains Al-Aly. “This is what we are doing, drawing a landscape of benefits and risks.” This opens the door to the possibility that in the future, after many reformulations and research, we can talk about an Ozempic for dementia, alcoholism or Alzheimer’s. There is still a long way to go, but this study has drawn a first map to locate the path. And there are many companies willing to embark on this adventure. There is currently a scientific and commercial race to find the next revolutionary use of GLP-1 agonists. Everyone has in mind the case of Novo Nordisk, the Danish laboratory that presented Ozempic in 2018, and which today has a stock market capitalization of 382,000 million dollars, which makes it the largest company in Europe. This has enormous business and economic implications, but from the scientific world, the question is different. How does an anti-diabetes drug have so many and varied effects? “Medicines don’t work surgically. They are designed to do one thing, but the reality is that this is almost never the case,” reflects Al-Aly. “Biology is complex and multiple, and if you touch one thing you will create a network of various effects.” GLP-1 acts on the intestine, but also on the brain, affecting areas that are involved in impulse control and reward signaling. This would explain why they help mitigate addiction problems. These medications would also affect the blood vessels, and in doing so have a potential effect on the heart. There is research that suggests that they also reduce inflammation, including that of the brain, which could explain their protective effect against neurodegenerative diseases. “But there is also another simpler theory that can explain all these positive health effects,” explains Al-Aly. Obesity is considered a disease in itself, but also the gateway to many others. It is the fifth risk factor for death in the world and every year 2.8 million adults die as a result of this condition. “When we treat obesity, it is normal that this affects other diseases, since it is the mother of them all,” summarizes Al-Aly. The expert has not yet decided, with the available scientific evidence, on which of these two theories has more force. The first would mean that we are talking about a miracle drug with multiple uses. The second would be less profitable for companies, would fill … Read more

‘It’s a chain strategy’

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The queen of the mornings, Ana Rosa Quintana, returns to her post. After several days of rumors, it was the presenter herself who confirmed the news during the live broadcast this Wednesday, January 22 on Telecinco: “I’m going back to the mornings. I found out this morning and it’s a programming strategy of the chain. I have been here for 21 years and I am in favor of helping in any way I can,” he began explaining while the statement published by Mediaset was broadcast on the screen. © GTRES Ana Rosa Quintaba leaves her program, AfternoonARafter just over a year of broadcast, as it should be remembered, which premiered on September 18, 2023. Despite the fact that Mediaset’s star presenter began to captain this ship with great enthusiasm, and which they announced as ‘more research, more climate, more style, more life, more emotions, more humor, more at street level and with more heart’. This is… ‘TardeAR’, Finally, its afternoon journey ends next Monday. © GTRES Information that has caught off guard both the collaborators who were with her at the time on the television set and the rest of the workers at her production company, Unicorn Content, who have found out at the same time as the public. “The network will premiere the twentieth season of Ana Rosa’s program next Monday, February 3 (09:00 a.m.). Telecinco thus remodels its morning slot, which will begin with Ana Terradillos at the head of The Critical Look, will continue with Ana Rosa’s program and will conclude with Joaquín Prat in Let’s see“, the presenter began by reading the header of the press release. © Mediaset Of course, Ana Rosa Quintaba wanted to make it clear, in response to Boris Izaguirre’s question, that the AfternoonARwill continue. “It is a source of pride that the network continues to trust our production company to do the entire morning and then the afternoon. We have to rebuild the morning and the afternoon will continue. Thank God that all the programs continue, as a producer it is a relief because all the jobs continue. Very excited, she continued explaining what this change means to her: “My heart is broken. Here I have discovered a lot of friends, but it is also true that I am reunited with my entire team with whom I have been for 18 years. And then now “We are going to walk because there is room for everything.” “My job is my job, but I also have to support my network. I have always been a morning person and I will continue to get up early,” he continued explaining before his nephew, Kike Quintana, appeared on the set: “What I most like What matters to me is knowing what happens to me. They have plugged me in and seeing where I am going to go,” he said, laughing. © Mediaset “Next Monday, February 3, one of the most emblematic brands of the network will return to the mornings of Telecinco, which during its 18 years on broadcast was a benchmark on the strip: ‘The Ana Rosa Program’. Your presenter, Ana Rosa Quintanait will be put again in front of this mythical magazineproduced in collaboration with Unicorn Content, which from Monday to Friday will address the most relevant issues of the present and that in this new stage it will have nnew sections and collaborators”, reads the press release issued by the Fuencarral network. © GTRES

from his beginnings on television to his well-known partner

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The third season of Alpha Males continues to sweep Netflix. The series, which addresses the deconstruction of toxic masculinity from a point of absurd and rapid humor, based on the experiences of four friends: Santi, Pedro, Raúl and Luis, played by Gorka Otxoa, Fernando Gil, Raúl Tejón and Fele Martínez, Not only has it made us smile, but it has put the focus on the character of Irene. She is a feminist writer and activist specialized in sexist behavior, who from the beginning has a great connection with Santi. They will have an affair that does not end as he expects and that will end up turning his life upside down. Behind this journalist is the actress Paloma Bloyd who, like the role he plays in fiction, has an equally interesting personal story. © Netflix What was your childhood like? Paloma has multicultural roots that have greatly influenced both her life and her professional career. Born in Chicago 36 years ago and she is the daughter of an American father and an Asturian mother, from Gijón. At nine months old, Bloyd reached Asturiaswhere he spent the first years of his life, but at nine his family moved to USAdividing his time between Florida and Chicago. His childhood was spent between both countries and, in 18 years, he went to up to 13 schools. But it was in the prestigious Actors’ Studio from her hometown where she discovered her true vocation, leaving behind the psychology studies she had begun to train as an actress. © Getty Images This event marked the beginning of her artistic career and Paloma began to go on stage to participate in local plays before returning to Spain, where she would continue her training in the Higher School of Dramatic Art (ESAD) of Asturias. © Four TV A talent show and all the details of his career Although she was training for acting, her first appearance on television was not as an actress, but as a contestant on the show Supermodel in 2007, where he coincided with Alba Carrillo and Noelia López, among others. This was a springboard that put her in front of viewers for the first time and opened the doors to the world of acting. It was in this talent show where he caught the attention of Verónica Forqué, follower of the format with her daughter. The protagonist of Get down to the Moorwho at that time was directing in the theater Adultery, He was the one who gave Paloma her first big opportunity, offering her a role in the play. © Gtresonline © RTVE Since that moment, Paloma’s career has continued to advance, working on successful series such as Doctor Mateo, The Boarding School, Red Eagle, The Boat and The one that is comingamong others. One of his most notable works is his role as Deborah Stern in the acclaimed Tell me how it happened. In this fiction, in which she participated in 92 episodes, she played an American woman who marries Toni Alcantaramaking him settle down. This character allowed him to demonstrate his talent for playing complex and emotionally challenging roles. © Telecinco Cinema © Telecinco Cinema Paloma Bloyd has also accumulated great successes in cinema. In 2010 he shared scenes with big stars like Bruce Willis and Sigourney Weaver in The Cold Light of Day. A year later, he participated in There will be no peace for the wicked next to Jose Coronado. But, without a doubt, his great success came in 2014 with Sorry if I call you love, the Spanish adaptation of the famous novel by Federico Moccia, where she got into the skin of the vital and determined Niki, a character with whom the public fell in love with her. © @palomabloyd Your most personal side The actress is very discreet and reserved regarding her private life. Paloma maintains a discreet relationship with Diego Losada, presenter of News Four, although both prefer to keep their courtship away from the media spotlight. They have not shared photos together, but we have been able to see them both posing with each other. Rita, the interpreter’s pet, a dog from whom she is never separated. © @diegolosada © @palomabloyd With the journalist he shares, in addition to his love for animals, his passion for motorcycles and music; Not in vain, Diego has a rock band called Durden. In her profile, we see Paloma enjoying nature, especially the sea, and how, whenever she can, she escapes to Asturias. His hobbies also include fashion, sports, with disciplines such as cycling, surfing, kitesurfing and skateboarding, among others, as well as travel.

Trump, implacable in Davos: demands less fiscal burden on the EU, a drop in oil to Arabia and more than doubling military spending in countries like Spain

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Historic speech by the new president of the United States, Donald Trump, in his telematic speech before the auditorium of the World Economic Forum in Davos. Trump has surpassed…

Tell me what bacteria live in your intestine and I will tell you who your friends are | Health and well-being

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Mencius, a Chinese philosopher, wrote a handful of centuries ago that “friendship is one mind in two bodies.” Modern science could add another element: friendship is also a microbiota in two bodies. A study has found that the more people interact, the more similar the composition of the microorganisms living in their intestines becomes, even if they do not live in the same household. The investigation, recently published in the magazine Naturealso ensures that an individual’s microbiome is determined not only by their closest social contacts, but also by the connections of these contacts. That is, the friends of your friends. To know the details of this investigation you have to take a trip to the western heart of the Honduran jungle. It was in this Caribbean country where scientists from Yale University worked for ten years until they recruited a group of 1,787 adults, spread across 18 isolated villages, to donate a sample of their feces. All participants had a traditional diet and practically did not consume antibiotics or other medications. Nicholas Christakis, lead author of the study, explains that they were “very lucky that the participants were helpful and engaged.” The scientists needed to be able to trace each of the volunteers’ contacts with certainty, something that would have been much more complicated to do in cities like Madrid or Barcelona. The towns of Honduras, in this case, were perfect. More information Before continuing to advance with the results of this research, it is worth explaining what the microbiota is and why it is important. Francisco Guarner, director of the Digestive System Research Unit at the Vall d’Hebron General Hospital in Barcelona, ​​has a definition: “It is the bacteria communityviruses and fungi that colonize the digestive tract. We could think of it as another organ of the human body, a set of biological capacities that help the survival of an individual.” Although this organ It lives within us, it functions under its own rules and hierarchies. It is organized in its own way and it is not easy to manipulate it. “It is essential for the digestion of food. It provides us with many enzymes and metabolic pathways that humans do not have,” adds the expert. Thanks to the microbiota we can, for example, digest fiber. They are also essential for the development of a balanced immune system. For decades, science has explored the composition of the microbiota to understand how it is generated in each person. Mireia Vallés Colomer, director of the Microbiome Research Group at Pompeu Fabra University, details that vertical transmission had been, until now, the most likely explanation. “We receive these microorganisms, in large part, from our mothers, through childbirth and breastfeeding. We also share bacteria that our grandmother passed to our mother,” he details. However, the new study ventures that the microbiota changes throughout life, and that those largely responsible for these changes are our social contacts. A horizontal transmission. “We were very surprised by the reach of microbes that networks of people share. In fact, we can predict who your friends are based on how similar the microbes in your stool are to theirs,” says Christakis. Data suggests that people living in the same house share up to 14% of the microbial strains in their intestines. While those who do not live together, but usually spend time together, share 10%. The research has also been able to determine that individuals who live in the same town, but who do not usually interact too frequently, share only 4%. There is, the authors say, a chain of transmission because friends of friends share more strains than would be expected by mere chance. The transmission method There is a question that continues to swirl around this research and that is to understand how strains are transmitted bacteria from one microbiota to the other. “We do not have a conclusive answer about how this transmission occurs,” says Vallés. And he adds: “What is hypothesized is that what reaches the intestine has to pass through the mouth. “Many bacteria in the microbiome don’t tolerate direct contact with oxygen for very long, so close contact is needed, but we don’t know exactly what that looks like.” Guarner, however, details that “the fecal-oral route “It seems to be the most important transmission vector.” That is to say, although we clean ourselves and more or less control our hygiene, in some previous studies it has been detected that the bacteria that are typically found in the intestine also appear on the hands. This is how they then reach the mouth. Some of the bacteria manage to survive this journey from the intestine because they travel in the form of spores, similar to those of fungi. “With this transmission mechanism it does not have to be extremely direct contact, it can be through a towel or clothing,” details Guarner. There is no need to be alarmed. This transfer of microorganisms It is what, in some way, keeps us alive. So much so, that new lines of research on the relationship between microbiota and health suggest that a healthy and fit community of microorganisms has an impact on several aspects of our well-being. Some researchers are trying to establish a direct relationship between the microbiota and non-communicable diseasessuch as cardiovascular diseases, diabetes and even depression. Guarner explains: “This is still a bit speculative, but normally what happens is that these types of diseases are associated with a poor microbiome.” Vallés contributes that “it has been observed that people with the so-called ‘modern diseases’ suffer an alteration in the composition of their microbiome.” But it is not that there is a particular bacteria responsible for these diseases, but rather it is the loss of diversity in general that worsens the state of health. In this case, the research opens the door to continue analyzing whether these non-communicable diseases, in fact, do have a transmissibility factor. And if an entire community of people has a weakened microbiota, these diseases could proliferate more easily … Read more

the new generation” takes roll call and introduces us to the new students with a nod to the original series

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The countdown begins! Next February 16, Physics or Chemistry. The new generation, the spin off of the Spanish teen series that marked a before and after in the 2000s, will hit the screens of Atresplayer. Very soon, the halls of the Zurbaran They will be filled with new students, loves, heartbreaks, confrontations, friendships and memories for a lifetime. Antena 3 is already warming up and has released a teaser and a trailer for this long-awaited fiction that, although with a renewed air, preserves the irreverent and daring plots of the original production, but updated to connect with the Generation Z. © Atresmedia In the first video, just over a minute long, the first thing they do is take roll call and introduce us to the students. One by one, we see the new characters that will fill the classrooms of the famous institute, on which their names are superimposed on the screen: Koldo, Dani, Bárbara, Marina, Pelayo, Carlota, Jeremy, Jon, Asia, Iria and Leleplayed by the young actors Kiko Bena, Biel Castaño, Julia Camus, Carla Domínguez, Biel Antón, María Bernardeau, Rocky, Miguel Fernández, Rocío Velayos, Esther Mejorada and Santi Garzozirespectively, will be in charge of bringing us closer to the stories, joys, fears, challenges and challenges that we deal with every day in a time of ups and downs such as adolescence. © Atresmedia In the images we see how each of the boys is illuminated by a different color: yellows, greens, reds, pinks and blues mix in a rainbow that could reflect the diversity and different personalities of the new students, all very different, but with more things in common than they thought. © Atresmedia © Atresmedia But the big moment comes right after, with the wink that the newcomers give to Yoli (Andrea Duro), Paula (Angy García), Ruth (Ursula Corberó), Cabano (Maxi Iglesias) and Fer (Javier Calvo), his predecessors in Zurbarán, and to all the followers of the original series. The new protagonists paraphrase the iconic song of get lost that served as a theme for the mother fiction, which marked an entire generation and still resonates today. Esther Mejorada, who plays Iria, begins to recite the first verses: “I neither hide nor dare,” a phrase that immediately resonates with fans of the series and connects the past with the present of the new production. As the trailer progresses, his companions join in, completing the lyrics until they reach the final chorus: “It’s physics or chemistry.” © Atresmedia © Atresmedia In the second appetizer that Antena 3 has given to fans of the series, the institute reopens its doors and is filled with life. The school, which has more than 20 years of history, remains the same; The only thing that has changed, as a voice-over says, “are their students. This complicated generation who do everything that shouldn’t be done.” All this accompanied by images of the new students, along with their names, so that we become familiar with them. © Atresmedia © Atresmedia In just two minutes, the trailer shows us where the new plots are heading. Young people break the rules and prohibitions imposed by the educational center and live the rebellion of adolescence, experiencing their first times: at parties, in love, in sex, in grief… This new class of students They will face serious problems, in addition to those inherent to age, such as the emotional impact of a traumatic event: the death of Silvia, a Zurbarán colleague. Although they are not all friends, they will be forced to understand each other. © Atresmedia © Atresmedia Furthermore, the DNA of Physics or chemistry remains unchanged, they will once again seek to break taboos, and future viewers will find everything that made the original series great, but without losing the problems that affect young people today. From what we have been able to see, there are many high-voltage scenes, which show the diversity in relationships and the difficulty that some teenagers have in fitting into society because they are considered different. Friendships, fears, doubts and insecurities will also be present this season. © Atresmedia As in the previous preview, they have left the biggest surprise for last: it returns Olympia, the iconic character played by Ana Milan in FoQ, will be in this new stage, although it has not been confirmed if it will be a cameo or if it will be a regular character with a presence in all chapters. In this way, he would join the rest of the teachers trained by Israel Elejalde (Eden), Itziar Miranda (Love is forever), Silma Lopez (Valeria), Cuca Bunting (Without tits there is no paradise), Alex Sie (red eagle) and Anais Tovar, who, With their different ways of seeing life, they will star in stories that will inevitably be intertwined with those of the students. © Atresmedia That’s how it is FoQ. The new generation The plot focuses on the first times of teenagers: the first drunkenness, the first parties, the first ‘I love you’… and the first duel. The new Zurbarán school year begins marked by the loss of a student, which leads the parents’ association, which now runs the center, to make a decision: create a support group for the students. Thus, eight very different young people end up sharing a space in which they will collide completely, but where they will also end up knowing themselves and sharing their desire to live and fall in love.

Johann Hari, journalist: “The idea that obesity is a sin is deeply rooted in our culture” | Health and well-being

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A couple of days after starting to take Ozempicsays the journalist and writer Johann Hari (Glasgow, 46 years old), he woke up with a strange sensation, unknown to him: he was not hungry. He got out of bed and went out to have breakfast at the bar, the usual breakfast, a chicken sandwich with mayonnaise. He took a couple of bites and couldn’t finish it. It was full. The medicine, belonging to that generation of drugs that have revolutionized The fight against obesity by imitating the effect of a hormone (GLP-1) that tells us when we are full, was restoring a lost perception: that of satiety. Hari tells this and other anecdotes about his experience with these medications in his new book Lose weight at any price. How Ozempic and other drugs are going to revolutionize our diet and our physical and mental health (Península), which reaches bookstores today. In these pages, the journalist, who has been overweight since he was young, embarks on a journey, accompanied by obesity experts and scientists who have participated in the development of the new drugs, for the benefits and risks of these treatments, the uncertainties that surround them and the uncertain scenarios that open in the field of health and beyond it. The journalist attends EL PAÍS by videoconference from London. More information Ask. He has spoken to many scientists. What has impressed you the most about what they have told you? Answer. Which obesity it really does you. Since I was seven years old I knew that being overweight is not good for your health, but I was surprised by the evidence of how serious it is. If you are obese, you are much more likely to suffer a heart attack, stroke, dementia and cancer. If you are obese by the time you are 18, you are 70% more likely to develop type 2 diabetes. And diabetes is the leading preventable cause of blindness in the UK and limb amputation in the US. Q. He assures that these anti-obesity drugs are destined to be the defining medicine of our time, like birth control pills or Prozac at other times in the last century, for example. Why do you say it? R. Because obesity is the biggest cause of death in the Western world. And now we have a medicine that, if you take it, reverses it and puts an end to it. It’s amazing. So all of us who are overweight or obese have a choice, but we have to compare the risks of remaining obese with the risks of these medications and think about it a lot. (These drugs) They are going to have enormous effects. Q. How can they change our lives and our culture? R. The change is enormous. Jefferies Financial, which is a financial consulting firm, made a report for American airlines saying that they may have to spend much less money on jet fuel, because it costs more money to fly with heavier people and that is going to be a much smaller population. Also in Los Angeles there has been an increase in demand for jewelers to change and adjust wedding rings because people have lost so much weight that the rings no longer fit on their fingers. Approximately 20% of Americans have already tried these medications. This is huge. This is an astonishing scientific advance that will profoundly change society for better and worse. “The foods we eat are undermining our ability to feel full” Q. Regarding this negative part, he exposes some issues that the consumption of these medications entails, such as the risk of losing the culture of body positive or what would happen if people with eating disorders access these drugs that help them lose weight. Have you found answers to these questions? R. The invention of these drugs is like the discovery of fire. Fire is a great tool if I use it to heat my house, but it is terrible if I use it to burn my house down. And in the same way, when something as powerful as this is discovered, it will have great positive effects and great negative effects. If you are overweight or obese and start taking these medications, for example, you are 20% less likely to have a heart attack or stroke in the next 18 months. But you also mentioned something that worries me a lot: when you take these medications, you eat much less; and that’s good if you’re obese like me, but people with an eating disorderanorexia for example, if you are thin and start taking these medications, you can kill yourself with them. Therefore, one of the things we must do is regulate these medications very strictly. Q. The book also delves into what makes ultra-processed foods so addictive. Do they cause a kind of short circuit in our brain systems? R. If you look at a photograph of a beach in Spain in 1979, the year I was born, everyone is very thin and you wonder: where are the obese people? So, obesity was very low. Modern humans have been around for 300,000 years, but obesity was extremely rare. And basically, during my lifetime, it exploded. What happened? We know the answer: Obesity skyrockets everywhere people make a change, when they go from eating mostly fresh foods they prepared that day to eating primarily processed and ultra-processed foodsThat is, food is made up of chemicals in factories in a process that is not even called cooking, it is called making food. This new type of food affects us in very different ways. The foods we eat are undermining our ability to feel full and what these new medications do is restore the feeling of satiety. Q. And what about the industry’s responsibility in this context? R. Need regulate the food industry to prevent children from being exposed to these foods that make them sick and undermine their ability to feel full. I’m talking about a long-term solution and we … Read more

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