weight

There are those who are adding fungi such as cordyceps to coffee to lose weight. Science has many reservations

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Coffee is a food, with numerous positive effects on our body. We get more and more about this Positive coffee actionbut we have determined to improve it adding supplements as proteins either Spirulina. One of the latest trends? Enrich coffee with fungi. So that? To lose weight. And here the evidence is not so clear that this trend of ‘Mushroom Coffee’ is so healthy that invites a coffee with cordyceps to drink. The promise. Eating mushrooms or fungi has nothing weird, but a few years ago we began to see how the food industry It began to add them to other foods to create improved versions of them. One of the first brands that added fungi to the cocoa or coffee was FOUR SIGMICan American company that creates “functional foods” and well -being supplements. That is, coffee is not only coffee: it has a series of additions vegetables to relieve these, support the immune system or accelerate weight loss. The latter is what a more recent grabs Trend in networks like Tiktokthe baptized as ‘Mushroom Coffee’. There are several brands that sell coffee with fungi Cordyceps coffee. The defenders claim that coffee (and other foods) can be enhanced with medicinal fungi whose compounds carry a series of positive effects. Among those fungi are Reishithe León hairhe Maitake or the Shiitake (great in broths)but also the most famous cordyceps. Yes, that parasitic fungus that makes Some ants become ‘zombies‘And what is protagonist of the Apocalypse of ‘The Last of Us’. These fungi can increase energy production and improve metabolic function, helping in the burning of fats. They can also help control hunger, stabilize glucose levels and have Probiotic properties that favor both digestion and nutrient absorption. Market. And it is not a bizarre or the US thing: you can Buy coffee With cordyceps In Amazon If you want the healthy effects of coffee more, Chow they announcegreater energy and improvement in your mental clarity. There are different estimates, but this coffee market is expected to grow at a rate of between 5.4% and 5.7% during the next decade. There are studies that place their value at 1,203.4 million dollars in 2023 with a growth up to 1,833.4 million by 2031. They are considerable figures, but we compare, the estimate of specialty coffee is 62,500 million by 2032 and that of the entire market It will be of 632,000 million for that year. But well, it seems that this trend, little by little, is consolidated and grows. The small print. The logic here seems simple. In the case of protein: if it is a good supplement and coffee is a good food, mixing them works. With fungi and coffee the same thing happens, but something that should not be overlooked: there is a lack of research. The relationship between coffee and weight loss is well documented, being a good stimulating before performing some training and selling the caffeine as supplement. But, although the properties of these fungi are also documented, evidence on coffee with fungi and its action in weight loss or mental well -being is limited. Clinical trials are missing that confirm its direct effectiveness to lose weight and most of those available studies are in animals. Also, as we read in VogueNutritionist Marta Marcè comments that it is not usually specified whether the extract is from the fruiting body (rich in properties) or the roots (less powerful), in addition to using very low doses. And sometimes It is not even the real fungus. Dangers. Although cordyceps has a bad reputation due to fiction products in which it has been the protagonist and its effect on some insectsusually has no health hazards. Cordyceps coffee is approved by the USDA -The United States Department of Agriculture-, but you have to take some things into account. It may produce some allergies in certain people and it is necessary Influence when combining it With other stimulating products or drugs, but most importantly, above all, it is to know where those fungi that supplement chocolate or cocoa. Marketing, already such Because here the danger is how that fungus has been manipulated and the example we have had in Colombia, where a health alert on cordyceps supplements not regulated or fraudulent. And if you dare to try it, be from reliable and out of curiosity, not so much for its numerous promises, that millions move in the other part of the world. Images | Conasi, Four Sigmatic In Xataka | It turns out that the myth that marriage fattens is true. But only for men

Losing weight without losing muscle is the great challenge of drugs such as Ozempic. A protein keeps the key to face it

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It is usual for us to often get news about hopeful scientific advances made in mice. These experiments always leave a question in the air, if the discovery can be applicable to humans. This does not always happen, but sometimes MITCH Silence the expression of a simple protein in our muscles can lead to weight loss and, more, more, It can allow us to lose weight Without putting our muscle mass at risk. The protein in question is called Mtch2 (Mithochondrial Carrier Homolog 2), but has been nicknamed “Mitch” by those who study the compound and its effects. The last analysis of this protein and its associated gene has observed that its “erased” in human cells causes in these lower efficiency Energy What is perhaps more important, this silenced causes cells to stop using carbohydrates as a priority energy source and in place they preferably use body fat. Different fuels. The cells of our body need energy and billions of years of evolution have given rise to a series of biological mechanisms that allow us to maintain a calorie reserve that allow us to feed these cells in times of greater shortage. These mechanisms imply that our cells can resort to different fuels according to the situation. While the carbohydrates we consume and the fats that we use as a reserve are the main fuel Ozempic. From mitones to mitochondria. According to Explain the responsible teamthe new study has its bases in a previous experiment conducted with mice that observed in the rodents an “improvement” in their body composition in the form of “protection” against obesity and the development of more muscle fibers. This accompanied by greater consumption of greater oxygen consumption and an increase in resistance. The results were promising but left the team with a doubt, if it would be possible to “inoculate” the body against obesity by silencing the expression of a protein without this negatively affecting muscle mass. To look for an answer, the team went on to focus on the role of the mitochondría, the organelle in charge of providing energy to the cell. The key is in the fact that the “mitch” protein plays an important role in the merger of the mitochondria, a fusion capable of increasing the efficiency of these organelles. By silencing protein, organelles would lose the ability to resort to this fusion which also implies less efficiency and thereby a greater need to consume energy resources of our body. It only remained to prove if this was also true in human cells. Less efficiency, more consumption. They thus verified that by silencing the protein in human cells, the “mitochondrial network” was undone and, as expected, energy efficiency fell. This left the cell in a “permanent state of energy deprivation.” And what is more, the team also found that this led to the cells to prioritize the use of fats as a primary energy source, instead of other possible sources such as carbohydrates. “After erasing Mitch, we examined, every few hours, the effect that it had in more than 100 substances that take part in the metabolism of human cells,” pointed in a press release Sabita Chourasia, co -author of the study. “We saw an increase in breathing, the process in which the cell produces energy from nutrients, such as carbohydrates and fats. This explains the increase in muscle resistance of previous experiments in mice.” The details of the study were published In an article In the magazine Journal embo. An intermediate step. The study takes an important step in the long process between the first results in animal models and the design of a treatment for weight loss based on what was learned. In following studies, the team intends to elucidate new aspects about Mitch’s role in the accumulation of fat in the body. The fact that women usually have higher levels of this protein can help researchers discover if Mitch is also responsible for the differentiation of fatty cells. In Xataka | We are increasingly clear that our microbiome is key to our health. Our protein sources can also alter it Image | Weizmann Institute of Science

Obssing with losing weight is a very bad idea to lose weight. Luckily, science has many more effective

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A young doctor appears before his boss and, although he does not say it out loud, he thinks “the last time I was in front of him, I swept at least a liter. But now I’m going to sweat at least ten, that guy will find out what is to sweat!” Then, do not sweat a drop. It is not fiction, it is A real case collected by psychiatrist Viktor Frankl In 1994. He did to explain that many times our fears, objectives and intentions play against us. And yes, we are talking about losing weight. Against us? It’s as if, for using A metaphor of another psychologists (Steven C. Hayes)“We fell into a deep hole and the only thing we had to go out was with a shovel. As we don’t know very well what to do and we despair, we started using the shovel.” The result, despite working day and night, is that we are deeper than before. What in the background tells us a good number of psychologists (from Logotherapists to Specialists in acceptance and commitment) is that we are so culturally attached to certain behavioral strategies that, although they are not useful, we cannot get rid of them. The obsession with “losing weight” is a problem. And yes, obsession is the word. In Spain, where 52% of the adult population presents overweight or obesity, seven out of ten people (72%) They have tried to lose weight at least once in their life. In fact, According to the Mapfre Foundation datathey have done it, on average, about seven times. That leads to “53% of Spaniards has ever followed a popular or miracle diet with the aim of losing weight.” It is not an accident; It is the consequence of what I commented: in the popular imaginary, the way of losing weight is that. That is to say, In words Giuseppe Russolillopresident of the Spanish Academy of Nutrition and Dietetics, “the population is not fully aware that the methods that use weight losing are extremes and can put their health at risk and that the recovery of the lost weight is frequent.” And what can we do? The first is to banish false myths. Sï, obesity is a health problem; but Not so clear that overweight is in general terms. “The life expectancy of people overweight is not less than that of Normopeso”, He told us Juan Ramón BarradaProfessor at the University of Zaragoza. Many ideas that we have above all this and that we use to justify our behaviors, are still disciplinary stories. That does not mean that health is not important. It means that many of those ideas about overweight, health and beauty are cultural strategies equivalent to getting to cabin being inside a well. So? There are no scientific knowledge that can help us? “From what we can extract from current investigations, there are three tips that can be given to anyone: Eat healthyexercise and Accept your body. Today, everything is reduced to weight loss, “he continued Barrada. Therefore, “we must be clear that stigmatizing people overweight or obesity such as ‘vague’ or ‘lack of will’ is to promote suffering” unjustified. And do it with ourselves too. Luckily, as Barrada pointed out, there is another way of doing things. Image | I Yunmai In Xataka | The scientific reason why miracle diets do not work is

Reducing weight loss carbohydrates seemed a perfect plan. We have just discovered that it comes with unforeseen risks

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Carbohydrates or carbohydrates are a fundamental macronutrient in our diet. They represent, together with the fats, the main energy contribution to our body. Carbohydrates are also protagonists in some diets destined for weight loss, diets based on the fact that, in the absence of these nutrients, our body will resort to the energy stored in their fatty tissue. A plan that is not infallible. DNA damage. A new study has found a mechanism that could link low carbohydrate diets with a Risk increase of suffering from colorectal cancer. The union link would be in the microorganisms that reside in our digestive system, our intestinal microbiome. In a study conducted with mice, the team responsible for the analysis observed that these types of diets could worsen the deterioration of DNA caused by some of the microbes that usually inhabit our digestive tract. This facilitates the appearance of polyps that in turn increase the risk of appearance of this type of tumors. “Colorectal cancer has always been seen as the consequence of a number of diverse factors, including diet, intestinal microbioma, environment and genetic,” explained in a press release Alberto Martin, co -author of the study. “Our question was, does the diet affect the ability of specific bacteria to cause cancer?” Three diets under study. In his study, the team tested three types of diet: a “normal”, a carbohydrates, and a “western” rich in fat and sugar. He did it by combining these diets with different types of usual bacteria between our intestinal microbiota and suspects of keeping some kind of relationship with the risk of colorectal cancer. They found a combination of diet and microorganism with potential to trigger adverse relationships, that of the low carbohydrate diet and a variety of bacteria of the species Escherichia coli (E. coli). They observed that this diet encouraged production by the bacterium of the colibactin, a compound with the ability to damage the DNA and with it of producing cancer. The key I could be in the fiberthe team points out. This type of diets facilitates inflammation, altering the microbial community of its interior, which in turn creates an ideal environment for the propagation of the E. coli. A fallen barrier. The team also observed that the mucous barrier that separates epithelia cells (the outermost cells of the intestine) of bacteria was reduced, which could also facilitate that colibactin reaches intestine cells. This would increase the harmful potential of the compound. The details of the study have been published In an article In the magazine Nature Microbiology. And what about humans? Studies with mice have an obvious limitation, and it is that extrapolating what is observed in these rodents to our own species is not always possible. The team He stood out for it The need to confirm their findings in people, although they were also optimistic about the possibility that their study could be applied in cancer prevention. The microbioma in the spotlight. This is not the only recent study that has put in the spotlight to the bacteria of the species E. coli already the colibactin in regards to colorectal cancer. A few days ago We had the news of A study Made with patients from 11 countries who found exposure tests at an early age to this toxin could be linked to an increased risk of these types of tumors. In Xataka | During millennia, humanity has eaten what it played. Now he has started eating what he wants and that has consequences Image | Pixabay

Ozempic has made thousands of people lose weight brutally. Then they have put their closet funds for sale

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Novo Nordisk, the Ozempic manufacturer, has just presented the results of the first quarter and the data are impressive: we talk about 3,891 million euros, 14% more than last year. And, of course, that He has shot the price of the company. The most interesting, however, is why. And the answer is very simple: the treatments against obesity have risen 67%. It is what allows us to intuit that the Ozempic revolution (and the rest of the GLP-1 agonists go far beyond what we might think. So much so that he is putting up legs The second -hand market. Something is changing. In mid -2024, second -hand sales platforms began to see how the clothes offered in their systems changed. In the previous two years, large -scale women’s clothing ads had grown surprisingly: “A 103% increase in 3xl size ads, 80% in 4xl size and 73% in 5xl size”. Not only that, Poshmark analyzed the ads and discovered “a 78% increase in the new ads that mention ‘weight loss’ in the title or description.” Dressed Collective, specialized in second -hand sale of high quality products, has also detected a similar phenomenon and Goodwillfinds, which reverts donated clothing, says they are increasingly donated. Vinted He has also noticed. How do we know that all this has to do with Ozempic? We can’t be sure, it’s true. But, as they point out in Fortune, one in eight Americans already USA SEMAGLUTIDA OR ANOTHER GLP-1 agonist and the trend has been growing very closely to how the use of these medications grew. And, whatever it is, it is an issue that everyone begins to intuit that is serious. In fact, there are more and more resale programs of the brands themselves. Given these market changes, brands such as Levi’s, Patagonia and Carhartt Wip have begun to mount their own stores that allow them to also be present in this “second life” of their products. After all, As they point out in Vogue Business“The resale has been one of the only retail trade engines in recent years.” In fact, the market has been bent since 2021. However, not all the mountain is oregano. The problem is evident: as thousands of people lose weight significantly and They decide to purge their cabinetsthe stocks of second -hand stores are unbalanced: there is a lot of big clothes to sell and few people who want to buy it. That is, if analysts are right, we are going to A great readjustment of the fashion we produce, sell and buy. In a world pregnant with data and more data, it may seem curious that the first to realize have been Second -hand platformsbut little by that we think it is so predictable that it scares. Above all, To luxury brands. Image | YAP In Xataka | XL models: When you are harassed by your body in real life and influencer admired on Instagram

More and more people take a “pacifier” of vinegar or herbs early to lose weight

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Until recently – and some video may still appear Scrolleando In Tiktok – they marked trend the Morning Shedswhere people recorded showing step by step how their day began. Between cafes, cold showers and positive statements, somewhat more questionable practices were also sneaking. But the curious thing is not only what they did, but what has remained: now, many of these videos focus solely on what they take in the morning. A morning habit. In social networks, especially in Tiktok, the morning chupitos have taken prominence. What started as A punctual gesture between celebrities “Such as the chest of wheat grass,” it has become a viral phenomenon that floods the feeds of hundreds of users. From ginger chupitos to herbal combined, the concept is always the same: a quick dose that promises great results. But beyond the format, the question arises from whether the idea that a simple drink can be the key to thinning and detoxifying the body is really transmitted. There is one that stands out. Among all these drinks, apple vinegar has won a special prominence. In the videos we can see how Drink apple vinegar pacifier Easy under the pretext that it will help them flatten the belly and burn fat. Yes, it is true that some studies They have observed That consumption of this type of vinegar can slightly reduce blood glucose levels and total cholesterol. Now some specialists They have warned on the possible adverse effects of its excess consumption and on an empty stomach ranging from the irritation of the stomach or the esophagus to the damage to the dental enamel. There is even more. This trend of Shots morning is not limited to apple vinegar, there are also infusions of Tik Tok or ginger and turmeric chupitos that have entered the category of natural remedies presented as rapid solutions to detoxify the body or accelerate metabolism. “I’m going to show you this Tik Tok recipe,” A user comments While preparing a tea with ingredients that, according to what you have seen, can help lose weight. However, some experts They have pointed out That many of these combinations do not have sufficient scientific support and can have adverse effects. For example, excessive green tea consumption It can interfere In iron absorption. Behind the investigations. Despite the rise of morning chupitos on social networks, specialists They have coincided that there are no conclusive evidence that supports the alleged detox or slimming benefits. The available evidence is limited and, in many cases, the observed effects are minimal or circumstantial. More than resorting to fast solutions, experts They have insisted in prioritizing a balanced and sustainable long -term diet. A healthy intestine. For a while now, hashtags like #gutok and #guthealth They have popularized Jengibre chupitos, turmeric supplements and probiotics that, supposedly, help eliminate swelling and improve intestinal health. However, what really needs intestinal microbiome is dietary fiber from cereals, whole grains, fruits and vegetables, such as He explained for The Guardian Dr. Saman Khalesi. Along the same lines, natural infusions such as green tea or chamomile have been viralized, associated with anti -inflammatory and digestive properties. The culture of immediacy. We live in an era where everything seems to be fast, from purchases to the results. In that sense, it is not surprising that the morning chupitos have captured the attention of many users on social networks. The promise of rapid and visible results appeals to those who seek immediate changes in their health, but specialists insist that it is important to contextualize these practices. To what extent are these morning gestures provide real benefits or only perpetuate the illusion of express solutions? Image | Pxhere and Pexels Xataka | We take more and more mercury through fish. There are those who want to solve it with “design” probiotics

Summer is approaching and with him the new obsessive trend to lose weight quickly: the patches to lose weight

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There are nine weeks left for summer and social networks have not taken to remember it. This year, the trend is a clear two -way revival that He has flooded everything: Not only outfits with y2k hats or minimal tops, but also thin body. Quite back the discourse of bodily positivity has remained, and the obsession with weight loss has returned strongly. This time, in the form of stickers. Slimming patches. These products, marketed under names as Weightless either Diet patchThey are transdermal adhesives that are placed on the skin on the wrist or belly. The Reels In social networks and manufacturers ensure that they help lose weight, reduce appetite or accelerate metabolism. The promise is simple: pégate it and lose weight, with no more effort than to remember every so often. Some even present with slogans such as “needleless version” of medicines such as Ozempicdespite having absolutely nothing in common beyond marketing. Does it really work? According to a Bloomberg articlethe theory behind these patches is that they release “natural” ingredients to the body through the skin. Some include compounds such as berberine, green tea extract, caffeine or bullfighting. However, there is no serious scientific evidence that supports these compounds that can be absorbed by the skin in significant amounts to reduce weight. As They have detailed In Medical News Today, some experts have agreed that these products are sold as supplements without strict regulation and it is practically impossible to know what they really contain. As He explained Professor Nerys Astbury of the University of Oxford in Bloomberg, although some medications are administered transdermally (such as nicotine or contraceptives), it has not been shown that appetite suppressors can do it effectively. Boom to lose weight. This whole situation occurs in a context in which obesity medications are more fashionable than ever. Products like Ozempic, Wegovy either Zepboundbased on the GLP-1 molecule, they have been revolutionaries in the treatment of overweight. Unlike viral patches, these do have clinical studies, medical approval and proven results. But of course, they require recipe, medical monitoring and, above all, a puncture. Hence the idea of ​​a “LPG-1 in patch” sounds so tempting. A background problem. What really is at stake is not only the patches, but what they represent. There are many videos about “losing weight” with increasingly crazy routines and, now, it has touched the turn of Loss to lose weight stickers. These types of rapid solutions perpetuate the mentality of thinning is a process that can be outsourced in a patch, without the need for long -term commitments, exercise or changes in the diet. A “perfect body” culture is promoted regardless of cost, whether physical or psychological. In this sense, social networks are playing a key role, presenting these patches as an “easy” and “pain” of losing weight, not to mention the associated risks or realities behind these products. While the young women immerse themselves in this wave of weight loss, we are faced with a new form of social pressure that resurrects the cult of extreme thinness. The two thousand aesthetics, which glorified thinness, sneaks back into our screens and, with it, the return to the idea of ​​aesthetic pressure to be happy. Image | Tiktok Xataka | “I never say that I have thinned thanks to Ozempic”: the taboo of the ‘Ozempicazo’, the people who hide them consume it

We have been using sweeteners that provide zero calories. Now we understand why they don’t always help lose weight

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Sugar is one of the most daily foods and one on which food controversies do not scarce. Excessive sugar consumption can be linked to various problems, from the oral to diabetes. The artificial sweeteners that we sometimes use to reduce the consumption of conventional sugars can be healthier, but no less controversial. Less sugar, more hungry. A recent study He has found that some artificial sweeteners could be affecting the signals that manage our appetite at the brain level. The team responsible for the study observed that the Sucralosa had a less satiating effect than sucrose, conventional or table sugar. The Sucralosa. Sucralosa is a artificial sweetenera disaccharide or compound sugar such as the union of two simple sugars. Its sweetest capacity is up to 600 times higher than that of sucrose, but our body does not absorb it in the same way. This implies that this sweetener has no caloric contribution to our body. This could explain the observed phenomenon: our body would perceive the sweet taste and prepare for calorie ingestion. The body would simply be responding to the absence of energy received. 75 participants. In the study, 75 participants who worked as both of the experimental group and control group in two sessions separate days or weeks from each other took part. Participants, men and women, some with “healthy” weight, others overweight or obesity, consumed three drinks prepared in the experimental sessions to which they underwent. These preparations were a sweetened drink with sucralose, another with conventional sugar (sucrose), and another simple water. The order in which they assigned each drink was random. The team later studied the participants’ response to each drink. Before and after the test they carried out functional magnetic resonances, they took blood samples and asked the participants for their feeling of hunger. They observed that the sucralose increased appetite and activity in the hypothalamus and that it did it to a greater extent among the participants with obesity. The team also detected changes in how the hypothalamus communicated with other brain regions. The details of the study were published In an article In the magazine Nature Metabolism. Old acquaintances. The key can be in the hormones that our body produces when eating, hormones such as insulin and LPG-1 (Glucagon -like peptide 1). This last hormone is produced in the stomach when we eat and fulfills a double function: on the one hand warns the pancreas that we will need insulin to manage digerida glucose; and by transmits to our brain the message that we have fed and satiated. “The body uses these hormones to tell the brain that you have consumed calories, to reduce hunger,” Explain in a press release Kathleen Alanna Page, co -author of the study. “The Sucralosa did not have that effect, and the differences in hormonal responses to the sugar compared to sugar were even more pronounced in participants with obesity.” Much to investigate. According to the team itself, there are still some unknowns to solve in this context. One question, for example, is how this sweetener affects our brain activity in the long term. To do this, they explain, longitudinal studies will be necessary that also analyze the weight and food behaviors of the patients. Another issue to solve is how other factors affect, such as sex, this relationship. The team indicated that during the experiment, the brain activity of women showed greater variability than that of men, which implies the possibility of differences to study. In Xataka | Some researchers have analyzed the impact of sugary drinks on world health. They have taken their hands to the head Image | Faran Raufi

"I never say that I have lost weight thanks to Ozempic": The ‘Ozempicazozo’ taboo, the people who hide that they consume it

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There is a certain pattern around the social perception of thinness: we glorify it, yes, but we stigmatize the shortcuts to achieve it. AND That little contradiction has become very visible with the rise of Ozempic. Who thinns with effort receives admiration; Who does it with medication receives contempt. “Ozempicazo“It is the derogatory term that is being used in networks to indicate to those who are suspected that they have lost weight by resorting to this drug. Figures such as Ibai Llanos in Spain either Mike Pompeo in the United States They have been suspicious objects after their bodily transformation. A few weeks ago we published a report in which those who turned to Ozempic to lose weight They told us their long -term experience. Today we rescue some of their voices and add new ones to talk about this phenomenon. How complicated it can be to admit the use of Ozempic. Ismael, 35 -year -old Alicante, explains that “people see very well that you are thinner, they congratulate and comply with you, but when you tell them how you have achieved it, the perception changes.” In his case, he went from touching 100 kilos at 81 kilos, something he considers more acceptable for his stature. In Xataka Ozempic will soon become a thing of the past: this is what we know about the new generation of drugs for weight loss “It is a double moral, I have friends who put protein powder, creatine and several more things to be strong, with them there is never a problem. If I turn to a drug to lose overweight, then they do tell me that I have not struggled, that it is a shortcut,” he explains. “It seems that losing weight must imply suffering to be legitimate. So I stopped giving explanations about my weight loss, I don’t comment on, I thank and change the subject. “ Ismael’s point is that no one questions the use of pain or antidepressants for mental health, but to lose weight, pharmacology is considered a trap. Clara, which fell from 87 to 69 kilos, synthesizes it: “I have tried or remember how many diets without results, or with results but rebound effect, and when I find something effective, it seems that it is not acceptable because I have not been enough hungry.” Cristina, a 46 -year -old Valencian, has lost more than 16 kilos with Rybelsus (pills) first and Mounjaro (Injectable and Ozempic competitor) later. “I never say that I have lost weight with Ozempic, nor that it is with a puncture or with pills. I have turned it around,” he confesses. When asked for his weight loss, he turns half truths: “I tell that I did an analytical and saw that I had a little high thyroid and insulin resistance, so they gave me a treatment and that has derived in a certain weight loss.” In Xataka If the alcohol industry no longer had enough problems, it has now encountered one more: Ozempic “It’s like I feel bad to put it,” he explains about his reluctance to reveal the real method. “It is as forbidden, as is frowned upon.” This stigma is so entrenched that even when someone asked him directly if he used Ozempic, he denied it: “I got out of my heart to tell him no“. This contradiction generates frustration:” Now that I think about it, it gives me anger. Why do I hide? If my money I spend it on what I want. “ The Dr. Alicia Taboadasubspecialized family doctor in cardiovascular risk and endocrinological diseases, offers A nuanced vision of the phenomenon: “First of all, I would like to remember that obesity is a chronic disease and in the same way that we treat other diseases with drugs, it is normal to use a medication that has shown to lower weight and reduce cardiovascular risk, joint problems and even mental problems.” According to Dr. Taboada, the stigma has its nuances: “As for the people who hide Ozempic, They are normally patients who have a discreet overweight or who want to lose a few kilos. A patient with morbid obesity has no shame in saying that Ozempic is being punctured. “ There are legitimate criticisms, mainly The shortage that has affected diabetic patients. “The fact that it was so criticized has also been because until now we only had Ozempic, a drug in principle only for diabetics,” explains Dr. Taboada. “The one that many people were using it made the diabetics run out of the drug. But today this would not have to be because there is because it exists Wegovywhich is the same molecule but specific for weight control. “ Criticism increases to public figures that do not transparent its methods. Influencers that attribute physical transformations exclusively to diet and exercise, omitting possible pharmacological aids, They generate unreal expectations in vulnerable audiences. It is complicated. {“Videid”: “X7ZO910”, “Autoplay”: False, “Title”: “Added sugars: how to avoid them and improve the diet?”, “Tag”: “sugar”, “Duration”: “220”} “We have met people who do not want to prick, who want to make a normal diet,” says Dr. Taboada. “And really if they do well, if they make food changes, they get weight off too. You never have to force anyone. To clicking you will be easier because you are not going to go hungry, it is true, but if you have a lot of willpower, you can make a diet without the need for any drug.” The rebound effect adds another layer to the stigma. Pilar recovered 30 kilos after suspending the treatment, reinforcing the narrative that the method was not “authentic” or “sustainable.” On this, the doctor is clear: “It is said that they are drugs that should be taken for life, but unfortunately their price makes not everyone to do it, which is the vast majority. The most important thing is to establish changes in the lifestyle, because if we leave that drug, the patient will bounce.” Outstanding image | HAVEREDAS in … Read more

This is what we know about the new generation of drugs for weight loss

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Many pharmaceuticals and laboratories have spent months to work seeking to replicate the success of drugs such as Ozempic, Wegovy or Zepbound. Based on compounds originally devised as diabetes treatments (semaglutida and tirzepatida) that ended up triumphing as a method to lose weight. Pharmaceuticals responsible for these have not stopped working. New generation. Novo Nordisk, the Danish company responsible for the development of Ozempic and its active compound Semaglutida, announced a few days ago New advances In Cagrisema clinical trials, a drug that combines semaglutida with another similar compound, Cagrilintida. Now the pharmacist has announced another novelty in the development of the new generation of drugs capable of fighting diabetes and helping to reduce our weight, an exclusive license agreement for UBT251, a triple agonist associated with three different receptors. Danish is not the only pharmaceutical in this race. Cagrisema A few months ago, Novo Nordisk gave us new details Cagrisema. This is a drug based on Cagrilintida, in turn a compound that emulates amiline (and also calcitonin), similar to how the semagglutide emulates the peptide similar to type 1 glucagon (LPG-1). Redefine 2. In Your last announcementNovo Nordisk realized some results of the redefine 2 trials, the third phase of the clinical trials with which the safety and effectiveness of the new combined drug has been tested. The essay studied these factors over 68 weeks in more than 1,200 participants. The trial showed that the average weight loss of the group under treatment was 15.7%, considerably higher than the weight loss of the group to which a placebo was administered, which was 3.1%. The detailed results of the clinical trials of the Redfine program (Redefine 1 and Redefine 2), will be presented later this year, while the date the company manages for the approval of these treatments by the regulatory agencies is the first quarter of 2026. Triple agonist. But perhaps the main course is yet to come. This same week, the Danish pharmacist He also announced An exclusive license agreement for a new compound, now known as UBT251. Until now we already had double agonist drugs, such as the tirzepatid Zepbound and Mounjaro of the American pharmacist Eli Lilly. These drugs function as analogues of the GLP-1 and GIP hormones, but not the glucagon. New agreement. The agreement has been signed between Novo Nordisk and Chinese Laboratory United Biotechnology. By virtue of the contract, the latter will maintain the rights for the development, manufacture and marketing of the drug in continental China, Hong Kong, Macao and Taiwan; while the European will be responsible for these activities in the rest of the world. To the race. Novo Nordisk was the pharmacist who opened the melon of drugs against diabetes converted to treatments for weight loss but may not be the leader in the race to achieve the triple agonist drug, the new generation of medications of the Ozempic family. And is that the American Lilly advances in the development of the Festatrutidawhich is already found In phase III of their clinical trials. In Xataka | “I lost 55 kilos, but I recovered 30 when leaving it”: we talked to the Spaniards who have tried the roller coaster of Ozempic Image | HAVEREDAS / I Yunmai

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