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Some people believe that sleeping on your side or stomach creates “sleep wrinkles” on your face. It’s exactly the opposite

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The Internet is full of golden rules for have ‘eternal youth’this being the holy grail that many would like to have in their hands right now. Among these pieces of advice, there are several that can be quite annoying, such as that you should not sleep leaning on the side that is wrinkled. But… how true is this? The benefits of sleeping well. The sleeping position is essential to have a good rest. Because sleeping on your stomach is not the same as sleeping on your left side. In the first case, the cervical spine can suffer a lot and in the second the hated gastric reflux. can be seen reduced. But now it comes into play that sleeping on one side or the other can cause more wrinkles on the face due to the hated gravity that generates a mechanical effect that causes the face to fall and wrinkles to appear. But science disagrees on this one and puts the blame more on biology with cortisol and collagen. The myth of ‘Sleep Wrinkles’. The theory seems logical: if you spend 8 hours squishing your face into a pillow, that mechanical compression should leave a mark. There is often talk of “sleep wrinkles” (sleep wrinkles), which, unlike expression lines, caused by smiling or frowning, would be caused by having your face against the pillow. It is something that some experts defend like those of The Aesthetic Society, which suggest that sleeping on your stomach or side favors the appearance of vertical lines due to this chronic pressure. Other opinions. The clinical evidence It is quite limited in this casesince many of the statements that defend this myth come from the field of cosmetic surgery and with very limited groups of people. There are even articles that suggest that there is no clear relationship between sleeping in a certain way and having more wrinkles. The consensus right now is that sleeping on your back could theoretically reduce the formation of compression lines. But obsessing over this is not the best, since if having this position is uncomfortable and the quality of sleep decreases, then the biological weight it will entail will have a great impact on wrinkles. The real threat. This is where science stops being speculative and becomes blunt. If there is something that ages your skin, it is not the pillow, It’s sleep deprivation. When you get little sleep, the body enters a state of physiological stress, raising levels of the hated cortisol, the stress hormone. And elevated cortisol is the great enemy of our skin’s youth. This is because it can inhibit the cells that make collagen (the scaffolding of the skin), making the skin less elastic and increases metalloproteinases. This word, so long, is nothing more than an enzyme that breaks down that fundamental collagen that we have in our skin and that keeps it firm. If we do not produce it or destroy it, the wrinkles will appear there. With data. A key clinical study presented in ScienceDaily showed strong results: People with chronic poor sleep quality showed clinical signs of accelerated aging with fine wrinkles, uneven pigmentation, and sagging. But the most important thing is that if UV radiation from sunlight was also added to all these factors, the skin’s recovery would get worse. And this is where the need to have sun protection when going outside came in. Images | Katelyn G Isabella Fischer In Xataka | There is a ‘good’ fat that hides a secret to aging better and being in shape. All that remains is to get the pill

wells, drought and the hidden side of the avocado

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Avocado is undoubtedly a very delicious food and also in high demand for its good macros, which has led to an increase in its production. This proliferation in its cultivation seems to bring good news for our land (especially because it sells well), but on the Costa del Sol and the Tropical Coast of Malaga and Granada the great environmental impacts are already seen which is generating such as the plowing of the slopes and a large water consumption that aggravates the drought already typical of southern Spain. A great consumption. To put figures, More than 20,000 hectares are now dedicated to avocados in these provinceswith some 5,000 hectares converted from dry land to irrigated land, with dubious legality behind it, which has also caused the appearance up to 250 illegal wells in 2023. This expansion, which represents 30% of the Andalusian avocado area (about 9,400 hectares in total), has replaced traditional crops with hypertensive tropical crops despite the climate crisis. All to opt for a crop that can undoubtedly give a great economic return. Environmentalism. A recent complaint made through Along with this complaint, which points to the serious environmental problems that are being experienced, different images are shown that undoubtedly speak for themselves to understand how this crop is affecting the geography. Publication in X by Santiago M. Barajas | Via X What we are seeing is not just agriculture; It is an industrial transformation of the landscape that is pushing the water and geological resources of Malaga and Granada to the limit. This is how avocado and mango have gone from being “green gold” to becoming an environmental time bomb. Destruction engineering. Traditionally, agriculture in these areas was adapted to the natural orography of the land. But now, the model that has been imposed, driven by the very high profitability of the tropical fruit, does the opposite: adapt the orography to the crop by force. According to Ecologists in Action and confirm various edaphic studiesthe implementation of these crops requires heavy machinery to break slopes. The process eliminates the original vegetation cover to create artificial terraces. The result? A severe degradation of the soil in its surface horizons. A problem with storms. With this degradation, what is caused is the elimination of natural vegetation, which produces a “sealing” of the soil and consequently the appearance of cracks that nullify its biological functions. The problem arises when torrential rains appear (increasingly more frequent in the Mediterranean), which causes the water to not filter and run away, dragging nutrients and causing massive erosion. This is something that translates into the use of more fertilizers by farmers, which end up contaminating the subsoil. In short, we are facing a vicious cycle of chemical and physical degradation. An infinite thirst. The avocado is a fruit that fits perfectly in the rainforest, but has now been transplanted in an area with a semi-arid Mediterranean climate. An ideal place for traditional dryland crops such as olive or almond trees that can survive on what falls from the sky. But avocado or mango in a hypertensive model demand about 7,500 cubic meters of water per hectare per year. These demands Added to the large number of plantations that exist, as we have commented previously, it leads to great water tension that we have seen reflected in the La Viñuela reservoir, which has reached only 7% of its capacity in 2023, and which has reached La Axarquía in Malaga. to a critical situation. And this deficit is not solved with rain, but with drilling machines that open wells in the area. In this way, the direct consequence is clear: overexploitation of aquifers and their salinization due to marine intrusion. An escalated problem. This avocado bubble does not stop increasing in our country. Given the collapse that has been experienced in Malagathe model has been replicated in Cádiz, Hueva or Murcia, which in the end are regions that already suffer their own water stress due to not receiving much rainfall throughout the year. But not only has he been emigrating from the provinces, but he has also escalated to the judicial field, where the prosecution points it is already being investigated a possible environmental crime with damage to the public water domain valued at 10 million euros and the illegal theft of up to 26 cubic hectometers of water. And in many of these regions citizens have had to suffer supply cuts due to this shortage, while this agricultural model continued to demand A solution. What is proposed In this case it is the ordered de-escalation of these crops. To achieve this, the goal is to stop new irrigation talks and close illegal wells. The problem is that it faces a very important leg of the economy of some of these provinces, against the change in the landscapes of the region. In Xataka | Andalusia has become a hostile land for the avocado. So an unexpected region is taking over: Galicia

Convenience stores were an emblem of Japan. Until the demographic crisis has revealed the dark side of opening 24 hours

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The stores japanese convenienceknown as konbini, are not simple shops where you buy fast food or basic products, they are a deep part of the social fabric of the country. Its success is measured not only in numbers (more than 55,000 establishments spread across the 47 prefectures) but in the way in which they accompany daily life: they allow you to pay bills, send packages, print documents, buy tickets for shows, resolve unforeseen events, take refuge in case of emergency or simply take a break in them. And now that the country doesn’t stop agingthe stores are mortally wounded. The konbini. Let’s think that, in urban neighborhoods, rural towns or isolated coastal areas, these establishments have become the minimum infrastructure indispensable where there used to be post offices, banks or small family businesses that have now disappeared. The store, therefore, is not just a business: it is a safe space, open and available 24 hours a day, an emotional and logistical support point that has shaped the Japanese daily rhythm and has captivated even to millions of touristswho find in these establishments a mix of efficiency, warmth and aesthetic thoroughness that is difficult to replicate. Efficiency and expansion. I remembered the new york times in summer that the development of the Japanese konbini has been the result of an evolution of decades. Since 7-Eleven opened your first store In Japan in 1974, the combination of non-stop hours, quality fresh food (onigiri, bentō, noodles, seasonal desserts) and integrated services made the model a unique phenomenon. For many residents, these stores are literally the closest store, the most accessible ATM, the place to go when something is missing or something happens. The associated image is one of precision: perfectly organized shelves, impeccable coffee machines, attentive employees, continually renewed food and a sense of total availability. From Japan to the world. This internal success was projected outwards, so that 7-Eleven, today Japanese owned, is the largest retail chain on the planet, and global expansion plans aim mainly to North America. The konbini became an exportable image of Japan: efficient, friendly, reliable. The hidden reverse. But not everything shined the same. one piece from the Financial Times has revealed that behind that facade of functional perfection A franchise system is under increasingly intense tensions. Japan agesthe active population is decreasing and small businesses are experiencing increasing difficulties to hire staff. The model requires stores open 24 hours a day, seven days a week, and the pressure not to close falls squarely on the owners. He Akiko’s case and her husband, a 7-Eleven manager who worked without a day’s rest for six months until dying by suicide, starkly revealed the human price of this silent perfection. And more. It was not an isolated case: a labor inspection recognized the relationship between death and overwork, but the root of the problem is structural. Franchisees must deliver between 40% and 70% of gross profit to the parent company, which reduces their margin and exposes them to absorbing personnel, overtime and unforeseen charges. Visible efficiency therefore has an invisible cost. The crisis of the model. Faced with the problem, the chains 7-Eleven, FamilyMart and Lawson have tried make schedules more flexibleintroduce automatic checkouts, ordering systems assisted by AI and robots cleaning to reduce the need for labor. But none of these measures solve the main equation: fewer available workers and more opening hours supported by fewer people. Domestic consumption is also not growing as before, which limits the owners’ ability to increase payrolls. As minimum wages rise, margins narrow even more. many managers they work for free for dozens of hours to keep their stores open. Some they confess that, in the current state, closing would be a more rational option than continuing to operate. The fragility of the system thus becomes visible: if there are no new franchisees willing to take over, the model can collapse. Adaptation or goodbye. The response of the companies points towards a profound transformation of the model. 7-Eleven study contracts renewed from 2027, possibly moving towards the “mega-franchise” model, where the same owner manages multiple stores and distributes human resources between them. However, this implies a concentration of the business and could further displace the small independent owners who historically defined the konbini as a community space. The central question is whether the konbini will continue to be a connected capillary network to the territory or whether it will become a centralized corporate system, more profitable but less close. The great dilemma. If you will, the konbini was born as proximity symbol and frictionless service, and became part of emotional memory from Japan: open places when everything else is closed, spaces where the daily routine has a friendly pause. But that same ideal has been held for decades by people whose efforts they have become invisible beneath the surface of efficiency. Today, the system faces a limit that is not technological, but human. The future of the konbini will depend on whether Japan manages to rebalance the contract between the community, the company and those who keep the doors open at any time, 365 days a year. If it manages to adapt without sacrificing those who support it, it will continue to be an intimate and essential institution. If not, it could become the emblem of a society that knew how to take care of every detail… except for the people who made it possible. Image | Pexels, Japanexperterna, Shankar S. In Xataka | While half the planet aspires to retire, in Japan the opposite is true: 100-year-olds who only want to work In Xataka | The aging population and a poor pension system have a new symbol in Japan: grandmothers are rented

August has been an extremely warm month in Spain. That has had a side effect: make us older

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This summer has left repeated scenes: empty squares at the time of the nap, nights in the heat and a Mediterranean turned into a pressure pot. Spain has suffered suffocating days They will go to statistics, but the most serious is not measured in degrees. According to a recent study, heat waves do not leave when the temperature drops. They leave a silent trail in the body: they accelerate biological aging. A disturbing finding. A recent study Posted in Nature Climate Change It has shown that repeated exposure to heat waves accelerates biological aging. The work, led by the University of Hong Kong, followed 25,000 people for 15 years in Taiwan. The results speak for themselves: four extra days of heat wave in a period of two years were translated in nine days added to the biological age of the participants. In manual workers, more exposed to the sun and heat, that effect shot up to 33 days. “The impact of heat on our body is comparable to tobacco, alcohol, poor diet or lack of exercise,” The research team has summarized to The Guardian. The biological clock under pressure. How did they get to that conclusion? The scientists calculated the biological age from different markers: blood pressure, inflammation, cholesterol and the functioning of lungs, liver and kidneys. When comparing them with the real age of each person, the conclusion was clear: who had spent more time under heat waves showed accelerated aging. The exact reason is still unknown. The main hypothesis is that high temperatures damage DNA and submit the body to constant stress. “If the exhibition accumulates for decades, the impact on health will be much greater than we have now measured,” has pointed to The Guardian Dr. Cui Guo, main author of the study. More evidence: heat at all ages. This finding does not come alone. In 2024, another job Posted in Nature He revealed that early exposure to cold and heat interferes with the development of the white matter of the brain in children. The consequences, the authors warned, could extend throughout life. The conclusion is clear: heat does not understand ages. Inference affects developing brains; In adulthood, it accelerates the organism’s wear. Can the damage be stopped? The same study offers an interesting nuance: the harmful effect seemed to be reduced over time, probably because people learn to protect themselves better. Searching for shadow, hydrating or using air conditioning made a certain difference. Even so, the biological footprint never disappeared completely. The problem is that not everyone has the same possibilities to adapt. Older people, outdoor workers or those who live in neighborhoods with less resources suffer a much greater impact, As the study collects. Prevention, experts coincide, goes through reinforcing Urban design: More trees, more shadow, better isolated homes and just access to cooling. Individually, recommendations remain simple but effective: hydrate, avoid hours of heat and seek refuge in fresh places. The invisible heat scar. Until now we thought about heat as something passenger: annoying, exhausting and dangerous in extreme days. But scientific evidence points to something more disturbing. The heat, the experts say, does not leave at all when the thermometer goes down: it stays inside, accelerating the wear of the organism and leaving an invisible scar. For researchers, this finding is a turn in the way of understanding health. And the warning is clear: if the planet continues to heat up, we will not only have longer summers, also bodies that age faster. Image | Unspash Xataka | The sea is 30 degrees in the Balearic Islands and that worries meteorologists: the Mediterranean is a pressure cooker

The answer was on the other side of the Pacific, in Japan

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It is not enough to promise that a plane is less noisy. You have to prove it. That is what NASA proposed with its X-59an experimental plane that wants to change The future of supersonic flight. To achieve this, I needed data. Very precise data. And therefore, although the project is American, a key part of validation was carried out in Japan, in one of the supersonic reference facilities in Asia. The X-59 Quesst is an experimental plane created with a very specific mission: demonstrate that it can be flown at supersonic speed without that meaning a rumble on land. What NASA wants to eliminate is not speed, but noise. The classic boom Sonic, that dry burst that rumbles when an plane overcomes the sound barrier, remains one of the great obstacles for supersonic flight Return to commercial aviation. The X-59, on the other hand, promises something different: A slight THUMPbarely noticeable from the ground, thanks to a design that controls – and disintegrates – the shock waves before they are based on an acoustic explosion. But it is not enough to design a stylized and elongated form. It is not enough to simulate it on a computer or anticipate its behavior with computational models. What defines X-59 is not only its silhouette, but the sonic firm that projects When flies to Mach 1.4. That firm, that acoustic footprint should be measured with surgical precision. And that’s where Japan enters the scene. NASA did not do everything at home: key part of the validation was done in Japan Although the epicenter of the project is located in Palmdale, California, under the direction of Lockheed Martin Skunk Works, part of its most delicate validation was carried out on the other side of the planet. Instead of limiting yourself to try your model in your own facilities, NASA decided to repeat the trials In a supersonic wind tunnel of the Japanese space agency (Jaxa), located in Chofu, Tokyo. There, researchers from both agencies They exposed a plane modelreduced to 1.62 % of its actual size – 50 centimeters from tip to tail – to conditions that simulated its cruise speed. The objective was clear: to verify how the air flowed around the aircraft and, above all, register with the highest possible precision level its sonic signature. Japan’s choice was not symbolic. As NASA itself detailsthis was the third round of wind tunnel tests carried out with that same model: one was made in Ohio, at the Glenn Research Center; another, in the same Jaxa tunnel years before; And the latter, also in Chofu, was raised as part of a cross validation strategy. Even if you put the model in another wind tunnel, a slightly different version of the data is obtained, that is something good, Melissa Carter explainedresponsible for the NASA Supersonic project. “By using the same model in both tunnels, we can increase the certainty of the data and our understanding of the X-59 design.” The measurement of the pressure profile – the acoustic footprint that leaves the plane when it breaks the sound barrier – does not admit errors. And the best way to reduce any margin of uncertainty is to verify that, under different conditions And with independent instrumentation, the results remain consistent. That is what allows collaboration with Jaxa. As part of an agreement signed in 2020both agencies pledged to share data, compare methodologies and repeat essays in both countries, thus reinforcing the solidity of the entire experiment. The wind tunnel where the tests were performed is not any. It is a supersonic installation operated by Jaxa, with a section of just over a meter by one meter. Although their dimensions may seem modest, they are ideal for working with very small models such as X-59. In it, the air flow can reach sufficient speeds to simulate real flight conditions, which is just what NASA engineers were looking for. For Jaxa, the opportunity was also key. The Japanese agency has been developing its own “silent” supersonic flight program for years, With projects like Sky Frontier. Sharing information with NASA allows you refine your own designs, Learn from different approaches and validate your simulation tools with real data. In return, it offers experience, equipment and infrastructure that complement those of the United States. Images | NASA (1, 2, 3) | Roméo A. In Xataka | Ryanair’s new competition does not come from any European airline: it comes from India and has an ambitious plan

If it is better to do it side or mouth

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The time comes to sleep, you lie in bed, close your eyes and start the dance from one side to another. But what really is the best posture? First one side, but it does not end how to fit; Up it seems that it is a bit strange, and then you return to the other side until, in the end, by tiredness, one ends up sleeping. Although the posture – which we usually ignore – can make a difference in a repairing and a poor rest. It’s not just closing your eyes. According to a study Posted in Handbook of Clinical Neurology (2011)we spend a third of our life sleeping or trying to do it. According to Mayo Clinicduring that time the body “repairs and recharges.” However, more and more studies show that not all sleeping positions are the same, since the position can condition our short and long term health. A common problem, but little visible. Sleeping badly does not show when you wake up. Sometimes it crawls during the day: fatigue, lack of concentration, physical discomfort. A recent National Geographic report I pointed That a bad posture when sleeping can aggravate common ailments such as back pain or reflux, and complicate more serious ones, such as sleep apnea. Dr. Meir Kryger, a specialist in sleep medicine and professor emeritus at Yale, warned that, when it is not, this apnea can affect mood, memory, blood pressure and even increase the risk of death. What is the ideal position? Most sources consulted coincide: side, and if possible, on the left. This position is associated with less lumbar pain, less snoring and better digestion. According to HeathlineHe stressed that he can also facilitate breathing and contribute to the proper functioning of the brain. Dr. W. Christopher Winter, In statements collected by the BBCHe explained that this position prevents the aorta artery from being compressed and facilitates venous return, which improves circulation. In addition, this position can be of great help to pregnant women. As has detailed MAY CLINIC, Sleep on that side in the last quarter of pregnancy avoids the compression of the vena cava and favors blood flow to the placenta and the fetus. The most common error. It usually appears on hot nights, when the body seeks freshness and ends up lying on my back, without knowing that it is choosing the worst posture. Dr. Lois Krahn, Accessed by Mayic Cliniche has detailed that sleeping mouth can get the apnea of ​​sleep by allowing the language and jaw to fall back and obstruct the airway. However, the other option: sleeping face down, is not recommended. According to Healthlinethis position can generate pain in the neck and back, since it forces to twist the head and compress the thorax, hindering breathing. This can lead to chronic pain. Forgotten allies. Not everything is reduced to posture. As Dr. Cherney explained in Heathline, the type of mattress imports and the pillow also imports. On the one hand, a mattress too soft makes the joints sink, while a very hard one can be uncomfortable and not adapt to body shape. On the other hand, it recommends using an ergonomic pillow between the knees for those who sleep from side, since it favors vertebral alignment and avoids tension in the hip and lower back. In addition, he warned that when sleeping on his side the head should be aligned with his shoulders and never tilted towards the chest, since that causes cervical pain. A health act. Sleeping well does not depend only on the number of hours. It also influences, and much, the way we place the body every night. The medical evidence clearly points out that sleeping sideways – and especially on the left – can make a real difference in sleep quality. It is not a fashion or a soft recommendation: it is a matter of health that affects breathing, digestion and deep rest. And even if it costs more in summer, with heat or with more, it is worth trying. Sometimes, the body only needs a good side. Image | Pexels Xataka | Australia created the world’s first climate visa. Now it has 40% of the population of another country calling the door

We just found the bathrooms of a Pompeii mansion. A sample of luxury and the darkest side of the Romans

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Pompeya is one of the great archaeological treasures of the world. 2,000 years ago, The pyroclastic wave of Vesubio He swept and buried the cities of Pompeii and Herculano and, although archaeological excavations began in 1739, we still continue discovering the secrets of that civilization. It is estimated that a third of the city continues to remain underground, but in recent years we have found interesting details such as the genome of a Pompeyan or carbonized papyrus rolls with such succulent details as the possible location of Plato’s tomb. During the past year, there was an important step to better understand what the society of the time was like. First, one “Black room”About 15 meters long by six wide that it is estimated, it would have been a banquet room. The black paint of the walls would serve to hide the soot of the oil lamps and something surprising is that the frescoes of the walls were perfectly preserved. The second great discovery was the “Blue room” This, perhaps, was more interesting due not only to the fact that the frescoes were also in a perfect condition, but to the blue pigment that is not common in Pompeian spaces, since it was reserved for the most outstanding rooms of the town. In addition, there were large amphorae and a multitude of remains of … clams. Now, everything makes sense thanks to what has been qualified as “a unique discovery in a century”: the blue and black room were part of a house for the richest among the rich. Pompeya’s house for the richest among the rich Both the black room and the blue room are part of the same complex: a luxury village with one of the largest and most structured private bathrooms that have been discovered … in history. And, to get an idea of ​​the magnitude of the installation, we must imagine something like a spa, but private. Archaeologists who are doing excavation work have detailed BBC News what the house was like, and the truth is that the bathroom occupies a luxury place. It is a spa complex that is the heart of the great residence and has hot and cold rooms, as well as a huge immersion pool. The rooms are decorated with red paint on the walls, fresh, stone banks and mosaic floor. Archaeologists define the place as the perfect example of the “Pompeii effect.” This means that it is preserved so well that it seems that the place has just been abandoned, alive until nothing is done when, really, almost 2,000 years ago that a soul is given a bath in those facilities. The house. In green, laundry. In orange, the bakery/kitchen. In pink, private residence. In purple, the bathrooms But it is not just the huge bathroom: the complex had the black room, the blue, the aforementioned spa, a laundry, rooms and a bakery, plus the private house itself. It is believed that it belonged to Aulus Rustius Verus, an influential Pompeyan politician, and can be the greatest discovery in the town so far. “There are only a few houses that have a private bathroom complex, so it was something really reserved for the richest of the rich. And this is so huge that it is probably the largest bathroom complex in a private house in Pompeya, ”says Gabriel Zuchtriegel, director of the Pompeya Archaeological Park. Detail of the bathrooms with the black room in purple and the direct access to the patio porticado with the pool. From there, you could go to other bathrooms such as the hot and cold And that the huge bathroom was next to the bakery and the dining room is not something unusual. The link between the BAOS and the great dining room gives an idea of ​​how the house was a scenario for the celebration of banquets and to make contacts between the high spheres of the time. Celebrating a gun with guests and then enjoying a bathroom, or vice versa, was a political tool to collect electoral support from guests or simply to boast power. And what attracts attention is the pool, with a depth of one meter, occupying the central space of a 10 x 10 meter porticated patio. Zuchtriegel comments that “everything was designed to set up a show in which the owner was the center of attention. The paintings, with themes of the Trojan War and scenes that represent athletes, represented an environment full of culture and erudition, as well as relaxation. ” In addition, he argues that “the public, grateful and satiated, would have applauded the show mounted by the host and owner of the house with sincere admiration, becoming the subject of conversation for a while.” And, beyond the bathrooms themselves, the rear boiler room has been found with pipes and lead systems that heated and distributed hot water, with a valve system that regulated the flow in the different spa rooms. And it is something that also allows you to see the differences of life between the classes, with the owners of the house giving sumptuous bathrooms while the slaves ‘roasted’ feeding the ovens to heat the water. You can see hot water pipes Not everyone was so lucky Now, not all discoveries allow us to look at scenes as relaxing as a good comilona or a relaxing bath. In a small room adjacent to the Blue Room, the remains of two Pompeyans who could not escape the eruption have been found. It is estimated that they were a man and a woman who could not escape because the pyroclastic flow already ran freely through the streets. It was what caused the collapse of a wall that crushed the man, while the woman was still alive. Quickly, the room was filled with the lava, causing the death of the woman. The bone analysis shows that the male skeleton was from someone of a young age, but with wear in the bones that indicates that it was someone of … Read more

The atlas of side effects (positive and negative) of Ozempic discovered | Health and well-being

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All medications have side effects, just take a look at any leaflet to see this. But there are not many cases in which these amount to the main effect. This is what happened a few years ago with GLP-1 agonists, medications used for decades to treat type 2 diabetes that began to demonstrate weight-loss effects. After several reformulations, new commercial brands, such as Ozempic and Wegovy, became an effective way to end obesity. But science is proving that there are many other side effects that could become major ones. GLP-1 is a molecular Swiss army knife, a kind of all-purpose drug. They affect our bodies in ways we still don’t fully understand. But today we are closer to listing. A team of scientists from the University of Washington School of Medicine has published the first detailed atlas of the side effects of these drugs. They have found benefits for cognitive and behavioral health, while revealing an increased risk of developing pancreatitis and kidney conditions. “Until now we had seen anecdotes and reports here and there. “Some people saying that it can affect this or that,” explained its main author, the clinical epidemiologist, in the presentation of the study. Ziyad Al-Aly, from the John J. Cochran Veterans Hospital. “But no one, no one had thoroughly investigated the effectiveness and risks of GLP-1 and all the ways it can affect health.” The study was published this Monday in the journal Nature Medicineshowcase of the best world science. More information “We did an analysis that comprehensively mapped the associations between GLP-1 and 175 potential health effects,” Al-Aly notes. The benefits, beyond weight loss, included a lower risk of substance use disorders and a reduction in suicidal ideation, schizophrenia, and other psychotic disorders. They also observed a reduction in cognitive disorders, such as Alzheimer’s and dementia. And finally, a reduction in the risk of clotting disorders, including stroke. “We found that these drugs have a wide range of beneficial effects, but all this does not come without risks,” warns the expert. The study confirms that, in some cases, they can cause gastrointestinal problems, such as nausea and vomiting. This is quite common and has already been documented in some patients. An increased risk of gastroparesis or stomach paralysis in rare cases and an increased risk of low blood pressure have also been seen. The analysis also notes that the drug may increase the risk of sleep problems and headaches, kidney stones, and drug-induced kidney inflammation. For these reasons, the authors recommend that, when evaluating this treatment, it should always be done under medical supervision and after an individualized analysis. “It is an observational study, although it has a large database and has been carried out for a long time,” he explains. Christopher Moralesan endocrinologist at the Virgen Macarena University Hospital in Seville, who was not involved in the study. The study does not demonstrate, therefore, that the medication is the cause of the listed effects. But these are consistent enough (risk reduction between 10 and 20%) and the database large enough (almost two million patients over three years) to think there is a direct relationship. “With Big Data you can scrape these results in very large databases and this is positive. But we must remember that here we can only verify association, not causality.” The objective of this research, in the words of its own authors, was not to analyze a specific effect and demonstrate causality, but to build an atlas of the association of risks and benefits of this relatively new medicine. “It’s like when Christopher Columbus arrived in America, and he thought about mapping it to get his bearings,” explains Al-Aly. “This is what we are doing, drawing a landscape of benefits and risks.” This opens the door to the possibility that in the future, after many reformulations and research, we can talk about an Ozempic for dementia, alcoholism or Alzheimer’s. There is still a long way to go, but this study has drawn a first map to locate the path. And there are many companies willing to embark on this adventure. There is currently a scientific and commercial race to find the next revolutionary use of GLP-1 agonists. Everyone has in mind the case of Novo Nordisk, the Danish laboratory that presented Ozempic in 2018, and which today has a stock market capitalization of 382,000 million dollars, which makes it the largest company in Europe. This has enormous business and economic implications, but from the scientific world, the question is different. How does an anti-diabetes drug have so many and varied effects? “Medicines don’t work surgically. They are designed to do one thing, but the reality is that this is almost never the case,” reflects Al-Aly. “Biology is complex and multiple, and if you touch one thing you will create a network of various effects.” GLP-1 acts on the intestine, but also on the brain, affecting areas that are involved in impulse control and reward signaling. This would explain why they help mitigate addiction problems. These medications would also affect the blood vessels, and in doing so have a potential effect on the heart. There is research that suggests that they also reduce inflammation, including that of the brain, which could explain their protective effect against neurodegenerative diseases. “But there is also another simpler theory that can explain all these positive health effects,” explains Al-Aly. Obesity is considered a disease in itself, but also the gateway to many others. It is the fifth risk factor for death in the world and every year 2.8 million adults die as a result of this condition. “When we treat obesity, it is normal that this affects other diseases, since it is the mother of them all,” summarizes Al-Aly. The expert has not yet decided, with the available scientific evidence, on which of these two theories has more force. The first would mean that we are talking about a miracle drug with multiple uses. The second would be less profitable for companies, would fill … Read more

Aguirre sees the positive side of trying young people on the South American tour of Mexico

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Before playing two games for South America, coach Javier Aguirre said that the result in both games would be the least important. The essential thing was to see the performance of the young players who received the opportunity in the absence of the usual starters who were not loaned by their clubs. In the matches against Internacional de Porto Alegre from Brazil and River Plate from Argentina, “Vasco” Aguire made 14 players debut with El Tri. One of them was Gilberto Mora, who became the youngest player to debut with the national team. The Tijuana midfielder is 16 years and three months old. Mexico defeated Inter 2-0 and then lost by the same score against River. “I leave with the feeling that the tour was worth it,” Aguirre said the day before. “You have to keep balance and draw conclusions. It’s good for me for the future. The objective of the tour was met. There are three or four players who really deserve a chance on the next occasions.” The veteran coach did not want to go into detail about who those players are who could fight for a place in the Nations League, where Mexico will have its next official match on March 20 against Canada. Who took advantage? Although he has few spotlights, recovery midfielder Elías Montiel is the next jewel of the Pachuca quarry and in both matches he showed why. At just 19 years old, the player became a starter for the Tuzos in the previous tournament and was one of the most outstanding in the last edition of the Intercontinental Cup. Aguirre summoned him for both matches and he was one of the few who repeated his lineup in both matches. The problem for Montiel is that in that position there is tough competition for ownership. Edson Álvarez (Fulham) and Luis Chávez (Dinamo Moscow), both with World Cup experience, usually occupy those positions. Luis Romo (Chivas) also fights for minutes. A similar case is that of Jorge Ruvalcaba, who excelled with a goal and several dangerous attempts against the Brazilians. The Pumas winger, with experience in Europe with Standard de Lieja, moves along the left wing, a sector where Julián Quiñones, Alexis Vega, César Huerta and Hirving Lozano fight to be starters. Of the rest, goalkeeper Raúl Rangel, full-back Jesús Gallardo and forward Guillermo Martínez, the only ones previously mentioned by Aguirre, fulfilled what was expected and will surely continue to be regular in the calls. What’s next? In Aguirre’s original plan, in addition to playing games outside of friendly environments such as the fields of the United States, it was contemplated to carry out “mini-cycles” of training with players from the local league. That idea was presented and approved by then-high commissioner Juan Carlos Rodriguez, who resigned from his position in December. After the little support shown by the clubs to release players for the South American tour, it is unlikely that they will want to release them for training sessions originally scheduled from Monday to Wednesday. If nothing changes, Aguirre will have to wait until mid-March to have a full team again before facing Canada in the Nations League.

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