We have been told that drinking water on an empty stomach helps you lose weight. Scientific evidence says otherwise

The Internet and social networks are full of supposedly easy tricks that promise almost miraculous results with a minimum effort for our body. One of these tricks is a habit that many people do as if it were a ritual: drinking a large glass of water, “yes or yes”, as soon as we get out of bed in the morning. This simple gesture promises to ‘wake up’ the intestines, activate the metabolism and promote weight loss. It’s a myth. What we hear on social networks is not always true, since we must face a large number of myths that have no scientific support behind them. And right now the best scientific evidence does not support this idea, Although it is true that drinking water increases our energy production. Thermogenesis. To understand where this widespread myth comes from, we must analyze the term “water-induced thermogenesis”, that is, the ability of our body to begin producing energy after drinking a glass of water. Here is a classic study In the medical literature it was observed that the consumption of 500 ml of water managed to increase the metabolic rate by around 30% during a period of 30 to 40 minutes. But although this percentage may seem incredible, the reality is that the acceleration of the metabolism translated into a total expenditure of 24 kilocalories. That is to say, its effect was so small that short-term weight loss was hardly going to be noticed due to this. It has been verified. Subsequent research in the fields of endocrinology and nutrition has attempted to replicate these data in different contexts. We have one of the examples in a clinical trial that evaluated the physiological effects in overweight or obese people, where an increase in energy expenditure of 24% was found for 60 minutes after ingesting 500 ml of water. But again it was seen that this slight temporary metabolic rebound does not imply a fat loss that is relevant in itself. On the scale. If now, instead of staying in the laboratory, we go to the real effect that this habit has on patients, we find that the narrative of water on an empty stomach as a slimming remedy loses much of its support, since the scientific evidence on weight loss attributable to water consumption is, in general terms, limited and of low to moderate quality. And the studies that have been done, despite pointing to weight loss, have a follow-up that is too short and a methodology that prevents giving a firm conclusion about applying this recommendation. The power of water. That dismantling the myth of a glass of water on an empty stomach is anticlimactic does not mean that hydration has no value in a weight control strategy. And the evidence suggests that drinking water helps to lose weight indirectly, since the mere fact of modifying the diet to go from a high consumption of sugary soft drinks or industrial juices to drinking water eliminates hundreds of calories a day with little effort. In addition, various trials suggest that drinking water before meals makes us feel full much sooner, which will reduce the amount of calories that we end up eating and, therefore, advancing a little further in the diet. Images | engin akyurt In Xataka | We believed that with Ozempic, people who lost weight exercised more. we believed wrong

This is how going to bed with a full stomach affects sleep

Closing the computer late, shuffling home and sitting down to dinner at ten at night. For us it is a picture of customs; For the rest of Europe, an incomprehensible eccentricity. However, the shock is not only cultural but also biological. Although our social “normality” dictates that dinner is served after dark, our body tells a very different story. Evolutionarily, our body is not designed to digest large amounts of food when the sun has set. It’s not just about counting the calories we put on the plate; The real problem, the one that acts as a real time bomb for our health, is what the clock ticks when we put the fork in our mouth. Eating dinner late is altering our metabolism, sabotaging our quality of sleep and, silently, increasing our cardiovascular risk. Your pancreas doesn’t know that in Spain they have late dinners. To understand this phenomenon, we must look to the chrononutritionan emerging field of study investigating the close relationship between food intake and circadian rhythms. Our body works like an orchestra perfectly synchronized by light and darkness. By eating dinner at odd hours we are desynchronizing “peripheral watches” of vital cells located in the pancreas or liver. Meal timing acts as a critical signal for these peripheral biological clocks, which can modulate the quality of our sleep by regulating the rhythm of our central clock. The immediate consequence is a drastic worsening of glucose tolerance and insulin secretion. When we really should be sleeping. Here the body comes into conflict. On the one hand, there is a large release of cortisol (the well-known stress hormone) and, on the other, the release of melatonin is delayed, which is the master key to falling asleep. In fact, large-scale data support this: comprehensive analyzes of chrononutrition patterns reveal that later meal times—including the first meal, middle meal, and last meal of the day—as well as greater number of meals, are directly associated with higher scores on the Pittsburgh Sleep Quality Index (PSQI), which translates into a worse rest. Added to this is a problem purely mechanical: A reduced time gap between the last meal and bedtime can lead to a prolonged sleep latency period, that is, we toss and turn more before falling asleep. And digesting while lying down is the perfect recipe for the appearance of gastric reflux, a discomfort that can ruin anyone’s night. You eat the same as your early-rising neighbor and you gain more weight. According to the study published in The Journal of Clinical Endocrinology and Metabolismadults who eat dinner at 10:00 p.m. burn 10% less fat and suffer a 20% higher blood sugar spike than those who eat dinner at 6:00 p.m., even if both groups eat exactly the same and go to bed at the same time. Alexis Supan, dietician at the Cleveland Clinic, summed it up perfectly: “When you eat late at night you are going against your body’s circadian rhythm.” The natural limit should be marked by the beginning of melatonin secretion. The researcher Marta Garaulet, a world reference in chrononutrition, has already demonstrated that people who eat later at midday lose less weight than those who eat early, even when they consume the same calories, expend the same energy and sleep the same. The time alone makes the difference. The consequences of ignoring this limit go far beyond the scale. A study led by the institute ISGlobalbased on cohort NutriNet-Santé with more than 100,000 participants, concluded that dining after 9:00 p.m. It is associated with increased cardiovascular risk, especially impacting the risk of cerebrovascular disease in women. On an emotional level, a recent meta-analysis from 2025 details that eating late worsens the rhythms of key neurotransmitters such as serotonin and dopamine, increasing the risk of depression. On top of that we hit the same clock twice. But there is a modern factor that makes this scenario worse: screens. Not only do we eat dinner late, but we do so under the beam of our cell phones. Light of any kind suppresses melatonin, but as you warn harvardthe blue night light does it in a much more powerful way, blocking it for twice as long as other lights and moving our circadian rhythms out of phase by up to three hours. Recent clinical studies have demonstrated that exposure to blue LED light significantly suppresses melatonin secretion after two hours of exposure and maintains this suppression over time. We have a late dinner and then look at our phones in bed: a combination that our biological clock simply cannot accommodate. Our children are headed towards the same error. The problem worsens when we look at the new generations. The magazine The Lancet has warned that Spain could be the fourth country in the world with the highest childhood obesity in 2050. The VALORNUT project of the Complutense University has shed light on this: Late dinners and very long “eating windows” in children translate into more improvised diets, with lower nutritional value and worse cholesterol profiles. Furthermore, 60% of these children sleep fewer hours. The experts’ recommendation it’s clear: concentrate all meals in a period of less than 12 hours. The solution is to adjust the clock. So when should we have dinner? The golden rule agreed upon by experts is to allow between three and four hours to pass between the last meal and the time of going to sleep. If we take the Spanish average of going to bed around 00:30, we should be finishing dinner, at the latest, at 21:00. Here it is important to qualify the context. We have been cushioning this metabolic blow in part for decades thanks to a cultural pillar: the Spanish Mediterranean diet tends to make dinner a much lighter meal than the midday meal, leaving the energy weight of the day in earlier hours. A late, heavy, ultra-processed dinner followed by a trip straight to bed is not the same as a light dinner with some physical activity before going to sleep. … Read more

This is ‘celiacase’, the molecule that destroys gluten in the stomach

For those who live with celiac disease, the time to sit at the table outside the home usually comes accompanied by a shadow of worry to know if you can eat something without danger. Today, the only and universal treatment is to have a strict gluten-free diet for life; However, avoiding traces and cross-contamination in the real world is a daunting task. Now, a team of Spanish researchers has taken a giant step to change this panorama with a new molecule: celiacase. With Spanish signature. Here the discovery was made by the Institute of Molecular Biology of Barcelona and other institutions. that they have proposed the use of an enzyme that is capable of destroying gluten in the stomach, as occurs, for example, with lactase supplementation in the lactose intolerant. But the most interesting of all is that this enzyme It has been inspired by the digestive juices of a carnivorous plant. The stomach barrier. To understand why celiacase is so special, we must first understand why gluten is so problematic, and that is that when we ingest gluten, for example, from a cereal, the digestive system is unable to completely break it down. The result is that large and resistant fragments remain floating, called immunogenic gluten peptides, among which a particularly toxic one called 33-mer stands out. Upon reaching the small intestine of a person with celiac disease, this intact fragment triggers a massive autoimmune response that destroys the intestinal villi and causes severe inflammation. That is why the goal here was to try to get a drug that would degrade these toxic fragments before they reach the intestine, but the problem is that the stomach and its acid were a big problem to have an enzyme that did its job well. And this is where botany comes into play. A carnivorous plant. In 2022, the CSIC I had already set the focus in neprosin, which is a natural enzyme present in the digestive fluid of carnivorous plants of the genus Nepenthes. These are plants that use neprosin to digest insects that fall into their traps, operating in high acidity conditions. In this way, taking neprosin as a base, researchers have redesigned and genetically perfected it in the laboratory to create “celiac disease.” Here the results indicate that the new molecule is stable and displays its maximum effectiveness when it comes to degrading gluten in the acidic pH of the stomach. In a matter of minutes, celiacase acts like a molecular scissors that cuts the GIPs and the lethal 33-mer, neutralizing gluten before gastric emptying into the intestine. What has been seen? The detailed study demonstrates that the molecule works at very low doses in mice, and points out that when gluten is given there is less atrophy of the villi of the small intestine. In addition, a significant decrease in the levels of inflammation and antibodies typical of the disease was observed. But the most interesting thing is that it respects the natural composition of the microbiome in the intestine. Cautiously. In biomedicine we are already accustomed to everything going too slowly, although for the sake of our own safety. In this case we are talking about a treatment in the preclinical phase that does not seek to replace the gluten-free diet or allow the patient to have a pizza with wheat flour, but rather it is an aid especially when exposed to places where there may be traces such as restaurants. As an extra security system. But for now this is something that must wait and undergo human study before it finally hits the market in the coming years. Images | freepik In Xataka | How to deduct celiac disease expenses in 2025 income: in which communities it is possible and how to do it in the 2026 declaration

Some people believe that sleeping on your side or stomach creates “sleep wrinkles” on your face. It’s exactly the opposite

The Internet is full of golden rules for have ‘eternal youth’this being the holy grail that many would like to have in their hands right now. Among these pieces of advice, there are several that can be quite annoying, such as that you should not sleep leaning on the side that is wrinkled. But… how true is this? The benefits of sleeping well. The sleeping position is essential to have a good rest. Because sleeping on your stomach is not the same as sleeping on your left side. In the first case, the cervical spine can suffer a lot and in the second the hated gastric reflux. can be seen reduced. But now it comes into play that sleeping on one side or the other can cause more wrinkles on the face due to the hated gravity that generates a mechanical effect that causes the face to fall and wrinkles to appear. But science disagrees on this one and puts the blame more on biology with cortisol and collagen. The myth of ‘Sleep Wrinkles’. The theory seems logical: if you spend 8 hours squishing your face into a pillow, that mechanical compression should leave a mark. There is often talk of “sleep wrinkles” (sleep wrinkles), which, unlike expression lines, caused by smiling or frowning, would be caused by having your face against the pillow. It is something that some experts defend like those of The Aesthetic Society, which suggest that sleeping on your stomach or side favors the appearance of vertical lines due to this chronic pressure. Other opinions. The clinical evidence It is quite limited in this casesince many of the statements that defend this myth come from the field of cosmetic surgery and with very limited groups of people. There are even articles that suggest that there is no clear relationship between sleeping in a certain way and having more wrinkles. The consensus right now is that sleeping on your back could theoretically reduce the formation of compression lines. But obsessing over this is not the best, since if having this position is uncomfortable and the quality of sleep decreases, then the biological weight it will entail will have a great impact on wrinkles. The real threat. This is where science stops being speculative and becomes blunt. If there is something that ages your skin, it is not the pillow, It’s sleep deprivation. When you get little sleep, the body enters a state of physiological stress, raising levels of the hated cortisol, the stress hormone. And elevated cortisol is the great enemy of our skin’s youth. This is because it can inhibit the cells that make collagen (the scaffolding of the skin), making the skin less elastic and increases metalloproteinases. This word, so long, is nothing more than an enzyme that breaks down that fundamental collagen that we have in our skin and that keeps it firm. If we do not produce it or destroy it, the wrinkles will appear there. With data. A key clinical study presented in ScienceDaily showed strong results: People with chronic poor sleep quality showed clinical signs of accelerated aging with fine wrinkles, uneven pigmentation, and sagging. But the most important thing is that if UV radiation from sunlight was also added to all these factors, the skin’s recovery would get worse. And this is where the need to have sun protection when going outside came in. Images | Katelyn G Isabella Fischer In Xataka | There is a ‘good’ fat that hides a secret to aging better and being in shape. All that remains is to get the pill

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