destroys

retatrutide destroys all weight loss records

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The pharmacological race against obesity continues to advance with the aim of finding a drug that allows weight loss in a simple way, and among the examples that we have on the table right now, Ozempic stands out. But now science is advancing a new active ingredient that in the first studies points to a average weight loss of 30.3% in 104 weeksa threshold that has never been crossed with other treatments and that can set a great precedent. The essay. The protagonist of this story is the retatrutida, and it promises to set a great precedent after this essay published by the pharmaceutical company Eli Lilly. To understand the clinical magnitude of the finding, we must go to the basis of the study of the trial called TRIUMPH-1which has been specifically designed to evaluate the efficacy and safety of retatrutide in adults who are obese or overweight. In addition, it has also analyzed the effect on patients who have associated diseases. How has it been achieved? Overcome the barrier that other very important treatments such as Ozempic or wegovy It is something that attracts a lot of attention, and the key to retatrutide lies in the mechanism of action. And while semaglutide (active ingredient in Ozempic) is an agonist of a single receptor, which It is GLP-1retatrutide acts as a triple agonist. That is, the molecule is capable of coupling to three hormonal receptors: GLP-1, GIP and glucagon. This triple pathway not only slows gastric emptying, suppresses appetite and improves insulin secretion, but direct stimulation of the glucagon receptor appears to increase basal energy expenditure. The latter is vital because, in addition to drastically reducing intake, it pushes the metabolism to burn more energy at rest. And this is the key. A predictable escalation. This is something that could already be seen that was going to arrive at some point, since previous medical literature already talked about the effects that this triple agonist could have. For example, in phase 2 of the trial, retatrutide had already demonstrated average weight loss 24.2% at 48 weeks with the maximum dose of 12 mg. But the key has come with the extension of the follow-up time up to 104 weeks, which has been the missing piece of the puzzle to verify if the therapeutic effect stagnated or if the patient continued to lose body mass with prolonged use. You have to be cautious. In an accelerated and highly competitive sector of pharmacology focused on obesity, it is necessary to know that this figure of 30.3% comes directly from the pharmaceutical company itself and not from a scientific source that has had a review behind it. Although the design of the trial is perfectly planned and the history of the clinical program provides a solid basis, there is still the publication of the definitive scientific article to analyze the “small print” and what logically does not want to be disseminated from a commercial perspective. It will be at that moment where key points can be revealed, such as, for example, the safety of this molecule and the exact metabolic impact. Images | freepik In Xataka | Ozempic’s great challenge is the rebound effect. Science already has two promising solutions to avoid it

This is ‘celiacase’, the molecule that destroys gluten in the stomach

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For those who live with celiac disease, the time to sit at the table outside the home usually comes accompanied by a shadow of worry to know if you can eat something without danger. Today, the only and universal treatment is to have a strict gluten-free diet for life; However, avoiding traces and cross-contamination in the real world is a daunting task. Now, a team of Spanish researchers has taken a giant step to change this panorama with a new molecule: celiacase. With Spanish signature. Here the discovery was made by the Institute of Molecular Biology of Barcelona and other institutions. that they have proposed the use of an enzyme that is capable of destroying gluten in the stomach, as occurs, for example, with lactase supplementation in the lactose intolerant. But the most interesting of all is that this enzyme It has been inspired by the digestive juices of a carnivorous plant. The stomach barrier. To understand why celiacase is so special, we must first understand why gluten is so problematic, and that is that when we ingest gluten, for example, from a cereal, the digestive system is unable to completely break it down. The result is that large and resistant fragments remain floating, called immunogenic gluten peptides, among which a particularly toxic one called 33-mer stands out. Upon reaching the small intestine of a person with celiac disease, this intact fragment triggers a massive autoimmune response that destroys the intestinal villi and causes severe inflammation. That is why the goal here was to try to get a drug that would degrade these toxic fragments before they reach the intestine, but the problem is that the stomach and its acid were a big problem to have an enzyme that did its job well. And this is where botany comes into play. A carnivorous plant. In 2022, the CSIC I had already set the focus in neprosin, which is a natural enzyme present in the digestive fluid of carnivorous plants of the genus Nepenthes. These are plants that use neprosin to digest insects that fall into their traps, operating in high acidity conditions. In this way, taking neprosin as a base, researchers have redesigned and genetically perfected it in the laboratory to create “celiac disease.” Here the results indicate that the new molecule is stable and displays its maximum effectiveness when it comes to degrading gluten in the acidic pH of the stomach. In a matter of minutes, celiacase acts like a molecular scissors that cuts the GIPs and the lethal 33-mer, neutralizing gluten before gastric emptying into the intestine. What has been seen? The detailed study demonstrates that the molecule works at very low doses in mice, and points out that when gluten is given there is less atrophy of the villi of the small intestine. In addition, a significant decrease in the levels of inflammation and antibodies typical of the disease was observed. But the most interesting thing is that it respects the natural composition of the microbiome in the intestine. Cautiously. In biomedicine we are already accustomed to everything going too slowly, although for the sake of our own safety. In this case we are talking about a treatment in the preclinical phase that does not seek to replace the gluten-free diet or allow the patient to have a pizza with wheat flour, but rather it is an aid especially when exposed to places where there may be traces such as restaurants. As an extra security system. But for now this is something that must wait and undergo human study before it finally hits the market in the coming years. Images | freepik In Xataka | How to deduct celiac disease expenses in 2025 income: in which communities it is possible and how to do it in the 2026 declaration

Japan destroys the data transmission record again with 1.02 petabits per second. The impressive has been the distance

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Japan has established A new record World Cup in data transmission per fiber optic, sending information to 1.02 Petabits per second through 1,808 kilometers away. The achievement, achieved by a joint team of Electric Industries Summit and the National Institute of Information and Communication Technologies (NICT) From Japan, it marks a new milestone in long -distance optical communications. And best of all: it has been achieved with fiber optics compatible with any device. The key technological jump. The advance does not reside solely in speed, but in the distance traveled maintaining a standard cable diameter. The previous records in speed Pure had reached 1.7 Petabits per second, but only covered 63.7 kilometers. This new brand multiplies by 28 the distance without increasing the thickness of the cable, bringing technology to real commercial applications. Image: Ispreview How it works. The system uses an optical fiber of 19 nuclei integrated in a cable with standard coating diameter of 0.125 millimeters, the same as the current fibers. Instead of a single beam of light, the fiber transports 19 parallel signals taking advantage of both the C and L bands of the optical spectrum. Electric Sumitomo optimized the structure and disposition of the nuclei to minimize losses, while NICT developed amplifiers capable of simultaneously enhancing the signals of all nuclei. Dimension of achievement. To contextualize the magnitude: 1 Petabit is equivalent to 1,000 terabits or 1 million gigabits per second. Compared to The average broadband speed in Spain (which is usually around 250 Mbps), this record is approximately 4 million times faster. At this theoretically, 10 million 8K video channels could be transmitted simultaneously. Or download the entire Netflix library in seconds. Practical implications. The record establishes a new standard within the framework of “capacity-duty” (1.86 exabits per second-kilometer) using standard diameter fiber. This means that future networks could exponentially multiply their ability without changing the existing physical infrastructure. Intercontinental submarine cableslike those that connect Europe with America, they could benefit from this technology, although at greater distances (more than 5,000 kilometers) the speeds would be lower but still impressive. The way to commercialization. Although these advances will not immediately reach domestic connections, they do mark the future of long -distance communications. The team now works on improving the efficiency of amplifiers and signal processing to bring technology closer to its real implementation. Global Internet traffic grows, but it’s nice to know that the optical fiber and the form of the cables we use today, they are still enough to evolve in this field. Cover image | Kirill Sh In Xataka | Mobile’s internet is going wrong: what can you do when you don’t have a connection

Grok 4 destroys the tests and aims to be the most advanced AI model. The problem is that Elon Musk continues to sabotage his answers

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Xai has launched Grok 4its new artificial intelligence model that is sweeping the most demanding performance tests in the sector. The model exceeds OpenAi, Google and Anthropic proposals in multiple benchmarks. And is that in the absence of knowing OpenAI’s strategy with GPT-5At the moment it has all the ballots of being the most pointer the model. However, Grok continues to drag the usual problems: controversial responses, offensive content and an Elon Musk using the model to subtract credibility. The numbers speak alone. In the test Humanity’s last examconsidered one of the most difficult to measure abilities of AI, XAI states that Grok 4 has achieved 25.4% Without additional tools, surpassing O3 of Openai (21%) and Gemini 2.5 Pro from Google (21.6%). But it is with Grok 4 Heavy, its multiagente version, where the results shoot: according to the company, reaches 44.4% With ‘tools’, almost doubleing competition. Image: XAI In addition, at the benchmark ARC-AGI-2which measures the ability to solve complex visual patterns, Grok 4 has obtained 16.2%practically double the next commercial model. According to Musk“Grok 4 exceeds the doctoral level in all subjects, without exception”, an affirmation that, although it sounds to marketing, is supported by the results obtained. The revolutionary approach. Grok 4 Heavy works with A “multiple agents” system that work in parallel about the same problem, then comparing their results as if it were a study group. This architecture allows you to climb intelligence according to the available computational power, a concept that could redefine how we understand the AI ​​performance. Image: XAI The usual problems. The launch of Grok 4 occurs just after the previous version of the chatbot published anti -Semitic comments In X, even identifying as “Mechahitler” in some answers. XAI had to temporarily withdraw the service and eliminate offensive publications, while countries like Poland They announced complaints before the European Commission and Türkiye blocked access to chatbot. The cause was a modification in the system instructions that allowed the model “not to avoid politically incorrect statements.” Although Xai withdrew that guideline, the damage was already done. A constant sabotage. Despite these technical advances, Musk continues to condition Grok’s responses in ways that compromise their usefulness. The model performs automatic searches for the opinions of the tycoon in X to respond to controversial issues, turning the alleged search for “truth” into an echo of its creator’s ideas. This practice, confirmed By experts in AI like Carlos Santana, he once again demonstrates how Musk’s controversial decisions are directly influencing the development of the model. In addition, several researchers already They have managed to avoid Easily model safety barriers, making it generate content on chemical weapons, malicious software, drugs and other sensitive issues through relatively simple jailbreak techniques. Ethan Mollick, professor at Warton and an expert at AI, Point out The lack of transparency of the company: ‘There is no detailed technical documentation, risk analysis or explanations on how to avoid future incidents’. This opacity makes it difficult for companies to trust Grok for critical applications. Grok 4 prices. XAI Grok 4 Basic offers at a price of about 30 dollars a month. However, the company has also launched Supergrok Heavy, a subscription of $ 300 per month in which its most advanced model is offered and that directly becomes the most expensive market service on the market. What is coming. XAI plans to launch a programming model in August, multimodal agents in September and video generation in October. Also will integrate Grok 4 in Tesla vehicles Next week, expanding the scope of AI throughout the Musk ecosystem. The question is whether the company will separate the technical excellence of the media controversies that surround it, or if it will remain hostage of its founder’s impulsive decisions. Cover image | XAI In Xataka | We knew that AI would generate new jobs that did not exist before. What we did not expect is that he was fixing his pifias

The heat of the summer destroys the battery of your mobile. But there is a trick to give it a second life

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It’s summer, I get home with a 20% of battery and the Telephone quite hot. I stop to see some videos in Tiktok and … I appreciate how the battery jumps directly from that 20% to 16%. What noses have just passed? Bulk. Your mobile has an internal microcontroller that uses estimation algorithms based on different variables. Voltage Temperature Current Load cycles As the battery is degraded, The system is losing precision: Errors in the calculations (something especially simple if we only make partial load cycles) accumulate, the loss of battery capacity is not exactly estimated, and this ends up translating into reading errors that directly affect the most visible point: the percentage indicated by the phone. How to know that if my battery is not well calibrated. It is quite easy to know if your mobile has or not the barefoot battery, since its behavior will be quite erratic. It goes out before reaching 0%, in upper percentages. There are notable battery jumps, more than 1%, both loading and downloading. The device never marks 100% or 1%. That a mobile has the bare battery It does not translate into a malfunction in the same: The error focuses on the visible reading that the user perceives, not on the performance of the battery itself. Why summer affects bruise. Telephone batteries have a great enemy: heat. There is no time of the year in which they suffer greater wear and are more likely to barefoot, precisely because of the acceleration of this damage they suffer. If we do not remedy it, it will be practically inevitable that we suffer sudden turns off for ignoring the exact battery percentage, and that the mobile stops to load efficiently when reaching certain percentages (fast from 20%, slow from 80%). How to calibrate a battery. Calibrate the battery It is nothing more than the process to help software to get precise readings about the real capacity of the battery. We seek to learn new vacuum points (0%) and full (100%), so the process is something drastic. Load the phone to the fullest and leave it, at least, a couple more hours loading. Download the phone completely and leave it a few hours without lighting. By battery protection, there is some reserve capacity after that 0% that is not lost until a few hours. Load the phone up to 100%, and leave it an additional time until the phone reaches the maximum load point. Avoid using applications that promise this purpose: none works. The only way to force calibration is to perform this process manually. Is it advisable to calibrate the battery? Evidence about calibrating the battery is still limited. There are those who aim to do them every three monthsbut if we do not observe anomalous behavior, stress the battery at this level may not be recommended. Calibration is necessary when readings are wrong and end up translating into a real problem to estimate how much battery we have left. The manufacturers are in full war to achieve batteries that there are many more cycles to go down to 80%below which the industry considers the replacement of it. Image | Xataka In Xataka | Traveling by plane with a monstrous battery sounds great. Until airport safety thinks

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