mice

If we want to increase human fertility, mice have something to tell us: fecal transplants

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We knew that the bacteria that live in our intestine They are really positive and offer us extra protection against numerous threats from outside or even against Alzheimer’s. Now they have just added a new star function: they can help us improve our reproductive health. And all this with a simple fecal microbiota transplant. New evidence. This same month of March the magazine Nature has published an article that breaks with several scientific paradigms and demonstrates a bidirectional communication between the microbiome and women’s ovaries. The study here wanted to demonstrate that fecal microbiota transplant can completely remodel the behavior of the ovaries, reducing inflammation and even increasing reproductive success. But the most amazing thing about the experiment is not the ‘what’, but the ‘how’, since it has quite surprised the experimenters that the result has gone against what they expected. How is it possible? To understand this finding, we must first know the concept of ‘strobolome‘ which will give a lot to talk about in the coming years. In a simple way, it is a set of intestinal bacteria that are capable of metabolizing and modulating the level of estrogen, which is one of the main female sex hormones and closely related to reproduction. Until now, we knew that the microbiota played a role in almost every part of our body, ranging from digestion to our own mental health. But they wanted to go further, and in the past it was noted that they had already begun to explore how to transfer faeces from young mice to old ones, which would improve their ovarian reserve. But the best thing is that doing the opposite could accelerate the aging of the ovaries. The new study. Knowing this, this research team designed an experiment in which healthy adult mice were taken and given antibiotics to cleanse their intestinal flora. From here, they underwent a fecal microbiota transplant from mice in the ‘estropausal’ phase, which is like human menopause. What the researchers here were expecting is that if they were introduced to the microbiota of aged rats in reproductive decline, their ovaries would suffer damage. But the truth is that they were wrong. Results. The results here showed that adult females who received the “estropausal” microbiota not only did not worsen, but rather improved ovarian function and an increase in their fertility. Because? By thoroughly analyzing the organism of these ringworms, using sequencing of the genetic material of the ovaries, it was seen that the transplant had caused a massive remodeling of the ovarian transcriptome. That is, the way in which the genes in the ovaries were expressed had completely changed towards a “younger” profile. In addition, the analyzes revealed a drastic drop in the expression of genes linked to inflammation. The explanation that scientists are considering points directly to the strobolome, since it is possible that the microbiota of the stropausal mice, in its attempt to survive the natural drop in hormones of its original host, has developed brutal compensatory mechanisms. By transplanting these “surviving, super-optimized bacteria” into a young environment, they boosted the health of the recipient ovary. The future. Although in this case this effect has been seen in mouse animal modelsthe implications of this study may allow us to continue advancing treatments that can improve human reproductive health. The goal here is to be able to isolate what exactly are the specific microbial candidates or metabolites responsible for this improvement and in the future we could be talking about probiotic treatments or microbiome-based therapies to prolong fertility. Images | Kelly Sikkema CDC In Xataka | Drinking coffee in the morning has very positive consequences for someone unexpected in your body: the microbiota

Science had been looking for an alternative to laboratory mice for years without success. Until he found the moths

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In the world of science, the mouse has been for decades the undisputed king of the laboratory. However, it is an expensive, slow and, above all, ethically complex reign. That is why we have been looking for alternatives for years, and the answer may not be in a silicon chipbut an insect that you have probably seen eating the wax of a beehive. The advance. This is what researchers at the University of Exeter have arrived at, who have achieved a milestone that promises to change the rules of the game in the fight against superbacteria: They have genetically “hacked” dinner moth larvae to function as real-time biological indicators. The most impressive thing is that they even have a very visual indicator: they shine when you get sick and go off when the medicine is working correctly. The biological traffic light. The study, published this week in Naturedetails how the research team has achieved what seemed impossible: applying tools of genetic editing advanced these moths with unprecedented precision. And I know this is very important, since using insects to model human diseases had limitations, but this team has combined two key techniques. The techniques. The first of them is the system PiggyBac to be able to insert genes that produce fluorescent proteins into these moths, so they have basically gone from having larvae to biological “neon lights.” In this way, if bacteria or fungi are injected, fluorescence makes it possible to monitor the infection in vivo under the microscope. In addition, the famous technique was also included CRISPR-Cas9 to deactivate specific genes in the insect’s body. This is a tremendously positive thing, as it allows scientists to manipulate the larva’s immune system to see how it reacts to different pathogens, mimicking complex human conditions. The key data. The bottom line is that the modified larvae allow us to see if an antibiotic is working in real time. The indicator we have is fluorescence, which if it decreases indicates that the bacteria is dying from the antibiotic and the larva is surviving. All this in a visual, fast and cheap way. Why the moth. It may sound strange to compare a moth with a mammal such as the mouse, which may be more like us, but the Galleria mellonella He has an ace up his sleeve: your body temperature. Unlike the fruit fly, these larvae can breed and survive comfortably at 37°C, the average human body temperature, which is crucial because many human pathogens only activate their virulence genes at that temperature. Furthermore, their innate immune system is surprisingly similar to that of mammals in terms of structure and function of phagocytes, the cells that literally ‘eat’ pathogens that enter the body. Furthermore, with this animal model the use of 10,000 mice per year in the United Kingdom alone can be avoided. Against the clock of the resistance. The context of this advance is not trivial, since we are facing a race against the resistance of bacteria to our antibiotics. We need at this moment test thousands of new compounds fastand doing it in mice is a brutal bottleneck both because of the time it takes and the ethical questions that arise. On the other hand, these transgenic larvae allow for massive screening. Instead of waiting weeks to see results in mice, scientists here can test hundreds of compounds in larvae and get immediate visual readings on toxicity and efficacy. Images | Wikipedia Kalyan Sak In Xataka | Researchers removed Instagram and TikTok from 300 young people to see if their anxiety decreased. The results speak for themselves

China has just resolved one of the biggest doubts about going to Mars with the birth of six space mice

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For years, the great doubt of space biology It has not been whether we can have tomatoes and lettuce in orbit to be able to populate other planets, but whether our bodies will remain functional after returning from the vacuum of space. Something that above all interests us in order to reproduce. And in order to solve it, China sent a mouse who was in the Tiangong station to see if she was later capable of having babies and if they came with any serious alteration. Some babies for history. The result of this trip to Tiangong Station The truth is that it has been a successsince on December 10, 2025, a laboratory of the Chinese Academy of Sciences (CAS) witnessed an apparently everyday but scientifically extraordinary event: the birth of nine baby mice. The special thing, logically, was not the birth, but the fact that his mother had been in space for several weeks (although with some problems) subjected to microgravity and cosmic radiation. Now, six of these babies have survived and are growing normally. It was not without incident. The experiment was a priori quite simple: launch four mice (two males and two females) into space on October 31 and leave them there for two weeks. All this accompanied by adequate food for the duration of the mission. But in the end there were major problems that forced extend the stay in space. And this was a huge inconvenience, since the critical shortage of solid food for the mice could literally cause the mice to die and the mission to be a disaster. And that is why on Earth they began to look for the most suitable food to feed these animals and the result was liquid soy milk, which was the only thing available at the station. Completely monitored. In order to have good traceability of what the mice do in space, scientists kept the mice monitored with artificial intelligence at all times. In this way, it was possible to know at the moment what they ate and even the stress patterns they presented, circadian rhythms and possible anomalies in real time. And everything was taken care of in detail, to the point that the soy milk was supplied with a negative pressure pumping system to prevent liquid bubbles from floating around the cabin. The progression. Once this problem was resolved, on November 14, 2025, the animals returned to earth and natural conception occurred. The result was that 9 calves were born and only six survived in good health. The problem of microgravity. Until this experiment, there was a well-founded fear in the scientific community: that ionizing radiation and the absence of gravity would “break” something in the hormonal axis or in the integrity of the DNA of the gametes. Something that would prevent us from reproducing normally, which would prevent, for example, the colonization of Mars. Precisely, cosmic radiation acts as a shower of high-energy particles that can cause double-strand breaks in DNA. On Earth, our atmosphere protects us, but at 400 km altitude, mice (and humans) are exposed to a much higher dose. Researcher Wang Hongmei highlights that the fact that the offspring are viable suggests that the cellular repair mechanisms of mammals are capable of compensating for the damage suffered during short-duration flights. A competition. As with everything related to space, there is a great rivalry between the United States and China. In this way, if we look back we see that China He had already managed to partially develop mouse embryos in space in 2020. Subsequently, NASA in 2019 conducted researchers on the International Space Station to analyze the bone density loss and muscle in space. What’s next. The experiment does not end with childbirth. Now, scientists monitor what they call “second-generation effects.” The aim is to determine if these six mice will develop health problems in the medium term or if their fertility will be affected when they reach maturity. In this way, if these mice do not present infertility, we can see that space travel is not a sentence of sterility. China’s next big step will be to attempt the reproductive cycle in orbit: conception, gestation and birth without setting foot on Earth. Something that will be fundamental for to be able to understand if humans in space can have some kind of possibility of reproducing without the protection of our beloved atmosphere. Images | Frenjamin Benklin POT In Xataka | Thinking that we are alone in the universe is arrogant. The question is why the aliens haven’t contacted us yet

Russia sent 75 mice to space in a Soviet design capsule. All have returned except 10

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A few days ago landed in the Russian steppe A capsule falls from the sky reminiscent of the dawn of the space race. It was the descent module of the Bion-M mission No. 2, launched a month before the space from the Baikonur cosmodrome. Its crew: cell cultures, seeds, 1,500 fruit flies and 75 male mice, of which 65 have survived. 30 days of polar orbit. The ship orbit the Earth from Pole to Polo to expose its passengers to the levels of cosmic radiation that the crew of the future Russian Space Station will receive. That is, 33% higher than those experienced by the International Space Station. The mice They were divided into groups: Some genetically modified, other treaties with a special medicine and a control group. The objective was to quantify the damage of radiation in its body and test countermeasures such as drugs or shields that could have direct applications both in the Earth’s orbit and in future trips to the Moon and Mars. The new Russian cosmonauts. They will not go down in history like the Laika dog, but the mice have played their role. The mission has been a success and the 10 specimens that died did so for reasons that the director of the Russian biomedical problems, Oleg Orlov, attributes that they were male miceaggressive and with “complex intragrupal conflicts.” Is it a success that 10 mice died? If we compare it with the previous mission, it is. In the first Bion-M, which took place in 2013, a failure in the life support systems caused the death of 29 of the 45 mice on board. That now 87% of animals have survived, and that deaths occur due to natural or behavioral causes, it is a great improvement. A capsule like Yuri Gagarin. Of course, the return of the mice has not been precisely quiet. As explained in detail Daniel Marín’s disseminator In its blog, the Bion-M spacecraft is a spherical capsule derived from the Vostok, the same that led Yuri Gagarin to space. This design does not allow maneuvers to soften the reentry, so landing is somewhat aggressive. For sample, the capsule caused a small fire in the ombourg steppe after impacting the ground. But the cause was not the impact, but the solid fuel retrocohetes located in the parachute lines. The fire was quickly controlled. And the flies? As we said, the biosatellite also transported a complete biological laboratory with fungi, lichens, seeds and about 1,500 fruit flies, part of a multigenerational experiment. According to the Russian Academy of Sciencesthe flies that traveled in the Bion-M No. 2 are the seventh generation of a line that originated in the International Space Station. During the 30 -day mission, the ninth and tenth generation were born. The plan is that, after a few more generations on Earth, their descendants are sent again to the International Space Station, continuing an insect lineage that has never known normal terrestrial gravity. Now, scientists have months of work analyzing recovered biological data and samples. The 65 surviving mice and their interplanetary travel companions are a valuable source of information that will help make the next space trips safer. Image | ROSCOSMOS In Xataka | The ruins of the Soviet space program in Kazakhstan: a hangar surrounded by death and fascination

mice that do not fattens although they consume a fat diet

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What makes us fat? The question is simple, but the answer is not. We could simply say that it is a mathematical issue, calories that enter through calories that burn, but it would be to simplify the matter too much, forgetting that each body metabolizes food differently and that different foods and combinations of food can lead to slightly different results. A simple protein. The deficiency of a simple protein, CD44, Avoid in an experiment that a group of mice will gain weight even being subjected to a high diet in fat. The team responsible for the experiment tried to inquire into the role that this protein plays in metabolic health and obesity, a role, according to the results, of great importance. “We had previously pointed out that the deficiency of CD44 suppressed neuroinflamation. Give Metabolic, ”he explained In a press release Cheng Sun, co -author of the study. CD44. But what exactly is this protein and what do we know about its function in the body? CD44 is one Transmembrane proteina protein located in the cell membrane that crosses this layer that covers the cell. As explained by the team itself, this protein “plays an essential role in transcending extracellular stimuli within intracellular signal waterfalls”, thus contributes to metabolic regulation. This protein is also of special importance for cancer cells. Closing the step. The team genetically modified a group of mice to force the lack of this protein. In doing so, they observed that, even when they were provided with a high fat diet, the modified mice did not fat while the control population (not modified mice) did gain weight until developing obesity. The team responsible for the study He also points out The possible mechanism behind this relationship between lack of protein and thinness. They explain that this relationship can be attributed to the suppression of the so -called adipogenesis in the white adipose tissue. That is, the creation of the cells responsible for storing precisely where we accumulate more is avoided. The details of the study were published In an article In the magazine The American Journal of Pathology. A new route. The team compares this path for weight loss with the one used by drugs such as Ozempicthe so-called LPG-1 (since its competence active emulates the effects of the peptide similar to type-1 glucagon). Very different routes in each case. As detailed by the team itself, the agonists of the GLP-1 receptors regulate the appetite and the metabolism of the glucose; Inhibition of the CD44 protein, meanwhile, acts preventing the formation of fat cells. This difference, they emphasize, implies that protein inhibitors could be used as accessories to treatments such as Ozempic when weight loss is sought. In Xataka | The Greek yogurt has conquered the supermarket yogurts. All thanks to the magic word: protein Image | EMW / I Yunmai

Russia wants to know how trips will affect us to Mars, so you will throw a thousand flies and 75 mice in a rocket

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He Baikonur Cosmodrome, in Kazakhstanhe has witnessed the launch of the Soyuz-2.1b rocket that has put the mission into orbit Bion-M No. 2. This Russian space agency project, Roscosmos, is a crucial step in the investigation of the effects of the microgravityand above all, the Cosmic radiationabout living organisms. But on board they are not human, but travel flies or mice, among other organisms. A varied crew on the ship. As if it were Noah’s ark, 75 mice are found in this ship, more than 1,000 fruit fliescellular crops, microorganisms and plant seeds. For a month, these ‘bionautas’ will orbit the earth in a polo pole trajectory, at an altitude that will expose them to the levels of cosmic radiation significantly higher than those experienced in the International Space Station. A “high -tech mice hotel”. The true protagonists of this mission are the 75 mice, who will travel in a specially designed passenger cabin: a “mini hotel”. Each unit is equipped with food, lighting, ventilation and waste systems to guarantee their well -being during the trip. In addition, chips have been implemented in some of the rodents to be able to monitor the constants in real time. Scientists have divided mice into three groups to compare the results. The first will remain on earth in normal conditions, which is what we call in science ‘control group’. The second will live in a land laboratory in flight equipment identical to those of the satellite. The third group, of course, will be the one who travels to space. In this way, the effects of the space flight of other variables can be isolated. Why are they chosen to mice. It has already become an iconic image to see how in biomedical research Mouse is used as the ideal test ‘subject’. And it is not a coincidence. The mouse has a genetic very similar to human, they have a short life cycle to see changes throughout several generations and are very economical to maintain and feed. On the other hand, for this specific investigation the mice They are very radiation sensitiveso they make it the ideal subjects to give us more information on the effect of this physical phenomenon. It has important implications for our health. The objective of this mission is clear: knowing how this radiation will affect astronauts traveling to the moon or Mars. Cosmic radiation In the long term you can damage cell DNAdrastically increasing the risks of long -term cancer, and what you want is to quantify the real damage and prove countermedons as armor for ships and drugs that avoid these undesirable effects. But it also has medical applications here on Earth. Its results can give us more weapons to fight aging, since the rapid loss of bone and muscle mass suffered by astronauts is a perfect model to study osteoporosis and sarcopenia to find new treatments. There are more research apart from mice. In collaboration with the Vernadsky Institute of Geochemistry and Analytical Chemistry, the mission transports 16 test tubes with dust simulations and lunar rocks. The objective is to study how radiation and space emptiness affect these materials, information of great value for the future development of lunar bases. Other experiments on board will investigate the susceptibility of organisms to radiation, the development of new life support systems and possible medical benefits in the earth derived from spatial biological research. Continuing the legacy of the bion-m No. 1. This mission It was launched in 2013 And he also spent 30 days in the orbit. However, the new mission will orbitate a 97 degree inclination, which will increase exposure to cosmic radiation compared to its predecessor. It is not the first time that it is investigated in space. There are many precedents that exist of space missions that have aimed at investigation. For example, I know analyzed the potential risks of fertility in space in mice or even the Japanese wanted to see If you can procreate in space through mouse embryos. Images | Spacex Joshua J. Cotten In Xataka | Spacex is on its way to having more money than NASA. He has succeeded, in part, because he does not pay taxes

Mice, keyboards, headphones and more. Five chollos to take advantage of PCComponent Play in Peripherals Logitech

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PCComponentes has launched a new campaign with enough offers in Logitech peripherals. The campaign called Play Days is now available and will end on June 2, so until then it can be used to buy mice, keyboards, headphones and other peripherals. In this article we will review which are the five best chollos. Logitech G502 x Plus Lightspeed by 104.99 eurosa comfortable gaming mouse in hand and with optical-mechanical hybrid switches. Logitech G915 x Lightspeed Tkl by 141.31 eurosa mechanical keyboard in TKL format with trimodal connectivity, macro keys and multimedia wheel. Logitech G923 by 274 eurosa steering wheel with pedals that is compatible with computers and consoles PlayStation 4 and PlayStation 5. Logitech G Pro X Lightspeed by 109.99 eurossome gaming headphones with Lightspeed technology and blue vo! ce. Logitech G Yeti GX by 94.99 eurosa compact microphone that works with Lighttsync. Logitech G502 x Plus Lightspeed One of the biggest discounts is found in the mouse Logitech G502 x Plus Lightspeed. The mouse currently has a usual price of 169 euros, but during the PCComponent Play Days campaign it remains for 104.99 euros. The most remarkable of this Gaming mouse It has an excellent construction that makes it very comfortable in hand. Includes Lightspeed technologyso it is wireless, and comes with light-mechanical hybrid switches light. In addition, it includes the Hero 25K sensor and is compatible with the Logitech G Hub software. Logitech G G502 x Plus Lightspeed * Some price may have changed from the last review Logitech G915 x Lightspeed Tkl If we talk about mechanical keyboards, one of those who have a better discount is the Logitech G915 x Lightspeed Tklwhose price has dropped into PCComponentes until the 141.30 euros. It is a Mechanical keyboard With TKL format (comes without numerical pad) that includes macro keys on the “FN” keys. It has trimodal connectivity (2.4 GHz, Bluetooth and cable), low profile switches and double molding PBT keys. The keys and lighting can be customized through the Logitech G Hub software. Logitech G915 x Lightspeed Tkl * Some price may have changed from the last review Logitech G923 Not all Logitech peripherals that we find in the PCComponent play days are exclusive to PC. The store also has reduced by 274 euros (previously cost 429 euros) Logitech G923a steering wheel with pedals that is compatible with PC, PlayStation 4 and PlayStation 5. Includes Trueforce technology, allows to adjust sensitivity and includes materials such as a black leather steering wheel coating and polished metal pedals. The same steering wheel is also available, but with the compatibility of PC, Xbox One and Xbox Series X and S for a price of 248.99 euros. Logitech G923 (PC, PS4 and PS5) * Some price may have changed from the last review LOGITECH G PRO X Lightspeed Without a doubt, we have the best discount on the headphones LOGITECH G PRO X in its version with Lightspeed technology (wireless). They have cost 229 euros to have a price of 109.99 euros with the 52%discount. These Bluetooth headphones are compatible with the Blue Vo! Ce technology that reduces noise and eliminates the microphone syliso, include 50 mm transducers, offer an enveloping sound and the headband coating includes viscoelastic foam to offer greater comfort. * Some price may have changed from the last review Logitech G Yeti GX Finally, we can also find a good price in the microphone Logitech G Yeti GXa fairly complete model that has dropped in price on PCComponentes to the 94.99 euros. He microphone It is compatible with the Logitech G Hub software, it has a very compact design, it uses supercardioid pattern and has intelligent audio block to reduce environmental noise. * Some price may have changed from the last review Some of the links of this article are affiliated and can report a benefit to Xataka. In case of non -availability, offers may vary. Images | PCComponentes y Buyadicción (Cabecera), Logitech In Xataka | Best wireless headphones. Which to buy and 19 models from 20 euros to 450 euros In Xataka | What a mouse use of Xataka editors. 13 recommended mice to work and play

We have discovered that cutting the consumption of an amino acid is related to more life expectancy. In mice, yes

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Virtually anything, in excess, can end up being harmful. Water is no exception and amino acids, the “bricks of life” are not. This was demonstrated by a study conducted from one of those compounds. In moderation. In study, conducted in mice, noticed that cutting the intake of isoleucine in the diet of animals helped increase the life expectancy of rodents by 33%. Isoleucine. Isoleucine is one of the essential amino acids. Amino acids are essential molecules for life as they represent The links from which proteins are created. We know thousands of proteins, all of them composed from about twenty amino acids. Our body can synthesize more than half of the amino acids that it requires to create proteins, but nine of these amino acids, the so -called essential, we must obtain them from our food. This is the case of isoleucine, an amino acid that we can find in a diversity of foods such as eggs, soybeans, meat and fish. A previous track. The study started from a Previous indication. A study conducted ten years ago in the state of Wisconsin observed that the diets of people with obesity were richer in this amino acid than the average population. In mice. For Study this correlationthe team went to the laboratory and studied its effect on mice. Laboratory animals divided into three groups: one control, to which no food restrictions were applied, another whose diet was altered to reduce the presence of amino acids, and another whose diet was normal in the presence of amino acids except in Isoleucine. The amount of isoleucine that this group received was ⅔ less than the standard. The mice were six months when they started these diets, which would be equivalent to an age of 30 years in humans. Analziating results. The team observed that the two groups of mice with amino acid restiring lost body fat at the beginning but those who had all the restricted amino acids lost it again soon. More important, the team observed that mice in this diet with less isoleucine increased their life expectancy: 7% in females and 33% in males. Another relevant detail that they observed is that the mice in this diet would ingest more calories. Possibly, they point out, to compensate for the lack of nutritional contribution of this component. Despite this, they also burned more of these calories, which led them to maintain a lower body mass than the rest of the study mice. The details of the study were published In an article In the magazine Cell metabolism. And what about humans? The team responsible for the study was likely that the restriction of this amino acid can have a similar effect on humans. For now that possibility is little more than speculative but the fact that the greatest presence of this amino acid in the diets of people with obesity is already observed implies another indication of the existence of some relationship. Beyond the biological differences between one species, the human diet is much less controllable than that of laboratory mice. The field of nutrition is extremely complex, with an infinity of nutrients, some of which interact with each other. He effect of other factors As our physical activity or tobacco consumption also affect our health and our life expectancy, making it difficult to elucidate the net impact of a nutrient on the human body. In Xataka | We believed that creatine was one of the most useful supplements to gain muscle mass. We are no longer so sure Image | Moerschy

We have studied the bones of some mice that passed 37 days in space. The results are not optimistic

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In November of this year, if there are no unforeseen events, in November of this year humanity will celebrate an anniversary. They will be fulfilled 25 years of human presence continued in space. The exploration of the last border has advanced significantly and humans spend more time in space and aspire to get further. But that has a price. The cost of microgravity. A team of researchers has analyzed The effects of a spatial mission on mice and the results do not invite optimism. They observed that the stay severely affected the bones of these rodents, who lost bone density in parts of their body. The femur, great victim. This loss of bone mass was not given in all areas equally. The team observed, for example, that the femur was one of the bones where the most extended bone cavities. In contrast, the lumbar zone of mammalian spine were the least affected. This makes the study responsible for the study suspect that the main trigger for this loss of bone density is in the microgravity. For example, the team indicates an alternative hypothesis, radiation. As they explain, the mice in the ISS were not exposed to large doses of radiation from space, but if this had been the loss of bone mass would have occurred from outside, that is, that the bones closest to the surface would have been more damaged, while the most surrounded by muscle bones would have been more protected. 37 days in orbit. The experiment used mice to explore how long rooms in space affect. They were used Two groups of micesome that were sent to the space station for a mission of 37 days and others that remained on Earth as a control group. The team responsible for the study simulated flight conditions in the control group to be able to make the conditions similar in everything except in the space stay. Similar, not identical. Those responsible for the study explain in a video how mice and humans keep important biological similarities that imply the changes we see in some are probably also giving in others. There are also differences to consider. For example, the fact that humans are bipeds implies that the bones of our lumbar zone have a more important role in supporting the weight of the upper part of our body. This implies that these bones are probably more affected in humans than in mice. The details of the study were published In an article In the magazine Plos One. If you don’t use it, you lose it. The body often tries to optimize resources. That is why a possible explanation to this phenomenon is there, in the idea that, since the bones in microgravity do not need to endure the weight of our body, they lose mass and density. Other risks. The study points to microgravity as the main suspect of the loss of bone density but this is not the only risk to take into account when we devise long -term space trips. Radiation is perhaps the most important in this sense, to the point that it was considered as a candidate to cause bone mass loss in mice. Radiation implies an additional problem and that, although in places like the moon and Mars the seriousness of the bodies could reduce the deterioration of the bones associated with the microgravity conditions, the same cannot be said of radiation. Moreover, the radiation in these environments is greater since the International Space Station even protected by the Earth’s magnetic shield. In Xataka | The 24 most spectacular videos and photos from the International Space Station Image | POT / Rukmani Cahill, et al. (2025)

Patents linked to Switch 2 show the operation of the Joy-Con as if they were computer mice

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A patent filtered and linked to switch 2originally published in August 2023, shows characteristics of the Joy-Con de Switch 2 They didn’t know each other until now. The main and most noticeable for the change that supposes with respect to the controllers of the first switch is The use of controls as if they were computer micea characteristic that Nintendo has not confirmed but suggested that it could be included among the novelties of its new console. It was in the console presentation video (the only source of official information at the time of Switch 2), where the two controls are seen sliding down a surface by the color dorsos that connect to the screen. In the patent you see a hand holding a joy-with with the SR buttons supported on the surface and eye, the thumb on the stick. It seems to be intuited that the movement sensor will be in the same back as the aforementioned buttons. They are not the only secrets that reveal these patent documents: two more traditional grips are also raised, such as PlayStation and Xbox controls, but that would include (at least one of them) sensors to be also used as mice. Japanese terms that could be translated as ‘sensor to operate as a mouse’ appear in the documents 28 times. Recall that patent documents are not guarantee of anythingonly that Nintendo has explored in that direction, but added to the clues that the presentation spot gives, the bets are more or less safe. They are small clues that round out what will be the new Nintendo presentation of the characteristics of the console, on April 6 at 3:00 p.m. Until then it is unlikely that more official confirmations of the characteristics of the Switch 2 will arrive, although elements such as this “mouse mode” are given by guaranteed. Header | Nintendo In Xataka | Switch 2 appears to be more of the same. But that is exactly the strategy that Nintendo needs right now

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