essential

19 Essential Excel Formulas to Master the Application

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We are going to tell you the 19 Essential Excel Formulaswith a compilation for you to squeeze out the spreadsheets of Microsoft Office. Excel. This tool is together with Google Sheets one of the best alternatives to create spreadsheets, and these resources are initial ideas so you can see what you can do with it. And if you don’t know enough, remember that we have also shown you the best excel tricks. Excel formulas are the heart of the program, since they are what will allow you to do all types of calculations, and they can adapt the program to your needs. Today we will review the most useful formulas for the general public, with examples of how to use each. Excel files can be opened in other appsremember it, but if you use another one, the way you proceed with the formulas could be different. And these formulas are our basic proposals, but don’t be afraid to modify or combine them. And if you think there is any other that should be on the list, we invite you to tell us in the comments section so that other readers can benefit from the knowledge of our xatakeros. Simple math operations Before getting into more complicated formulas, let’s see how to do the simpler math operations: addition, subtraction, multiplication and division. Technically only the sum is a formula, since in the rest of the cases special operators are used. ADDITION– This formula adds the values ​​of the cells inside it. Supports both separate cells and intervals. Example: =SUM(A1:A50) Subtractions: To subtract the values ​​of two cells you must use the subtraction symbol “-” between them. Example: = A2 – A3 Multiplications: to multiply the values ​​of two cells you must insert an asterisk * between them. Example: = A1 * A3 * A5 * A8 Divisions: to divide the values ​​of two cells you must include the line / between them. Example: = A2 / C2 Excel respects the logical order of mathematical operations (multiplications and divisions first, then addition and subtraction) and supports the use of parenthesis to give priority to some operations over others. This way, you can create formulas like = (A1 + C2) * C7 / 10 + (D2 – D1). AVERAGE The average formula returns the value of arithmetic average of the cells you pass or range of cells you pass as a parameter. This result is also known as the mean or arithmetic mean. Use:=AVERAGE (cells with numbers) Example:=AVERAGE (A2:B2) MAX and MIN If instead of wanting to know the arithmetic mean you want to know what the highest value or lowest value of a set, you have at your disposal two formulas with predictable names: MAX and MIN. You can use them with separate cells or ranges of cells. Use: =MAX(cells) / =MIN(cells) Example: =MAX(A2:C8) / =MIN(A2,B4,C3,29) YES.ERROR SI.ERROR is a formula that will get you out of more than one trouble. With it you can avoid mistakes #DIV/0! and the like. This formula allows you return a value in case another operation fails. This is quite common with divisions, since any division by zero will give an error, which can cause a chain reaction of errors. The operation in question can be an operation or any other formula. Use: =IF.ERROR( operation, value if there is an error) Example: =IF.ERROR (MAX(A2:A3) / MIN(C3:F9),”There has been an error”) YEAH SI is one of the most powerful formulas in EXCEL and with it you can return a different result depending on if the condition is met. This way, you could use it to have one cell say “APPROVED” if another is a number greater than 5, or “SUSPENDED” if it is less. Use: =IF(condition, value if the condition is met, value if it is not met) Example: =YES(B2=”Madrid”,”Spain”,”Other country”) WILL COUNT COUNTA is one of the formulas for counting values. Unlike simple COUNT, WILL COUNT also count values ​​that are not numbers. The only thing it ignores are empty cells, so it can be useful for you to know how many entries a table has, regardless of whether the data is numeric or not. Use: =COUNT(range of cells) Example: =COUNT(A:A) COUNTIF The COUNTIF formula is a kind of mixture of the previous two. It will count the specified range of cells as long as when they meet certain requirements. These may have a certain value or meet certain conditions. Use: =COUNTIF(cell range, criterion) Example: =COUNTIF(C2:C, “Pepe”) SUM IF This is the equivalent for sums of the previous one. SUMIF is just as essential and very intuitive for users who already understand COUNTIF: it adds only the values ​​that meet a given criterion, without the need to manually filter. Use: =SUMIF(criterion_range; criterion, sum_range) Example: =SUMIF(B2:B50; “Madrid”; C2:C50) → adds all the values ​​of C only when the corresponding cell in B says “Madrid”. RANDOM.BETWEEN This formula generates a random number between two other given numbers, and is therefore ideal when you need to choose something at random. The generated number changes each time the sheet is regenerated (for example, when you type a new value). Use: =RANDOM.BETWEEN(smallest number; largest number) Example: =RANDOM.BETWEEN (1;10) DAYS The date calculations They are always a tricky subject if you have to do them by hand, but everything is much easier when a formula does the hard work for you. DAYS he tells you number of days difference between two dates. Use: =DAYS(first date, second date) Example: =DAYS (“2/2/2018”, B2) NOW Another Excel essential is the NOW formula. This generates the date for the current moment and it is data that will be automatically updated every time you open the sheet or its values ​​are recalculated (because you change a cell, for example). This formula does not require any parameters. Use: =NOW() Example: =NOW() DAYSEM SEMDAY is another useful formula related to dates, which returns numerically the day of the week of a date. Monday is 1, Tuesday is 2, and so on, although there are several ways to start … Read more

They are essential for the defense of the country

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Finland has learned to live on alert throughout its history. During the Cold War, until flying trees were invented to mislead the Soviets. And since the conflict between Russia and Ukraine began in 2022, the threat of an eventual Russian invasion has once again flown over the horizon. In December 2025, NATO Secretary General Mark Rutte warned to the allies (the EU) in the face of a possible attack by Russia in the next five years. Faced with a Russian incursion into Europe, Finland is on the front line. The Nordic country knows it: It has been involving the entire population in defense for decades. Not even supermarkets are spared. The Nordic total defense. Finland, Sweden, Norway and Denmark have been applying a model in which the military and civil sectors operate in combination for decades: the total defense. In short, defense is the responsibility of the entire society, not just the army. This model is also not limited to times of war, but is always active, with courses, drills and contingency plans. And it does not only contemplate a traditional war, but also any threat, such as cyberattacks or sabotage. Of all the Nordic countries, Finland has the most developed system (and Denmark dismantled it almost completely): it did not lower its guard with the end of the cold war and your last update describes comprehensive security as the foundation of resilience in Finnish society. What happens in supermarkets. A practical example of how total defense reaches all levels is in supermarkets: they have the obligation to maintain strategic reserves of essential products, such as flour, sugar or oil; which they keep in cellars or underground bunkers with emergency generators. Thus, no matter what happens, supply to the population is guaranteed. The BBC collects the example of Group S and Kesko, the two largest supermarket chains in the Nordic country: together exceed 80% quota of food retail trade). In addition, they participate in preparation committees alongside administration officials and undergo drills. Why it is important. Because preparing for war in times of war is normal (there is no choice), but doing so and maintaining it in times of peace is more complicated. The Nordic plan requires a social assembly between civil and military society that moves in difficult terrain: can a democratic and market society function as a cohesive defense system without falling into authoritarianism? Considering the Finnish reality, it seems so. Of course, psychologist Jennifer De Paola from the University of Helsinki explains for the English medium that there are two pillars on which this total security is based and makes it unviable for other states: trust in institutions and a high level of social equality. The level of corruption in Finland is very low: it ranks second (out of 182 countries) in the Corruption Perception Index. Spain ranks 49 55. Since childhood. Thinking about a war looming in the future is a frightening possibility because of everything it implies, so this permanent alert mode could potentially be a problem for the emotional stability of the population. It’s no secret that preparing for the worst creates anxiety. Paola tells something curious: when asking children between 10 and 12 years old to draw happy people, I expected to find drawings related to fun. What he found was that they associate happiness with security and unhappiness with insecurity. It is no coincidence: it is the result of decades of socialization in a culture where collective security is a value internalized since childhood. In Xataka | Now that Europe has sent its troops to Greenland, a question emerges that no one wants to ask: what happens if the US invades it? In Xataka | When the USSR declared war, Finland decided to protect its roads in a peculiar way: with flying trees Cover | András Rátonyi and Tara Clark

For Finland, protecting its roads in World War II was essential, so flying trees were invented

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In a war it is not only doing and being, but also appearing. We have already seen recently how Iran pretended to have parked fighters so that Israel wastes its missiles, but this trick of playing catch-up is older than gunpowder. In fact, in World War II the United States had until ‘Ghost Army’ who was dedicated to these tasks. Precisely within the framework of the second war on a planetary scale, this curious story of concealment of infrastructurewhich is run by Finland. Finland is a Nordic country located on the Scandinavian Peninsula, the easternmost of the triad made up of Norway, Sweden and Finland. That makes it have a border with Russia, only at that time it was the USSR. Its situation on the map made it fight three wars in three different positions: the Winter War where it was attacked by the Soviets, the Continuation War in which the USSR attacked it, taking advantage of the Nazis’ Operation Barbarossa and the Lapland Warin which he fought against Germany after signing his armistice with the USSR. The photo that illustrates the cover of this piece and that you can see in full immediately after this paragraph was taken by Osvald Hedenström and is preserved in the photographic archive of the Finnish Defense Forces, along with the legend written by the photographer: “The Finns have camouflaged the 10 km from the border on the Raatteen road with country roads, with fir trees that seem to hang in the air, because right on the border there is an observation tower erected by the Russians. Suomussalmi, Kuivajärvi 1941.06.27” Flying trees on the Raatteen road. Sa-Kuva The cheapest camouflage of World War II That is to say, the legend makes three facts clear: that there was camouflage that covered the 10 kilometers of road from the border, which included rural roads and the main highway, and that the threat was a Soviet observation tower right on the muga. As? With fir trees lying. The Finnish army was noticeably inferior to the Soviet one, so they took advantage of the terrain, explains Colonel Petteri Jouko, a military historian at the Finnish National Defense University. for Atlas Obscura: “The Finns did not have the funds to purchase large quantities of artificial camouflage, such as nets, they did use trees, leaves and foliage to confuse the enemy” Because Finland is also a country with exuberant nature: the density of its forests is around 75% of the territory. according to the FAOso discovering critical infrastructure for the movement of troops and supplies such as roads or railways was a piece of cake for the Soviets. Obviously this resource of camouflaged roads was only effective for sky-level observationbut not for reconnaissance aircraft. Trees laid to hide critical infrastructure. Sa-Kuva This camouflage technique was technically simple but arduous. The Finns cut down the pine trees near the roads and then suspended them with steel cables that they had tied to other trees at the ends, although they also used wooden poles. The result, as can be seen just above, in another photograph from the Finnish archive, is that it seemed that the trees were flying over the roads, which from a bird’s eye view appeared to be just another leafy forest. Currently, none of these tree structures have survived; the passage of time and the abandonment of these rural roads has condemned them to their disappearance. In Xataka | Ukraine has found the antidote to Russian kamikaze drones in World War II: an optical illusion worth 500 euros In Xataka | A secret Nazi bunker in Germany hides the most sought-after treasure on the entire planet: hundreds of tons of rare earths Cover and photographs | SA-kuva (Finnish Defense Forces photo archive)

Free PS4 and PS5 games in March 2026 for PlayStation Plus Essential, Extra and Premium

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One more month is ending, and Sony has already published the list of games that will be given to you at no additional cost in March 2026 if you have a subscription to PlayStation Plus. These are 4 new titles that will be available starting March 3 for subscribers of any of the versions of this service, and which you can play whenever you want at no additional cost as long as you maintain your subscription. PlayStation 5 It is backward compatible with the PS4, which means that you can play all the games from the previous generation on it. In the list of games we are going to put you games with official prices from the official Sony website, which may sometimes be different from what you will find in stores, but which serve as a reference to see the value of the games you get. Free games for PS4 and PS5 PGA Tour 2K25 (PS5), valued at 74.99 euros. The annual game for golf lovers, where competitions such as the PGA Championship, the US Open and the Open Championship have debuted this year. You can create a player and start a career where you can win tournaments and climb the rankings. You have the file in 3DGames. Monster Hunter Rise (PS4 and PS5), valued at 39.99 euros. A new installment of this popular saga, where you can face some of the most iconic monsters. You will also have new mechanics, new creatures and a story inspired by Japanese folklore. You have the analysis in ExtraLifeand the tab in 3DGames. Slime Rancher 2 (PS5), valued at 29.99 euros. A second installment of this title where you will have to travel through a mysterious land to capture and raise slimes, as well as carry out other activities. You have the file in 3DGames. The Elder Scrolls Online Collection: Gold Road (PS4 and PS5), valued at 19.99 euros. If you have never given this Elder Scrolls online game a chance, this is a great opportunity, since it is a pack with its main areas. In Xataka Basics | The best free games on Playstation 5 that you can play right now

Free PS4 and PS5 games in February 2026 for PlayStation Plus Essential, Extra and Premium

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Let’s tell you what they are the games that Sony will give you at no additional cost in February 2026 if you have subscription to PlayStation Plus. These are 3 new titles that will be available from February for all subscribers of any of the versions of this service, and which you can play whenever you want at no additional cost as long as you maintain your subscription. PlayStation 5 It is backward compatible with the PS4, which means that you can play all the games from the previous generation on it. In the list of games we are going to put you games with official prices from the official Sony website, which may sometimes be different from what you will find in stores, but which serve as a reference to see the value of the games you get. Free games for PS4 and PS5 Undisputed (PS5), valued at 49.99 euros. A boxing simulator with over 70 boxers and fighters, although some can only be unlocked by punching. It has many different scenarios, with intuitive controls and intense combat. You have the file in 3DGames. Subnautica: Below Zero (PS5, PS4), valued at 29.99 euros. A new episode of the fantastic Subnautica that is sold separately. It takes us to a new frozen region where we face new challenges for our survival. You have the file in 3DGames. Ultros (PS5, PS4), valued at 24.99 euros. A metroidvania with exploration and combat. Locked in a narrative loop, we will have to face multiple challenges while we progress our character. You have the file in 3DGames. Ace Combat 7: Skies Unknown (PS4), valued at 69.99 euros. A flight simulator where you have to control fighter planes. You can pilot about 30 planes. You have the file in 3DGames.

seven essential pillars to beat the US

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That the power that dominates AI has many roles in dictating the rules of the game at a global level is an open secret. China knows this and has stepped on the accelerator by putting on the table an ambitious plan for 2027 that concerns absolutely all key sectors. Your goal? Being able to securely and reliably provide key AI technologies that are deeply and high-level integrated into a new era of industrialization. Towards the global forefront. The plan is called “Opinions on the implementation of the special action Artificial Intelligence + Manufacturing“, has 2027 as a deadline and a maximum aspiration: that both its artificial intelligence industry and its application at an industrial level are at the global forefront, promoting what they call “new quality productive forces.” To get an idea of ​​its relevance and transversality, it is signed by eight government departments, including the Ministry of Industry and Information Technology, the Cyberspace Administration of China and the National Development and Reform Commission. The seven essential pillars. If there is something that stands out about the program, it is how concrete and detailed it is when it comes to materializing it. Thus, the seven key tasks are: laying the foundation through innovation, AI-driven improvements, product advancements, development of key actors, strengthening the ecosystem, ensuring security and international cooperation. Breaking down how, these are some of the measures to apply: Software and hardware innovation: coordinate the development of AI chips with the necessary software. Integration into production: Introduce AI models into core manufacturing processes, not just administrative tasks. Robotics and machinery: Accelerate the use of AI in industrial robots and machine tools. Open Ecosystem: Build a world-leading open source community. Security: develop technologies to protect algorithms and training data of industrial models. Some dizzying goals in less than two years. And if your measures are concrete, the objectives for the deep application of AI even more so: Large models: Deploy three to five general-purpose AI models for manufacturing, plus specific models for key industries. Data: Creation of 100 high-quality industrial data sets Real use cases: Promote 500 real case application scenarios in factories. Companies: promote two or three leading global companies in the AI ​​ecosystem, seeking strategic concentration of resources and leadership, along OpenAI or DeepSeek. Likewise, it wants to select a thousand model companies among specialized SMEs to support them. Sovereignty and leadership. In conclusion, what China has proposed is a comprehensive roadmap for the Asian giant not only to consume AI, but for its industrial sector to be the basis of technological development to ensure its technical independence in chips and algorithms before the end of the decade. In Xataka | China has an ambitious plan to surpass the West in technology. And it has already chosen its 18 companies to achieve it Cover | Composition with images of idnaklss and Iván Linares with Midjourney

We believed that Stack Overflow was essential for programming. AI is proving the opposite

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For more than a decade, programming and Stack Overflow They were almost synonymous. When faced with an error, a question, or a line of code that didn’t work, the gesture was automatic: open the browser, search for the exact question and trust that someone, somewhere in the world, had already gone through the same thing. Today that reflection begins to fail. Not because the problems have disappeared, but because the conversation seems to have shifted. The data suggests that the place where millions of developers asked new questions in public is becoming increasingly silent. Therefore, the value of Stack Overflow was not just in accumulating answers, but in how it constructed them. Each question was left open, debated and refined until the community agreed on which solution deserved to be highlighted. This process turned the platform into a technical thermometer: it allowed us to detect which languages ​​were growing, which frameworks generated the most friction, and where the real problems of modern development were. Over time, that dynamic led many to assume that the software ecosystem as we know it would be difficult to understand without this collective repository. The data that set off the alarms To understand what is happening, perceptions are not enough. The graph comes from Stack Exchange Data Explorer (SEDE)a public tool that allows you to run SQL queries on historical data from the Stack Exchange network. In this case, the number of new ones has been measured questions posted on Stack Overflow month after month. It is an imperfect metric, but very revealing when its evolution over time is analyzed. The fall of Stack Overflow reflected in a Stack Exchange chart The data allows the recent history of Stack Overflow to be divided into fairly clear stages. Between 2008 and 2014, the platform experienced a phase of accelerated expansion, coinciding with its adoption as a global reference to resolve programming doubts. Starting in 2015 and until 2021, it enters a long stage of maturity, with high and relatively stable volumes of new questions. The turning point comes in 2022, when the trend reverses and the number of queries begins to fall steadily, a moment that coincides in time with the public emergence of tools such as ChatGPTa change of context that helps interpret the chronology, although it does not explain it on its own. A historic low: The fall not only continues, but accelerates in the last section. Data from that series shows a decline from around 17,000 questions per month at the beginning of 2025 to approximately 3,800 in January 2026, the lowest level reflected in the graph in its final stretch. This fall marks a before and after, because it no longer speaks of progressive wear and tear, but rather of an abrupt change in the use of the platform. The need for help does not disappear, but it changes location. Compared to Stack Overflow’s open model, AI offers immediate responses adapted to the context that the user provides, with results that may vary in quality and precision. You don’t have to formulate the question well for a broad audience or expose yourself to public corrections. Just ask for it. That comfort does not in itself prove a direct causal relationship, but it fits with the moment when public participation begins to fade. AI enters the workflow: The internal x-ray reinforces what the graph suggests. According to Stack Overflow’s 2025 Developer Surveyconducted among more than 49,000 developers around the world, the use of AI tools already reaches 84% ​​of those surveyed, compared to 76% the previous year. GPT models lead that adoption, followed by Claude Sonnet and Gemini Flash. It is not a marginal technology, but rather a layer integrated into everyday life, which helps contextualize why fewer and fewer doubts are raised in public. OverflowAI and the product pivot: Far from ignoring the change, Stack Overflow has begun to integrate artificial intelligence into its own proposal. OverflowAI is a suite designed to allow semantic searches and AI-generated responses that summarize knowledge already validated by the community. The idea is not to replace human responses, but to reorganize and make more accessible the enormous archive accumulated over years. In a context of falling new questions, the platform tries to remain useful as a point of consultation, although the interaction no longer takes the traditional form of the forum. Integrate into the AI ​​ecosystem: In parallel with the collapse of new questions, Stack Overflow has closed agreements with OpenAI and Google Cloud achieved between 2024 and 2025 that place their content within the flow of development and improvement of language models. These agreements allow the platform’s technical file to be used as a reference to increase the accuracy of the responses. In practice, references to Stack Overflow may appear in some technical responses generated by AI assistants, although this does not in itself imply a stable return on direct participation by developers. With this panorama, the question is no longer whether Stack Overflow has lost centrality, but what it means today to “continue to exist” for a platform like this. Data shows that public questions have dropped to historic lows, while accumulated knowledge continues to have value on and off site. Stack Overflow may stop being the place where you ask questions and become, above all, a silent layer that feeds other systems. What remains up in the air is whether this transformation is compatible with the open spirit that made it essential. Images | Xataka with Gemini 3 Pro In Xataka | As Google enters the AI ​​race, Samsung has opted for a more intriguing move

five essential LEGO sets to give as gifts on Three Wise Men

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One of the most magical nights of the year is approaching. If you want to surprise a geek of some of the most famous sagas and franchises of all time (such as Harry Potter, Star Wars, Marvel and more), you can do so by giving them a LEGO set. These are some of the best options that you can consider. LEGO 76450 Harry Potter Book Corner: Hogwarts Express As a die-hard Harry Potter fan that I am, this LEGO Harry Potter Book Corner: Hogwarts Express set It is one of the ones that has caught my attention the most in a while. Above all, I like it because it looks great on a shelf, since it works as a bookend. This set from the legendary building brick firm recreates the scene in which Harry Potter and the Weasly family cross platform 9 3/4 at King’s Cross train station. It is a set of 832 pieces and it comes with minifigures harry potterRon and his two pets: Hedwig the owl and Scabbers the rat. LEGO Harry Potter Book Corner: Hogwarts Express The price could vary. We earn commission from these links LEGO 72037 Mario Kart If there is a well-known game on the console nintendo switchthat is, without a doubt, ‘Mario Kart‘. Now, thanks to this set LEGO 72037 Mario Kart You will be able to have the famous plumber in his car at home, like in the legendary video game. To have this set assembled at home you will need some space, since it is a large set (measures 22 x 32 x 19 cm) and is made up of 1,972 pieces. The figure of Mario has joints in arms and it is a perfect LEGO set to display in a gaming room. LEGO Mario Kart: Mario and Standard Kart The price could vary. We earn commission from these links LEGO 76313 Marvel Logo If you are planning to give something to a marve fanl in Three Wise Men, this is the LEGO set that you will surely love. It is about the LEGO set 76313 Marvel: Logowhich is perfect for displaying on any shelf. Recommended for ages 12 and up, this LEGO set (931 pieces) comes with mini figures of some protagonists of the saga Marvel. Among them, you can find Iron Man, The Avengers, Hulk, Thor, Black Life and Captain America. LEGO Marvel: MARVEL Logo and Minifigures The price could vary. We earn commission from these links LEGO 75375 Star Wars: Millennium Falcon Star Wars is one of the most successful film franchises in the history of cinema. If you want to give something to a fan of hers, this LEGO set 75375 Star Wars: Millennium Falcon It is perfect to surprise. This LEGO set of Star Wars includes a total of 921 pieces and it comes full of details. Unlike other constructions from the firm, this one has a compact size, with a height of 13 cm, 24 cm in length and 19 cm in width. It also includes an identification plate, support and a commemorative token for the 25th anniversary of the collaboration between LEGO and Star Wars. LEGO Star Wars 75375 Millennium Falcon The price could vary. We earn commission from these links LEGO One Piece Set 75639 – Going Merry Pirate Ship He LEGO set 75639 One Piece-Going Merry Boat It is a set from the famous building block brand with which you can build the iconic Straw Hats ship. It is composed of 1,376 pieces and recommended for ages 10 and up. Its dimensions are 34 cm high, 39 cm long and 20 cm wide. It presents an incredible level of detail and comes with five minifigures (Zoro, Naomi, Usopp, Luffy and Sanji). Additionally, it includes four “Wanted” posters, although these are random. LEGO 75639 One Piece Going Merry Pirate Ship Toy The price could vary. We earn commission from these links Some of the links in this article are affiliated and may provide a benefit to Xataka. In case of non-availability, offers may vary. Images | LEGO In Xataka | Your favorite series, comics and movies also in LEGO: 15 construction kits ideal to assemble yourself or give as a gift In Xataka | LEGO constructions on another level: the Technic Series has the models that any collector would dream of

It is essential to give us the key to leukemia

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The bone marrow is undoubtedly one of the most complex, and at the same time vital, tissues in the human body. It can be said that it is the “blood factory” of the body where stem cells are born that keep us alive and that gives rise to our defenses or our red blood cells. However, studying it is a real nightmare as it is encapsulated within the bone such as the femur. Until now, scientists had to choose between study cells on a flat piece of plastic (which looks nothing like the real body) or use micewhich, spoiler: they are not human. That is why there is now a real revolution in this field, since they have managed to create a great model that will make life much easier for science. The study published in Stem Cell just changed the rules of the game. A team of researchers have managed to create eVON, a macroscale, 3D, vascularized model of the human bone marrow that not only has cells, but “breathes”, has functioning blood vessels and even nerves. Why does it matter? Although it seems insignificant, the reality is that right now there were many doubts about how they develop diseases as aggressive as leukemia. In this case, this piece of tissue engineering opens the door to finally understanding how leukemia works and how to cure it without depending so much on animal models that are not faithful to the anatomy and physiology of humans. Until now, the solution to research also involved taking a Petri dish, which is nothing more than a piece of plastic, and cultivating the stem cells here that will give rise to the components that we have in our blood. Logically, they died quickly here, since they lacked the environment where they were truly comfortable ‘living’. It is what is known as endosteal niche. This niche is the specific neighborhood within the bone where stem cells interact with blood vessels, bone, and nerves to decide whether to multiply or become white or red blood cells. Something fundamental to understand what is happening there. We already have a solution. eVON is presented as a wonderful alternative, since it has three key elements: A ‘scaffold’ composed of the same mineral that we have in bone to imitate the hard structure of the trabecular bone human. No white gelatin, but something that feels like a real bone. Stem cells that have been reprogrammed in the laboratory to generate both bone and blood tissue. Functional vascularization, thanks to the fact that they have managed to make the cells form networks of capillaries and blood vessels that penetrate the artificial bone. And the truth is that they have managed to introduce all the components that are around them into our marrow. Most surprising is the level of detail: The model spontaneously developed sympathetic nervous system nerve fibers and macrophage-like cells, creating an entire ecosystem that no one had ever had to explicitly “design” cell by cell. They have literally created a blood factory. The fight against leukemia. Acute myeloid leukemia is a cancer that is undoubtedly devastating and that often “hides” in the bones themselves, making it very resistant to chemotherapy since it is difficult for the medication to reach the bones. The good news comes when the study shows that eVON recreates the exact molecular signals that tumor cells use to survive. And this is fundamental, since attacking these genes is like hitting their weak point. In short, it gives us the necessary tools to be able to kill tumor cells and cause them to die. The test. To prove that their “artificial bone” was robust, the researchers did something worthy of science fiction: they implanted the eVON tissue under the skin of mice. And the truth is that the result was very good: the human tissue integrated with the mouse and the human blood vessels connected with those of the mouse. In this way, the human stem cells survived and were able to repopulate the mouse blood with functional human cells. But logically there are still challenges that must be overcome, such as the size of this model. To do this, it still needs to be reduced so that large-scale tests can be carried out with drugs that can kill these tumor cells. Images | ANIRUDH National Cancer Institute In Xataka | 125,000 years ago Neanderthals ate bones to survive. Today we discovered that they were right

Free PS4 and PS5 games in October 2025 for PlayStation Plus Essential, Extra and Premium

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Let’s tell you what are The games that Sony will give you without additional cost in October 2025 If you have subscription to PlayStation Plus. These are 3 new titles that will be available From October For all subscribers of any of the versions of this service, and those that you can play when you want without additional cost while maintaining your subscription. PlayStation 5 It is retrocompatible with the PS4, which means that you can play in it all the games of the previous generation. In the list of games we will put you Games with official prices of the official Sony website, which can sometimes be different from those that you will find in the stores, but that serve as a reference to see the value of the games you get. Free games for PS4 and PS5 Alan Wake 2 (PS5), valued at 59.99 euros. The second part of this magnificent game in which you will have to solve a series of murders, exploring two worlds with two different characters. You have the analysis in Lifextraand the file in 3DJUGOS. Cocoon (PS4, PS5), valued at 24.99 euros. Another game of mysteries, in this case cosmic mysteries solving various puzzles. A great title of the mind that brought us limbo or inside. You have the analysis in Lifextraand the file in 3DJUGOS. Goat Simulator 3 (PS4, PS5), valued at 29.99 euros. Third part of this authentic madness with which you can go with the goat in the most literal way. A realistic sandbox where you can do all kinds of adventures. You have the file in 3DJUGOS. In Xataka Basics | How to format and restore your PlayStation 5 to your factory values

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