For years we blamed testosterone for men living shorter lives. Now we know that the culprit is a chromosome

For decades, biology has observed an incontestable demographic fact: women live longer than men. It has often been blamed lifestyleto testosterone or to the greater male propensity for risky activities. However, science has found a much more subtle and genetic culprit that we carry in all our cells and that literally we start to lose as we get older. A genetics class. In a very general way, we must remember that all our genetic information is collected in 46 chromosomes which are found within the nuclei of our cells in pairs. But there is a part of all these chromosomes that define us as men or women: The presence of two X chromosomes defines women and the presence of one X chromosome with one Y defines men. Although there is great genetic complexity behind something as redundant as a pair of chromosomes, what interests us in this case is that science has seen a effect called mLOYwhich is literally the loss of Y chromosome mosaic in men. And different scientific articles suggest that it is not a simple side effect of getting older, but rather it is a “silent killer” that explains much of the longevity gap between the sexes. The runaway chromosome. For a long time, the Y chromosome was considered the “little brother” of the genome. Small, with few genes and almost exclusively responsible for determining the male sex with no other known functions, almost all of which fall on the X chromosome of considerable size. But the truth is that we were wrong, and the Y chromosome has great importance in the adult life of men. The mLOY phenomenon. This occurs when the cells that are in charge of manufacturing the blood elementslike erythrocytes, platelets, or lymphocytes, suffer errors when dividing and lose the Y chromosome. Something that generates a “mosaic” in our body, that is, some white blood cells have the Y chromosome while others do not. But what is disturbing is the frequency with which it occurs, since, according to the data reviewed, this is something that has been detected in 40% of men at age 60 and in 70% of men at age 90. There is damage. Until recently, it was believed that losing this chromosome was benign and normal, a simple “genetic gray hair.” But the evidence accumulated between 2022 and 2025, including massive UK Biobank studies and the recent German studio LURIChas set off alarm bells: losing the Y chromosome is not harmless and has important side effects. The heart. One of these side effects is precisely heart failure, which is a very prevalent disease in the elderly. Here science has been able to see that, by eliminating the Y chromosome in mice, the animals rapidly developed cardiac fibrosis. That is, their hearts were filled with scar tissue, becoming rigid and, therefore, having great difficulty pumping blood. But it is not the only disease that occurs, since in the United Kingdom Biobank, men with mLOY in more than 40% of their white blood cells had a 31% higher risk of dying from cardiovascular causes. And even the LURIC study published last year, carried out on 1,700 men, found that the mLOY effect increased the risk of fatal heart attack by almost 50%. More diseases. Beyond the heart, the impact of losing the Y chromosome also affects our body’s defense system to be able to combat different threats. Among them we have cancer, since the immune system needs the Y chromosome to effectively monitor the tumor cells that arise. Its loss is associated with a worse prognosis in bladder cancer and other solid tumors, since it is as if our body’s security guards had gone partially blind. In addition to cancer, the frequency of mLOY has also been seen to be up to 10 times higher in patients who have Alzheimer’swith studies showing an almost 3 times higher risk of developing the disease. The COVID. During the pandemic we saw that older men died much more than women without fully understanding why. We now know that the loss of the Y chromosome increases 54% risk of fatality for being infected with COVID in the elderly, finally offering a biological explanation for this bias. Is there a solution? It may seem depressing to know that a part of our DNA decides to abandon us and cause us so many problems, but in reality, it is a hopeful finding. And it is hopeful, since, seeing that the loss of the Y chromosome is a direct cause of a disease, therapeutic doors open. In experiments with mice, it has been seen that treatment with an antifibrotic drug was able to reverse the cardiac damage caused by the loss of the chromosome. This means that the mLOY effect can be used as a marker in a blood test, as happens with cholesterol, to predict a patient’s cardiac risk and to be able to give preventive treatments to delay it and improve the patient’s quality of life. Images | nrd Miroslaw Miras In Xataka | The X chromosome has new clues about aging: why women tend to live longer than men

When Spacex suffered his worst incident, Elon Musk blamed a sniper of the competition. The FBI had to intervene

On the morning of September 1, 2016, Spacex suffered one of the most cautious and controversial incidents in its history. A Falcon 9 rocket that was vertical on the launch platform Suddenly exploded With the Israeli satellite A Amos-6 aboard. Elon Musk accused the competition. A violent explosion. It was one of the first times that Spacex operated the Falcon 9 rocket with cryogenic propelants, a technique that consists in superfrging the fuel and oxidant to maximize its performance. Before the launch, Spacex had planned a static ignition test, a routine procedure in which engines are tested with the rocket anchored to the platform, but everything was twisted eight minutes before ignition. A violent explosion transformed what was a rocket into a huge fireball. The payload was shot. Mark Zuckerberg’s anger. The AMOS-6 satellite was not any load. With a cost of 200 million dollars, he had a powerful customer: Mark Zuckerberg. Goal, then Facebook, had reached an agreement to provide Free Internet Access in Africa Thanks to the satellite. After the explosion, Zuck He publicly expressed A “deep disappointment” for the rocket explosion, comments that did not sit well in Spacex, where morality was on the ground. According to Ars Techcnicathis incident was one of the points of origin of the bad relationship between Elon Musk and Mark Zuckerberg, which years later would lead the first to eliminate Spacex and Tesla’s Facebook pages. The theory of the sniper. The most trospid of the incident was, however, the theory promoted by Elon Musk about the possible intervention of a sniper. Theory in which Spacex insisted throughout the official investigation of the incident, According to documentation that has just become public. Although Spacex engineers shuffled hundreds of hypotheses, Elon Musk promoted the idea of ​​an external sabotage: the shot of a sniper. It sounds crazy, but Musk saw the two main indications convincing: the break began about 60 meters high, on the side of the rocket that looked towards a building leased by its main competitor, United Launch Alliance. An alleged ULA shot. The ULA building, a joint business of Boeing and Lockheed Martin, was a kilometer and a half of the Spacex launch platform, a reasonable distance for a sniper. Put to believe, even seemed to see a flash on the roof of the building, coinciding with the time it would take a projectile to reach the rocket. The rivalry between SpaceX and ULA had then reached its peak. Ul still dominated the market of military and government launches, the most lucrative, but Spacex had just won a battle in the courts to compete for these contracts. However, accusing a sabotage competitor without evidence was a serious accusation. The FBI came to intervene. Azuzados by Musk, Spacex engineers thoroughly investigated the sniper theory. They tried to access the ULA roof and performed shooting against pressurized helium tanks to see if they exploited similarly to Falcon 9. The insistence was such that the Federal Aviation Administration had to intervene with a letter that denied the involvement of third parties. There was no sniper, although, as the documentation of the journalist Eric Berger has revealed For your book Recentryeven the FBI investigated the case. The federal agents reviewed the Spacex analysis and the video material, but they concluded that “there were no indications that suggested that sabotage or any other criminal activity played a role in the explosion of Falcon 9”. With this, FAA considered the closed matter. What happened then. The real cause of the rocket explosion and, with it, of the AMOS-6 satellite, was the process of loading propellents. In its eagerness to accelerate the refueling process with super -refrained liquid oxygen, the Spacex equipment filled the helium tanks too fast, heating the aluminum coating of the rocket and causing its deformation and rupture. Spacex would put the hair of Punta to the NASA security office for its procedure “Load and Go”, which proposed to raise astronauts to the rocket before loading fuel. Over time, not only would demonstrate the reliability of Falcon 9 (Last year he completed 137 launches against the five of ULA), but would become the main supplier of NASA manned releases to the International Space Station. Images | And combinator, Uslaunchreport, CNN Money (YouTube) In Xataka | Texas has a new city. Until a few days ago, it was only Spacex’s base in Boca Chica

In 2021 Texas stayed in the dark for days. Politicians blamed the wind, but the culprit was an old acquaintance

The story occurred in February 2021when a historic winter storm that affected much of the state of Texas generated the last great electric blackout. Between February 13 and 17, extremely low temperatures and adverse weather conditions caused the disconnection of more than 4.5 million homes and business, some for several days. The event is considered one of the blackouts more serious in history Modern of the United States, so much that politics tried to take advantage of the “guilty.” The mirage of the wind. As we said, in February 2021, Texas lived one of the most serious energy crises in its modern history, when a winter storm paralyzed a good part of the state, causing massive power cuts, dozens of deaths and extreme conditions that affected millions. In the midst of chaos, the governor Greg Abbott appeared on national television (in Sean Hannity program, in Fox News) to directly hold the renewable energies of collapse, and especially wind. In a sharp statement, he said that the ruling showed that the State and the country continued to need fossil fuels to guarantee the winter supply. However, the accusation, repeated by other leaders conservatives and related media, not only It was wrong but deeply interested, because the data showed that the main person in charge of the collapse had been … Natural gas, not the wind. The Texas Network and its fragility. Texas has a unique electrical grid, known as Ercot (Electric Reliability Council of Texas), which operates almost independent of the rest of the national network. This deliberate disconnection, designed to avoid federal regulations, also prevents the State from importing electricity easily in case of emergency. Thus, when temperatures fell dramatically in February 2021, many electric plants (especially those fed with natural gas) They were not prepared To operate in freezing conditions. The pipes froze, the valves failed and gas production collapsed, just at the time of greatest energy demand. Although some wind turbines also froze, their weight on the network was relatively small: about 7 % of the production planned for that time of the year, according to expert calculations. Most cuts came from thermal and nuclear plants that could not operate due to lack of fuel or technical problems derived from extreme cold. Politics in a blackout. Despite this evidence, the narrative that was quickly imposed in conservative sectors was that the ruling had been caused by clean energy. From Fox News to the Wall Street JournalHE They multiplied the voices that ridiculed the renewables, called them “non -reliable” and demanded a return to coal -based energy. An old ideological campaign against environmental policies was reactivated and, in particular, against the Green New Deal promoted by some Democratic legislators. Even false images were shared, such as a photograph of frozen turbines supposedly in Texas that It turned out to be from Swedencaptured years ago during a thaw test. Social networks, media and politicians such as Congresswoman Lauren Bobert or state senator Mike Thompson They spread without contrast Uninformed arguments that placed wind and solar energy as guilty of the blackout, reinforcing a rhetoric that had been downed long before the incident. The response of experts. Numerous researchers and electrical systems specialists They denied the official version repeated by the governor and other leaders. Jesse Jenkins, engineer of the Energy System of Princeton, summarized in a phrase What happened: “All generation sources are being beaten.” Indeed, freezing affected both gas and coal, nuclear and renewable plants. The problem was not a single technology, but the lack of preparation of the infrastructure set in the face of extreme weather conditions. Leah Stokes, political scientist at the University of California in Santa Barbara, The irony stressed to New York Times of the situation: the same fossil fuels that were feeding climate change were those that had failed in an increasingly common weather scenario. From that prism, what did not support the system was not renewable energy, but an obsolete network model, little resilient and possibly more focused on economic efficiency than in climate emergencies. Climate change as a backdrop. Plus: the crisis occurred just when Joe Biden came to the presidency and had signed his First executive orders In climatic matters, reincorporating the United States to the Paris Agreement and canceling the Keystone XL pipeline. Under that context, the Texas blackout became a discursive battlefield between those who asked for more investment in clean energy and resilience, and who defended the continuous and reinforced use of fossil fuels. Biden had made it clear that his vision went through Modernize infrastructure Energy of the country, generate green jobs and reduce emissions towards a zero net target in 2050, but the storm served the opposition sectors as excuse to discredit said agenda. Broken system Far from demonstrating an alleged “uselessness” of wind energy, the Texas blackout In 2021 it was a more warning about the vulnerabilities of an energy system unable to adapt to the 21st century climate. While the authorities blamed the turbines, millions of people froze without heating, hospitals worked with emergency generators, and citizens (such as state deputy Brandon Woodard, in Kansas) they wondered if those interruptions would become A new standard. If you want also, the event left a teaching: reliability does not depend on a type of energy source, but on an integrated, resistant and modernized system that combines technologies, storage, interconnections and preparation against climatic extremes that will be more frequent. In Texas, loading the blame for the wind was a convenient, but dangerous distraction. As almost always, the true enemy were not renewable, but negligence. Image | POT In Xataka | The precedent closest to the great blackout of Spain was lived in 2003. And it also began in the interconnected network In Xataka | Having solar panels at home sounds very good in case of national blackout. The problem is that they do not always work

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