Sora’s AI is resurrecting dead celebrities to turn them into cheap viral content: it’s technological nonsense

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What of digitally resurrect deceased public figures It’s not new, but Sora 2 by OpenAI is crossing the line from homage to pure morbid entertainment, with videos ranging from harmless humor to the most explicit cruelty. This phenomenon, which has provoked the indignation of relatives of the daughter of actor Robin Williams, raises serious ethical and legal questions. What is happening. Michael Jackson shows up at a KFC and steals a man’s fried chicken while dancing away. Pope John Paul II does some skate tricks. Albert Einstein gives an interview after a UFC fight. These are just a few examples of what people are doing with Sora 2. There’s more: Martin Luther King, Kennedy, Nixon…many videos have a humorous and seemingly harmless tone. Others, however, are in very bad taste, such as those that show a Stephen Hawking being abused brutally. And the worst thing is that no one seems to be stopping it. The Robin Williams case. Zelda Williams, daughter of the late actor, has used her Instagram account to show her rejection of this trend. “Please stop sending me AI-generated videos of dad. Stop believing that I want to see them or that I will understand them. I don’t want them and I won’t understand them,” he said in his message. Although he does not give details about whether the videos he has received are made with Sora 2, his complaint comes just a few days after its release. The cameos. They are the great novelty of Sora 2 and one of the reasons for its popularity. In fact, the app was launched with a cameo by Sam Altman that has already generated all kinds of memes. With cameos you can create funny videos of yourself or a friend, but Sora won’t let you make videos of real people unless they have given their consent. Except if those people are dead. Blurred boundaries. In it Sora security document 2OpenAI states that “only you can decide who can use your cameo, and you can revoke access at any time. We also take steps to block depictions of public figures.” However, they don’t say anything about public figures who have died, and from what we’re seeing, it doesn’t seem like these guidelines apply in the same way. According to the TechCrunch teststhe app does not allow you to create videos of Jimmy Carter or Michael Jackson (although there are published videos), but it does not cause problems when doing so with Robin Williams or Richard Nixon. defaming the dead. Although it is ethically questionable, at a legal level things change. In the United States, where OpenAI operates, legally it is not possible to open a process for defaming a deceased personso the company would not have any responsibility. In Spain it is similar; the Organic Law 1/1982 includes the right to honor, personal and family privacy and one’s own image. However, according to the article 32 of the civil codecivil personality is extinguished after death. Yes, it could be the case that heirs claim the right to honor of the deceasedbut it is a complex process and full of nuances. The new AI dump. At the beginning of the year we talked about how Junk AI or ‘AI Slop’ had flooded the networks. Were most disturbing videosof very bad tastebut they were clearly made with AI. With Sora 2 a dangerous door opens and it is that of a new AI dump more realistic than ever. If we add to this the use of the image of deceased people as if they were toys with which we can do whatever we want, no matter how legal it may be, it sets a very worrying precedent. Image | tiktok In Xataka | OpenAI and AMD have just signed more than just an AI agreement: it’s the barter of desperation

Data centers shooting the light of light in the houses

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Spain is betting very strong for the development and creation of new data centers. The AI ​​boom has infected our country, and although that attracts investment and economic capital, it can also lead to serious problems for consumers. Especially a very clear one: that we pay more for the light. Spain, care with data centers. In recent months we have seen how Data centers construction projects grow In our country. It is estimated that in the Community of Madrid there will be a power of 1.7 GW in 2030, which is paradoxical, because it is the region with greater energy deficit in Spain and the one that is staying with a good part of these projects. Aragon, in another league. Aragon has so many projects of data centers that He showed his disappointment When he knew that the reinforcement of the electricity network for those facilities throughout Spain will be 3.8 GW. Those responsible for the Aragonese government described the figure of “scarce”, especially considering that this region has projects that projects that projects that projects that They would exhaust that capacity alone. The US teaches us (worrying) future. A Bloomberg investigation It reveals how in the last five years the creation of new data centers is making the light invoice rise remarkably. Those centers, previously dedicated to expanding the cloud infrastructure and now totally focused on the AI ​​boom, are behind that increase in light invoice. Energy consumption is triggered in these facilities, and ends up affecting electricity prices in surrounding regions. Prices that almost quadruplic. In 2020 Baltimore residents paid average $ 17 per MW/h. In 2025 that price is $ 38 per MW/h. In Buffalo the thing is even worse, and prices have tripled in five years: they have gone from $ 11 to 33 per MW/h. In the areas of the United States close to large concentrations of data centers, the wholesale price of electricity has risen up to 267% In the last five years. LMP are nodes of the electricity grid that determine the wholesale price of electricity. Almost three out of four have seen price increases when they are close to data centers. Those who are in farther areas have come to see their reduced prices. Source: Bloomberg. Unequal climb. The study reveals how wholesale electricity prices in the US have increased significantly in recent years, although it is true that these increases have been applied unequally at the geographical level: certain areas have seen modest increases, but others have seen how the light of the light was fired and grew up to that aforementioned 267%, close to quadruple. The condemnation of data centers. 70% of the points at which price increases were recorded are less than 80 kilometers of data centers with significant activity. It is a fact that makes it clear that the impact of these data centers on the light of the residents is clear. And this goes to more. Current estimates, Indicates Bnefprevent the energy demand for data centers in the US will double for 2035 and will be the largest increase in energy demand since the 60s. Thus, in ten years that demand will represent 9% of the total. At the global level, the data centers are expected to consume more than 4% of the electricity consumed in 2035. If those facilities were a country, they would be the room in energy consumption, only behind China, USA and India. Perfect storm. The demand is also linked to the rise of cryptodivisas, the impulse of manufacturing in the US and the “electrification of the economy”, which includes areas such as electric vehicles or domestic heating systems. The withdrawal of traditional mining facilities in areas such as Baltimore has only aggravated the economic problem: there is less energy supply and more demand, which makes prices again increase. The world already knows what comes over and is reacting. What is happening in the US is already causing reactions in other countries. Holland: Water and energy needs made the Amsterdam City Council in 2019 imposed A moratorium for the construction of new data centers. Singapore: also established a pause for the creation of this type of facilities between 2019 and 2022, although the government made clear which would be more selective in future projects. Ireland: In 2024 the country reached a worrying milestone. Data centers They already consumed more than households. 5% of the country’s total consumption went through in 2015 to 18% in 2022 and 21% in 2023. Household consumption represented that year 18%. The solution: that the Big Tech pay that invoice. Public service companies in the US such as Dominion Power are clear that “data centers should pay the full cost of their energy consumption.” Large technological ones know very well that these facilities raise an extraordinary energy demand, and They are investigating solutions like him Use of SMR reactors for their AI data centers. The idea is interesting, But complex. Supply and demand. Spain faces a future in which energy supply and demand could be unbalanced as it is already happening in the United States. If data centers begin to impose more and more load on the network, it is reasonable to think that the cost of electricity increases and causes the least desirable effect for users: the rise in the light invoice. Renewables could help mitigate the problem, but only If the network is capable of absorbing Both the new generation and the new mass demand of the data centers. Image | Microsoft

There are fewer and fewer North Koreans fighting with Russia in Ukraine. An army has arrived with an irrefutable promise: Cubans

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For months, reports about foreign fighters in Ukraine indicated to North Korea as the main source of soldiers sent to support Russia. Then there was official confirmation by both nations. Quietly, however, that balance is shifting in surprising ways. On the board of the war in Eastern Europe, another country begins to displace Pyongyang in the role of largest supplier of troops to Moscow, an unexpected turn that reveals both the fragility of Russia and the depth of its authoritarian alliances. The Cuban front. What began as a regional invasion has transformed into a global war, in which Russia not only faces Ukraine and its Western allies, but also mobilize a network of regimes to sustain the war effort. Among them, Cuba emerges as an unexpected actor: according to Ukrainian estimates, up to 25,000 Cubans They could join the Russian front, becoming the largest foreign force in Ukraine, above the North Korean contingents. For the Kremlin, the usefulness of this formula it is evident: The casualties of foreign fighters do not generate internal protests, do not require compensation to Russian families and reduce the political cost of the conflict. In a country with more than one million estimated casualtiesattract soldiers overseas It is also a matter of strategic survival. A formula that is difficult to reject. The main motivation for many Cuban recruits is simple: economic. On an island mired in one of the worst crises in recent decades, where the average salary barely exceeds 20 dollars a month, the promises of charge $2,000 a month They fight any ideological objection. Some accept the contracts convinced, others are deceived with job offers in construction or factories, to discover upon arriving in Russia that their destination is the battle front. Analysts like Cristina López-Gottardi they point out that the economic attraction is irresistible, but they also highlight the political dimension: Havana obtains income from remittances from combatants and consolidates its alignment with Moscow, presenting it as a gesture of “revolutionary loyalty” and, incidentally, a symbolic challenge to Washington. Experts point out that the regime seeks reinforce your narrative anti-American, presenting participation as an act of internationalist solidarity, although in practice it is a source of foreign currency in times of hardship. Mercenaries, coercion and globality. The Cuban presence is part of a broader trend: the growing Russian dependence on foreign fighters. According to intelligence data, in 2025 almost half of the prisoners captured in Ukraine They were not Russian citizenswhen in 2022 they barely represented 1%. From Africans recruited under threats of deportation, until deceived students With false job offers in “shampoo factories”, including North Koreans sent as cannon fodder, Moscow turns to a whole mosaic of forced soldiers or mercenaries. In this sense, the Cuban contribution not only strengthens the Russian lines, but also magnify the image of a war waged by an international authoritarian axis that includes Iran, Venezuela, North Korea and now Cuba, sharing weapons, technology and experience on a battlefield converted into a laboratory for modern warfare with drones, electronic warfare and new combat tactics. Cuba as a diplomatic target. Cuban involvement in Ukraine has not gone unnoticed by the United States. The Trump administration has decided to use it as a central argument in his diplomatic offensive against Havana at the UN. An internal State Department cable, dated October 2, instructed US delegations to pressure allies to vote against the traditional annual resolution demanding an end to the US embargo on Cuba. Year after year, the measure has had overwhelming support (in 2024, 187 countries voted in favor and only the United States and Israel against), although Washington hopes to reduce that margin by presenting evidence that the Miguel Díaz-Canel regime has become in active accomplice of Russian aggression, with between 1,000 and 5,000 fighters deployed on the front. In the documents is underlined that Cuba “has failed to protect its citizens from being used as pawns” in the war, and the regime is accused of “undermining democracy” in the region, particularly through its alliance with Venezuela. The embargo and sanctions. Washington’s strategy seeks to disarm the Havana narrative, which presents the embargo as the root of all their evils. The diplomatic cable instructs to highlight the corruption and incompetence of the Cuban government, in addition to highlighting that the economic problems do not derive from the sanctions, but from its mismanagement. Trump, upon his return to the presidency, has hardened the restrictions: has reinstated Cuba to the list of countries sponsoring terrorism, has further limited financial transactions and has sanctioned third countries that collaborate with Cuban doctors abroad. Faced with this pressure, the Cuban regime accuses Washington of seeking a pretext for aggression and even instrumentalizing the anti-drug fight in the Caribbean as an excuse to increase tension. That said, the backdrop seems different: the combination internal collapse and military alliance with Moscow places Cuba at the epicenter of the geopolitical struggle between Washington and the authoritarian bloc. Military school. Beyond the diplomatic balances, what worries many analysts is that the war in Ukraine has become an involuntary academy for allied armies of Russia. Every foreign contingent that steps on the front learn first hand the techniques of the first great drone war in history: from swarm operations to electronic warfare. As warns Bill Colefounder of Peace Through Strength Institute“the real danger is not the thousands of Cubans or North Koreans sent, but what they learn and then export to other conflicts in Latin America, Africa or Asia.” This transfer of war knowledge turns war into a multiplier of global instability, with authoritarian regimes absorbing tactics and adapting them to their own scenarios. The Cuban paradox. The participation of thousands of Cubans in the Ukrainian war also reveals a paradox: while for the Havana regime it represents both a source of foreign currency and a reaffirmation of its anti-American identity, for Moscow it is a cheap solution and politically comfortable to internal wear and tear, and for Washington an opportunity to intensify diplomatic pressure … Read more

To Taylor Swift fans

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Two phenomena has unleashed the launch of Taylor Swift’s new album, ‘The Life of A Showgirl’. An expected one: the top of the sales lists has been perched, taking a couple of previous records and confirming it as the main superstar pop of the moment. Another not so much: a the Swifties They have not finished convincing the product. That The specialized criticism He has Ojeriza Taylor Swift has nothing strange, but … his own fans? Is the status quo In the paradisiaca Villa Taylor? One hundred million nioles. The album arrived at the stores on October 3 and immediately beat his first records: 2.7 million copies on its first day alone in the US, beating the previous Swift record, being the second highest sales figure in a week in history (only ” of Adele goes ahead). As we havethe movie-documentary that accompanies the launch, ‘The Official Release Party of A Showgirl’ raised almost 50 million dollars in its first weekend in the US. A few criticisms. Swift’s new has been said to be “A musical thread just friendly“. That “His music has never been so unattractive“. What is a”masterpiece CRINGE“. That is full of” classic design pop songs, with standard stanza and chorus arrangements and rarely exceed four minutes “(And it’s not a praise). And that “it is more enjoyable if you do not take Taylor Swift – the artist, the character, the person— too seriously“But of course, criticism. Who pays for pitchfork at this point? Fans disappointment. The Swifties More loyal are also experiencing some disappointment. The more or less objective causes, or that enter the most conventional musical analysis are innumerable. There seems to be a certain consensus in which The letters and musical complexity It is very far Of those who are considered their best albums, ‘Folklore’ and ‘Evermore’ (and that ‘Wood’, a song full of sexual references trying to make a kind of Sabrina Carpenter for all audiences, is a bit embarrassing). There are those who point to their fiance, Travis Kelce, It is a terrible museand has made the diva enter an era of artistic conformism far away from the music he made up when he had a six -year relationship with actor Joe Alwyn. Criticism and more criticism. In Tiktok the thing is getting, as expected, even more passionate and personal: innumerable Accounts are criticizing heroften defending that the frivolous and disconnected approach from public opinion and what happens in the world has made this new album isolated in a vacuum, In a kind of bubble that emphasizes that we are not facing a “real” artist, but before a diva, with problems outside his fans. Criticism about their way of doing business with innumerable variants and added to the album that convert the experience of launch into a Festival of microtransactions. It defends itself. After a week of criticism, Taylor Swift made an appearance in the podcast ‘The Zane Lowe Show‘by Apple Music and commented that his reaction before all this is to “embrace chaos.” He also made his version of “The bad press is also a press”: “If it is the first week since the launch of my album and you mention my name or the title, you are helping.” He added: “I respect people’s subjective opinions very much about art. I am not the art police. (…) Our goal as artists is to be a mirror.” In Xataka | The last world tour of Taylor Swift has charged a victim and is the earth: 286,000 km in private jet

so you can get two free double tickets to attend this event about AI

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freepik is one of the leading Spanish companies in artificial intelligence and this year at Xataka we are Media Partner of Upscale Confthe AI ​​event that the Malaga firm organizes between November 4 and 5 in its hometown. It is going to be an event full of conferences, panels and networking opportunities with AI as the protagonist and from Xataka we want you, our xatakeros, to be able to experience it with us in the first person. So, with the help of Freepik we are going to draw two double tickets so that two lucky people (and their respective companions) can live this experience. How to win two double tickets to Upscale Conf Upscale Conf | Image: Xataka This is the third edition of Upscale Conf. The first took place in Malaga last November, the second was in San Francisco and this time Freepik has once again bet on its land. During these two days, attendees will be able to enjoy conferences from industry personalities and creators, panels and conversations, practical workshops and hands-on sessions and networking opportunities. A very dynamic event whose agenda and participants you can find now on the official website. Minor spoilers: there will be designers, creative directors, founders and CEOs of companies such as ElevenLabs, Google Cloud, The Dor Brothers, SpeciaGuestX or GenreAI, among many others. Upscale Conf | Image: Xataka As we said, the event will take place between November 4 and 5 at the Sohrlin space Andalusia and it will be packed with AI. It sounds really good, even more so when you can win one of two double tickets that we are raffling off. Be careful, each entry has a value of 500 euros (350 euros in early bird). Participating is extremely easy and the mechanics are as follows: Sign up in this form before October 15 by entering your personal information (make sure you enter your email correctly!) Each entry will be assigned a number. Once we have collected all the participants, 25 random numbers will be chosen. The chosen numbers will be the winners of a double entry and will be contacted by the organization The draw includes two double tickets. Travel, accommodation, meals and other associated expenses are the responsibility of the winners. Upscale Conf | Image: Xataka If the winner does not respond to the organization with his or her acceptance of the prize within 48 hours, a new draw will be held. If the second party does not get in touch, a third party will be contacted and if the second party does not respond either, the prize will be declared void. You can consult the legal bases here. Let’s remember: Upscale Conf will take place on the days November 4 and 5 in space Sohrlin Andalusia in Malaga. You can find all the schedules and agenda on the event website. Good luck and see you at Upscale Conf! Images | freepik

The Nobel Prize in Chemistry of 2025 is taken by Susumu Kitagawa, Richard Robson and Omar Yaghi

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The Nobel Prize for Chemistry of 2025 It has been granted to Susumu Kitagawa, Richard Robson and Omar Yaghi for “the development of metalorganic structures.” A great advance that is mostly thought to be able to extract water from the air in arid environments such as desert or extract water pollutants or capture carbon dioxide. All this thanks to the great cavities through which the molecules can flow. The material of the 21st century. The new materials that have created the winners so far have been used on a small scale. But the truth is that it has important applications such as in the electronic industry, where it can be used to contain some of the toxic gases that are necessary to produce semiconductors. Although you can also see its arms application to be able to be used as chemical weapons. But the most striking can undoubtedly be the capacity of capturing carbon dioxide that occurs in industrial and power plants to reduce its carbon footprint and not contribute to the greenhouse effect. The pools. This year the truth is that a lot of doubts about who could take this Nobel was again again. The roads pointed out that the prize would be taken by the catalysis of a single atom, which is a technique that allows the most efficient and sustainable reactions to be made. And this is something that goes very much of what was expected for this year 2025: being as sustainable as possible in the field of science and mobility. This means that other advances such as the development of batteries that have less impacts, work the environment or also materials with energy applications have been in the pool for receiving one of the greatest awards in this field. Chemistry views magazine He also did different surveys To know what the scientific community thinks about the award. In this case, most pointed out that the field of biochemistry would be the award -winning this year and there was a rivalry with each other, it would be European or American. Although where almost all coincided (89%) is that it would be a man the graceful. The Nobel Prize for Chemistry. This award has been distributed on 116 occasions in which it has fallen to 194 people. As curiosities, it should be noted that the youngest award to date has been Frédéric Joliot with 35 years. But at the other extremes we have John B. Goodenaugh, with 97 years, who was awarded in 2019. The problem we have in this case is that there are very few women who have received this award, being Marie Curie the first to do so in 1911 (which also won the Physics in 1903). It should also be noted that with this recognition the stage of awards for disciplines in Health Sciences closes. Now there is only the turn for literature tomorrow and on Friday the Peace Prize. In addition to these, on Monday the Prize for Economic Sciences will be announced again, which was not established by Alfred Nobel. In Xataka | It costs to see a sponge and think that life on earth began thanks to them. But we are getting clearer every time

The Alhambra and its environment are a jewel of world heritage. Now a threat has emerged: solar panels

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For decades Granada can boast of having a world category jewel, the set formed by the Alhambra, Generalife and Albaicín, registered all three in The list Unesco World Heritage. Now the city sees how clouds loom About them. And for an unexpected azón: a photovoltaic plant that, according to icomos (An organism associated with UNESCO) threatens the environment. In fact advises “Slighted” that is paralyzed. What happened? That Icomos (The International Council of Monuments and Sites) has just yielded a jug of cold water on a project that It has been weating for some time Granada local policy: a photovoltaic plant of something more than three hectares that will be built in The Farguea neighborhood of Granada. What Icomos said is that, if carried out, the installation will negatively affect the Alhambra, the Generalife and the Albaicín neighborhood, three Historical jewels included for years in the Unesco World Heritage list. Beyond its content and arguments, the warning is important because Icomos is not any entity. The Council is associated with UNESCO and is dedicated precisely to ensure the “Protection and value” of heritage. Its report also includes some ears to the Spanish authorities and has served to enliven (even more) the debate that For months surrounds a plant that has encountered the opposition of politicians, neighbors and Ecologists. What would the installation be like? The plant is called San Gregorio I and, As needed The countryI would occupy about three hectares to produce 4.95 MW. It is actually part of a broader project that includes two others facilities, stadium plus i and sotoscuro i, of a size more or less similar. The key is where it is projected: The Fargue (Alquería del Fargue), an area of ​​Granada located in the district of Albaicín. In June the PSOE proposed In full paralyzing the macroplanta to “protect the landscape and cultural heritage of the city”, especially the surroundings of the Alhambra and the Darro valley, considered a good of cultural interest (BIC) Since 2024. It is not the only one. Neighbors and Ecologists in Action also mislead the impact that the project would have in the area. What has Icomos said? That criticisms are more than founded. In your report the agency concludes that the photovoltaic plant entails “a very high risk of negative impact” for the surroundings of the Alhambra, the Generalife and the Albaicín, a set including on the UNESCO heritage list. Hence, their authors “strongly advise the stoppage of the planned actions” and give a small touch of attention to the Spanish authorities, to which they warn that they must be “much more vigilant and careful” in the face of projects that affect the protected heritage. How would the plant affect? It depends on what we are talking about exactly. The effect would not be the same in all cases. If we focus on the Alhambra, Generalife and Albaicín the problem is the visual impact. “The Alhambra is more than the fortified monumental complex. The Alhambra territory includes the general’s past Point out in The country José Castillo Ruiz, professor at the University of Granada (UGR). Is it so serious? “The visual impact of an industrial element like this goes much further than a simple discordant element (…). They seriously alter the heritage values ​​of the Alhambra as a historical set, monument and world heritage,” insists The expert, who warns of the loss of centenary olive trees or the alteration of the environment, breaking “continuity” between the Alhambra, the city of Granada, the Valley and the rest of the environment. If we speak specifically of the Valle del Darro the report, in fact warns of a clear environmental impact. Things are very different for project promoters, which They assure that the final affectation will be “minimal” and already contemplate incorporating “corrective measures.” Does it say anything else? Yes. The report remember That San Gregorio I is only one of the three photovoltaic plants that you want to boost in the area, so it slides that its promoter seeks avoid An environmental impact statement (DIA). In total the three photovoltaic plants will approach (although staying below) of the ten hectares that would require activating that procedure. As for processing, icomos insists in which it does not arrive with opening a public exposure process “without effective advertising”. The ideal is to find a way to guarantee “a public participation” during the process, a “real nature”. Why is it important? The controversy around the plant It is not new. A months ago environmentalists and neighbors They already warned of their impact on the territory, the olive groves and holm oaks, biodiversity and even spoke of “disorder and speculation.” The Icomos report is relevant because it has fueled the debate and oxygen to critics, For whom The document “Raises Project death certificate”. Right now its promoters They are pending of construction permits (in which the City Council plays a key role) and the resolution of allegations. Their critics rely on the ICOMOS document for claim That the Alhambra Board or the rest of the institutions move token, which goes even to transfer their complaints to UNESCO itself. Images | Wikipedia (Jebulon) and Sharon Mollerus (Flickr) In Xataka | Mediterranean countries seemed ideal for solar panels. Until the dust storms arrived

The new strategy against Alzheimer’s is not to attack, but to ‘reprogram’ the brain to clean itself

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Alzheimer’s can be resemble a great fortress with a large number of defenses that makes it very difficult for us. One of its most formidable defenses is blood brain barriera biological wall that protects the brain from harmful substances, but, ironically, also prevents the entry of most drugs. In Alzheimer’s patients, this barrier not only blocks help, but also becomes an accomplice to the disease. But we have already found a way to access and attack this pathology. The investigation. A team of scientists has been able to develop a radically new strategy to treat Alzheimer’s. Instead of trying to force entry into the brain, they have created smart nanocapsules that “reprogram” the barrier itself to do its job again: actively cleaning up toxic waste. Something that they have already tested in mice, and they have given spectacular results: a reduction of almost 45% of the amyloid load in just two hours and a cognitive recovery that was maintained for six months. The problem. In order to understand this advance, we must know exactly how ‘access’ to our brain works. The blood-brain barrier (BBB) ​​functions as an incredibly strict customs checkpoint. Like any border, it must have an entry and exit gate and in this case it is the LRP1 receiver. In the case of a healthy brain, LRP1 will be responsible for capturing beta-amyloid proteins and transporting them out of the brain for elimination. But in the case of a brain that is already old, and more markedly in Alzheimer’s, the amount of these LRP1 receptors is reduced, causing beta-amyloid to end up accumulating in our neurons, causing this disease to begin to show signs of presence. The discovery. In this case, the research team discovered that the fate of the LRP1 receptor depends on how it interacts with the molecules that bind to it. This is where the concept of “greedy,” or total bonding strength, comes into play. Very strong union. If a molecule clings too tightly to LRP1 (as beta-amyloid aggregates do in Alzheimer’s), the receptor activates an emergency pathway that sends it directly to be destroyed in the cellular “dumping ground” that is the lysosomes. This makes the problem even worse, as it eliminates the few exit doors left in the brain to take out the ‘garbage’. Moderate union. Or average greed. If the binding is “just right,” the receptor activates a non-destructive express transport pathway (the PACSIN2 pathway). This pathway creates a kind of tubular tunnel that transports cargo through the barrier quickly and safely, preserving the LRP1 receptor so it can continue working. In fact, this pathway even promotes the expression of more LRP1 receptors, which is what interests us most in this situation. The result. Based on this principle, the researchers designed nanocapsules called “polymersomes” (A₄₀-POs). They are tiny spheres decorated with a very specific number of “keys” (angiopep-2 ligands) on their surface. The number of these keys was calculated to achieve that perfect “medium greed”, with the aim of achieving the result similar to that of a moderate union. Results. When they administered these nanocapsules to model mice with advanced Alzheimer’s, the effects were surprising. A massive brain cleanse was achieved in just two hours, causing beta-amyloid protein levels in the mice’s brains to be reduced by 45%. In order to confirm that the protein was not just moving from place to place, its blood levels were measured. The result was an 8-fold increase, which shows that the blood-brain barrier was expelling the ‘waste’. The tests. In order to see the result in practice, behavioral tests such as the Morris water maze were carried out. Here treated Alzheimer’s mice showed significant improvement in spatial learning and memory. In this case, their performance became comparable to healthy mice without the disease. Most strikingly, these cognitive benefits persisted for up to six months after a single course of treatment, suggesting a long-term restorative effect. More than a drug. This work represents a paradigm shift. Most therapeutic strategies for Alzheimer’s treat the blood-brain barrier as an obstacle to overcome. This new approach treats it as a dysfunctional biological system that can be repaired by adding more exit doors for the organism to maintain this homeostasis. By using these nanocapsules with the “perfect keychain”, not only is the existing beta-amyloid removed, but the brain’s natural cleaning mechanism is reactivated. The treatment was able to restore levels of LRP1 and the beneficial transport pathway (PACSIN2) while reducing the destructive pathway. In essence, nanocapsules are not the drug itself, but a tool to reprogram the biology of the brain so that it heals itself. Although the results have been obtained in mouse models and the path to human trials is long and complex, this research opens a completely new and hopeful therapeutic avenue. The idea of ​​”repairing the barrier instead of just breaking it down” could be the key not only to Alzheimer’s, but also to other neurodegenerative diseases where transport and brain clearance play a key role. Images | Bhautik Patel In Xataka | We have a new “theory of everything” to understand Alzheimer’s. Its key is in some small granules

From Europe its “welfare state” was envied. But it is increasingly difficult to pay, and France is the best example

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Europa presumed for decades of having found the perfect formula to combine economic prosperity with social justice: hospitals open to all, affordable universities and worthy retirements after a work life. That pact between generations, envied on the other side of the Atlantic, became the identity mark of the continent. And yet They begin to become visible. And one of its banners wobbles: France. A price too high. I told this week The Washington Post. Europe lives a historical crossroads: the social model that guaranteed universal health, accessible education and decent retirements begins to show cracks that can no longer be hidden. France It is the epicenter of that tension. There, the runaled public debt, political paralysis and succession of Fallen prime ministers In just fifteen months they show deep wear. The State Spend more than any other country rich in social protection, but that expense seems unsustainable in a context of low growth and growing polarization. The recent resignation From Prime Minister Sébastien Lecornu, unable to agre as inalienable. Model under generational pressure. There are more, since, in France, new generations feel that they inherit a system that they cannot sustain. He Post counted Cases of young people such as Anastasia Blay, who depend on intermittent subsidies to survive, convinced that they should not load with the mistakes of the past or give up a decent life. In front of them, retirees like Christine Boucau-Podorski They defend The pensions achieved after decades of hard work and are willing to limited sacrifices, but not losing acquired rights. This struggle between young and old reflects the intergenerational shock that crosses To all of Europe: Who pays the invoice, what benefits should be preserved and to what extent intergenerational solidarity can continue to be the base of the European social contract. Germany and France Wobm up. Fragility is not limited to France. Germany, the other great Historical support of the European Union, faces industrial recessiondeterioration of infrastructure and a government that admits since “the current system is unassumable.” Political tensions are intense, with the social democratic opposition refusing to accept drastic cuts and the extreme right by capitalizing citizen discomfort. Meanwhile, the Ultras games grow On both sides of the rhine fed by social disenchantment and the feeling of stagnation. The paradox is that Italy or Spainonce considered weak links, they exhibit today greater stability macroeconomic than European locomotives. The center, formerly balancing, has become the area of ​​greatest uncertainty, which weakens the European project at a time of growing external threats. The southern paradox. It is quite striking that countries historically seen as fragile, such as Spain and Italy, today appear (either They seem) as relatively more stable. Italy, after decades of political instability, lives its strongest period with a controversial government that has even achieved An improvement of the credit rating. Spain, meanwhile, has reduced by half unemployment in the last decade and maintains growth above the European average, despite spend less on well -being than France or Germany. This roles investment shows to what extent the clichés of the southern Europe have been exceeded: the Mediterranean nations, previously accused of fiscal laxity, seem to have learned to navigate austerity, while “the rich north” It sinks in its own budgetary rigidity. The perfect storm. The challenge is aggravated by external factors that multiply internal pressures. The Russian Invasion of Ukraine pushes to increase the defense expensejust when public coffers They are already exhausted. China Compete fiercely With European industry, from electric cars to nuclear energy, eroding the international position of German and French manufactures. And the United States, far from offering security, Add uncertainty with a president who changes position in a matter of days and threatens tariffs to his own allies. Europe must decide If prioritize shield Your welfare state, to reorient resources towards military security or find a balance that does not sacrifice either global competitiveness or social cohesion. The great unknown. Experts Like Andreas Eisl They argue that the dilemma is first of all politician: it is not if Europe can maintain its social model, but to what extent it wants to do it and what sacrifices is willing to assume. Attempts to apply cuts, such as 44,000 million euros proposed in the budget that demolished Prime Minister François Bayrou, have caused A massive rejection on the street and fed polarization. However, mathematics is relentless: with a aging populationa Birth in Declive and one Increasing resistance To immigration, the fiscal base narrows while the needs increase. Europe may not be on the verge of a Greek collapse, or it does not seem, but the sustainability of its “way of life” indicates that it has ceased to be An unquestionable dogma. And that is, perhaps, the true battle of the future: if the old continent manages to reinvent his social contract without dynamiting him in the process. Image | Pexels, Martin Greslou In Xataka | Spain has a big problem with the generational relief of the labor market: 3.5 million young workers are missing In Xataka | Birth in Poland is a disaster and hotels have had an idea: money for those who conceive in a stay

the five best board games to play with someone in October

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Although we often focus on the cell phones, watches, headphones and other devices When Amazon launches its campaigns, there are also many offers on other topics further away from technology. That is why today we wanted to bring together a series of board games to encourage entertainment during the month of Octoberespecially in the run-up to Halloween. Of course, all games are on sale at the Prime Deal Party. Zombie Burrito by 20.49 eurosa game in which players throw themselves into burritos. Marvel Zombies by 84.69 eurosa game that brings together some of Marvel’s most memorable characters, whether or not they have become zombies. Nightmare before Christmas by 28.89 eurosa game in which we can embody our favorite character from the movie. Zombie Kittens by 14.99 eurosa zombie version of the iconic card game. Alien: the fate of Nostromo by 34.99 eurosa cooperative game in which we must survive the stalking of the xenomorph. Zombie Burrito There are games that offer a more active proposal when it comes to facing other players and here Throw Throw Burrito has a lot to say. Your version Zombie burritowhich on Amazon has a price of 20.49 eurosvaries in mechanics, but always with the goal in mind of using the burritos to compete against other players. The objective is to form teams, collect cards in each round and If it’s time for battle… let’s throw the donkey. This version is completely themed, so we can find variations in its cards with respect to the original game. There are antidote cards, survivor cards, zombie cards and, of course, battle cards. The idea is to form teams between zombies and survivors. It is a game for three to six players in which the fun lies in the card that allows the donkey to be used. They are made of foam and are very soft, but I recommend that you clear the table and, above all, that don’t play next to a television. For what may happen. The price could vary. We earn commission from these links Marvel Zombies After the first season of ‘What would happen if…?‘ on Disney+, a game arrived that adapted both one of its episodes and the comics themselves. ‘Marvel Zombies‘ is a series that has just been released, so it is a good time to delve into the board game which now has a price of 84.69 eurosespecially during the month of October and especially on Halloween. Marvel Zombies It is a game that is based on Zombicide and its objective is not exactly to kill zombies, but to kill humans. In this version we have to face both SHIELD and the superheroes who are still human. Yes, we really are the zombies. The more missions and objectives we complete, the more points we will receive. But the more points we have, the more they will try to hunt us down. It is a game for one to six players and some of Marvel’s most iconic characters appear. There are also many expansions, which gives more dynamism to each game if we decide to opt for them. The price could vary. We earn commission from these links Nightmare before Christmas Whether it’s Halloween or Christmas, it’s always good to see ‘Nightmare before Christmas‘. The film directed by Henry Selick and produced by Tim Burton has its own board game and now has a price on Amazon of 28.89 euros. It is a game with games for two to six players in which we must take charge of our favorite character. Each of them has their own deck of cards and the goal is to get all the party tokens we can. Nightmare before Christmas The price could vary. We earn commission from these links Zombie Kittens Exploding Kittens It has so many editions that it is difficult to keep track of them. And how could it be otherwise, it also has a zombie version for 14.99 euros. Zombie Kittens It leads us to play games in which if we get the Exploding Kitten card, we die, but we don’t lose. We can rise from the dead with the Zombie Kitten card to take revenge. The last player left alive wins, but it is not easy at all. It includes many action cards, games can be played with two to five players and can be enjoyed with or without other expansions. Exploding Kittens | Zombie Kittens | Card Game for Cat and Explosion Lovers| From 7 Years | From 2 to 5 Players | 15 Minutes per Game | Spanish The price could vary. We earn commission from these links Alien: the fate of Nostromo Alien is such a long-running saga that it is not surprising that it has its own board game. Under the name of Alien: the fate of the Nostromothis game that has a price of 34.99 euros takes us on a tour of the iconic ship of ‘Alien, the eighth passenger‘, the first film released in 1979. It is a cooperative strategy game in which we must solve missions, collect objects and make tools to survive while avoiding the xenomorph. Each game can be played by one to five players. Alien: the fate of Nostromo The price could vary. We earn commission from these links Some of the links in this article are affiliated and may provide a benefit to Xataka. In case of non-availability, offers may vary. Images | Exploding Kittens, CMON, Mixlore, Ravensburger In Xataka | The 41 Best Board Games: From ‘Catan’ to ‘Gloomhaven’ In Xataka | These are the board games that are never missing in my suitcase when I go on vacation with my partner

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