Japan has been cloning the same mouse continuously for 20 years. In the 58th generation, biology has said “enough”

When we talk about cloning living beings, many of us may think of the famous experiment. with Dolly the sheep. But he was not the only one, since in Japan a biologist has spent the last two decades taking life to its most extreme limit, since since 2005 his team has set itself a major challenge: serially cloning mice from a single original female donor. 20 years and more than 1,000 mice later, the experiment has collided with biology. A collapse. The results of this great cloning experiment were published recently in Nature and reveal the definitive collapse of the genetic line in generation number 58. A very important finding that not only demonstrates that the continued asexual reproduction of mammals is unsustainable, but also shows us why evolution opted so strongly for sexual reproduction and the constant renewal of DNA in our species. His story. The experiment by Japanese researcher Wakayama is a milestone in reproductive biology. In 2013, the team had already managed to clone up to 25 generations, as was then published in Cell Stem Cell; yesHowever, what seemed like a theoretically infinite process began to show serious cracks from generation 25-27. As the generations progressed, birth rates began to plummet, to the point where we are now, where he points out in his latest article that the incessant accumulation of genetic mutations was a constant. Here it was seen how the animals began to have serious genetic alterations with complete losses of chromosomes with a probability three times higher than natural sexual reproduction. Its consequences. That an animal sees its genetic material altered is not harmless, because these alterations were seen to directly affect embryonic development and the placenta, making each new generation more difficult to obtain than the previous one. But the critical point came in generation 58 of the mice, where the model finally collapsed. And the culprit of this collapse was none other than these genetic alterations, which curiously did not alter the physique of the individuals, who seemed completely healthy, but the weight of the genetic damage made it impossible to continue the chain. The impressions. From the Spanish countryside, Lluís Montoliu, CSIC researcher, has qualified this “heroic” experiment, since it suggests that this test would be impossible to do in Europe due to ethical standards and animal welfare that exist. But he sees it as important, since it proves the evolutionary superiority of sexual reproduction. The other side of the coin. Big questions arise here, since if serial cloning fails due to DNA fragmentation and damage… How is biology protected when it uses sexual reproduction? Here the answer is to have a constant renewal of the interior of our cells. Paradoxically, while science shows that copying the same DNA over and over again leads to genetic disaster, new clinical studies on human fertility are revealing that, to maintain the highest quality in male genetic material, frequent renewal is key. But in addition, it also makes it clear that we are still quite far from being able to clone humans to have two identical people, because in the end it is something that can go really wrong. Images | digitale.de In Xataka | A team of experts wants to resurrect extinct bison. There are many reasons to be skeptical

In 1967, a war veteran believed that moving around a computer could be easier. So he created the first mouse

Things were clear from minute one. When Douglas Engelbarthead of the Augmentation Research Center (ARC), at Stanford, wanted to interview a new recruit, gave him a pencil attached to a brick and then asked him to write his name on a piece of paper. Difficult, right?, joked Engelbart, a doctor in electrical engineering and a pioneer in computer development. Well, people would encounter the same problems, he explained to the candidates, if they were not able to offer them more agile and simple tools to use computers. He wasn’t talking just to talk. Engelbart, together with one of his colleagues, also an engineer William Englishwas the father of the first mouse computer in the 1960s. Only that one was not called a mouse, but XY Position Indicator for a Display System; and its design was quite different from the modern peripherals that we use today. To begin with, it was made of wood and had a pair of metal wheels. This is your story. Make it easy for people: “Click” In the early 1960s, Engelbart, a World War II veteran, recent PhD and with just a couple of years of experience at the Stanford Research Institute —today known as SRI— had a clear idea: he wanted accessible technology. And simple. In 1945, while serving in the US Navy, he had read an article by the inventor Vannevar Bush who encouraged scientists to bring knowledge to the streets and he was determined to transfer that slogan to his own field. The golden opportunity came when the Department of Defense, through DARPAgave him the necessary support to set up his own center in the SRI, the ARC. There he had nearly fifty people working for him and efforts were focused on answering a question: What would the future of computer communication be like? At that time, computing had been in development for decades; IBM had manufactured the IBM 650 and the team was convinced of the enormous potential of the sector. The question was how to use it and prevent the systems from being as unwieldy as a pencil stuck to a brick. At that time the most popular devices for pointing on a screen were optical pencilsa system similar to that used in military radars. Since 1961 Engelbart, however, ruminated on an alternative. To make interaction with computers more efficient: install a pair of small wheels across a table so that the user could operate the screen cursor with them. One would rotate horizontally and the other vertically and its operation would be very similar to that of the planimeter commonly used by surveyors, geographers and architects. The idea had been recorded in his notebook, but already in the 1960s, with the financial backing of DARPA, his own team and extra help from NASAEngelbart was able to delve into it. The veteran and his colleagues gathered the best signaling equipment that existed and made a kind of brainstorming which left half a dozen proposals for working with monitors, some of the most curious, such as a joystick or a light pen. Perhaps the most striking of all was a mechanism that was fixed under the table and operated with the knee. A prototype nicknamed “mouse” Also included among that amalgam was a small device manufactured by Bill English after reviewing his notes from the beginning of the decade with Engelbart. The prototype basically consisted of a carved redwood block which included two wheels crimped at the bottom and a button at the top. Your name: XY Position Indicator for a Display System. Its appearance, compact and with a cable protruding, However, it ended up earning him the nickname “mouse.”. It was so comfortable that it prevailed over the rest of the laboratory’s alternatives and the team included it as a standard piece in their research. The SRI applied for the mouse patent in 1967 and received it in 1970. Engelbart and his companions did not stop there. They continued looking for a “companion” for the mouse, another device that the user could operate with their free hand and could use to enter commands and text. After several tests they opted for a device similar to a telephone with five keys. They also carried out tests to perfect the mouse design as much as possible. “We did a lot of experiments to see how many buttons it should have. We tried up to five. We decided on three. That’s all we could fit in. Now, the three-button mouse has become standard, except for the Mac,” Engelbart himself recalled in 2004, in an interview with Wired. With all this material and the rest of the inventions developed by his team, the war veteran decided to put on a gala performance. One like a beast. In 1968 they organized known as “mother of all demos”a historic conference held in San Francisco in which Engelbart showed all the functions they had developed over the last few years. “For 90 minutes, the stunned audience of more than a thousand professionals witnessed many of the features of modern computing for the first time: live video conferencing, document sharing, word processing, windows, and a strange pointing device jokingly referred to as “the mouse“The elements of the screen were linked to others through associative links or hypertexts,” explains the Computer History Museum. “People were amazed. In one hour, it defined the era of modern computing,” English commented to New York Times in 1996. Shortly after that historic achievement, however, the team began to lose its drive. Some staff questioned the lab’s drift, DARPA cut its funding, and other research centers began to emerge, such as the Xerox in Palo Alto (PARC). Result? Many of Engelbart’s employees sought new destinations. With them went the very concept of the mouse. The device, with a trackball, ended up being incorporated into the Xerox Alto computer and in 1983 Apple marketed it with its computer Lisa. After a while –as you remember Washington Post— Steve Jobs’ company was behind almost half of … Read more

It has Windows, it is light and it already comes with a mouse

HP has presented at CES 2026 in Las Vegas a product that tells us a lot about the trend toward miniaturization in technology. The product in question is the EliteBoard G1a, a computer that is integrated into a keyboard. Best of all, we are not talking about a futuristic concept or a prototype, but rather a functional device that the company will launch on the market in March of this year. A complete PC in keyboard format The EliteBoard G1a looks like a conventional office keyboard, but inside it houses all the components necessary to function as a personal computer: processor AMD Ryzen AI of the 300 series, RAM memory, storage, fan, stereo speakers and connection ports. Simply connect it to a monitor using USB-Cturn on the included and factory-paired Bluetooth mouse, and the device is ready to go. The idea of ​​integrating a computer into a keyboard it’s not completely new. He Commodore 64 popularized this format in the 80s, and more recently Raspberry Pi has marketed models such as the Pi 400 and the Pi 500although the latter are aimed at a more technical audience and work with Linux operating systems. The main difference of the EliteBoard compared to these alternatives is that HP is committed to Windows 11 Pro for business and more powerful x86 processorsmaking it a more accessible and familiar option for professional environments that do not require advanced technical knowledge. Configuration and specifications HP will offer the EliteBoard G1a in two versions: one with a fixed USB-C cable and another with a detachable cable. The first includes an additional USB4 port as compensation. Furthermore, both variants can power up to four 4K monitors at 60 Hz. In terms of processor options, users will be able to choose between models ranging from the Ryzen AI 5 350 to the Ryzen AI 7 370 Pro. The integrated NPU reaches up to 50 TOPS, which classifies the device as Copilot+ PC within the Microsoft program. The device supports configurations with up to 64 GB of DDR5 RAM in two SODIMM slots and up to 2TB of M.2 NVMe storage. Additionally, HP includes a 35 Wh internal battery as an option, which the company says provides around 3.5 hours of battery life. A fingerprint reader can also be added to expand login options. Design designed for mobility With a thickness of just 12 mm and a weight that ranges between 726 and 750 grams Depending on configuration, the EliteBoard G1a is significantly lighter and more compact than a traditional laptop. The keys have 2mm of travel, and HP claims the typing experience is “tuned for desktop space.” According to the company, the keyboard is spill-resistant and its modular design allows you to replace the top part in a few minutes. The bottom panel is removable for easy access to the cooling fan and other internal components. Who is it intended for? HP presents this product as a solution for hybrid work environments and shared spaces where employees do not have a fixed position assigned. The idea is to offer an ultra-portable device that can be quickly set up anywhere. “Work is being redesigned in real time: where it happens, how it happens, and what tools employees need to stay productive,” affirms Guayente Sanmartin, senior vice president of Business Systems and Display Solutions at HP. The company also argues that many workers use their laptops with the lid closed connected to external monitors. If you are a user who is going to have an external screen permanently connected, the truth is that it is a more than convenient solution in the use cases described. Price and availability The HP EliteBoard G1a will be launched in March 2026although the company has not yet confirmed the official price. We will have to wait to find out more information about it. Images | H.P. In Xataka | The computers of the future have found an unexpected ally to store information: fungi

I have already tried the ‘mouse’ mode of Nintendo Switch 2. Open a door so far closed on consoles

In 2017, the First Nintendo Switch He arrived to revolutionize the way of playing. He did it with his concept of hybrid console, but also thanks to some controls that have established themselves as more versatile controls. It was something they had to maintain with Nintendo Switch 2and with the first trailer of the console, we saw that they could have given a twist to the controls. As? Turning the joy-with a mouse. Like those of a lifelong computer. This is not a tremendously new. In fact, Lenovo Legion Goa Consolidated PC That he drinks a lot of Nintendo Switch, he already had a way to turn his right command into a mouse thanks to an optical sensor. With Windows as an operating system, compatibility was total, but the doubt was to what extent the Nintendo Switch 2 mouse mode would be useful. After playing a few hours with the joy-with mouse, I have to tell you that they work really well and makes sense for certain gamesbut for Shooters, which are perhaps ideals for a mouse, it doesn’t convince me so much. And it will also depend a lot on the endurance of your hands. Turning the Joy-Con Nintendo Switch 2 is not a machine to do experiments. The 152 million switch soldand going up, they are a reflection that the company has achieved a product that people liked. They don’t need something groundbreaking As switch or Wii in your day, but a continuous console. But within that line, it is interesting to see that they have tried to take a step further apart from with power improvement. In the First Nintendo Switch 2 impressions After a day trying it I have already told that I like that the joy-with are larger, because it is easier to control games like ‘Doom‘ either ‘Wolfenstein‘With the sticks and fit better in the palm of the hand. And apart from size, a change comes with optical technology. In the area that joins the Joy-Con with the console, Nintendo has added an optical sensor that basically converts each command into a mouse. There are games that will be controlled with the two Joy-Con in this way, but I think the best uses will be those that convert Switch 2 into a kind of desktop PC. Image | Xataka And you don’t have to make strange configurations or anything to go from the wireless joy-with the joy-with mouse: the screen decouplas, you put it in a “vertical” position, supporting that sensor on a surface, and if you have previously configured it when configuring the console, a pointer appears automatically on the screen. Image | Xataka And ready, it’s like a mouse, with triggers serving as choice buttons. In the console box comes an addition that is an coupling for that area. The joy-with works as a mouse without it, but in this way you have a somewhat more slippery base, you protect the song of the joy-with of any element that is on the table and it may be suggestion, but I think it slides better. Good Gimmick technological or something useful? Let’s see it And the sensations playing with the Switch 2 mouse Launching, there are several games who take advantage of this mouse function. One is ‘Welcomo Tour’ that “minigame” (of 10 euros) that serves to know the entrails and characteristics of the console. There are some mini -games that allow us to explore that control mode and it is curious, but it does not happen. ‘Civilization VII‘It is also compatible With this way, but I could not try it. The one I have played (in any of its modes) is’Cyberpunk 2077‘. When we first executed it, the game tells us that it allows us to play in several ways. It is one of the most generous in this regard because it takes advantage of the accelerometer of the Joy-Con, in the mouse mode and the touch screen (well by CD Projakt there), and it really is the one that allows me to imagine what it will be like to play ‘Metroid Prime 4‘In this way. By default, the game control is through the ‘normal’ command, but in the configuration section, we can select that mouse mode. There are several configurations that we can do to play more comfortable in this regard and I have to say one thing: the sensor that Nintendo has placed in the Joy-with seems very good to me. Image | Xataka On a completely, flat surface, the answer is great, but on the couch, it works very well when sliding on the furniture fabric. With fine cloth shorts it is not going so well because the fabric wrinkles, but in jeans they are also quite precise. That is, if you play in the living room, you don’t have to look for a table or a flat surface: the control is necessary in another type of surface. The left joy-with (because I am right-handed, but having a sensor in both, left-handed ones can also play perfectly) serves to move the character and point, while the right controls the trigger of the weapon, ABXY buttons still have their predetermined actions And the right stick is a scroll bar. And, as I say, you play well: something straight at the beginning because the triggers are very sensitive and you can throw a grenade easily, it happened to me, but you get used to easy. Now, there is an ergonomics problem. In a conventional mouse (in a good one), the manufacturer has bothered to study anatomy to launch a device that can adapt to many arches differently. My partner John Tones already commented After trying switch a few weeks ago. Image | Xataka That does not happen in this case and the 20 minutes was already fatigued. In addition, as they continue to ask you to press buttons of that command for actions such as jumping, selecting or speaking, You always have the arched thumb of moreforcing a position that, … Read more

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