“Exercise tells the muscles to cleanse and reset”
The effects of physical exercise for older people They are more than proven. It helps them improve their cardiovascular health, improves mobility, reduces fractures and, in general, provides a long list of benefits. It is good at all stages of life, but when we get older it becomes essential. However, as well studied as this is, until recently it was unclear why it is so beneficial. Knowing the reason is necessary, as it can help squeeze those advantages even more. Now, a team of scientists from Duke-NUS Medical School, in collaboration with Cardiff University and Singapore General Hospital, has taken a big step in this directionby discovering the molecular pathways that cause both the deterioration of muscle health in advanced ages and the benefits of physical exercise for older people. Molecular pathways that suffer. This study is supported by previous research, which already pointed to the possible involvement of the mTORC1 pathway, involved in the regulation of the synthesis and elimination of muscle proteins. This pathway must maintain a balance between the synthesis of new proteins and the elimination of those that are damaged. However, it has been seen that, as we get older, this pathway becomes deregulated, tipping the balance towards the synthesis of new proteins. Damaged proteins that should normally be removed accumulate, causing stress on muscle cells and leading to a progressive loss of strength. This pathway, in turn, is regulated by another, called DEAF 1. As these scientists have seen, when its activity increases, the expression of genes in the mTORC1 pathway increases, causing this imbalance towards protein synthesis. Furthermore, what these scientists saw in experiments with fruit flies and mice is that the activity of DEAF 1 is regulated by the activity of a group of proteins that also exist in humans: FOXOs. They keep them in line. The problem is that FOXO activity decreases with age, giving free rein to DEAF 1 and, with it, an imbalance in the synthesis and elimination of muscle proteins. The role of physical exercise in older people. In their study, these scientists have seen that physical exercise reactivates FOXOs proteins. Therefore, physical exercise in older people aid to maintain balance in the synthesis and elimination of muscle proteins, improving muscle mass and increasing the benefits associated with it. Also stem cells. DEAF 1 does not influence muscles only by deregulating protein synthesis and elimination. It is also related to the synthesis of muscle stem cells. This normally decreases with age. Therefore, finding ways to maintain good activity levels is key. Physical exercise in older people also helps in that sense. It is not the same for everyone. In their study, these scientists have seen that, unfortunately, physical exercise does not always seem to be a good tool alone. There are people for whom it is enough, while others must resort to additional strategies to improve their health. This is the path through which they must continue studying. Not just for seniors. This study is not only aimed at studying the benefits of physical exercise in older people. Its authors believe that it can also be useful for patients who have lost muscle mass due to recovering from surgery, a fall, or diseases such as cancer. Be that as it may, the initial key is to understand the mechanisms that reduce the muscle health of older people. According to one of the authors of the studyPriscillia Choy Sze Mun, “physical exercise tells the muscles to cleanse and reset.” Logically, we will have to study more. To begin with, it would be necessary to verify that, no matter how much the mechanisms are shared, what has been seen in mice can be extrapolated to humans. If so, we would have key knowledge to improve physical exercise programs for older people. Knowledge is power and, in science, knowing the whys of things is very powerful. Images | Magnificent In Xataka | In the fever to train strength, the gym has faced competition: more and more people train on the street