“Exercise cannot be optional for those taking Ozempic”

The classic and generally effective recipe for losing weight is summarized in two combined measures: taking care of your diet and increasing physical exercise to tip the calorie balance until it becomes negative. That is the canonical formula, but the arrival of drugs like Ozempic, wegovy o Mounjaro has turned it upside down. So much so that we are even giving up those basics. Thus, a paradoxical fact occurs: there are people losing weight (with Ozempic and similar) and exercising less. This indicates the breakdown of a healthy metabolic virtuous circle: losing weight invites us to move more, which in turn promotes weight loss. Thinner. Less athletes. a study presented at the prestigious annual meeting of the Endocrine Society (ENDO 2026) evidence that adults with obesity who lost weight with GLP-1 receptor agonist drugs have significantly reduced their physical activity. That is, after losing weight they exercise less. More specifically: when analyzing 753 patients with obesity and the data from their respective activity bracelets, it was discovered that daily steps fell from 5,047 to 4,487 (560 fewer steps) and the time of moderate or intense exercise fell from 27.9 to 22.2 minutes per day. Those who reduced their activity the most were men and those people with joint or muscle pain. Why is it important. Because these Ozempic-type drugs are not limited to reducing body fat, but can also contribute to losing lean muscle mass: a body composition analysis of the STEP 1 trial points out that weight loss with semaglutide corresponds to a reduction in lean mass of up to 40% of the total weight lost. That is why physical activity is essential to maintain strength and general health. If these people move less, the problem worsens. From a public health perspective, the need to offer explicit exercise prescription to the millions of people who take these drugs is imperative. As explains Dr. Sajana Maharjanlead author of the study: “The findings of our study reinforce the idea that exercise cannot be optional for people taking these medications. Specific interventions that encourage physical activity along with obesity medication are needed.” Context. GLP-1 receptor agonist drugs act in the brain by reducing the feeling of hunger and, as a consequence, caloric intake. What was not clear until now is its effect on the desire to move. There is previous animal studies who had already suggested that GLP-1 can reduce locomotor activity by acting on the dopaminergic reward system, for example, in micebut this work transfers it to humans with real information. Until now, studies on physical activity in patients treated with Ozempic and similar drugs have used questionnaires that people fill out alone, which opens the door to overestimation of actual exercise. However, for this work They have combined real data from Fitbit with the NIH All of Us program. In detail. Of the 1,950 patients who started treatment, only 753 had sufficient fitness tracker data for analysis. The sample presented a relevant heterogeneous case mix: 81.9% had musculoskeletal pain, 67.3% had hypertension and 48.1% had type 2 diabetes, which adds an important bias since they are complex patients with reasons to move little, with or without the drug. 560 fewer steps may not seem like much compared to the recommended daily total (friendly reminder: They are not the mythical 10,000 steps) of the WHO, but it has its importance: if the minimum ideal around 7,000 – 8,000 steps daily to obtain cardiovascular benefit and these patients are already below, any additional reduction takes them even further away from the minimum health goals. Yes, but. The study has some important limitations. To begin with, there is no control group (obese patients who did not take this type of drug), so although this is an important clue, it cannot be said with certainty that the drop in activity is caused by the drug and not another factor. Besides, the sample is heavily biased towards women (almost 8 out of 10) and towards people who already used Fitbit regularly, who do not represent all patients with obesity. In Xataka | Ozempic’s great challenge is the rebound effect. Science already has two promising solutions to avoid it In Xataka | We thought Ozempic was only for weight loss. Science is seeing that it can end alcoholism Cover | Flickr and Gabin Vallet

There are those who want the V-16 beacon to be optional. The director of the DGT has a message: “There is no going back”

126 days. That is how long the V-16 beacon has been mandatory in our country. A period in which, due to the DGT’s own unclear information, it is not clear whether the agents are fining or not for not having it in the car. What is certain is that there are still those who doubt its effectiveness and try to get the triangles to return. For them, Pere Navarro has a message. “There is no mark behind”. The statements are from Pere Navarro, director of the DGT, who in the forum Pedestrians and road safety organized in A Coruña and in which the city council and the Galician Federation of Municipalities and Provinces have participated has assured the following collected by Motorpassion: “(The beacon) is here to stay, there is no going back. It is an important safety element and is mandatory. And it also serves to avoid accidents” The director of the DGT has thus tried to settle a controversy that continues to rage despite the fact that since last January 1 This signaling element is mandatory, replacing the classic emergency triangles. Because? Pere Navarro’s response obeys the amendment that Vox has registered in Congress to try to reverse the use of the connected V-16 beacon. Or, at least, significantly modify its use. The intention of the political group is that the V-16 beacon is only an optional addition to the emergency triangles but that the latter are the ones that are really mandatory. Vox also searches end connectivity of the device, a focus of controversy despite the fact that the signaling object cannot be identified with the driver who activates it. “Everything is advantages”. For his part, Navarro is clear about it and has made it known in the forum: “everything is an advantage.” In words collected by elDiario.eyesthe director of the DGT defends that not getting out of the car in the event of a breakdown before signaling the danger is a step forward. Let us remember that From 2023 it is mandatory to stay in the car in the event of a breakdown unless the driver and passengers have access to a safe place to wait for emergency or help services. Navarro has also pointed out that “we should be proud” of the use of the beacon, after the European Commission confirmed that it is an object fully in line with European law although at first it was doubted how it was implemented. Surrounded by controversy. Since the connected V-16 beacon project was launched, the DGT has had to face all kinds of controversies. Various associations have questioned its effectivenessproducts were sold that have been invalidated by lack connectivity and along the way we have seen it flourish a very lucrative business to companies based in China. Furthermore, it is also not clear whether an agent would fine us or not if we do not have it. In a press conference, the Minister of the Interior Fernando Grande-Marlaska pointed out that was not going to be fined for a “reasonable” period of time but it was never determined what time window that definition includes. However, we know that just a few days after the new signaling system became mandatory there were already agents who fined the drivers. In Xataka | “We have not done it well”: the DGT assumes that something has failed in the arrival of the V-16 beacons

The latest Stranger Things deepfake is so amazing that it shows that reality is beginning to be optional

This week, a Brazilian content creator named ederxavier3d published an amazing video on his Instagram account. In it they appeared several of the protagonists of the series ‘Stranger Things’ making just the gestures and expressions that he made in the lower window. He explained that he had achieved it in a simple way and thanks to the new Kling 2.6 and its characteristic Motion Control. This option allows the movements we make in a video to be transferred to any real or fictitious person, regardless of the style in which they are represented (it can be a comic book character) with an amazing result. And in the case of the Brazilian creator’s video it can be clearly seen: these videos could perfectly pass for real in almost all cases. It is true that if you look closely you can sense that something is wrong, but only because the video has been shared making it clear that it was created with AI. This video has once again awakened a debate that has been linked to this type of deepfakes for some time. Justine Moore, partner at investment firm a16z, explained that “we are not prepared for how quickly (video) production flows are going to change with AI. Some of the latest video models have immediate implications for Hollywood. Endless character swaps at negligible costs.” How the story has changed. In April 2023 we proposed a little game to all of you who read us: Would you be able to distinguish a real image from one generated by AI? At that time, AI was already achieving remarkable results—the image of the Pope with the coat proved it—but the feeling was that we could still tell whether an image had been created with an AI or not. With the video things were even clearer.because at that time AI video generation I was in diapers. Three years later things are very different, and there are several AI platforms (I see 3, Sora 2Kling, Runway) that generate videos that anyone could easily confuse without problems. Tell Will Smith. ederxavier3d’s video also demonstrates this, and in fact something unique happened with it: there were rumors that the Stranger Things characters had actually recorded those appearances and the creator had imitated their movements, and then rumors appeared that denied that this was true and that suggested that from the beginning the videos were nothing more than what they seemed: deepfakes created with AI. A priori everything would suggest that this is the case: the Kling 2.6 feature is not at all new and other platforms allow our movements and gestures – and even our voice – to be transferred to a character generated by AI. The problem is that At this point it is almost impossible to distinguish whether that person who appears on the screen is real or not. This technology is extraordinarily striking and causes that “wow effect” that AI companies so seek, but despite the creative options it offers, the risks here seem especially notable. The identity theft It is now easier to achieve than ever, and that will probably mean that we will see many more dangerous cases. It is enough to remind the employee that transferred 25 million dollars believing that the person who told him via videoconference was his real boss. It is not clear how, for example, Hollywood studios will react to this technology, but for now some are already taking action on the matter to try to protect themselves. The best example is Matthew McConaughey, who these days has “patented himself” to have one more legal resource (which we are not sure is necessary) to protect yourself against possible videos impersonating you. The implications are enormous, and we are entering an era in which something disturbing is going to happen: We will not be able to trust what we see on a screen. In Xataka | “Hello, I’m your grandson and I need $3,000”: there are already scams on the elderly with voices generated by AI

from working 120 hours to thinking that in 20 years work will be optional

Elon Musk gained his reputation as a tireless worker when became public that his days at Tesla stretched beyond 120 hours a week and that he even slept in his office at the Austin gigafactory during the production crisis of Model 3. However, the millionaire seems to have changed his mind upon seeing the evolution of AI and has surprised the world with a futuristic vision about work: “working will be optional,” assured the richest person in the world in a recent speech at an investor forum in Saudi Arabia. From 996 to “working is optional”. Elon Musk, famous for defending 80-hour days to achieve great goals, published a message in November 2018 on his social network wrote the millionaire In an interview on the podcast ‘People by WTF’ by Nikil Kamath, Musk has changed his mind and has come to believe that, in a period of “between 10 and 20 years, work will be optional. Like a hobby” thanks to the increase in productivity promised by the evolution of AI and the progressive arrival of humanoid robots like Optimus that Tesla is developing. In his talk with Kamath, Musk compared working to growing vegetables in your own garden: “You can grow your own vegetables in your garden or you can go to the store to buy them. It’s much harder to grow your own vegetables. But some people like to grow their vegetables, and that’s fine. But it will be optional, that way, is my prediction,” said the Tesla CEO. Its formula: universal income. Musk believes that a universal income It will cover all the basic expenses of the population, eliminating the need for mandatory employment. This would allow people to live in the countryside or the city without depending on a job near an office. The businessman added: “You won’t have to be in a city for a job. If you can think of it, you can have it, that will be the future.” This vision of a population financed by a universal basic income aligns with the experiments with basic income funded by Sam Altman, former founding partner of OpenAI and Musk’s current rival. The future of AI comes together. With this change of heart regarding the workday, Elon Musk aligns himself with figures like Bill Gates, who predict that AI will automate almost everything and lead to three-day work weeks in less than a decade. Eric Yuan, CEO of Zoom, also pointed out in an interview with The New York Timesto the theory of the three-day week thanks to the increase in productivity. Jensen Huang, CEO of Nvidia, it coincided a few days ago with Musk on stage at the Saudi Arabia Investor Forum. There he agreed with the Tesla CEO’s postulate. Huang has long argued that AI will boost the four-day work week, promoting idea generation and projects beyond current capabilities. AI is a concern for Gen Z. While the predictions of technological CEOs come true, the reality is that the evolution of AI has become a serious concern for young people of generation Z who are starting your working career. The first data They already point out that some large companies are reducing hiring in entry-level positions, which were usually occupied by recent graduates. A recent survey from the Deutsche Bank Research Institute revealed that generation Z was “very concerned” about AI stealing job opportunities. As the question moves to older generations, that concern fades away. In Xataka | We still don’t have a four-day week and there are already CEOs dreaming of the next level: working only three days Image | Flickr (Gage Skidmore)

10% “optional” tip

Matías, editor in Xataka, was eating with a friend in an Argentine restaurant in Malaga and asked for the account to pay. Upon receiving the ticket, he observed that he included something that we are not used to in Spain, but that he begins to be seen in the hospitality industry: A suggested tip of 5%. Being optional, they decided not to pay it. The phenomenon. The case that Matías lived in the restaurant ‘The brand‘In Malaga it is not unique. To suggest or recommend tips is something that we can see for a long time in the tickets shared in Google Maps of Restaurants in Madrid as Manero either My seathat upload the bet of the case of Malaga to 10% of the recommended tip, which converts a 197 euros account into one of 217 euros. What began with isolated cases is not so much, especially in Madrid or Barcelona, more Influence of foreign tourists. It is observed more frequently in establishments oriented to foreign tourists with Greater purchasing power and tip cultureand where digital terminals are more established with automatic proposal to leave tip. Less classic tip than before. A couple of years ago, the hospitality employer of Spain He affirmed that from the pandemic We pay less in cashsomething that blocks with the European Central Bank figureswhich encourages that “less and less tips are left,” according to the business organization. Tips to the American. In the United States, tips are not mandatory by law, but it is almost obliged to leave a tip of between 15 and 20%. The logic behind the behavior has to do with the fact that the US minimum federal minimum wage for workers with tips is 2.13 dollars per houran amount that has not changed since 1991. That the sector’s figure is so pyrrhic (compared to our more than 9 euros gross per hour) makes people tip: the worker has no other way to get decent income if not. In practice, more forced than the theory, when eating in the United States in groups of between a minimum of four and six people, most establishments impose a 18% tip (free) without giving option not to pay it. Since the last update of the minimum wage, which has varied a lot is the value of money, with accumulated inflation of 137.19% in 34 years. And just its upward evolution with other factors is what has made the Americans leave less tip in 2024 than in the previous six years. As a curiosity, although the practice is so settled in the United States, it has European origin. It is estimated that in England in the 16th century. Why is it not so popular where he was born. The reason for the practice is not so widespread in Spain and in Europe is related to its nature: here the waiters do not depend on the tip if it were part of the legal salary, but has always been more a prize. And this makes it come to hate our behavioreven when we leave 70 dollars, which we consider here a fortune. The suggestion in the ticket in that case went from $ 130 (20%) to $ 163 (25%). Bad practices. If the tip suggestion with percentage is already shocking for the Spaniards, it is more to see a case in which a tip has tried to camouflage as part of a total payment, broken down confusing to confuse. I told it Toni onsalo in xshowing a ticket with 10% “optional” tip camouflaged before a large total account. There are already waiters who They position themselves against practiceconsidering that it encourages precariousness and low salaries. Another less obvious case Lawtips reviewed itseeing a tickt with suggested tip in large, which can be misleading. From Facua They regretted “The bad arts of entrepreneurs” who try to “project in consumers a responsibility they do not have.” Rubén Sánchez, general secretary of the organization, was clear that with something that “may induce the error, it would be clearly violated Spanish legislation and the company could be denounced.” The future of tips, according to the US. Although in Spain we are still very far, in the United States it is common for years to pay a tablet with a built -in dataphone there is a selected tip figure as a default option. Those figures, which is not unreasonable to see in 30%, They are increasingly high, because they work When generating more income. Reducing the percentage manually or selecting a low option is always a somewhat uncomfortable procedure of the client to whom he has served. Another booming trend in the country: that they ask for workers from establishments that have only printed a ticket and pressed a screen, or removed a bottle of water from a freezer. Image | Christiann Koepke (UNSPLASH) and Klaudia (UNSPLASH) In Xataka | Help the waiter collect the table seems like a kind gesture: psychologists see something much deeper

This optional package costs 230,000 euros

The Bugatti Tourbillon is not a car, it is a declaration of purchasing power in the form of Hybrid supercard with zero label. The basic model of this Bugatti filigree has a base price of 3.8 million euros (without taxes), but the extras They can inflate the invoice end. An example: the New package “Equipe Pur Sang” Cuesta The same as a new Porsche 911 GT3. Bugatti justifies this additional cost with a clear philosophy: its customers not only look for speed, They seek absolute exclusivity. Bugatti said that only 250 units of the Tourbillon will be manufactured, so it is not known how many of those will leave the concessionaire with this “vitamin” equipment. That will turn these jewels of mechanical engineering into museum pieces very coveted by collectors that can afford to pay an invoice of almost 4.5 million euros since the personalization “Equipe Pur Sang” would have a estimated price of 230,000 euros. Eight exhaust tubes and carbon fiber in sight The check @bugattitourbillon.registry He has leaked the images of the “Equipe Sang” package mounted. This personalization visually transforms the Tourbillon by adding some elements that enhance the sporting character (in case it did not have it sufficiently marked). Without a doubt, their most striking feature are the Eight exhaust pipes Chrome that looks like its rear, in front of the four rectangular tubes in double tube configuration of the original model. The four added escapes do not improve performance, but the visual effect, creating an aggressive silhouette that dominates the rear. This configuration of four tubes on each side marks a milestone itself since it is the largest number of escapes that have ever ridden in a bugatti. Thus, the Bugatti Tourbillon “Equipe Pur Sang” would be overcoming the six -escape configuration that the Bugatti La Vaiture Noire. The details of this customization are not limited to the rear, the front has been modified by redesigning air inlets, leaving a more aerodynamic divisor. The impressive aspect of this beast with zero DGT labelIt is completed with carbon fiber finish exposed in the body, painted in Matt Vermillion tones (orange red) and Matt Red. Details such as the “Equipe Pur Sang” logo on the bumper, spoiled and dashboard underline their exclusivity. The personalization of the “Equipe Pur Sang” reaches the interior with a new airline color for the upholstery, which is finished with the logos of the limited series embroidered in the heads of the seats in the same colors Matt Vermillion and Matt Red that looks in the body. V16 hybrid with electric soul Under its hood no modification is known, so it is expected to maintain its atmospheric V16 propeller of 8.3 liters combined with three electric motors, delivering 1,800 hp and 3,000 Nm. This brutal combination allows to accelerate from 0 to 100 km/h in 2 seconds and reach 445 km/h, stratospheric figures for a 1995 kg car. To counteract Its voracity of fuelincludes a 24.8 kWh battery that offers up to 60 km of electrical autonomy. A technical paradox: the same car that burns fuel with eight tubes can move silently through the city. Bugatti demonstrates that even in the electric era, the show of a combustion engine continues to sell. In Xataka | Rolls-Royce wanted In Xataka | In 1984, Ford manufactured four RS200 s units in Ferrari red: today they cost the same as an authentic ferrari Image | Bugatti

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