Cases in young people are skyrocketing and science points to our lifestyle

When we think of patients with colon cancerour mind can automatically go to a middle-aged person with different risk factors behind them. However, epidemiology is documenting a radical change in statisticssince more and more young people are being diagnosed with this type of cancer, which makes us reflect to look for the ‘why’. The experts. Winette van der Graaf, professor of Medical Oncology at the Netherlands Cancer Institute (NKI), points to this new reality and states that “I would never have imagined that I would be seeing patients with colorectal cancer at the age of 19” as collect The Country. With this phrase he gives voice to a global trend that epidemiological studies continue to confirm, since cancer is no longer a disease almost exclusively of old age, and the incidence is growing at a rate four times faster in young people than in older people. An explosion. Data supports the medical concern through multiple international macro studies, such as the one published in 2024 in The Lancet. Here, 50 countries were analyzed and showed that early-onset colorectal cancer (between 25 and 49 years) is increasing in 27 of them. But the most revealing data is in 20 of those 27 territories, where the increase in cases is exclusive to young people or is advancing much faster than in the adult population. The fastest pace is taken by countries such as New Zealand or Chile, growing at 4.0% annually, and Puerto Rico with 3.8%. Furthermore, in 14 countries, including Spain, the United States and the United Kingdom, cases are increasing in young people while remaining stable in those over 50 years of age. Among the youngest. The figures here are scary, since, according to the data From the CDC, data on colorectal cancer among adolescents tripled between 1999 and 2020. If we go into detail, in the 20 to 24 year old group they grew by 185%, while in the 10 to 14 year old age group the growth was 500% as the incidence went from 0.1 to 0.6 cases per 100,000 children. The Spanish case. Here, a study based on real data from the Virgen de la Victoria Hospital published in JCO Global Oncology in 2024 analyzed more than 24,500 patients and found that 22.2% had early-onset cancer, being present before the age of 50. And we can go further, by making a list of the types of cancer that have increased the most in our territory: Sarcoma: increased by 43.4% in young people compared to 28.6% in older people. Kidney: rose 27.8% in young people compared to 20.1% in older people. Testicle: grew by 16.3% in young people, while its incidence fell by 13.1% in older people. Because? Here experts point to a combination of very diverse factors that try to explain it, although none of them is definitive. One of these is an inadequate diet with an increase in the consumption of red meat and calcium-deficient diets that is complemented by a tendency toward a sedentary lifestyle. But in addition, the excessive use of antibiotics could be severely altering our intestinal microbiota, added to the impact of bacterial infections during childhood. And it even goes further by considering the role of the exposure we have since childhood to chemical elements such as pesticides or pollution in general to give it an explanation. Images | brgfx on Magnific Julia Koblitz In Xataka | Neither cure nor die: why the next great revolution against cancer is to make it chronic

A sedentary lifestyle is not only destroying your body, it is also changing your personality

Sitting is a problem. Better said: sitting is a lot of problems. Sedentary lifestyle is the fourth risk factor for death globally and is behind one in four cancers of the breast, uterus or colon. And the thing doesn’t end there. Its impact is undeniable: it doubles the risk of cardiovascular disease and type 2 diabetes, slows down glucose metabolism, and reduces fat synthesis. In addition, with one hand it hinders the burning of calories; while the other causes loss of muscle mass, bone weakness and bone demineralization. But we have known that for a long time. What is not usually said is that, in addition, sitting changes our personality. The personality? Indeed. In recent years, researchers have been building a growing body of evidence associating physically inactive lifestyles with small (but measurable) declines in several personality traits over decades. Since 2018, We know that baseline physical inactivity predicts declines in four of the big five personality traits: responsibility, openness, extraversion and agreeableness. It’s true that the effects are small (and the evidence is observational), but they are surprisingly consistent. Does exercising protect our personality? It is not clear. As I said, the studies are observational: that means that we know that both variables go hand in hand, but not that one ‘acts’ as a protector of the other. However, we don’t always need clear causality to see where the problem is. And the problem sits at the very center of Western society. Spain is a good example: between 27.4% and 36.4% of Spaniards aged 16 and over declared themselves sedentary in their free time according to the INE. And they are right: if the WHO recommendation speaks of between 150 and 300 minutes of physical activity per week, almost half of Spaniards do not reach it. Sedentary lifestyle is, without a doubt, a silent epidemic that is straining our health system and, if these researchers are right, is changing who we are. Because, although there is debate about all thisthe idea that an active lifestyle is a protective factor for personality stability throughout life is gaining strength among experts. It is true that we do not know the specific mechanisms, but the psychological plausibility of the matter is beyond any doubt. It’s time to get going. Image | Kate Sade In Xataka | Cereals yes, but wrapped in black cardboard: the packaging business aimed exclusively at men

Colon cancers are increasing alarmingly among young people. We have a suspect: sedentary lifestyle

colon cancer It is one of the tumors that has increased its incidence the most in young adults over the last few decades, a trend that is very worrying because has made science need to answer why. One of the most important points are the factors that are influencing more and more young people to begin to have tumors in their digestive system. A big problem. Colon cancer is undoubtedly one of the most aggressive diseases that we endure, and also really frequent among the population, with a really aggressive treatment with surgeries that can mean the removal of part of the colonbut also with a high mortality behind them. Its early diagnosis is so relevant that in Spain there are many autonomous communities that have screening programs either screening (although sometimes they fail like in Andalusia) to begin treatment in the case of positive cases, as soon as possible to increase their chances of survival. The problem is that this horrible disease is becoming increasingly prevalent, and science is seeing many factors that are important to take into account to try to reduce the chances of suffering from it. Quantified. This trend has been reflected in a published study in Annals of Internal Medicine which has detected that in many countries the number of cases among those under fifty years of age has grown up to four times faster than in older people. In the end, it is a phenomenon that has revived the debate about the causes and future strategies that must be taken in prevention and early detection. This is extremely important, since a timely diagnosis can mean a big difference in life expectancy who has a patient. The reasons. As stated in the Institute for Cancer Research, London After studying forty-two different countries, two main explanations have been identified. The first is the screening that is done among adults. Although it is very positive to do screening among the population for this disease, the reality is that there is an age limit from which these tests are carried out. This does not occur among the younger population who do not receive this type of screening tests on a regular basis, which may explain the accelerated growth in this group, since cancers are not diagnosed in the early stages. The second reason given is obesity. In this case It is considered a very important risk factor which drives the increased probability of suffering from colon cancer in young people and adults of all ages. Although it remains to be seen if there is an increase in its relationship with the younger population. Environmental factors. In addition to these two causes, the research led by the CNIO Digital Genomics Group in Spain provides new evidence about why this may occur. In his published study In Nature, the influence of the intestinal microbiota, particularly certain strains of E.coli intestinal, producers of the toxin colibactin. As we already sawthis can cause great genetic damage to colon cells that can accelerate tumor development. But other factors associated with the patients’ lifestyle are also being considered. In this case, the increase in type 2 diabetesespecially when there is a sedentary habit and unhealthy diets that seem to increase the risk of having this type of cancer. A Swedish study with a national cohort showed that people with diabetes reach an equivalent risk of colorectal cancer at younger ages than those who do not suffer from it, requiring prevention and monitoring before the standard screening age in the general population. But ultra-processed diets also come in here, excessive consumption of alcohol or even sugary drinkswhich can be an important risk factor. Prevention. Experts agree that there is no single and definitive cause, but rather a combination of genetic, biological, environmental and social factors. While research continues, it is proposed to implement comprehensive prevention policies that adapt to these realities. To do this, they aim to apply personalized screening that includes risk factors such as obesity, diabetes or family history. But we must also focus on research into how our microbiota can have an important implication in this. This forces us to have to take great care of what we eat and maintain adequate intestinal health. But the most relevant thing is to adapt the recommendations for starting screening for high-risk groups, such as young people who have diabetes or a family history so that they begin surveillance at age 40. Images | Ramon Inciarte Julia Koblitz In Xataka | Until now, different types of cancer required different types of treatment. A new vaccine wants to change that

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