lifestyle

We have been believing for years that women live longer because of their lifestyle. Science has a much deeper explanation

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If we take a look at the World Bank’s global statistics, there is an unbreakable pattern that repeats itself in practically every country in the world: Women live longer than men. Conventional wisdom often dismisses this phenomenon with a quick response based on lifestyle or “men take more risks.” And although there is some truth in this, the scientific reality is much more complex. Because? To understand female longevity, We must focus on the DNA that we have in all our cells. Something very basic is that women have two X chromosomes, while men have one X chromosome and one Y chromosome. A fundamental difference, because that second X chromosome in women acts as a kind of backup. This means that if a gene on one X chromosome suffers a mutation or is damaged, the female body can turn to the healthy copy on the other chromosome. Men, however, play a single card, since if their only X chromosome has a defect, there is no plan B. In addition, this chromosome is vital because it houses a large number of genes related to the immune system, which gives women a more robust response to infections. It goes further. Genetics is not everything here, but the body has an ace up its sleeve, which are the mitochondria, which are nothing more than the “power plants” of our cells. These organelles are inherited only maternally and, as proposed in 2007sexual differentiation has a direct biological cost for men, translating into lower mitochondrial function and, therefore, greater cellular oxidative stress that accelerates aging. The hormones. Beyond genetics and mitochondria, we must mention sex hormones, which are in very different proportions between sexes. Estrogens, for example, are the main female sex hormones that, in addition to regulating the reproductive cycle, act as a powerful antioxidant shield. Among its effects stands out maintaining the flexibility of blood vessels, reducing “bad” cholesterol and preventing inflammation. This largely explains why the incidence of cardiovascular disease in women is significantly lower before menopause. In the man. On the other side of the coin we have testosterone. Although it is crucial for the development of muscle and bone mass, high levels of this hormone in men are historically associated with increased cardiovascular risk at an early age and long-term depression of the immune system. The evolution. Someone may fall into the idea that this system is something exclusive to humans, but evolutionary biology shows us otherwise. Here, a 2025 study analyzed 1,176 species and the results revealed that in mammals, females live on average 13% longer than males. The reason lies in reproductive strategies and the biological wear and tear derived from male sexual competition, such as fights over territory or mating. However, it was seen that andIn birds, males live 5% longer; since in the avian world, males usually have two identical sex chromosomes (ZZ) and females have different sex chromosomes (ZW). Furthermore, in many bird species, parental care is shared or falls to the male, which reduces their risk behaviors. Human behavior. Of course, biology does not operate in a vacuum and genetic and hormonal factors must be added. the behavioral gap and social. For example, the consumption of toxic substances has a greater prevalence in men, being associated with cancer, cirrhosis or respiratory diseases. But, as we have said before, testosterone is also linked to a greater propensity to take risks, which translates into higher mortality rates from traffic accidents or cases of violence. On the other hand, women suffer from “invulnerability syndrome” which causes them to seek preventive medical services much more frequently. Men tend to postpone visits to the doctor until diseases are in more advanced stages, making treatment difficult. In addition, women tend to build stronger social and emotional support networks, a factor directly linked to greater survival in old age. Images | Age Cymru In Xataka | 5 minutes of sleep, 2 of exercise and half a serving of vegetables: the macro study that supports a great longevity ‘hack’

“A sedentary lifestyle is an independent risk factor and it is not enough to ‘compensate’ for it with specific exercise”

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There are many people passing by much of her day glued to a chairin many cases because they are working, traveling by car or resting on the couch, with a sedentary lifestyle being a true routine in the lives of many people. Until now we knew that it was harmful, but now science has put exact numbers on how an uninterrupted sedentary lifestyle influences our health, and the most important thing is that it has been seen that it does not help to compensate for it. With a watch. A new study published in PLOS analyzed data from 91,292 people from the UK Bank, and unlike other epidemiological studies that rely on questionnaires filled out by the participants themselves, here they used accelerometry. That is, for years they have monitored the physical movement of all these people thanks to activity sensors on the wrist. After an average follow-up of 12.38 years, the researchers not only measured total inactivity time, but how it was distributed throughout the day. And that’s where the real enemy to our health comes in, which are blocks of uninterrupted time. You have to get up. The central finding of the study does not penalize the simple act of sitting so much, but rather doing it continuously. The researchers concluded that each additional hour of prolonged sedentary behavior, understood as periods of 30 minutes or more without getting up at any time, is associated with a 10% increase in the risk of cancer mortality. That is to say, spending long work days without moving at all is not free in the long term. The solution. Fortunately, the results also show that the human body is incredibly grateful when we break that stasis. Using statistical time substitution models, the study calculated what happens when we swap prolonged periods in the chair for different “doses” of daily physical activity. To give an example, replacing one hour a day of prolonged sedentary lifestyle with low-intensity activities such as walking at a normal pace or doing housework reduces the risk by 12%. But if we go further, changing just 30 minutes of uninterrupted sedentary lifestyle for moderate physical activity reduces the risk by 8%. The most important thing. The most efficient substitution has been found to require very little time, as swapping sedentary time for just five minutes a day of vigorous physical activity reduces the risk of cancer mortality by a staggering 22%. The golden rule. As is usual when analyzing medical literature, and as the authors and independent experts themselves emphasize, we must read the fine print. As it is an observational study, the data show a strong statistical association, but the design itself cannot demonstrate strict and absolute causality, leaving it exposed to certain biases, such as the UK Biobank volunteers usually having a healthier baseline profile than the population average. However, this research does not arrive in a vacuum since it is tremendously consistent with previous scientific evidence and gives robustness to what we already suspected. In 2022, a meta-analysis and umbrella review already warned about the strength of the relationship between a sedentary lifestyle and oncological risk. And at a closer level, a study by the Carlos III Health Institute in 2024 confirmed in the Spanish population that replacing just one hour a week of sitting time with physical activity managed to reduce general mortality. The experts. Nabil Djouder, head of the Group of Growth Factors, Nutrients and Cancer of the National Cancer Research Center (CNIO) in statement to SMC pointed out that this study “reinforces the idea that sedentary behavior is an independent risk factor and that it is not enough to ‘compensate’ for it with specific exercise.” Images | Vitaly Gariev In Xataka | Spending hours sitting in front of the screen is not only destroying your body, it is also changing your personality

“A sedentary lifestyle is an independent risk factor and it is not enough to ‘compensate’ for it with specific exercise”

by

There are many people passing by much of her day glued to a chairin many cases because they are working, traveling by car or resting on the couch, with a sedentary lifestyle being a true routine in the lives of many people. Until now we knew that it was harmful, but now science has put exact numbers on how an uninterrupted sedentary lifestyle influences our health, and the most important thing is that it has been seen that it does not help to compensate for it. With a watch. A new study published in PLOS analyzed data from 91,292 people from the UK Bank, and unlike other epidemiological studies that rely on questionnaires filled out by the participants themselves, here they used accelerometry. That is, for years they have monitored the physical movement of all these people thanks to activity sensors on the wrist. After an average follow-up of 12.38 years, the researchers not only measured total inactivity time, but how it was distributed throughout the day. And that’s where the real enemy to our health comes in, which are blocks of uninterrupted time. You have to get up. The central finding of the study does not penalize the simple act of sitting so much, but rather doing it continuously. The researchers concluded that each additional hour of prolonged sedentary behavior, understood as periods of 30 minutes or more without getting up at any time, is associated with a 10% increase in the risk of cancer mortality. That is to say, spending long work days without moving at all is not free in the long term. The solution. Fortunately, the results also show that the human body is incredibly grateful when we break that stasis. Using statistical time substitution models, the study calculated what happens when we swap prolonged periods in the chair for different “doses” of daily physical activity. To give an example, replacing one hour a day of prolonged sedentary lifestyle with low-intensity activities such as walking at a normal pace or doing housework reduces the risk by 12%. But if we go further, changing just 30 minutes of uninterrupted sedentary lifestyle for moderate physical activity reduces the risk by 8%. The most important thing. The most efficient substitution has been found to require very little time, as swapping sedentary time for just five minutes a day of vigorous physical activity reduces the risk of cancer mortality by a staggering 22%. The golden rule. As is usual when analyzing medical literature, and as the authors and independent experts themselves emphasize, we must read the fine print. As it is an observational study, the data show a strong statistical association, but the design itself cannot demonstrate strict and absolute causality, leaving it exposed to certain biases, such as the UK Biobank volunteers usually having a healthier baseline profile than the population average. However, this research does not arrive in a vacuum since it is tremendously consistent with previous scientific evidence and gives robustness to what we already suspected. In 2022, a meta-analysis and umbrella review already warned about the strength of the relationship between a sedentary lifestyle and oncological risk. And at a closer level, a study by the Carlos III Health Institute in 2024 confirmed in the Spanish population that replacing just one hour a week of sitting time with physical activity managed to reduce general mortality. The experts. Nabil Djouder, head of the Group of Growth Factors, Nutrients and Cancer of the National Cancer Research Center (CNIO) in statement to SMC pointed out that this study “reinforces the idea that sedentary behavior is an independent risk factor and that it is not enough to ‘compensate’ for it with specific exercise.” Images | Vitaly Gariev In Xataka | Spending hours sitting in front of the screen is not only destroying your body, it is also changing your personality

Cases in young people are skyrocketing and science points to our lifestyle

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When we think of patients with colon cancerour mind can automatically go to a middle-aged person with different risk factors behind them. However, epidemiology is documenting a radical change in statisticssince more and more young people are being diagnosed with this type of cancer, which makes us reflect to look for the ‘why’. The experts. Winette van der Graaf, professor of Medical Oncology at the Netherlands Cancer Institute (NKI), points to this new reality and states that “I would never have imagined that I would be seeing patients with colorectal cancer at the age of 19” as collect The Country. With this phrase he gives voice to a global trend that epidemiological studies continue to confirm, since cancer is no longer a disease almost exclusively of old age, and the incidence is growing at a rate four times faster in young people than in older people. An explosion. Data supports the medical concern through multiple international macro studies, such as the one published in 2024 in The Lancet. Here, 50 countries were analyzed and showed that early-onset colorectal cancer (between 25 and 49 years) is increasing in 27 of them. But the most revealing data is in 20 of those 27 territories, where the increase in cases is exclusive to young people or is advancing much faster than in the adult population. The fastest pace is taken by countries such as New Zealand or Chile, growing at 4.0% annually, and Puerto Rico with 3.8%. Furthermore, in 14 countries, including Spain, the United States and the United Kingdom, cases are increasing in young people while remaining stable in those over 50 years of age. Among the youngest. The figures here are scary, since, according to the data From the CDC, data on colorectal cancer among adolescents tripled between 1999 and 2020. If we go into detail, in the 20 to 24 year old group they grew by 185%, while in the 10 to 14 year old age group the growth was 500% as the incidence went from 0.1 to 0.6 cases per 100,000 children. The Spanish case. Here, a study based on real data from the Virgen de la Victoria Hospital published in JCO Global Oncology in 2024 analyzed more than 24,500 patients and found that 22.2% had early-onset cancer, being present before the age of 50. And we can go further, by making a list of the types of cancer that have increased the most in our territory: Sarcoma: increased by 43.4% in young people compared to 28.6% in older people. Kidney: rose 27.8% in young people compared to 20.1% in older people. Testicle: grew by 16.3% in young people, while its incidence fell by 13.1% in older people. Because? Here experts point to a combination of very diverse factors that try to explain it, although none of them is definitive. One of these is an inadequate diet with an increase in the consumption of red meat and calcium-deficient diets that is complemented by a tendency toward a sedentary lifestyle. But in addition, the excessive use of antibiotics could be severely altering our intestinal microbiota, added to the impact of bacterial infections during childhood. And it even goes further by considering the role of the exposure we have since childhood to chemical elements such as pesticides or pollution in general to give it an explanation. Images | brgfx on Magnific Julia Koblitz In Xataka | Neither cure nor die: why the next great revolution against cancer is to make it chronic

A sedentary lifestyle is not only destroying your body, it is also changing your personality

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Sitting is a problem. Better said: sitting is a lot of problems. Sedentary lifestyle is the fourth risk factor for death globally and is behind one in four cancers of the breast, uterus or colon. And the thing doesn’t end there. Its impact is undeniable: it doubles the risk of cardiovascular disease and type 2 diabetes, slows down glucose metabolism, and reduces fat synthesis. In addition, with one hand it hinders the burning of calories; while the other causes loss of muscle mass, bone weakness and bone demineralization. But we have known that for a long time. What is not usually said is that, in addition, sitting changes our personality. The personality? Indeed. In recent years, researchers have been building a growing body of evidence associating physically inactive lifestyles with small (but measurable) declines in several personality traits over decades. Since 2018, We know that baseline physical inactivity predicts declines in four of the big five personality traits: responsibility, openness, extraversion and agreeableness. It’s true that the effects are small (and the evidence is observational), but they are surprisingly consistent. Does exercising protect our personality? It is not clear. As I said, the studies are observational: that means that we know that both variables go hand in hand, but not that one ‘acts’ as a protector of the other. However, we don’t always need clear causality to see where the problem is. And the problem sits at the very center of Western society. Spain is a good example: between 27.4% and 36.4% of Spaniards aged 16 and over declared themselves sedentary in their free time according to the INE. And they are right: if the WHO recommendation speaks of between 150 and 300 minutes of physical activity per week, almost half of Spaniards do not reach it. Sedentary lifestyle is, without a doubt, a silent epidemic that is straining our health system and, if these researchers are right, is changing who we are. Because, although there is debate about all thisthe idea that an active lifestyle is a protective factor for personality stability throughout life is gaining strength among experts. It is true that we do not know the specific mechanisms, but the psychological plausibility of the matter is beyond any doubt. It’s time to get going. Image | Kate Sade In Xataka | Cereals yes, but wrapped in black cardboard: the packaging business aimed exclusively at men

Colon cancers are increasing alarmingly among young people. We have a suspect: sedentary lifestyle

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colon cancer It is one of the tumors that has increased its incidence the most in young adults over the last few decades, a trend that is very worrying because has made science need to answer why. One of the most important points are the factors that are influencing more and more young people to begin to have tumors in their digestive system. A big problem. Colon cancer is undoubtedly one of the most aggressive diseases that we endure, and also really frequent among the population, with a really aggressive treatment with surgeries that can mean the removal of part of the colonbut also with a high mortality behind them. Its early diagnosis is so relevant that in Spain there are many autonomous communities that have screening programs either screening (although sometimes they fail like in Andalusia) to begin treatment in the case of positive cases, as soon as possible to increase their chances of survival. The problem is that this horrible disease is becoming increasingly prevalent, and science is seeing many factors that are important to take into account to try to reduce the chances of suffering from it. Quantified. This trend has been reflected in a published study in Annals of Internal Medicine which has detected that in many countries the number of cases among those under fifty years of age has grown up to four times faster than in older people. In the end, it is a phenomenon that has revived the debate about the causes and future strategies that must be taken in prevention and early detection. This is extremely important, since a timely diagnosis can mean a big difference in life expectancy who has a patient. The reasons. As stated in the Institute for Cancer Research, London After studying forty-two different countries, two main explanations have been identified. The first is the screening that is done among adults. Although it is very positive to do screening among the population for this disease, the reality is that there is an age limit from which these tests are carried out. This does not occur among the younger population who do not receive this type of screening tests on a regular basis, which may explain the accelerated growth in this group, since cancers are not diagnosed in the early stages. The second reason given is obesity. In this case It is considered a very important risk factor which drives the increased probability of suffering from colon cancer in young people and adults of all ages. Although it remains to be seen if there is an increase in its relationship with the younger population. Environmental factors. In addition to these two causes, the research led by the CNIO Digital Genomics Group in Spain provides new evidence about why this may occur. In his published study In Nature, the influence of the intestinal microbiota, particularly certain strains of E.coli intestinal, producers of the toxin colibactin. As we already sawthis can cause great genetic damage to colon cells that can accelerate tumor development. But other factors associated with the patients’ lifestyle are also being considered. In this case, the increase in type 2 diabetesespecially when there is a sedentary habit and unhealthy diets that seem to increase the risk of having this type of cancer. A Swedish study with a national cohort showed that people with diabetes reach an equivalent risk of colorectal cancer at younger ages than those who do not suffer from it, requiring prevention and monitoring before the standard screening age in the general population. But ultra-processed diets also come in here, excessive consumption of alcohol or even sugary drinkswhich can be an important risk factor. Prevention. Experts agree that there is no single and definitive cause, but rather a combination of genetic, biological, environmental and social factors. While research continues, it is proposed to implement comprehensive prevention policies that adapt to these realities. To do this, they aim to apply personalized screening that includes risk factors such as obesity, diabetes or family history. But we must also focus on research into how our microbiota can have an important implication in this. This forces us to have to take great care of what we eat and maintain adequate intestinal health. But the most relevant thing is to adapt the recommendations for starting screening for high-risk groups, such as young people who have diabetes or a family history so that they begin surveillance at age 40. Images | Ramon Inciarte Julia Koblitz In Xataka | Until now, different types of cancer required different types of treatment. A new vaccine wants to change that

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