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The five best technology offers at MediaMarkt and El Corte Inglés, today October 11

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Both MediaMarkt and El Corte Inglés have not waited long after Amazon’s Prime Offers Party to launch the most interesting discounts. Although there are many offers on mobile phones, we cannot forget about other devices that also have very large discounts. Therefore, in this article we are going to review what are the best offers from both stores. Honor 400 by 381.65 eurosa mid-range mobile phone that takes very good photographs and comes with a pair of free headphones. Samsung Galaxy Watch8 by 289 eurosan elegant smartwatch that has rarely been so cheap. Samsung Galaxy S25 Ultra by 1,099 eurosSamsung’s top high-end mobile with a much more reasonable price. JBL Bar 800 by 699.99 eurosa sound bar to which two wireless speakers can be attached and removed. Motorola Razr 60 Ultra by 866.15 eurosa folding mobile phone at the lowest price that MediaMarkt has had to date. Honor 400 Within the mid-range we can also find mobile phones with a good photographic section and the Honor 400 It stands out for this reason with excellent colorimetry and sharpness. By 381.65 euros include headphones Honor Earbuds Clip as a gift. He Honor 400For its part, it has a good 6.55-inch screen with a 120 Hz refresh rate, its processor is the Snapdragon 7 Gen 3 and its battery supports 66W fast charging. Honor 400 (256 GB) + Honor Earbuds clip The price could vary. We earn commission from these links Samsung Galaxy Watch8 If we talk about smart watches, the Samsung Galaxy Watch8 has dropped in price in its 40mm configuration. It is located in El Corte Inglés by 289 eurosalthough PcComponentes has it as 255.99 euros. It is a beautiful and elegant smartwatch that has a 1.34-inch screen, its operating system is WearOShas GPS and comes with many sensors to monitor physical activity, such as Samsung’s BioActive, in addition to more than 100 sports modes and Google Gemini. Samsung Galaxy Watch8 (40mm) The price could vary. We earn commission from these links Samsung Galaxy S25 Ultra Since its launch, we have seen several offers on the Samsung Galaxy S25 Ultra and MediaMarkt has one of the best right now. By 1,099 euroswe are talking about a high-end mobile that comes with an excellent 6.9-inch screen with Quad HD+ resolution and anti-reflective treatmentits processor is the Snapdragon 8 Elite, its battery offers very good autonomy, it comes with the integrated S-Pen and its main sensor is 200 MP. Samsung Galaxy S25 Ultra (256GB) The price could vary. We earn commission from these links JBL Bar 800 It’s not particularly cheap, but the sound bar JBL Bar 800 It is very practical for setting up a home theater. By 699.99 euroswe are talking about a model that, in addition to including a wireless subwoofer, comes with two wireless speakers that can be attached and removed from the bar itself. It offers a total power of 720W, is compatible with Dolby Atmos and works with Alexa. In addition, it has Bluetooth, WiFi and HDMI eARC connectivity, among other options. The price could vary. We earn commission from these links Motorola Razr 60 Ultra Folding phones are not especially cheap (mostly), but from time to time they receive very good offers. MediaMarkt now has at its minimum price the Motorola Razr 60 Ultra. By 866.15 euroswe are talking about a mobile phone with a good internal screen and a fairly large external panel (4 inches). Your processor is Snapdragon 8 Eliteits battery supports 68W fast charging and has 16 GB of RAM and 512 GB of internal storage. Motorola Razr 60 Ultra (512GB) The price could vary. We earn commission from these links Some of the links in this article are affiliated and may provide a benefit to Xataka. In case of non-availability, offers may vary. Images | MediaMarkt, El Corte Inglés and Compradicción (header), Honor, Samsung, JBL, Motorola In Xataka | The best mobile phones (2025), we have tested them and here are their analyzes In Xataka | Best sound bars in quality price (2025). Which one to buy and seven recommended models from 140 euros

Five years ago he worked from his bathroom on the brink of ruin. Today he runs a company valued at 8 billion

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The story of Shayne Coplan and Polymarket is one of those striking cases that you like to see in the past. And the founder of this company practically started from bankruptcy in a makeshift bathroom as an office to close a $2 billion investment on the New York Stock Exchange. Now, the prediction markets platform that he founded in 2020 has just reached a valuation of $8 billion after the agreement with Intercontinental Exchange (ICE), owner of the NYSE. The takeoff. Coplan’s situation in 2020 was not exactly an example of the American dream. Just like shared a while ago In a publication in X, he was seen working from a bathroom converted into an office, with hardly any money and alone in charge of the project. Five years later, its platform has become the largest prediction market in the world, where users bet on the results of real events, from elections to sports or culture. Wall Street’s bet. ICE has announced an investment of up to $2 billion in cash in Polymarket, valuing the company at approximately $8 billion before the capital injection. The agreement turns ICE into a global distributor from Polymarket data, which will provide sentiment indicators on topics relevant to financial markets. Additionally, both companies will collaborate on tokenization initiatives that combine traditional financial markets with blockchain technology. How the model works. Polymarket allows users to express their opinions by buying and selling shares on possible event outcomes. Each operation is executed peer-to-peer using smart contracts. Markets grow with the number of participants, and prices reflect the perceived probability of each outcome occurring. The platform gained notoriety for the accuracy of their predictions during the 2024 US presidential electionwhere he managed billions in bets. roller coaster. Polymarket’s trajectory has not been linear. In 2022, federal regulators forced the platform to block US users after an agreement with the Commodity Futures Trading Commission (CFTC). The company operated from abroad for three years. This year, Polymarket bought QCEXa CFTC-licensed derivatives exchange, to return to the US market. The operation came weeks after prosecutors closed an investigation into whether the company had allowed access to American users despite the ban. Return at the perfect time. The changing regulatory climate under the Trump administration has favored emerging sectors such as event contracts and cryptocurrencies. Polymarket received an undisclosed investment in August from 1789 Capital, a firm endorsed by Donald Trump Jr., who later joined the company’s advisory board. What’s coming now. Jeffrey Sprecher, CEO of ICE, admits proudly that the investment combines an institution founded in 1792 (the NYSE), with a company that “is revolutionizing decentralized finance.” For Coplan, the agreement marks the entry of prediction markets into the traditional financial system. It remains to be seen whether these markets can maintain their growth and become truly useful tools for institutional investors. For now, ICE has bet heavily on the response being positive. Cover image | Shayne Coplan and Matthew Reeves (BFA) In Xataka | There is a worrying symptom in the technological economy: Silicon Valley prefers to buy itself rather than invest in the future

40 years ago three researchers insisted on blurring the borders of quantum physics, today they have won the Nobel

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It was 1935 and Erwin Schrödinger was already tired of reading nonsense. It was not a decade since the birth of modern quantum mechanics, but the world had already filled with delusional pseudophilosophical reflections on what reality really was. It was then that poor Erwin inflated his noses and decided to talk to us about his cat. The happy cat of Schrödinger. Of his cat, of a closed opaque box and, in addition, of a container with a poisonous gas. The container in question is controlled by an opening device that only works if a radioactive particle disintegrates over a certain period of time. After that period, the probability that the cat is dead is 50% and that it is also alive of 50%. “If we do not open the box,” the standard version of this ‘paradox’ tells us, “the cat will be alive and dead at the same time.” Or, in other words, we could be calm: as long as we did not open the box, the cat would not be really dead. According to many interpreters, in fact, it would be the one that opens the box that kills the cat. No one understands poor Erwin. The interesting thing about all this is that, although it has been used to the fed up to illustrate The idea of ​​quantum overlapSchrödinger used it to demonstrate how absurd it was to apply categories of quantum mechanics to the real world (macroscopic). For the Austrian physicist, the happy cat would be alive or dead regardless of the opening of the box or not. But … what if not? However, half a century after all this, there were a group of researchers from the University of Berkeley who did not have it so clear. For some years it was known that we were missing a key piece to understand the process of molecular disintegration. That is, “the ability of individual particles to disintegrate is well known” (this is, for example, the physical fact that there is Behind carbon-14); What happens is that according to what we knew about physics, that could not be. The particles should not disintegrate. Between 1984 and 1985, John Clarke, Michel H. Devoret and John M. Martinis They performed a series of experiments With a closed electrical circuit with superconductors and showed that, well, Schrödinger was wrong. How was it wrong? As I say, the intention of the cat’s mental experiment was “to demonstrate the absurdity of this situation, since the special properties of quantum mechanics usually disappear on a macroscopic scale. The quantum properties of a complete cat cannot be demonstrated in a laboratory experiment.” However, since these researchers were successful in demonstrating that the very strange properties of the quantum world can also be seen in a larger system, none of this is so clear. This explains very well people like Anthony Leggett Because, although “a macroscopic system composed of numerous pairs of Cooper remains many orders of magnitude smaller than a kitten”, the key of the experiment is that “there are phenomena that involve a large number of particles that, together, behave as they predict quantum mechanics.” A Nobel to kill a cat. “It would surprise you very much if the ball suddenly appeared on the other side of the wall. In quantum mechanics, this type of phenomenon is called a tunnel effect and is precisely the type of phenomenon that has given it the reputation of being strange and not very intuitive,” explained the award committee. That is precisely what these researchers showed that it could happen at the macroscopic level. But they did something else. And I do not mean to lay the foundations that have allowed us to create the technological system we know: from the transistors of the computer microchips that we see everywhere to quantum cryptography. No. I mean blurring the wall that separated the world from the very small with the world we know. Along the way, “they killed a cat”; But because of the gap they opened, one of the best science we have was sneaked. Image | Nobel Foundation In Xataka | Don’t call it “Nobel Prize,” call it “how Swedes are dynamiting current science”

In 1995 some researchers discovered the “peaceful gene” of our body. Today their finding has earned them a Nobel

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The Nobel Committee at the Karolinska Institute of Stockholm has done it again. He has rewarded one of those investigations that, for years, seemed like a page note in textbooks, but today are the basis of revolutionary treatments. He Nobel Prize for Physiology and Medicine of 2025 He has been granted jointly to Japanese Shimon Sakaguchi and Americans Mary E. Brunkow and Fred Ramsdell for “their discoveries about Regulatory T cells And the role of Foxp3 gene In the immune function “ The beginning. Already in the previous decade, Sakaguchi had identified a subset of T lymphocytes that did not attack, but did the opposite: they suppressed the activity of other T lymphocytes. They were pacifying cells, a kind of riot police of the immune system. In 1995, He published a job Key that characterized these cells, today known as regulatory T cells (TREGS). The finding was transcendental. Sakaguchi showed that without these tregs, The immune system went crazy and began to attack the tissues of the body itself, causing devastating autoimmune diseases. He had discovered the natural mechanism of the body to maintain tolerance and avoid self -destruction. But the key piece of the puzzle was missing: what made a T cell become a peacemaker and not a soldier? Brunkow and Ramsdell. Although this discovery was transcendental, the reality is that there was a lot of skeptic that he did not believe in his theory. But the answer to the big question that stayed in the air came in 2001 (still far from the year 2025 and the delivery of this award). Here, on the one hand, Mary E. Brunkow’s team investigated a rare and deadly disease Autoimmune in children called IPEX syndrome. The investigation pointed to a gene as a cause of this disease: Foxp3. On the other hand, Fred Ramsdell’s team was studying a mouse model with very similar symptoms and reached the same conclusion: The defective gene was Foxp3. The connection. The connection was immediate and explosive: Foxp3 was the “master switch”. It is the gene that, when activated in a T lymphocyte, gives you the instructions to become a TREG. Without functional FOXP3, there are no regulatory T cells, and the immune system is uncontrolled. Sakaguchi’s discovery finally found his genetic explanation and already gave him enough weight so that the scientific community saw that he had sat a great precedent. A revolution. This double discovery, Sakaguchi’s cell phone and Brunkow and Ramsdell’s genetic, has completely changed the immunology paradigm and has opened two great therapeutic pathways with immense potential. On the one hand, the door opens up to the fight against autoimmune diseases since with the lack of tregs the body attacks itself. The solution in this case is to increase this type of cells, and there are already different clinical trials to extract patient T cells, “convert” them into the laboratory and re -inject them to the patient. Something we now know as ‘immunotherapy’. But it also serves for the fight against cancer. In these cases it has been seen how tumors are ‘intelligent’ and surround themselves with tregs to protect themselves to the immune system that tries to end these cells. These pacifying cells prevent “soldier” T lymphocytes from attacking cancer. The new immunotherapies seek precisely to temporarily deactivate these tregs or block the action of Foxp3 in the tumor environment, eliminating the protective coat of cancer so that the immune system can destroy it. This has been especially promising in tumors such as lymphoma. Time has passed. The most surprising of all this is the large amount of time between the initial discovery and recognition with a Nobel. If it is true that it has been expected to have a crucial relevance within the clinical aspect, with trials that give very good results for diseases that are really serious. Images | Wikipedia (2, 3) In Xataka | A Spanish team has taken a giant step in a hopeful cancer treatment: chemoinmunotherapy

Five of the best offers in technology during the day without VAT of Mediamarkt, today October 6

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Just one day for Amazon to begin his Prime Offers party, so many stores have launched some quite powerful campaigns in terms of quantity and quality of offers. Mediamarkt now has a Day without VAT which will end in a few hours (October 7 at 09:00 hours), so in this article we wanted to gather five of the best offers we can find in the campaign. Google Pixel 10 Pro XL by 1,049 euros By adding it to the cart, the lowest price that Mediamarkt has had to date. Portal PlayStation by 181.81 eurosa very practical accessory for the PlayStation 5. Kobo Clara Bw by 123.14 eurosa good price for one of the ereader with the best value for money. Honor 400 by 412.40 eurosa mobile with a good value for money that also includes gift headphones. ‘Donkey Kong Baniza‘ by 50.40 eurosa much more adjusted price for one of the last video games released by Nintendo. Google Pixel 10 Pro XL One of the best mobile offers during the day without Mediamarkt VAT is in the Google Pixel 10 Pro XLan excellent model that combining the discount of the campaign offered by the store by adding the mobile to the cart is left by 1,049 eurosits minimum historical price. He Google 10 Pro XL It is one of the last mobiles that the company has launched, and it is also the most big with a screen of no less than 6.8 inches. Incorporates the Google Tensioner G5 processor, its operating system will receive seven years of updates and its camera module consists of a 50 MP main sensora wide angle of 48 MP and a 5x telephoto of 48 MP. Google Pixel 10 Pro XL (256 GB) The price could vary. We obtain commission for these links Portal PlayStation The Portal PlayStation It is very practical for certain moments, as when traveling. It does not usually lower too much price, but now mediamarkt has it for 181.81 euros instead of 219.99 euros. It is a 8 -inch screen with integrated controls which allows playing playstation 5 videogames, although you can also play cloud games if you have the highest subscription level of the service, PlayStation Plus Premium. The price could vary. We obtain commission for these links Kobo Clara Bw After the last wave of offers in Kindle, other Ereader have also dropped in price. In Mediamarkt we can find a good discount the Kobo Clara Bwby 123.14 eurosone of the models with the best quality-price ratio of Rakuten. It is a 6 -inch screen ereader that is ideal for reading at home or outside it. Includes adjustable light, the letter can be customized (source, font, etc.) and offers excellent performance. The price could vary. We obtain commission for these links Honor 400 He Honor 400 It is another of the mobile phones with the best offer during the day without VAT of Mediamarkt. By 412.40 euroswe talk about a model that, in addition to including headphones Earbuds Gift Clipstands out mainly for its light design and with very good construction, its photographic section, which is excellent, and for its autonomy of almost two full days of use. The price could vary. We obtain commission for these links ‘Donkey Kong Baniza’ There has been much talk about the price of games for Nintendo Switch 2. Although they are still very expensive, some stores usually launch good offers. During the day without VAT, Mediamarkt has dropped the price of ‘Donkey Kong Baniza‘, one of the last video games launched by Nintendo that came out for approximately 50 euros, but is now reduced by 50.40 euros In physical format. Donkey Kong Baniza (Nintendo Switch 2) The price could vary. We obtain commission for these links Some of the links of this article are affiliated and can report a benefit to Xataka. In case of non -availability, offers may vary. Images | Mediamarkt and Buyardcion (header), Google, PlayStation, Kobo, Honor, Nintendo In Xataka | The best mobiles (2025), we have tried them and here are their analysis In Xataka | Best electronic books. What ebook buy and 11 recommended models

Openai presents something today, and all leaks point to the same: their own N8N

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A media specialized in AI, Testing Catog, He leaked this weekend what he will present today, Monday, October 6, Openai is his Devday event: a visual drag interface and release that allows to create automated workflows with AI agents, without the need to program. This event It has been scheduled for more than three monthsbut it has been on the horn when the filtration has arrived. Why is it important. If confirmed, Agent Builder would be the direct entry of OpenAI in a market dominated by N8NZapier and Make.com, with a brutal advantage: native integration with their own models. Current platforms greatly simplify the process, but continue to require complex API settings. Agent Builder, on the other hand, would offer direct access to OpenAI models from a unified interface. The leaked components include conditional logic, MCP connectors (One of the great protagonists in the AI ​​of 2025), user approvals, safety barriers and data transformation. The reaction. X has exploded with speculation from filtration. Many developers openly speak of a “N8N Killer” and a “threat to Zapier”. The OpenAi CEO, Sam Altman, has fueled the fire without confirming anything: “Excited by Devday tomorrow! New things to build with AI”. Between the lines. Filtration does not seem accidental. Openai has been sowing the pieces for months: Sdks for Agents. Web action functions in chatgpt. Infrastructure for autonomous deployments. Agent Builder would consolidate this architecture in an accessible tool that reduces the input barrier to create AI solutions. The Altman company has been moving from Apis Pure for some time to a larger ecosystem. Yes, but. If it materializes, the tool can catch users in their closed OpenAI ecosystem, which eliminates the flexibility offered by tools already underway by allowing several language models to be used. Open source platforms such as N8N maintain an important advantage, in any case: with them you can use Anthropic, Google models or any other supplier. Agent Builder will presumably stood you to OpenAI models exclusively. And now what. The Devday event starts in a few hours. If Agent Builder is confirmed, the rules of the automation market with AI will change. In Xataka | There is a new unicorn in Europe: it is called N8N, it is German and has converted the automation of workflows into something sexy Outstanding image | N8N

125,000 years ago the Neanderthals ate bones to survive. Today we discovered that they were right

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In the police comedy Brooklyn 99during a party the detective Charles Boyle meets the gastronomic writer Vivian Ludley, with whom he talks about the last meal on earth. The policeman, in a clamor for his love of French food, chooses El Hortelano: a tiny French bird that eats a single bite, with skin, viscera and bones. “A challenge to God”, They call it. Vivian replies that the practice is illegal, But he confesses that he had academic permission to try one: “The peak was very crispy,” he recalls with fascination. The scene may seem eccentric, but opens a question that is not less: what is in the bones that makes them so valuable – at the same time so controversial – in the history of food? Western oblivion. For centuries, the bones were a natural part of the human diet. The neardentals They came to ride “Fats of fat” in places like Neumark-Nord (Germany), where 125,000 years ago they broke bones of deer, horses and cattle to extract marrow and heat fragments with water until obtainable lipids. It was not a whim: it was survival, a way to avoid the so -called starvation of the rabbit, caused by eating too much lean protein without sufficient fat. Later, many cultures continued with practice. In sub -Saharan Africa, for example, rural communities even chew long bones as part of the daily diet. In Asia it is common to eat flags and fins of fried fish until they are crispy. And in Europe, popular cuisine always turned to the thorns of canned sardines and anchovies, softened by sterilization. However, speaking today of what bones are as such, this practice of consuming them disappeared. Most meat reaches the clean, boneless plate, ready to avoid discomforts. The bone has been relegated to the secondary paper of the broth. As Chef Jennifer McLAGAN explains: “We no longer see bones as useful. People consider them a discomfort, something to get rid of.” But that perception begins to crack through The search for “superfood”and the bones are on the table again. What is inside the bones? The short response would be essential nutrients. But I will not be so simplistic, the bones are mainly formed by calcium and phosphorusin addition to containing iron, magnesium and potassium. In protein terms, up to a 25 and 33% of the content of an animal It corresponds to collagen, a key structural protein for bones, skin and joints. In my case, I discovered it by accident. After an injury doing crossfitthe traumatologist told me about the importance of collagen To recover fabrics. Beyond prescribing supplements – which also opened the door to the veal bone broths, rich in natural collagen. It was my first conscious contact with this part of the animal we usually throw without thinking. Science behind. In a National Geographic report describe how bones They are one of the denser tissues in nutrients: they provide collagen, fat marrow and minerals. But science clarifies. An article, Posted in Frontiers in Nutritionpoints out that the benefits are modest: some trials show minor improvements in skin and joints, although with methodological limitations. A meta -analysis in Orthopec Reviews It points positive effects on bone and articulating health, but insists on the need for broader and standardized studies. In addition, we are not designed to bite hard bones: they can splinter, damage teeth or pierce the digestive tract. And large animals bones tend to accumulate heavy metals such as lead or cadmium, which advise against consuming them in excess or un controlled dust, According to Healthline. The heat and pressure of the long broths allow to extract collagen and minerals safely, and some studies They suggest a certain benefit when ingesting collagen peptides. However, the reviews of the studies consulted coincide: Quality trials are missing, with standardized protocols and clear clinical markers. A new trend? The interest in bones does not happen in a vacuum. A couple of months ago, the “Carnivorous Diet” for Babies: families that offer ribs or cord to their children as part of the Baby-Led Weaning. Health and expert authorities They coincide in which to introduce meat from six months is recommended by its iron and zinc. But they warn that a strictly carnivorous diet in babies lacks fiber and vitamin C, essential nutrients for development. At the same time, startups in Europe and Asia experiment with powdered bone -based products: breads, sausages, patches or nuggets that incorporate calcium and collagen without bothering the consumer. According to National Geographicthe initial results are positive: when the bone appears as an invisible ingredient, acceptance is high. Collagen is more present. Korean cosmetics and social networks They have converted To the collagen in a global phenomenon, associated not only to joint or bone health, but above all to beauty and anti -aging. From facial creams to soluble coffee powders, the promise is to erase wrinkles, combat sagging and rejuvenate the skin. However, skeptical voices such as that of the surgeon Afshin mosahebi Remember that scientific evidence It is limited and that, by ingesting it, the collagen does not reach the dermis: it decomposes in amino acids like any other protein. The bone broth is a nutritious and comforting classic, but Not a guaranteed age. The real secret to aging well is still in basic habits: do not smoke, protect from the sun, maintain a balanced diet and sleep enough. An unexpected return. Of the “fat factories” Neanderthals to Korean cosmetics, bones have accompanied humanity in multiple forms. Today they return to the scene between broths and collagen powders. The difference is that, this time, they do not arrive as a resource of survival, but as a market as a product: what was previously thrown, is now sold as a trend. Image | Freepik Xataka | Boomers trust pills and supplement, generation Z in “functional snacks”: two ways to look for the same

Five of the best technology offers in Mediamarkt and El Corte Inglés, today October 4

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There are very few days left for the arrival of the Prime offers party Amazon and some stores have already prepared by throwing their own campaigns. So much The English Court With your save VAT as Mediamarkt With their oktobertech and several offers they have very good discounts, so in this article we will review which are the best technology offers that will be available only today, October 4. Xiaomi Redmi Pad by 169 eurosa good tablet that comes with 256 GB of internal storage. Western Digital My Passport by 111.56 eurosan excellent hard drive with 5 TB capacity. Sony Ult Wear by 121.50 euros When registering in the store, some headphones with a very good value for money. ASUS VIVOBOOK GO 15 by 371.05 eurosa very balanced laptop. Fire TV Stick 4K by 35.90 eurosan ideal device to see steraming content. Xiaomi Redmi Pad It is not necessary to spend a lot of money to have a good tablet with which to see movies and series. Mediamarkt has an offer for 169 euros the Redmi Pad Se of Xiaomi, a tablet that incorporates a 11 -inch screen and 256 GB of internal storagealthough it admits microSD cards up to 1 TB. Its four speakers are compatible with Dolby Atmos and its processor is the Snapdragon 680 6nm. Xiaomi Redmi Pad SE (256 GB) The price could vary. We obtain commission for these links Western Digital My Passport If you are running out of internal storage on the computer, you may be interested in this hard drive Western Digital My Passport. In El Corte Inglés Cuesta 111.56 eurosalthough in Amazon it has a price of 106.61 euros. Has 5 TB of storagea good figure to save many photos, videos and files, and has the ability to protect the password and encryption data. Western Digital My Passport (5 TB) The price could vary. We obtain commission for these links Sony Ult Wear Sony’s headphones usually have quite high prices, but not all. The brand launched a while ago Sony Ult Wear We already liked them a lot for their value for money. Right now they are offer in Mediamarkt by 121.50 eurosprice that we will see only if we are registered in the store. Among its best characteristics we have to They are very comfortable even if used for hoursthey have one of the best active noise cancellations that we have experienced and their theoretical autonomy is up to 30 hours. The price could vary. We obtain commission for these links ASUS VIVOBOOK GO 15 If you need a laptop, but you want something economical, in El Corte Inglés there are enough options, but one of the most sweet is the model is the model ASUS VIVOBOOK GO 15. Not only has a good price of 371.05 eurosbut we talk about a laptop that comes with a OLED screensomething unusual in this price range. In addition, its panel is 15.6 inches, it comes with an Ryzen 5 processor together with 16 GB of RAM and 512 GB of SSD and its battery has a fast charge, allowing it to have it loaded up to 60% in just 50 minutes. ASUS VIVOBOOK GO 15 (E1504FA-BQ2448) The price could vary. We obtain commission for these links Fire TV Stick 4K Although it is a Amazon device, Mediamarkt also sells the Fire TV Stick 4Kand also have it on offer. By 35.90 euros We talk about a good device to “convert” any TV with at least an HDMI port on a smart TV, although it is also interesting if we have an old smart tv and we look for a better performance. This model is capable of reproducing in 4K and is compatible with Dolby Atmos and Dolby Vision, although for this we need a television that is also compatible with that resolution and both formats. The price could vary. We obtain commission for these links Some of the links of this article are affiliated and can report a benefit to Xataka. In case of non -availability, offers may vary. Images | Mediamarkt, El Corte Inglés y Buyadicción (header), Xiaomi, Wester Digital, Sony, Asus, Amazon In Xataka | Best tablets (2025). Which to buy and 8 recommended models for all pockets and needs In Xataka | Best Amazon Fire TV. Which to buy and recommended models to turn your TV into a smart TV depending on the use

29 years ago we clone to the Dolly sheep. Thanks to this, today we are one step closer to solving the fertility crisis

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Imagine a future in which the infertility caused by the lack of ovules or sperm is no longer an insurmountable obstacle. A future where two men can have a biological child together, or where A woman who has lost her ability to produce ovules For age or for a cancer treatment may have offspring with its own genetics. This future, which until now belonged to science fiction, is a little closer thanks to a revolutionary advance that has been published in Nature. Biology This advance, which seems like a science fiction, has been made by the team of researchers at Oregon Health & Science University, led by Dr. Shoukhrat Mitalipov. In this case they have managed to develop an experimental technique that forces a skin cell (somatic) to reduce your number of chromosomes in half. It is, in essence, the most crucial and complicated step in the creation of a gamete (an ovule or a sperm). A process they have called mitomeiosis. To be able to understand it, you have to know that all the cells of our body have in total 46 chromosomes in its nucleus. But there is an exception: sperm and gametes that They have 23 chromosomes. A very important number so that when an ovule and sperm merge, they have a total of 46 chromosomes. That is why it is revolutionary that they have managed to get a skin cell to have 23 chromosomes to be an ideal candidate to give offspring. The trick. The natural process to create these haploid cells (with 23 chromosomes) is called meiosis. A very complex type of cell division that has been investigating for a long time. This made it replicate in a laboratory, which is known as in vitro gametogenesis (IVG) was one of the greatest challenges of biology. Something that now reminds us of what we already saw with the Dolly sheep in the cloning process. OHSU’s team addressed the problem in an ingenious way. Using a technique similar to cloning, called nuclear somatic cell transfer (SCNT). A technique that is complex, but can be summarized in three different steps: The first thing is to take a donated human ovule and extract the genetic material. In this way, the ovule maintained all its cytoplasm with the organelles, which ultimately is like the machinery that the cell has to produce energy and carry out many processes such as meiosis. Once done, a skin cell is taken (a diploid cell with 46 chromosomes in a 2N state) and is extracted the nucleus inside. Now it only remains to introduce the core of the skin cell into the ovule that has been emptied. The result. In this case it was amazing, since the ovule cytoplasm could ‘deceive’ the skin’s core, forcing it prematurely into a state similar to the metaphase of the Meiosis. This caused its 46 chromosomes to be organized in a spindle ready to divide, despite having skipped the DNA duplication phase in the cell cycle that is before the division of the genetic material. The problem. However, here they met a wall. In nature, the entrance of the ‘active’ sperm to complete its division, being mediated by a large number of zinc. But in this case, when they tried to fertilize the SCNT ovules with sperm, the vast majority (almost 77%) remained ‘arrested’ without reacting. The natural signal was not enough for this artificial construction. The solution in this case went to develop an artificial ‘starter’ key. After sperm fertilization, they applied an assisted activation protocol an electrical pulse by electroporation to simulate the calcium entry caused by sperm to its entrance, followed by a treatment with a chemical inhibitor called Roscovitin. And it is something that ended up working. Forced activation made the modified ovules leave their arrest and complete the division. The 46 chromosomes of the cell were separated, leaving an average of 23 chromosomes within the fertilized ovum (now a zigoto) and expelling a small polar body from the rest, having achieved the long -awaited ploidy reduction that was the objective of this experiment. Progress. The embryos resulting from this experiment containing chromosomes of the skin and sperm cell, beginning to divide and even some reached the blastocyst phase (an early development of about 5-6 days), with a success rate of 8.8%. This shows that genomes can integrate and work together. It’s just a test. The authors who are still a long way forward, since for now it is a “proof of concept” by not being a perfect replica of natural meiosis. In this case, segregation is random unlike meiosis, where it is ensured that each daughter cell receives a copy of each of the 23 types of original chromosomes. In this project the separation of homologous chromosomes (the paternal and maternal) was completely random. This generates aneuploid embryos that are incompatible with life. In addition, it also lacks ‘cross -rise’ or crossovera vital mechanism in meiosis where paternal and maternal chromosomes exchange fragments creating genetic diversity. This is something that is not present in this process and that takes away a lot of variability. The future. Despite the limitations of this study, work is a fundamental milestone. It aligns with other laboratories such as the Japanese Katsuhiko Hayashi that in 2023 managed to create functional ovules From male mice skin cells, with which healthy offspring were born. In the long term, the implications of these studies give hope to those women who suffer from infertility due to lack of functional gametes and who want to have offspring with their own genetics. The same happens in same -sex couples that also open the door for a couple of men (using a skin cell to create an ovule) or women (creating sperm) can have biologically related son between both members of the couple. Although we cannot also forget that right now there is a fertility crisis that causes that in Spain, for example, there is reduced birth rate. This is also conditioned that it is … Read more

The eruption of a volcano was synonymous with danger 100 years ago. Today has made Iceland a theme park

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Exactly one year ago, Iceland took a unexplored path In his fight against mass tourism: in essence, tell the truth to the visitor. Thus began a marked campaign For a slogan: “No one will save you if you fall”, which unequivocally came to confirm the hordes of the dangers of getting too close to an erupting volcano. Today, Iceland wonders if it was worth “opening” both the world. The awakening that changed everything. In 2010, when Eyjafjalajökull volcano interrupted air traffic European with an ash cloud that paralyzed the continent, Iceland went from being a remote island and evoked in Nordic sagas to become a global stage. The images of glaciers, black beaches and hot springs spread by international chains aroused the curiosity of the world in a country that had just suffered the blow of The financial crisis. With the campaign Inspired by Icelandthe government and tourism industry They took the moment. From then on, the landing of low -cost airlines and Viral phenomena In social networks (including a Justin Bieber video clip between waterfalls and aircraft remains) they catapulted the island to essential destination. Mass tourism. In just fifteen years, the number of visitors went from less than half a million to More than 2.3 million annuallymultiplying the local population several times during the high season. Tourism revitalized villages, generated employment and transformed the economyto the point of becoming the Main motor of the country. Locations Like Vikonce agricultural, they saw how the stables gave way to guest houses, improvised coffees in school bus and attractions of adventure. Immigration accompanied This boom: in some municipalities, foreigners are already a majority, and the arrival of new residents has even caused an unexpected “baby boom”. For many mayors and local businessmen, current problems are preferable to the decline of peoples that previously seemed condemned to abandonment. The identity dilemma. However, obviously not everything is good news. Tourism has contributed economic vitality, employment and infrastructure, but also tensions. Farmers complain about visitors who enter their lands or feed horses without permission, even causing deaths of animals. In Vikthe massive arrival of foreign workers has altered the social and urban fabric, with prefabricated homes that change traditional aesthetics. Even in schools they have had to Put posters to prevent tourists from photographing children. In the environmental plane, basic systems as the sewer They have been overwhelmed. Many Icelanders recognize the prosperity that tourism has given them, but they wonder how much local culture can resist without diluting. Iceland as theme park. More than a decade later that Eyjafjalajökull Cover the European sky with ashes and put the country on the global map, many critics argue that the island has run the risk of becoming in a “volcanoes theme park.” The geysers, glaciers and mountains of fire are today part of an itinerary Almost prefabricated, driven by low -cost airlines and Instagram selfies, which concentrates crowds in a handful of iconic landscapes while other regions remain outside. What was previously perceived as an indomitable and mysterious territory has become a tourist decoration subject to the logic of rapid consumption, where the eruption that attracted the world was transformed In advertising claim permanent. For many Icelandic, the paradox is evident: the volcano that saved the economy now threatens to devour the essence of their country. The future. Thus, academics and analysts propose Diversify the routes and offer deepest experiences linked to the history and culture of the country, to prevent tourism from reduced to a handful of “postcard places.” Regions such as Western Fjords or Fisheries North are still relatively on the sidelines, although the opening of direct flights could change the situation. The issue, according to many Icelanders, is not to close the door to visitors, but rethink the model: Attract those who want a longer and more conscious experience, instead of fast visits dictated by social networks. The national phrase Þetta Reddast (“Everything will work out”) reflects the resilient optimism of the country, although now faces the most uncomfortable question: Can Iceland continue to receive the entire world without sacrificing what made it unique? Image | Pexels, Berserkur In Xataka | “No one will save you if you fall into the volcano”: Iceland reopens one of its greatest claims with the best anti -tourism slogan In Xataka | In Barcelona, ​​the anti-tourism movement is adopting a radical tactic: harass tourists down the street

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