promising

We have genetically edited a spider to produce a fluorescent red cloth. And the implications are promising

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Mutant spiders. It could be the premise of a film that mixes science fiction and terror, or someone’s nightmare with Arachnophobia. However, the first mutant spiders created by the human being respond to something much more innocent. But maybe even more interesting. Mutant spiders. A group of researchers He has genetically edited A group of spiders. The most curious of the results obtained by this team is probably a group of spiders that, after the edition, are capable of weaving a red spider web fluorescent spider. It is about First experiment of genetic edition in spiders of which we have knowledge. For this, the team resorted to specimens of the American domestic spider (PARASTIDA TEPIDARIORUM), A species that, like many others, uses its spider web not only for hunting but also to protect its eggs. A fascinating material. Spider silk is one of the most interesting materials in the animal world. Spiders are capable of segregating different types of fabric and among them, structural silks are among the most remarkable for their very tangled resistance that binds to its elasticity, lightness and the fact that it is a biodegradable material, explains the team responsible for the study. CRISPR-CAS9. In its experiment, the team turned to the “scissors” of genetic edition CRISPR-CAS9. They began the process focusing on a gene linked to the development of the eyes with the aim of obtaining a first easy result to identify. The team injected his tool of genetic edition in a female in order to eliminate the gene chosen in their reproductive cells and thus be able to detect changes in their litter. The Resutlanted: Spiders who did not develop their eyes. From the eyes to the silk. The first success led to repeat the test, but this time focusing on the genes responsible for coding some of the proteins present in the structural silk of the spiders. In doing so, spiders wove spider silk filaments of fluorescent red spider. The details of the experiment were published In an article In the magazine ANGEWANDTE CHEMIE. A first step. To be able to edit the genes responsible for the production of a material as interesting as the structural filaments of spider fabrics opens new doors when it comes to knowing this material and its biochemical origins. Of course, we can also pave the way for being able to synthesize it efficiently or even in the development of materials with similar properties. “We have demonstrated, for the first time in the world, that (the tool) CRISPR-CAS9 can be used” to incorporate a desired sequence in spider silk proteins, thus allowing the functionalization of these silk fibers, ” stood out in a press release Thomas Scheibel, co -author of the study. “The ability to apply CRISPR genetic edition to spider silk is very promising for material science; for example, it can be used to increase the already high spider silk breakage.” In Xataka | ‘The Last of Us’ is already happening in the animal world and the last species in suffering are the “spiders of the caverns” Image | Patrick Edwin Moran / University of Bayreuth

Using a mobile is a real challenge for older people. An Aragonese startup has a promising solution

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Is called Maximilianabut it is not a person. It is a mobile. Specifically, one specifically designed for our elders. The idea that this device raises is unique, already a difference from other mobiles for the elderly, everything is based on trying that these people have to touch anything to communicate with their loved ones both in video calls and normal calls and to alert possible emergencies. Innovating from Aragon. Many business projects are born from personal needs. This happened for Jorge Terreu (Zaragoza, 26 years old), who a few years ago was Erasmus in France and had trouble contacting his grandmother, Maximiliana. This is how the germ of her project was created: create a phone to be able to talk to her without her having to do anything. @Miguessal This mobile can save your grandfather’s life, because it makes video calls down alone. It was created by a grandson for his grandmother, Maximiliana, who did not manage with technology. What began as a gift, is today a mobile that thousands of people use. You can learn more about him at www.maximiliana.es. #Salvarvidas #Emercances #Primerosauxilios #Urgences #security ♬ Original sound – Miguel Assal The principle of something big. Terreu prepared a mobile prototype in which he started the video call and the phone answered alone. He sent it to his grandmother in Madrid and soon realized that this idea could serve many more people. In March 2020, during the pandemic he donated five phones adapted to a hospital in Zaragoza and verified how users were delighted, so he launched the adventure of creating his own company and his project of a mobile for seniors. What would be called, of course, like his grandmother. Maximiliana. They hardly have to touch it. People who use Maximilian mobiles hardly have to touch it, because they can receive video calls or messages without having to play in the interface. If a relative or friend makes a video call, Maximiliana sounds for a few seconds and automatically breaks. If it is the elderly the one who wants to call, the interface is especially intuitive and simple and is based on a “desk” on which the faces of the family appear. Just press one of them to make the call. Emergencies. Maximiliana also has emergency call options. Thus, if for example the elderly falls and cannot handle the mobile with precision, it is enough that it agitates it a bit to activate the emergency call to the assigned contact. In those calls the mobile uses the flashlight to emit the international relief signal. Always located. Another of the Maximiliana options It is what allows to know at all times the location of that elderly, something especially useful if they are lost or misplaced. The software also shows the battery available so that family members can warn that it loads it to continue using it without problems. THE MOBILE AS SERVICE. Maximiliana includes the mobile, the control app for the family and the accessories, such as the cord or antiahogo strap that allows the device to be hung by the neck. The product is not sold as a mobile without more, but as part of a subscription service. The “basic pack” cited costs 24.90 euros per month, but it is also possible to directly hire the SIM card (unlimited calls, 25 GB of the Internet) as part of the “complete pack” for 29.90 euros per month. Includes apps like WhatsApp. Maximilian mobiles remain mobile, and allow to continue accessing applications such as WhatsAppChamber or Gallery. The person in charge of the device – normally, a relative of the elderly – chooses from the control application which applications wants them to appear on the mobile. It is the relative who acts as “administrator”. The relatives of the people who use Maximiliana are the ones in charge of managing and configuring the mobile options. Thus, they can add contact faces, change order (up to six on the screen), or adjust the sound duration. A grandmother like Community Manager. As they pointed out In the countryMaximiliana’s team has been growing as the success of the service has been curdling, but there is a very special component in that template. Your Community Manager It is Conchita Polo, grandmother of Pedro Malo, partner of Terreu in the project. More than the phone matters the service. There are currently good options when offering Mobile for seniors And also tips for Adapt any Android phone To make it easier to use for them, but Maximiliana’s proposal is interesting because everything combines. Take advantage of the idea of parental controls that for example allow to know the location of our children or control the limits of use, but adapting it to a population sector that can certainly take advantage of it in a beneficial way. Image | Maximiliana In Xataka | What five mobiles would I recommend to give my grandfather this Christmas, for simplicity and quality-quality

AI agents are promising. But as in Tesla’s FSD, you better not take your hands from the steering wheel

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AI agents are one of the great trends of AI This year. There are many expectations put in these models of AI capable of completing a task from beginning to end for us and almost if our intervention. And yet, one thing seems clear: for the moment it will be better “not to remove your hands from the steering wheel” and watch every step they take to prevent the AI ​​agent from being starring. Autonomy and trust. The Tesla driving assistance system –badly called Total autonomous driving (FSD For its acronym in English) – it requires that the user trust him to get carried away and that the car takes us from a point of origin to a destination without human intervention. IA agents propose a similar idea, to complete a task from beginning to end autonomously, but for this we must trust that they are able to do so. decision making. The agents will require huge data amounts and access to updated sources of information to analyze such data and then make decisions. In the past we have seen how AI models are especially good at the time of Summarize concrete information Or to draw conclusions from limited data, which is very useful for that decision making. Learn from mistakes. Tesla cars receive FSD frequent updates to improve their behavior. These updates are nourished by the data collected by the company when your FSD system is used, what allows you to polish the service. Something similar is expected to happen with AI agents, which will improve – especially at the beginning – when they are updated and “learn from their mistakes” when processing user requests. AI and companies agents. These types of solutions will be especially striking in companies that can thus automate processes that previously required total or partial human intervention. And precisely that is why this type of integration must be done in a very controlled way, because let’s admit it: we cannot trust 100% of the current AI models. Tesla knows that FSD is imperfect. It happens of course in the FSD of Tesla, which since its inception has been involved in various accidents, some of them with fatalities. One of the most recent was notified in October 2024: the low visibility made a TESLA with FSD activated a few months ago will run a pedestrian. Tesla has been criticized on numerous occasions of misleading advertising and of save the maximum on radars and sensors To achieve greater profit margin. AI agents can be equally dangerous if they are used incorrectly and “without having their hands in the steering wheel.” Users and companies that begin to use them must keep these risks very present. The hands behind the wheel, please. The conclusion was already clear in the Tesla FSD system, but also in the case of agents. They have barely done only appear on the market shyly, but everything indicates that this is one of the great trends of AI by 2025. And the problem is that the models of AI are imperfect and therefore can make mistakes, but it is that in the agents of that error it will increase. That they tell Air Canada, who had to return money to a passenger which obtained an erroneous response from the airline chatbot. Or to Chevrolet, whose chatbot was “deceived” by a user who achieved Buy one of your cars for a dollar. Domino effect. The accumulation of errors in sequential tasks is a fundamental problem in current AI models. We could say that it is something like the domino effect or the compound error: an error in an initial action distorts all subsequent decisions, generating results increasingly far from what expected. Imagine that in applications such as finance, medicine or logistics: consequences could be terrible. Solution: Constant supervision. To avoid this problem there are several proposed solutions. One of them is the establishment of check points. Thus, at the end of each subtarte the system-and ideally, a human user, what is called Human-In-The-Loop (Hitl)-should verify that everything is going well. It is also possible to minimize the risk using redundant systems – for example, using different models of AI so that the AI ​​agent uses them separately – or taking advantage of the information of the standard limits: if an intermediate fact thrown by an AI agent is too diverted from what is expected, we should rebound that process. And for the moment, spent (very) bounded. We are in a preliminary phase, and AI agents are “learning to drive alone”, so to speak. And the best way they learn is to go step by step and always starting with relatively simple and very limited scenarios. Thus, the ideal is to try to apply them to very specific cases and with a limited and known casuistry, so that their answers are as precise. Image | Erik Witsoe In Xataka | Microsoft is very important that the agents of AI are the great ball of the year. And is being reorganized to achieve it

Apple’s most promising and expected mobile for 2025 is no iPhone 17. It is the iPhone se 4

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The iPhone 16 They were, above all, conservatives. The family presented by Apple last September It was continuous And little exciting. Except for the new processor and the new camera button –What do you think after this time?– The differences were minimal. It is the same as we have seen in recent years in the sector. Lying bored mobiles Not only happens to Apple: it happens to almost all manufacturers. That makes precisely the most anticipated iPhone of this year not any of the potentials iPhone 17although certainly the ultradelgado (And possibly, ultracaro) iPhone 17 Air Save the papers in terms of expectations. No. The most anticipated iPhone of the year is probably the iPhone Se 4. Rumors about the new “compact and affordable” terminal of Apple do not stop producing, and expectations are high. Especially because three years ago of the launch of the last iPhone SE (2022) And that opens the doors to many potential improvements. In fact, this smartphone is expected to be something like a “remastered iPhone 14.” 6.1 -inch OLED screen at 60 Hz, SOC Apple A18, 8 GB of memory, and a single 48 MP rear camera, in addition to the 12 MP front. Although the iPhone 16 already start from the 128 GB of capacity, it is likely that Apple has limited the capacity to 64 GB. It looks like a bet Certainly balancedespecially if that single photographic sensor behaves properly. It would be known to its price: in 2022 the iPhone left with a starting price of $ 429, but this would probably be sensibly more expensive for its screen, soc, camera or memory: it would not be unreasonable to think about a starting price of $ 499. That would be a breath of fresh air for an industry that has climbed into the car of “The more expensive, the better“. To manufacturers have gone very well with that strategy. In 2024 the growth of sales was modest, but one thing was clear: We are fond of spending more when we change mobile. The iPhone Se 4 –o iPhone SE (2025) – would precisely raise an alternative to that trend. One that also has many signs of triumphing for the mere fact that who makes this movement is Apple. The popularity of its mobiles is extraordinary, but Having an iPhone is increasingly expensive. At the moment the cheapest iPhone that the firm sells is the iPhone 15, which has a starting price of 859 euros in the official store. The price is undoubtedly high, especially considering that we are talking about the 2023 base model That is why the iPhone is so striking before even launching: having an entire iPhone about 550-600 euros surely do not seem bad option for lovers of the firm’s products. The commitments are much more acceptable. Recall that the iPhone SE (2022) kept the 4.7 -inch screen and even the legendary touch id. He was born forcing users to sacrifice too many things: if you wanted to have an affordable iPhone, you had to give up a lot. Here we would have an alternative already much more serious and according to the times: every screen, more than decent diagonal, and face ID. Tempting. Is the iPhone 4 the Apple (and segment) Super Survesses in 2025? It certainly has ballots to achieve it. The market is now extremely mature and still waiting for the AI ​​to reactive, but it does not seem that Apple Intelligence can do it in the short term. So re -bet for a potential “barotelle” – with many quotes talking about Apple – it is certainly something that will attract many users. The other face of the currency, of course, will be the one that (probably) raises that iPhone 17 Air, the new model for users willing to have the best iPhone. Tim cook He already mentioned To this type of customers once: Apple has them, so it is mandatory to offer them what they are willing to pay. Image | Xataka In Xataka | The iPhone 17 will be rendered to evidence, according to Chinese sources: steam cameras are necessary

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