If your renovation is a pain, think about the house that cost 120 times more than its original cost: a masterpiece

Renovate a house It is usually an exhausting experience: budgets that skyrocket, structural unforeseen events, provisional solutions that end up being permanent. Now imagine that this home is not just any apartment, but one of the great icons of the 20th century, visited by millions of people and examined to the millimeter by historians, engineers and conservators. Then the reform stops being a domestic problem and becomes a continuous battle against time. Thus an icon was born. The assignment that changed a career The year was 1934 when Edgar J. Kaufmann commissioned Frank Lloyd Wright a weekend house next to a waterfall in Bear RunPennsylvania. The architect then took an unprecedented decision: He decided not to look at the water from afar, but to literally build on it. The work, built between 1936 and 1938, almost immediately became in a manifesto of organic architecture: concrete terraces that float over the waterfall, local stone walls that sprout from the rock, spaces that open to the forest as if the house were an extension of the landscape. By January 1938 he already occupied the same cover of time and critics proclaimed it one of the great masterpieces in the history of architecture, one capable of reconcile modernity and nature in an unforgettable image. It happens that there is always a “but” in a work, and one like this was no different. Yes. That perfect image had a disproportionate price from day one. The original cost exceeded the planned budget almost four times and reached approximately $155,000 of the time, a figure equivalent to about 3.3/3.5 million current dollars. Added to this were Wright’s own fees and the expenses derived from a complex execution in a unique but remote environment, so that the project was born already financially stressed. What should be a weekend country house became a total commitment, technical and economic, to materialize a radical vision. And we come to the material that has given the work its name, although it almost took everything away. The gesture that made Fallingwater world famous, its large columnless cantilevers over the waterfall, was also its Achilles heel. During the work, the engineer in charge of concrete warned that only eight reinforcing bars had been placed on a main beam and that, for a span of that length, it should have been duplicated steel. However, Wright rejection the objections, arguing that adding more reinforcement would damage the structure and demanding absolute confidence in their judgment. The contractor, without warning, decided to increase the steel anyway. Even so, when removing the formwork the first cantilever deformed more than four centimeters and was left with a permanent arrow that today translates into a visible slope close to two degrees. And the cracks came before inhabiting it The problems were neither theoretical nor late. Even before the Kaufmann family moved in in 1937, there were already documented leaks and cracks on the concrete parapets. As the decades passed, some balconies began to sink. more than 20 centimeters with respect to its original position, and in the nineties engineers found that the cantilevers they had failed technically and required urgent reinforcements to avoid greater risk. The house that seemed to defy gravity rested on a more fragile balance than the iconic photograph suggested. If the waterfall was the soul of the project, the rain and snow were its nightmare. Flat roofs, terraces that function as roofs for lower rooms and masonry walls holes filled with rubble They made it easier for water to find invisible paths into the interior. So much so that since the 1940s the house was nicknamed with irony by its owners for the number of buckets needed to collect leaks, and almost ninety years later an intervention of 7 million dollars intended to seal covers, inject more than a dozen tons of grout on the walls and improve waterproofing. It didn’t matter the crazy price that had been used previously, many leaks they returned with time. The overhang of the living room seen from the bridge leading to the house At the end of the 20th century and the beginning of the 21st, a structural restoration was undertaken that would be decisive: the beams were drilled and introduced steel cables post-tensioned to “pull” the concrete and recover part of its original position. That operation prevented the sinking will progressbut it did not eliminate the need for ongoing maintenance. To give us an idea, from 1937 to today, the preservation of Fallingwater has already exceeded 19 million dollars, a figure multiplied by about 120 times the initial cost of construction and which illustrates the extent to which keeping the icon standing has been more expensive than its own creation. In 1963 the Kaufmann family donated the house to the Western Pennsylvania Conservancy, which opened it to the public the following year. Since then, more than 6 million of people have visited it, and its status as a National Historical Monument and UNESCO World Heritage Site consolidated his status as one of the masterpieces of the 20th century. Paradoxically, the same audacity that generated the cracks, deformations and leaks is what gave it its symbolic force: Fallingwater, or The Falling House, embodies the rhetoric of the American dream of merging with nature and dominating it at the same time, even when that ambition required paying an enormous structural and economic price. The history of this icon shows that architectural genius is not exempt material risk. Wright’s possibly exaggerated authorship, his conviction towards engineers and contractors, and his willingness to take concrete further of prudent limitsproduced a work that was both sublime and problematic. If you will, it is also an imperfect building that has needed decades of disagreements, revisions and reinforcements to remain standing. And precisely for that reason, more than a frozen postcard over a waterfall, Fallingwater It is proof that great works are born from the tension between vision and reality, and that even masterpieces can always be, literally, at the edge of the … Read more

Reddit’s AI has recommended heroin use to treat pain. It’s actually the most Reddit thing that could happen

In December of last year Reddit announced Reddit Answersa chatbot-type AI tool that draws on all the information shared by Reddit users. Everything was going well until he started giving medical advice and ended up recommending that a user take heroin. Knowing the tone of some users of the platform, this is actually the most Reddit could respond. what has happened. They tell it in 404Medium. The recommendation appeared on the r/FamilyMedicine subreddit in a question about how to manage pain without using opioid substances. First he suggested using kratom, an unregulated substance that is banned in some states. The user who created the thread asked about the use of heroin to manage pain, to which Reddit Answers gave several answers: one warned him of the danger, while another directed him to users who had had good experiences with heroin to treat pain. Angry moderators. The user who reported the responses, who is also a moderator and works in the health sector, published an extensive post warning of the danger of this type of response. He complains that moderators cannot deactivate Reddit Answers in their communities and that this is a problem especially when dealing with sensitive topics such as physical and mental health. Solution. Reddit Answers is still in beta, but has already been launched in many countries and languages. In the case of the mobile app, suggestions appear within the threads and, as we said, they cannot be deleted. After complaints from users, the platform made an important change and now Reddit Answers does not provide answers on sensitive topics. It now displays the following message: “Reddit Answers does not provide answers to some questions, including those that may be potentially unsafe or may violate Reddit policies.” The answers depend on the users. According to Reddit itselfthe replies feature uses artificial intelligence so we can “get answers, insights, and recommendations from all over Reddit.” That means that if a user tells in a thread that heroin saved their life, it can appear on Reddit Answers, which is exactly what happened. On a platform where anonymity is the norm, tone outputs either confessions of crazy stories They are the order of the day. Imagine that an AI responds to us based on the content of Forocoches. Well that. Image | Brett Jordan in Unsplash In Xataka | The price to pay for having AI is the looting of all Internet content. And Perplexity is just the latest example

In his battle for being the best back pain medicine, ibuprofen has just found a serious competitor: cannabis

Lumbar pain is something that can be very common in society by the clinic so annoying that it has associated as the problems getting up from a chair, to walk or even to bend down. This makes research focused on seeking a treatment for this type problem that exceeds anti -inflammatory and analgesic classics. AND The key may be precisely in cannabis. A study. Recently published, an investigation whose results have been published in Nature Medicine, He has shown that a cannabis extract can reduce chronic low back pain. The drug called Ver-01 not only calms pain, but also Improves sleep and physical function. But the most important of all is that it does not create any dependence or withdrawal syndrome, so it is an interesting option to opioid analgesics such as the Tramadol. The problem. Chronic low back pain is one of the main causes of disability worldwide, By affecting more than 600 million people approximately. Those who suffer from Manudo faces a dead end in the therapeutic field by not having a healing path beyond taking NSAIDs and trying to reinforce the muscles in the gym. But the big problem is in the most powerful analgesics offered when ibuprofen does not finish working, but that creates a big dependence problem in our society. What is it. Obviously, we are not talking about smoking cannabis. Ver-01 is a highly standardized pharmaceutical product that is an ‘complete spectrum extract’ obtained from a patented strain of Cannabis sativa called DKJ127. But … What does ‘complete spectrum’ mean? With this term we refer to that in addition to its main psychoactive component, the THC, the extract contains a complex mixture and characterized by other compounds of the plant like others Cannabinoids (Cannabigerol or Cannabidiol), Terpenos and flavonoids. This integral composition could be key in its efficacy and tolerability profile. Methodology. There is a lot of fear around the ‘cannabis’ and the use that can be given because it logically He has long highlighted all the harmful effects that can have its consumption prolonged over time. But given the need to find a therapeutic alternative, a team of researchers evaluated the effectiveness of VER-01 in a phase 3 clinical trial. That is, the last stage before approved a medicine for commercialization. To do this, a Multicentric studyrandomized and placebo controlled. That is, a group of 820 patients with this pathology were divided into two groups and in this way for 12 weeks 394 participants received VER-01, while 426 received an identical placebo in appearance and flavor. Results. The study fulfilled the objective that had marked from the beginning. Patients who took VER -01 experienced an average pain reduction of -1.9 points on a scale from 0 to 10 on the NIR scale (numeric pain scale). On the other hand, for the placebo group there was also an improvement, but less accused of -1.4 points at the level of pain. The question is … Has it been for the drug? Our “great friend” statistics tell us that it is a statistically significant result. And although the figure may seem modest, in the treatment of chronic pain these levels of improvement are that they are very relevant. In fact, the effects were even more pronounced in patients with severe pain and in those with a neuropathic pain component (caused by nerve damage) and which today is about all with gabapentin. Benefits. In addition to the improvement in pain levels, there has also been an important improvement in the dream. Patients who received VER-01 as a treatment saw that the quality of sleep and their ability to do daily physical activity improved a lot. This is crucial, because they are classically the two aspects most affected by low back pain. He does not stay here, since it was also determined that patients had a less need to resort to rescue medication compared to the placebo group. Something that also points us to the effect is more elongated. Sure. One of the most important aspects when designing a new drug is that it is safe and can be tolerated. VER-01 treatment was well tolerated, and what is relevant is that no sign of abuse, dependence or symptoms of abstinence was detected, even after a sharp interruption of treatment. Although it is not 100% safe, because as any medicine can have adverse effects. The positive thing is that the vast majority were mild to moderate and transitory intensity. The most common were dizziness, fatigue, nausea and dry mouth. A hope. This study is one of the most rigorous to date on a medication based on cannabis for chronic pain. Its results show that Ver-01 not only provides a reduction means of pain, but also addresses other problems that are associated. By offering an effective therapeutic option, safe for long-term use and without the ghost of addiction, VER-01 is emerging as a fundamental tool in the future of pain management. It still remains for the market to need to have the final approval of the FDA and subsequently its arrival to the rest of the markets, provided that the new comparative studies with other opioids are satisfactory. And it is that putting an investigation date is certainly very daring, but this treatment is closer than we think. Images | Rick Proctor Sasun Boughdayan In Xataka | There are so many people growing marijuana in their homes that Endesa has a problem. And it will solve it with ia

A massive study links it with a higher risk of chronic pain in adult

During generations, the message has been the same: menstrual pain is normal, a “girls” to endure. But the reality is that a pain of great draft never It is something that should have been normalized. Now, a Longitudinal study Published in The Lancet Regional Health – Europe comes to disassemble this myth and to give an alarm voice: Have painful periods In adolescence it is linked to health problems in the future. A public health problem. The methodology of this study has been based on the monitoring of more than a thousand participants in the United Kingdom for decades. In this way, not only has it been confirmed, it has been concluded that the more severe the menstrual pain at age 15, the greater the probability of developing chronic pain a decade later, at 26. In this way, menstrual pain goes from being normalized to a serious public health problem. A methodology with long -term views. To get to this conclusion, the researchers They used data of the Longitudinal Avon Study of Parents and Children (ALSPAC), An ambitious project that has followed the lives of thousands of people since birth in the 90s. They analyzed the information of 1,157 participants, evaluating the severity of their menstrual pain at 15 years classified as null, mild, moderate or severe. Subsequently, once these participants were already 26 years old, an analysis of their health status was carried out by asking if They suffered some kind of chronic pain. Something that was defined as a pain that lasted at least three months. Worrying figures. After adjusting the data to rule out the influence of other factors such as BMIthe socioeconomic level or previous mental health problems, the results were clear. The first of all, is that adolescents with moderate dysmenorrhea, that is, with strong enough pain to not be able to ignore it, they had an extra 65% probability of suffering chronic pain in the adult stage compared to those without menstrual pain. In the case of the most severe dysmenorrhea, which prevent normal activities, the risk is triggered up to 76% of suffering chronic pain in the future. These data translate into an increase in absolute risk of 12.7 and 16.2 percentage points, respectively. It is a difference too big to be ignored. The study also revealed how common this problem is: almost 60% of adolescents in the sample reported moderate to severe menstrual pain. A problem that extends through the body. One of the most interesting findings in the study is that the association is not limited to the classic abdominal or lumbar pain, which could be considered an extension menstrual pain. What happens in this case is that adolescents with severe dysmenorrhea show a greater risk of chronic head pain, back, knees, dolls, hips and thighs. Because? The authors of the study suggest that behind all this is a central sensitivity. To understand it, we must bear in mind that in adolescence there is a great neuroplasticity, where the nervous system is especially moldable. The repeated experience of intense and poorly managed pain, such as dysmenorrhea, can “train” the nervous system so that it becomes hypersensitive. In essence, the brain and spinal cord learns to be in a constant alert state, which increases vulnerability to develop other types of pain in the future, even in those areas that are not at all related. For Dr. Rachel Reid-McCann, principal researcher, “It is possible that the experience of moderate or severe menstrual pain can alter the structure of the brain and how it works in response to painful stimuli, making chronic pain more likely in the future.”. It is not a purely psychological. In the study itself, researchers have seen a relationship between dysmenorrhea and a subsequent increased symptoms related to anxiety and depression. But these factors only explained a small part of the connection with chronic pain and this reinforces the idea that the main cause is a physiological mechanism, and not simply that “pain is in the head.” You have to stop normalizing pain. The conclusion of the study is a call to action for father, educators and, above all, for the health system. Normalize menstrual pain and dispatch it as “is normal” has great long -term consequences. And that will go to the health system. The researchers point out that menstrual stigma and the lack of education on menstrual health cause many young people not to seek help, or that when they do, their complaints are minimized. In this way, it is believed that early identification and good control of dysmenorrhea can be key to improving the immediate well -being of adolescents and preventing the appearance of serious health problems in the future. Images | Saranya7 In Xataka | A baby, three parents (biological): a promising fertilization technique that, for now, we will not see in Spain

We have detected the gene that acts as a ‘switch’ of chronic pain. It is the principle of the analgesics revolution

Chronic pain is one of the worst convictions of modern medicine. Affects one in five peopleis the main cause of world dependence And to top it off, Current treatments They are insufficient or come with devastating side effects such as Opioid addiction as fentanyl. But now, A great investigation Posted in the prestigious magazine Nature It has opened a door that could change everything. A gene as responsible for chronic pain. An international team of scientists has identified a gene, the SLC45A4as a key actor in the perception of pain by the human. And it is not another gene on the list. They are the necessary instructions to manufacture a protein that acts as a “guardian” of the membrane of Our sensory neuronscontrolling the passage of mysterious molecules called polyamines. When manipulating this protein, researchers have reduced the intensity of certain pain without affecting other sensations such as The touch. The finding not only solves an old biological enigma, but also opens the door to a new generation of analgesics for patients with pains that are not controlled with current therapies. Following the track in the DNA of 130,000 people. Find a small gene Inside the human genome It is not something simple, taking into account the large amount of information that can be found In a sequencing. That is why researchers have resorted to brute force with the processing of a large amount of data. To do this, they analyzed the genetic information and pain questionnaires of more than 132,000 people from the UK Biobankone of the world’s greatest repositories of medical and genetic information. Looking for patterns in all data. Using a Complete genome association study (GWAS), which is like crossing thousands of data to find patterns, researchers discovered that certain variants of the SLC45A4 gene were significantly associated with the intensity of chronic pain that people reported. Something that could also explain the different pain thresholds that each person has. To ensure that it was not a coincidence, they replied the finding in two other gigantic databases such as the Million Veteran Program from the United States and Finngen of Finland. The result in both was similar, so the evidence began to clarify. But once you have the name of the gene, the question is: what exactly does this gene do to modulate pain? The guardian of the polyamines: solving a neuronal enigma. This is where history becomes very interesting. It was known that the SLC45A4 manufactured a conveyor protein, a kind of rotating door on the surface of the cells. But nobody knew what he transported. The investigation revealed that its load is the Polyaminessmall molecules that, despite being crucial for almost everything in the cell (From the reading of the DNA to growth), they had a role that was not known in pain. What was known is that during a pain situation polyamines increased, but the mechanism of action was a mystery. The reason for the mystery is that the effect was different depending on whether they were outside or inside the neuron, but the ‘door’ was not known through which they could enter or leave. Until now. The SLC45A4 protein is that door. Using advanced verification techniques. Before announcing a discovery like this, it is important to be verified with different techniques. In this case the Electronic Creomicroscopy To obtain a 3D map at the atomic level of the protein. In this way, they saw their structure with an amazing detail. But seeing it is not just to have a very beautiful photograph hanging in the office, but it could be understood how it was able to recognize polyamines and even a Modulable domain That the protein itself uses to inhibit itself, as an integrated key in its own lock. And this is something that opens many doors to future research related to chronic pain. Mice with the lowest pain threshold. The fire test came with the experiments in animals. The team created genetically modified mice so that they did not have the SLC45A4 gene. These mice were, in appearance, completely normal. However, when they were subjected to pain proof, the results were amazing. Specifically, mice were subjected to different tests, such as being on a hot plate or receiving a formalin injection, which is a chemical that Causes pain at high doses. Here it is as they showed a much greater resistance to chronic pain. But when they were given a quick puncture (acute pain) the answer was identical to that of normal mice. A pain regulator. And this difference is crucial in the investigation. It means that SLC45A4 is not a switch that when we go out ‘we stop feeling any type of pain, but is a fine regulator for persistent and deaf pain, precisely the type that characterizes chronic pain. Because living completely without pain is not a good idea. The pain in the end is an organism alert system that something is not doing well, for example, that we have appendicitis. If we ‘turn off’ acute pain are many emergency situations that we would literally stop attending until it was too late. And reason is known. The absence of the protein made a specific type of pain receptors, the so -called Polymodal nociceptors C or fibers C (Those that detect chemical or thermal pain), were much less excitable. That is, it was necessary to expose the receiver to a much stronger stimulus so that the neurons ‘trigger’ an action potential that reached the brain and gave the feeling of pain. Literally, the threshold potential was much lower and, therefore, resisted from great magnitude pain. A new hope for millions of people. This discovery is more than a simple scientific curiosity. By identifying this protein as the polyamine transporter in neurons related to nociception, a completely new window for drug design opens. And it is that current analgesics act on receptors or block (such as the case of ibuprofen with COX-2). Now, the drugs designed to modulate the activity of … Read more

Spending many hours in a row in front of the PC is more bearable with Sihoo Doro C300, the ideal chair to avoid back pain

Choosing chair to work or study at home is key if we want to avoid suffering those annoying back pain. The well-known Sihoo brand has several that can come great for this, being possibly the Doro C300 one of the best quality-price that we can choose if we seek comfort and a design designed to avoid bad positions. And be careful Because now we can take it at a brutal price: only 299.99 eurosthat we can also reduce 10% more if we use the XST10OFF code. SIHOO DORO C300 ERGONOMIC CHAIR * Some price may have changed from the last review A chair with dynamic lumbar support and designed to have good support always Although many users are launched by gaming chairs thinking that they are the most comfortable, the truth is that the office chairs They are a better option for our health. This Sihoo Doro C300 It will come great to be in front of a PC for many hours in a rowalways being comfortable and with a good position to take care of our health. One of the points that suffers the most from our body when we are sitting is lumbar, and precisely for this reason the C300 It has A body tracking system for this area. Thanks to this system, the chair will adapt at all times to our movements. This is the difference of most market chairs, since these have a rigidity that can go wrong for certain positions, something that does not happen with the C300. The support follows this same line, designed so that we have well supported our backs all the time. In fact, We can recline up to 130 degrees In those moments that we have rest or simply want to relax some of so much work stress. Here it also applies, in a great way, the body monitoring of which we talked above, so even very reclining we will have a good posture. Of course, we cannot ignore your seat, another key point to choose a chair. This is designed so that our weight is distributed correctly, causing us not to have any pressure on the thighs. In addition, it is manufactured (like support) in mesh fabric, Resistant to the passage of time and ideal in summer. His support, which is padded so that we can place both arms comfortably, They can be moved in 4 directionsmaking it very easy to configure them. A quite interesting point of them is that they are synchronized with the support of the seat when it is reclined, so we will always have them well placed. We cannot forget another key point: The headrest. This element is very important, since the neck is another of those parts of the body that suffer a lot. That of the C300 It can be adjusted with a simple mechanism, up, down, forward or backward. Moreover, you can even turn in small pleasant, everything we always have the best posture. Its pro version goes a little further, with more configuration options If we want to level up and our budget allows us, we can opt for the Pro version of the C300. This chair is identical to the previous one in several aspects, but it improves some parts to offer a more comfortable experience still. Its PVP is 799 euros, but right now we also have it on offer with a great discount: it stays in 559.99 euros. SIHOO DORO C300 PRO CHAIR * Some price may have changed from the last review In what points does this Doro C300 Pro de Sihoo stand? Without a doubt, its star point is easy to adapt to the height and weight of each person. The pro model is ideal for almost everyoneand can be adjusted comfortably for users of 1.50 to 1.90 meters. Not only that, but also your seat is bigger that you can adjust in depth as we want. Another very interesting element we have in your armrests, that move on in 6 different directionsthat is: up, down, forward, behind, in and out. This is especially useful if we are gamers, since to have comfort and precision you have to adjust them very well. Its support can be reclined a little more than the previous C300 (up to 135 degrees) and has A simple control on the side to adjust everything: From support to the seat. It doesn’t matter if we prefer this model or the previous one, any of these two Sihoo will give us what we are looking for: being comfortable and making the long hours of work or study more enjoyable. Some of the links of this article are affiliated and can report a benefit to Xataka. In case of non -availability, offers may vary. Images | Sihoo In Xataka | Purchase guide of how to make your job at home ergonomic In Xataka Selection | How to set up your home office: Guide for the purchase of supports, monitors and other peripherals, cables, headphones and more

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