In his battle for being the best back pain medicine, ibuprofen has just found a serious competitor: cannabis

Lumbar pain is something that can be very common in society by the clinic so annoying that it has associated as the problems getting up from a chair, to walk or even to bend down. This makes research focused on seeking a treatment for this type problem that exceeds anti -inflammatory and analgesic classics. AND The key may be precisely in cannabis. A study. Recently published, an investigation whose results have been published in Nature Medicine, He has shown that a cannabis extract can reduce chronic low back pain. The drug called Ver-01 not only calms pain, but also Improves sleep and physical function. But the most important of all is that it does not create any dependence or withdrawal syndrome, so it is an interesting option to opioid analgesics such as the Tramadol. The problem. Chronic low back pain is one of the main causes of disability worldwide, By affecting more than 600 million people approximately. Those who suffer from Manudo faces a dead end in the therapeutic field by not having a healing path beyond taking NSAIDs and trying to reinforce the muscles in the gym. But the big problem is in the most powerful analgesics offered when ibuprofen does not finish working, but that creates a big dependence problem in our society. What is it. Obviously, we are not talking about smoking cannabis. Ver-01 is a highly standardized pharmaceutical product that is an ‘complete spectrum extract’ obtained from a patented strain of Cannabis sativa called DKJ127. But … What does ‘complete spectrum’ mean? With this term we refer to that in addition to its main psychoactive component, the THC, the extract contains a complex mixture and characterized by other compounds of the plant like others Cannabinoids (Cannabigerol or Cannabidiol), Terpenos and flavonoids. This integral composition could be key in its efficacy and tolerability profile. Methodology. There is a lot of fear around the ‘cannabis’ and the use that can be given because it logically He has long highlighted all the harmful effects that can have its consumption prolonged over time. But given the need to find a therapeutic alternative, a team of researchers evaluated the effectiveness of VER-01 in a phase 3 clinical trial. That is, the last stage before approved a medicine for commercialization. To do this, a Multicentric studyrandomized and placebo controlled. That is, a group of 820 patients with this pathology were divided into two groups and in this way for 12 weeks 394 participants received VER-01, while 426 received an identical placebo in appearance and flavor. Results. The study fulfilled the objective that had marked from the beginning. Patients who took VER -01 experienced an average pain reduction of -1.9 points on a scale from 0 to 10 on the NIR scale (numeric pain scale). On the other hand, for the placebo group there was also an improvement, but less accused of -1.4 points at the level of pain. The question is … Has it been for the drug? Our “great friend” statistics tell us that it is a statistically significant result. And although the figure may seem modest, in the treatment of chronic pain these levels of improvement are that they are very relevant. In fact, the effects were even more pronounced in patients with severe pain and in those with a neuropathic pain component (caused by nerve damage) and which today is about all with gabapentin. Benefits. In addition to the improvement in pain levels, there has also been an important improvement in the dream. Patients who received VER-01 as a treatment saw that the quality of sleep and their ability to do daily physical activity improved a lot. This is crucial, because they are classically the two aspects most affected by low back pain. He does not stay here, since it was also determined that patients had a less need to resort to rescue medication compared to the placebo group. Something that also points us to the effect is more elongated. Sure. One of the most important aspects when designing a new drug is that it is safe and can be tolerated. VER-01 treatment was well tolerated, and what is relevant is that no sign of abuse, dependence or symptoms of abstinence was detected, even after a sharp interruption of treatment. Although it is not 100% safe, because as any medicine can have adverse effects. The positive thing is that the vast majority were mild to moderate and transitory intensity. The most common were dizziness, fatigue, nausea and dry mouth. A hope. This study is one of the most rigorous to date on a medication based on cannabis for chronic pain. Its results show that Ver-01 not only provides a reduction means of pain, but also addresses other problems that are associated. By offering an effective therapeutic option, safe for long-term use and without the ghost of addiction, VER-01 is emerging as a fundamental tool in the future of pain management. It still remains for the market to need to have the final approval of the FDA and subsequently its arrival to the rest of the markets, provided that the new comparative studies with other opioids are satisfactory. And it is that putting an investigation date is certainly very daring, but this treatment is closer than we think. Images | Rick Proctor Sasun Boughdayan In Xataka | There are so many people growing marijuana in their homes that Endesa has a problem. And it will solve it with ia

We are sending cannabis samples to space. They will be key to knowing if we can colonize the moon or Mars

Throughout our short space race we have sent the most diverse things to space: from golf balls up to 2,000 small jellyfish (that returned being 60,000), going through latea piece of the Wright brothers, an electric car, a gorilla costume and a pizza. Today to this peculiar list we have to add about 150 cannabis seeds. The reasons? Strictly scientific. Mayasat-1. That is the name they receive both the mission (Integrated within Mission Possible 2025) as the incubator on board which have traveled seeds, algae and human DNA, among other things. In total, 980 samples of 11 different customers. The incubator has been developed by the Genoplant Research Institute in Slovenia, but who has decided to send cannabis seeds to space has been Martian Grow. Transport-14 | Image: Genoplant Mayasat-1 | Image: Genoplant Three laps. Before addressing the why of cannabis, it is convenient to understand what the mission has consisted, whose duration has been three hours. Mayasat-1 took off on Monday 23 at 23:50 aboard a Falcon 9 from Spacex from Vandenberg Space Force Base in California. It reached a height of 520 kilometers (120 kilometers more than the International Space Station) and completed three laps around our planet. Specifically, through polar areas. Because? Because at the North and South poles exposure to radiation is very, much higher than that of Ecuador due to the magnetic field. The objectives. There are several, but they can be summarized as follows: Observe the survival of samples to radiation, microgravity and temperatures of space to have an idea of ​​its ability to resist extreme conditions. Investigate possible adaptations, such as genetic or structural changes, which may have occurred in response to the environmental stress factors. Study the possible implications for the cultivation of plants in space or advances in medicine. Serve as proof of concept for the realization of biological experiments in space. And now yes, cannabis. Božidar Radišič leads the initiative Martian Grow and works as a consultant at the Research Nature Institute in Slovenia. In statements collected by WiredRadišič believes that “sooner or later, we will have lunar bases and cannabis, with its versatility, it is the ideal plant to supply those projects.” In his own words, cannabis “can be a source of food, proteins, construction materials, textiles, hemp, plastic and medicines. I don’t think many other plants give us all these things.” But cannabis … Yes, it is associated with a very different recreational use, but its potential as a plant is tremendous. The Cannabis sativa l produces THC (tetrahydrocannabinol, the main psychoactive compound) and CBD (Cannabidiol, has no psychoactive effects), but these are only two of the More than 550 chemical compounds found to date. And although we do not know what effects each and every one of them has, we do know that the plant is surprisingly resistant. Image | Crystalweed Cannabis Hold on what you throw. Cannabis sativa is a plant that resists ultraviolet rays and gamma radiation (in fact, it is used in its industrial production to decontaminate it). It is also extremely versatile, being able to grow both in Mexico and India, Nepal, Netherlands or Afghanistan despite the fact that its origin is in the Himalayas. Nor is it a plant that needs too much water and can be grown in different types of soils. Their ballots to be a successful space crop are, therefore, abundant on paper. And why send seeds to space? We know that radiation and genetic mutation is able to generate new varieties of species with different properties. “So far more than 3,400 new varieties of more than 210 species of plants using genetic variation induced by radiation and improvement by mutations, “they explain from the International Atomic Energy Agency. For Radišič, that is precisely the key: “It’s about finding out if cosmic conditions affect cannabis genetics, and how they do it, and we may only discover it after several generations.” Radiation exposure can cause mutations, not all negative, not all positive. The key is to detect those that can play in favor of humanity. The problem, of course, is that we need more information. Image | Genoplant Further. We have already cultivated lettuce at the International Space Station, Thalian Arabidopsis on lunar soil and Sent seeds to spacebut all radiation exposure has been in low orbit (up to 2,000 kilometers high). The responses to the radiation of a plant at the International Space Station may not be the same as those of a plant on the moon (at 38,400 kilometers away) or on Mars (54.6 million kilometers). One of the projects that seek to explore how plants cultivated on the moon respond is Leafa NASA mission that will travel to our satellite in the mission Artemis III In 2027. Next steps. When the capsule returns, the Božidar Radišič team and the Faculty of Health Sciences of the University of Ljubljana will study the seeds, their possible mutations and adaptations to obtain results and see which compounds have altered and how. “Whether there are changes as if not, both results will be important for the future, so that we know how to grow cannabis in the space environment,” says Radišič to Wired. An important job. Colonizing the moon or Mars is not only a technological challenge, but also logistics. It is not viable to transport food to keep the population of another planet, so it is capital to learn to cultivate in lunar and Martian soils, completely inhospitable and hostile. There have been advances and research with different proposals For many yearsbut there is still no solution that seems perfect. Images | Genoplant In Xataka | We have found a plant capable of producing 40 cannabinoids. A closer plant evolutionarily to lettuce that to hemp

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