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The abuses have shot in the United States and the main suspect is also an old acquaintance in Europe: the SUV

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25 years ago, cars were more insecure. It is undoubted. Modern vehicles have been filled with radars, sensors and cameras that have turned our cars into authentic technological machines that squeak, stop and even dodge before an obstacle. But mortal abuses have shot in the United States. Every day we see less. And no, they are not your eyes. The study. It has been done by the Institute for Highway Safety (IIHS)an independent association that studies road safety on US roads. According to their data, mortal abuses to pedestrians in the United States have shot 37%. And in 42% if we talk about cyclists abuse. It is not a matter of cars being more insecure. On the contrary. Cars are safer than ever. At least for those who travel inside. Because the problem is that every time we see less what we have in front of us. And that, according to the IIHS, explains why this increase. Giant cars. The United States has always been a country of huge cars. In 2021, We already explained in Xataka that some of the best -selling cars in the country could have six children sitting in front and would not see them. One behind the other. Uploaded aboard a Cadillac Escalade, a driver would see only the head (and partially) of the sixth child sitting in the row. Just take a look at the best -selling cars in the United States To verify to what extent their drivers prefer large cars. The best-selling vehicle is the Ford-F Series, a pick-up with a multitude of versions. The second The Silverado Chevrolet (another pick-up) and the third classified is the most “restrained” Toyota Rav4. Of course, they are far from the Dacia Sandero, Renault Clio and Volkswagen Golf that take the first three positions on the list of best selling in Europe. However, little by we continue to go down, among the 10 best -selling cars on our continent we find up to four SUVs. We see less and less. The IIHS has studied What visibility has a driver less than 10 meters around your vehicle and if it has improved or worsened in the last 25 years with the launch of the new generations. And there are bad news: among the three best -selling SUVs in the United States, visibility has worsened considerably. According to his calculations, the driver of a Honda CR-V saw 68% of everything around a 10 meter radius. In your latest generation, you can only observe 28% of what surrounds you. A Ford F-150 does not get much better data. In a quarter of a century it has only lost 7% visibility. The problem is that 25 years ago it was so bad that the driver has gone from seeing 43% to 36%. In Azul, the blind points of one of the cars analyzed Huge blind spots. The problem is that cars have become machines with huge blind spots. The higher the nose, less visibility in short distances. The bigger the car front pillar, the less visibility we have diagonally. And even the rearview is a problem when the size is triggered. This has been measured in the IIHS with 360º cameras located at different heights to represent all the carvings of the drivers. Then, a software performs an average and calculates how far the driver begins to see or how much space is outside his viewing angle. In the upper image, the blue zone is the space that is covered to the driver. In Europe we also know them. Yes, in Europe we also know these cars well. If we take a look at SUV sales 25 years ago we will realize that Just 5% of the market share It was occupied by this type of cars. In 2025 More than half of the cars sold can be put within this category. For a five years, the SUV is the car that sells the most. But, in addition, cars have grown a barbarity in this quarter of a century. There are SUV versions that would seem more than unlikely 25 years ago, such as Toyota Yaris Cross. And the height of the cars has not grown much but their frontal ones have been muscular and are now larger. A BMW X3 measured 4,565 meters in 2004. Today measures 4,755 meters. A danger. Those who suffer the most the consequences of this excessive growth are pedestrians and cyclists. As we said, cars are safer in case of accident. And have a technological arsenal to avoid them, such as the rear camera to which forces the European Union. But lifting the front has very serious consequences in case of accident. In case of shockit is more likely that the pedestrian dies in the accident or that he receives serious injuries such as hip breakage. Also head injuries (if they bounce against the car) are more serious. The studies say That every 10 centimeters that the hood rises, the possibilities of receiving serious injuries increase by 27%. Photo | IIHS In Xataka | At night all pedestrians are brown: the abuse prevention system fails when it is most needed

“In five years we will be one of the three main manufacturers in the world, I am convinced”

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Turn the bus and face a huge industrial -looking door. Two inputs controlled by a garita under a gray structure topped in its upper area with three letters and their explanation with Hanzis (The Chinese characters that give it name). The bus takes various streets, turns left and right. Finally, take a last turn and leave us under a roofed space. To our left, a huge staircase guarded by two gigantic lions guarded by an immense and lonely esplanade. In the background five buildings are drawn that with its height, of no less than 30 floors, break with the plain of the square. To our right, the entrance door to an immense hall after the demonstrations of some of the more dotteras technologies of the Chinese car market. Yes, that one He is arriving in Europe and who aspires to become a reference. Will make it clear to us Stella Li, BYD Vice President. We ask what the company expects in the next five years, what will be after five years. Look with the decision he faces any as he asks to be done: “We will be one of the three main manufacturers in the world. I am convinced.” A meteoric career The image that projects the headquarters of Byd in Shenzhen (China) is the same as the one that gives off a good part of the city. The immensity of the plazas of Soviet reminiscences are mixed with gigantic skyscrapers of somewhat decadent appearance in their wrapping but that, without a doubt, welcome inside the gears that move the latest technology of the country. The gears are human that live in these buildings. More than 17 million people that push to make Shenzhen a megaciudad that drinks from a clearly communist appearance past and now lives from wild capitalism that permeates all corners. It is the city of shopping centers full of ultra -realistic falsification stores but also that of skyscrapers who play with breaking your neck, immense headquarters of Chinese banks, and dozens of skyscrapers that are thrown into an orgy of lights, colors and music three times a day to demonstrate the world that they have enough strength to wear their LED panel buildings and put them to dance to the rhythm they want to dance. The rhythm of the gears that hide under these last glazed moles are clear: money and technology. Crossing the huge glazed doors of the Byd headquarters already gives us an idea of ​​what we are going to find inside. Next to the marble and columns that never seem Byd manufactures in vertical integration, Much of its success. And it is that of the batteries that began to manufacture in 1994, the year in which the company was founded, it has passed to a giant that has already manufactured more than 10 million vehicles, which exceeded four million cars produced in just one year in 2024 and that is much more than that. It is a company that also manufactures luxury vehicles, subway cars, buses and an enormous amalgam of components for them, from the batteries to the semiconductors or heat pumps. “Our integral approach to production and batteries give us a unique competitive advantage. We hope to have a solid presence on all continents, with Europe as one of our priority markets”, Stella Li emphasizes us who knows where we want to go with that question where they will be in the next five years. That vertical integration is all that they want to teach us in our visit to the central headquarters. Start with a factory miniturization. The classic miniature trains game is made up of the rails through which vehicles that move the doors and other parts of the chassis move. We will see it with our own eyes the next day but we will get an idea of ​​how chassis and mechanical set marry to give way to the end of the line to a little Yangwang U8 in miniature, the huge SUV of more than five meters that is able to float on water. Later, at the end of the visit itself, we will have the opportunity to get on one and check The maximum luxury that proposes byd. Vehicles as excessive as well finished, topped with materials that fit the precision of the best models in the market. And with the eccentricities of the Chinese market claims, such as the drones parking that carries one of the vehicles parked at the entrance. We have entered for your past, we will go out for your future. Among others, the load of 1 MW for electric cars, a technology that Byd already has available in two carsbut that, Stella Li recognizes us, is thought above all for trucks and car fleets. Live, the system overwhelms, connecting to the same car two hoses that provide 500 kW each. The great advantage, in addition, is that if the car does not admit this type of load, the supplier can nurture two cars to a maximum of 500 kW, powers with which we do not dream in Spain for the moment. At the moment, they will put just over 4,000 points on the street. All byd patents We were notified The strategy is based on pillars of all kinds: a huge variety of products that seem to be cannibalized, its own technology sustained by an almost inconceivable variety of patents and a groundbreaking attitude towards the designs of the market in which enormous equipment and low prices are combined. That patent reaíla is proud throughout a wall that could well measure 20 meters. From top to bottom, talked with the certificates of each of them. They are, of course, those that allowed Byd to create LFP batteries that, they show us proud, They can be crossed by a nail and Do not burn in the process. The NCM facing the same test on your right does not run the same fate. A flash shakes the room and the heat of … Read more

main novelties and what mobile xiaomi, redmi and little will update

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Let’s tell you what are The novelties of Hyperos 2.2the latest version of the customization layer for Xiaomi, Redmi and little mobile. As its predecessor, it is again a minor update in which several characteristics are polished and others that remain pending with version 2.0 are added. We are going to start the article with the list of novelties, in which we explain each of the new features. Then we will pass with the list of devices that can updateboth mobile and tablets. It is the list of confirmed models, although there can be some timely inclusion. News of Hyperos 2.2 We start with the list of The main novelties of Hyperos 2.2. In it, we will be point by point with each of the novelties, explaining them to know what you can expect from them. Improvements in interface animations: The animations of the interface have softened and improved, such as opening and closing apps. You will notice that they are softer than until now. Horizontal app improvement The behavior of horizontal applications has been polished. Falls with gestures and some visualization problems have also been solved. More customization in desktop and lock screen: Advanced blur effects on desktop wallpapers can be applied, and the visibility of the names of the icons has been improved. You can also customize direct accesses, and new funds with lens effect are added. Calls without internet: You can make voice -free voice calls, although without clarifying how it works or what devices. But it seeks to advance in this type of alternative connectivity. Improvements in the camera app: The menus are simplified, and the adjustments have been changed so that they are easier to handle. There are also new water brands to customize your photos. Performance improvements: In general, the operating system has continued to optimize, specifically in storage management, animations and interaction with third -party applications. Compatible devices Here are the initial list of Mobile and tablets compatible with update. The list can vary, and the times in which the new version will arrive depend on each device: Little F7 Pro Little M6 Pro 4g Redmi Note 13 Pro 4g Little m6 Redmi 13 Redmi 13x Little x6 pro Redmi 12 Redmi 13c Little C65 Redmi 13r Redmi 13c 5g Redmi 14c Little C75 Redmi A3 Pro Xiaomi 13t Pro Xiaomi 14t Pro Little F6 pro Little F7 ultra Redmi Note 12 NFC 4G Redmi Note 12s Redmi Note 13 4G NFC Redmi Note 14 Pro 4g Redmi Note 14 pro+ Redmi Note 14 Pro Little x7 Redmi Note 14 Little M7 Pro 5g Redmi Pad 2 4g Redmi Pad Pro 5g Redmi Pad Pro Little pad Redmi Pad se 4g Redmi Pad Se 8.7 Wi-Fi Redmi Turbo 4 Little x7 pro Xiaomi 15 Ultra Xiaomi 15 Xiaomi Mix Flip Xiaomi Pad 6s Pro 12.4 In Xataka Basics | Advertising in Xiaomi mobiles: how to remove it from notifications and native apps in Miui or Hyperos

China is flooding from devices without a trace of Android. Huawei is the main responsible

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Huawei’s ability to respond to the numerous restrictions imposed by the United States government is being the best example. The company is in the process of continuing to it to go beyond the Kirin 9020marking rhythm of launches with The Pure 80 Ultra and its Advanced Chamber Systemand achieving what no other manufacturer had achieved to date: create a real alternative to Android. Huawei is working for the plan. Harmonyos It is a strategic turn towards the technological self -sufficiency that China has been chasing for decades. An own operating system, with national code and without a trace of Android, the platform that Huawei used in the initial phases of the system. At the end of 2024, Huawei’s Annual Results Report He presumed that more than one billion devices had Harmonyos. In this first half of 2025, we have some more specific data. At all rag. According to Canals, Huawei has sent a total 103 million smartphones with Harmonyos and 21 million tablets from 2021 at the end of 2024. Of those 103 million, almost half (46 million) were sent last year, showing how the last two years are being key to the growth of the company. The data, without context, are only data. To understand at what point Huawei is located to know that, in 2021, the estimates of sale of smartphones gave Huawei 10 million. The figure is important and shows an upward trend: Huawei has gone from the free fall that suffered between 2021 and 2022 to a sustained recovery process in the last two years. In 2022 the figure doubled to almost 20, to end up arriving at 2025 at 46 million. More prohibitions, more shipments. The United States Plan to isolate Huawei in the world has a double edge. The company has collapsed in Europe and left its position to its sister honorbut the efforts to grow nationwide are clearer than ever. Huawei is triumphing in China, and the consultants point out that it will be one of the mobile companies that will grow the most global in 2025 (growth marked by the path they are following in China). A plan that will accelerate with the license restrictions that affect its PCs. Huawei can no longer sell Windows computers: the first solution is Patch existing ones with Linuxthe second, Sell ​​your own computers with Harmonyos. The dream, getting closer. Huawei has made restrictions the greatest opportunity for growth in its history. An approach towards A device with 100% national components, A universal software ecosystem (mobile, tablet, pc, car, wearables) and, most importantly, The only possible and alternative rival to Android out of Apple and his proposal with iOS. Huawei is drawing an alternative scenario in which every Chinese manufacturer who wants to disconnect from the United States can have Harmonyos alternative. It is something that begins to be seen in industries such as that of automotive: manufacturers like Toyota are so far back in software that The only possible solution is to bet on alternatives such as Huawei or Xiaomi. For the moment, Xiaomi, Vivo, Oppo and even honor continue to see in Europe one of its main sales pillars. But China prepares to lead the technological worldand Harmonyos will play a fundamental role in their conquest. Image | Xataka In Xataka | Harmonyos shoots in China and already surpasses iOS. The following objective is global

The visual spectacularity of ‘The Witcher 4’ is ridiculous everything seen so far. And it is the main sin of the industry

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The technical demo of ‘The Witcher 4’ has left the players community speech and has become the star demo of the State of Unreal 2025where Epic Games has presented the latest news regarding its star graphic engine. A waste of overwhelming graphics that, at the same time, summarizes one of the great problems of the industry: being always dealing with futures. What has been seen. First of all, it should be emphasized that the seen is a technical demo IN-ENGINENot a video In-game. That is, it is the Unreal Engine 5 running in real time, nothing of a CGI scene, but it is not a captured fragment of the game. In this case it ran in a PlayStation 5, but CD Projakt wanted to make it clear that it is still not clear in which format the format will appear New installment of ‘The Witcher’. It is simply an exhibition of everything that the game can offer in terms of characters animations, fauna, mapping, reactions. A wonder that as we already knew, will star in an old acquaintance of the saga: Ciri. Mea guilt. This presentation also serves for CD Projakt Red to reassure players: The fiasco of ‘Cyberpunk 2077’ In consoles, they say (without hesitation, qualify as “disaster”), it will not be repeated. That is why they do not have a date for this ‘The Witcher 4’: the time that is necessary to become a “new reference” of games of this type will be in development. In times of ‘GTA VI‘It is not a bad purpose, but the truth is that the seen seems to be up to the circumstances: the magnitude of the scenarios, the naturalness of the movements, the realism of the gestures, the apparent diversity of possible reactions of the characters … is simply overwhelming. Three beasts. Currently, we have three graphic beasts outings of the mainstream With greater technical and monetary muscle of the industry: this ‘The Witcher 4’, which, like everything about CD Project Red, is at the visual avant -garde of the medium; ‘Gears of War E-Day‘, which we will possibly see gameplay Soon, and that in exhibitions like this kinematics made with the game engine we can expect a return in style of the saga; And, of course, ‘gta vi’, what has not yet shown gameplaybut that has taught incredibly realistic cinematics made with the game engine. Only the elders. That is, games of three industry giants (CD Projakt, Microsoft and Rockstar), whose launch we can set, in the best case, in the medium term: perhaps we do not have them to have them in our hands until entering 2026. And that is a problem: the games that technically push the industry, on the one hand come from the mastodons of the sector. Companies accustomed to operating with a franchise coup (such as these titles) and to ensure the shooting with revolutionary games in the visual … and only in that. The damn hype. And we return to the usual problem: the games are very expensive to produce (With its 100 million estimated budget, in fact, ‘GTA VI’ is going to be the most expensive in history, with 2,000 million), so the producers do not risk, and from the side of the players we complain that we are not going anywhere, and it is the fish that bite the tail. Those who have the waist to move in unpublished directions to the industry can not allow it, even if they have technological monsters such as Unreal Engine 5. And so we are looking at a distant future. So far away, that CD Projekt Red cannot even reveal what platforms ‘The Witcher 4’ is going to come out. Video games have always been held on promises, and we treasure enough bad experiences on the matter (yes, CD Projekt Red, we have already forgiven you, but the ‘Cyberpunk 2077’ bugs do not forget as well as so) as to distrust the “will arrive when it is.” ‘The Witcher 4’ looks like a heart attack, but paradoxically, we are tired of having to wait sitting. Header | CD Projakt Red In Xataka | All the questions and doubts that remain to be resolved from the Nintendo Switch 2 to a week of its launch

The main tips to be prepared

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Let’s give you a few tips on How to prepare for possible blackoutswith some things that we recommend you at home and remember. Our idea is not only focusing on international catastrophic blackouts, but also being prepared for those premises that can ever occur. Therefore, we are going to give you a small list with The most essential ideas and advice For these cases. Thus, in the event that you have a blackout you can have resources to be without electricity for several hours without this being an excessive problem. Have prepared lighting The blackouts can arrive at any time. If the lighting arrives during the day, it is not a problem, but if it happens during the night it will be necessary to have something in a drawer to see. They can be candles, but too An LED flashlight Help you in key moments. The lifelong wax candles are always useful and appealed, and some always have some in a drawer. Also matches or a lighter. As for the flashlight, to be LED to consume less, and if you go to batteries you have some new prepared. But the best is A flashlight with dynamoof those that have a crank with which to load them. It is a little more tedious to use them, but you don’t need batteries, and they are a very good long -term alternative not to depend on them. Have some external battery loaded Something that can save you a lot if a blackout lasts several hours is have an external battery at home. This will help to keep your mobile loaded, and to be able to use it to inform you or to entertain you while the light is restored. Ideally, it would be at least 5,000 mAh to have a little more than a mobile load, but ideally you should have some of 10,000 mAh. If you have several ports, better, although the essential thing is that you have USB-C. Yes, make sure Always have this battery chargedbecause if when a blackout happens you realize that you did not load it again the last time you used it on a hiking or festival, it will be as if you did not have it. You can also look at the loading power, as they can be 22.5W, 40W, and many things. These amounts what they measure is the power, and the greater the faster you can load the mobile. To choose from look at the load characteristics of your mobile, they are measured in the same way, and then look for a battery that equals them. You also need the USB-C cable to support those powers so that you do not make fun and you can take advantage of it. Have a fm radio batteries When you have an electric blackout at home, your wifi leaves. And if for some reason the mobile connectivity network of your operator fails, then you will stop having access to the Internet. We have already learned that this can happen and last hours, and in these cases it is very difficult to access information from what happens. Therefore, it is convenient that you have A FM Radio Pilas by housesomething analog and “lifelong.” In these cases in which you have neither electricity nor the Internet, it will be a good means to access the stations where they are informing what happens, or simply to entertain yourself with the programming. Have canned food that does not need to cook Something that should not be missing in your pantry is to have some food cans that do not need to cook. When they are in can, they will have a long duration and they will not expire in the short and medium term, so you can have them there for any emergency that may arise. Because you can have food in the fridge, but it is not advisable to be opening it so that the cold does not go and your food does not spoil, and if your kitchen is electric will stop working. Therefore, a canned meal that is already cooked and does not need preparation is a very valuable resource This also applies to all kinds of Non -perishable foodfrom rice and preserves that we have mentioned with nuts or energy bars. Also have A manual opening to open them. If you are a campist, that gas campsite may come well at home or in a localized storage room you can access. Keep your laptops loaded If you have laptops at homeit is advisable to always keep them with a good load. Because if you leave the light but you have the Internet and want to continue working or navigate online, nothing is more frustrating than lighting your old laptop and seeing that it is decarced. Therefore, every month or a few weeks review it, keep it updated and make sure have it well loaded and turn it off correctly when you stop using it to keep the maximum battery. Have bottled water Other tips we can give you are Have bottled water at homeand if you have no low to buy it. If your neighborhood community sends water to the houses with an electric pump and there is a cut throughout the building, you may be left without water, and have to drink and do other things is important. Other tips to be taken into account In addition to what we have told you, remember to have A first aid kit at home In case you have any accident. It is also necessary to have elementary medications for mnos one or two weeks, toilet paper, menstrual products, soap, disinfectant or alcohol. Always keep the tank of your car half full to start it and use it to load devices if necessary, an important contact list, and disconnect electronic devices before the light returns to prevent a voltage peak from damaging them. In Xataka Basics | Light has gone in almost all of Spain: what to do … Read more

A French people have to deal with an surprising incidence of ALS. The main suspect is a fungus

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Amyotrophic lateral sclerosis, also known as ELA (ALS in English) is a disease capable of wreaking havoc in our nervous system. Today It has no cure And what we know about its origin is quite limited. Throughout decades of study, we have been discovering risk factors related to the appearance of this disorder but perhaps the strangest was detected a few years ago in a town in the French Alps. The unique case of Montchavin. A few years ago, a group of researchers discovered that the French people of Montchavin, located near the Alpine border with Italy, has a high incidence of ELA. After investigating the case, the team pointed out as possible culprit To a very concrete element of local gastronomy, the fungus Gyromitra gigasa type of false colmenilla or false morilla. ELA. The Amyotrophic lateral sclerosisknown among other names as Lou Gehrig’s disease, is a disease that affects neurons, both in our brain and spinal cord. It is a disease that is progressing until it ends the life of who suffers it. Today we do not know a cure, although there are treatments that relieve Some symptoms and increase the life expectancy of patients. The symptoms of this disease usually appear from the age of 50, although there are earlier cases, and They can start With problems walking, writing or speaking. The disease It generates the loss of muscle strength and coordination capacity, problems that extend to different muscle groups. Unknown cause. Today we have no accurate record of what mechanisms unleash this ailment, although we know Some risk factors correlated with their appearance. What we do know is that about 10% of cases are related to a genetic variant, and that the disease is more common among men than among women. Among the known risk factors are tobacco and exposure to certain environmental toxins. A higher prevalence has also been detected among people who did military service. The incidence of this disease It is between one and 2.6 annual cases per 100,000 inhabitants; with an approximate prevalence of about six cases per 100,000 per 100,000 people. An enigma in the French Alps. A few years ago, the cases of Montchavin unleashed the curiosity of the French neurologist Emmeline Lagrange. The health and its team accounted for 14 cases of ELA diagnosed between 1990 and 2018 linked to residents in this town, including migrants and people who had their second residence in Montchavin. Examining the case, the team did not find genetic factors that could justify the high incidence in the town. Although they found cases of smokers, they also ran into healthy habits in the group. Nor did they find clues of possible pollutants in land, air or water, or radon traces, a pollutant that could also be linked to this disease. From Pacific to France. As the journalist Terence Monmany narrates In an article For the medium Knowablethe team found a thread to throw on the remote island of Guam. On this island located in the archipelago of the Mariana Islands, in the Western Pacific, another team had detected a possible relationship between the consumption of potentially toxic seeds and the prevalence of neurological diseases (including ELA) among the natives. Although science is not settled in the causes of this epidemic, this hypothesis placed the consumption of food in the center of the debate. According to Detaine Monmanythe native chamorros treated these seeds with water to reduce their toxicity before their culinary preparation. This process would not be able to eliminate all toxins, giving rise to subsequent neurological damage. Gyromitra gigas. Something similar could be happening in Montchavin, not with seeds but with a mushroom. As the team observed, the cases could be drawn up to people linked to the collection and consumption of the fungus Gyromitra gigasa type of false morilla. It is a fungus in a toxic principle, but that, as in the case of Guam, can be treated to reduce its toxicity. In spite of this, the team maintains in its work that the incidence of the ELA in the town can be linked to its toxins and DNA lesions caused by these in the long term. The details of that study were published in 2021 In an article In the magazine Journal of the Neurological Sciences. A spurious relationship? In Xataka | I am a journalist, I have ela and I can’t move anything from my body except my eyes … So I write articles with my pupils Image | Henk Monster / Alexey Laa

We are very close to having a “ozempic in pill.” His main competitor has developed it

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The success of drugs such as Ozempic, Wegovy either Zepbound He has unleashed a career in pharmaceutical laboratories around the world. These are based on compounds originally devised as treatments against type 2 diabetes but have devastated as weight loss formulas. Orforglipron. The American pharmaceutical has successfully overcome The third phase of your clinical trials. As the company explains, this formula is the first drug in its class to pass this test, the first oral agonist of LPG-1 receptors of a small molecule that can be consumed without restrictions on water or food consumption. GLP-1 agonist. Orforglipron, such as the semaglutida on which Ozempic and Wegovy are based, is an agonist of the peptide receptors similar to glucagon-1 (LPG-1), that is, it is based on a molecule that emulates this hormone that produces our body. LPG-1 is a peptide that is released in our body when we eat and transmits the message that we have eaten two recipients for two different purposes. On the one hand, this message transmits to the pancreas so that it begins to segregate the insulin that our body will require to metabolize the sugar consumed. Hence, this type of compound is used in patients with type 2 diabetes. The second message is transmitted to the brain, which interprets it as a feeling of satiety. Achieve The Achieve-1 trial, framed in the Achieve program, was carried out with the objective of evaluating the safety and efficacy of Orforglipron, contrasting its administration with the administration of a placebo in adults with type 2 diabetes and inappropriate glycemic control. The experiment also studied different dosages in the participants. The responsible team observed that, after 40 weeks, the average blood glucose levels They differ satisfactorily between the experimental group and the control group. The study also showed a reduction in the body mass of those who consumed the drug. “It is a pleasure to see that our last medicine (…) meets our expectations of safety and tolerability, glycemic control and weight loss, and we are waiting for additional readings of the data throughout this year,” indicated in a press release David A. Ricks, President and CEO of Lilly. The details of these clinical trials will be presented in the scientific sessions of the ADA (American Diabetes Association), as well as in a magazine in an article reviewed by pairs. Adverse effects. One of the most important purposes of clinical trials is the detection of possible adverse effects with which to evaluate whether the drug involves any important risk and if its possible adverse effects are compensated or not by their medical benefit. The side effects detected are not very different from those already found in treatments such as Ozempic. The most common adverse effects were gastrointestinal and “generally between soft and moderate in severity”: diarrhea, nausea, dyspepsia vomiting (indigestion or empacho) or constipation. Those responsible for the study indicated that no hepatic security problems were detected. A key step. Overcoming this third phase of clinical trials is a fundamental step for the arrival of the drug to pharmacies but does not imply its immediate approval. The final green light will have to give it the regulatory agencies of pharmacological products such as the US FDA or the European EMA. In Xataka | Ozempic will soon become a thing of the past: this is what we know about the new generation of drugs for weight loss Image | JESHOTS.com

The universe is becoming more chaotic and we don’t know why. The main suspect is dark energy

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From the first moments after the Big Bang, gravity has shaped the matter, giving rise to the intricate structures that define our universe. Galaxies, galaxy clusters and galactic filaments have evolved in ways that They almost always agree with Einstein’s general relativity theory. But something does not fit. The universe is more messy. A Recent study Directed by cosmologists from the University of Pennsylvania and the United States Lawrence Berkeley National Laboratory points out that the universe has become “more messy and complicated” over time. There are fewer agglomerations of the subject that predict physical models. The research crosses two very different types of data observed by the Atacama Cosmology Telescope and the spectroscopic instrument of Arizona’s dark energy. Combining both maps, scientists discovered that almost the whole history of structure formation coincides with the predictions of Einstein’s gravity, except for a small discrepancy in the agglomeration of matter of more recent times; For about 4,000 million years. A cosmic tomography. To build a multidimensional vision of the cosmos, scientists started from the oldest light we can observe: The cosmic microwave backgrounda radiation from 14,000 million years ago, when the universe was only 380,000 years old. But the journey of this ancestral light has not been in a straight line. It has been diverting and distorting the gravitational attraction of mass structures such as galaxies clusters, a predicted phenomenon by Einstein and known as gravitational lens. Overcoming the map of these distortions with the distribution of galaxies has allowed cosmologists to infer how matter is distributed over time. “It’s like a cosmic computerized tomography,” said Mathew Madhavacheril, co -author of the study, In a statement. “We can look through different cuts of cosmic history and track how matter has been agglomerating at different times.” Something does not fit. The “agglomeration” of matter (measured by density fluctuations) seems to be slightly lower in the most recent times than the models predict from the early universe. Cosmic structures have been grouped less intensely than we expected. The researchers are cautious: it is a small discrepancy that could be the result of chance and not the test of new physics. However, if the deviation turned out to be A statistical anomalycould point to unknown physical processes that influence how cosmic structures are formed and evolved. One of the hypotheses is that It has to do with dark energythe mysterious force responsible for the accelerated expansion of the universe. Perhaps dark energy is affecting the formation of structures in ways that current models do not capture completely, acting as a powerful force that moderates the large -scale agglomeration. Image | NASA, ESA, CSA In Xataka | The Euclid European telescope is already historical: its first data revalidates Einstein and put the dark matter on the map

become the main United States military pitcher

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When Elon Musk founded Spacex in 2002 with ambitions as grandiloquent as the conquest of Marsfew would have bet money to unseat the two giants of the US space industry: Boeing and Lockheed Martin. Now it is a reality in every way because Spacex has just officially become the main military pitcher in the United States. Sorpasso The US space force has awarded 13.7 billion dollars in public contracts to launch the most critical satellites of the Pentagon from here at the beginning of the next decade. Among them, new advanced GPS satellites and strategic communications systems capable of resisting even a nuclear conflict. Spacex has taken most of the cake with 28 missions, valued at 5.9 billion dollars. There are nine more than those awarded to United Launch Alliance (The Boeing and Lockheed Martin Joint-Venture), With 19. For its part, Blue Origin (Jeff Bezos’ Aerospace Company) has received seven missions. Goodbye to the duopoly. When the New Space emerged with new rocket startups such as Spacex and Blue Origin, Boeing and Lockheed Martin shielded their military contracts with a joint business called ULA. For years, and thanks to the demonstrated reliability of its rockets, the Pentagon continued to feed the duo with the exclusivity of its juicy contracts. Spacex got open a gap in 2015 with its first military contract after a hard legal battle to compete on equal terms. Since then, he has not only managed to consolidate, but to become the preferential provider of the space force with the highest number of contracts. Excuses are over. With about 140 successful releases In the last year and more competitive rates than competition thanks to its unique reuse capacity, the Pentagon does not have many excuses to maintain favor treatment with ULA instead of choosing Spacex. Spacex requested space force 212 million dollars per launch In his Falcon 9 rockets and Falcon Heavy, compared to the 282 million that Ula asked for the Vulcan and the 341 million asked for Blue Origin for the powerful New Glenn rocket, which has barely flown once. There is a game. In spite of everything, ULA still has a lot to offer with its new Vulcan rocket, especially thanks to the upper Centaur V stage that offers greater maneuverability and orbit thrust than the Spacex falcon. Blue originated on your part, has the most powerful rocket of the fourwith a huge cofia in which all kinds of loads fit, and the same reuse aspirations as Spacex. Of course, he has barely completed a test launch, and failed in his first attempt to land in a barge in the Atlantic. He has at least one certification flight to launch military charges. Images | Spacex, United States Department of Defense In Xataka | Spacex has shot at unsuspected levels. So much that Gwynne Shotwell has entered the list of billionaires

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