The waiting list for a liver transplant can be eternal, so they have created a solution: inject yourself with a miniature one

The National Transplant Organization of Spain makes it clear: The liver is one of the most requested organs on the transplant list, only behind the kidney. Only in the Spanish state in 2025 there were 310 people waiting and that Spain It is a world power in transplants. There are not enough donated and compatible organs to arrive in time for all those people who need them. This historical gap that no country has managed to close is a double tragedy: for the sick person, who waits without guarantees, and for the health system, which cannot offer them another way out. Liver transplant remains the only cure for certain conditions, and the path to it is full of obstacles: surgical complexity, compatibility problems, the exclusion of patients too fragile for surgery or lifelong immunosuppression. Even when an organ arrives on time, not everyone can receive it. Until now, there was no alternative. That could be about to change. The invention. An MIT research team led by Sangeeta Bhatia has developed “satellite livers”, a type of mini-livers capable of assuming the functions of the diseased liver without having to remove it. One is inside, its cells form a stable structure, connect to the person’s blood vessels and begin to produce proteins that the damaged liver can no longer make. They do not replace the entire organ, but they relieve it of its functions. They are actually small grafts of functional liver tissue that are administered via a syringe guided by ultrasound, that is, without surgery: minimal invasibility. Why is it important. Because it addresses the two big problems for those who need a liver: the shortage of available organs and those who cannot face a transplant operation. If you can have surgery, they act as a bridge until they find a suitable organ. And if you can’t, these mini livers cover the liver functions that your liver can’t do. In this way, satellite livers increase the spectrum of treatable patients. From a more general point of view, this invention is a milestone in liver tissue engineering: science has been trying to replicate the nearly 500 functions performed by the human liver for more than a decade. And if implemented in the different health systems, its impact is direct: according to the American Association for the Study of Liver Diseases (AASLD)chronic liver disease is the 12th leading cause of death in the United States and rising. Context. Although the liver is an organ with a remarkable regenerative capacity, it does not work miracles: when it exceeds a certain threshold of damage, regeneration is not enough and only the transplant remains. Since the 90s, medical science has been trying to transplant isolated hepatocytes, but the results were poor. Bhatia is not new to this either: has been there for more than 25 years investigating bioartificial liver models, which has served as a basis for understanding what conditions hepatocytes need to remain functional outside the liver. This MIT work is precisely the practical application of all this knowledge. How it works. The research team developed the idea of ​​turning these cells into an injectable along with hydrogel microspheres and fibroblasts. The spheres are intended to enable this route of administration by ensuring uniformity. Fibroblasts act as a support, helping hepatocytes survive and promoting the growth of new vessels into the tissue. Without blood supply, those cells would have their hours numbered. In the team’s experiments in mice, new vessels formed next to hepatocytes, allowing them to receive nutrients and function normally. In these rodents, the cells remained viable and secreting proteins during the eight weeks of the study. Yes, but. Although the results are tremendously promising, it is a preclinical study done in mice and the leap to humans is enormous. The human liver contains between 100,000 and 130,000 million hepatocytes and replicating a sufficient functional mass with injected cells is a challenge that this study has not yet addressed. Even assuming that we extrapolate this finding as is to humans, immunosuppressants would still need to be used. And it is not a minor problem: the fact that the immune system attacks weakened patients increases the risk of infections, tumors and kidney damage. In Xataka | The “silent” liver epidemic: we have a problem that escapes analysis and that science is already seeking to stop In Xataka | Fatty liver advances silently, but science has found unexpected allies: coffee and green tea Cover | Elen Sher and Magnificent

There are people asking Chatgpt how to inject Botox themselves

There are people injecting Botox and Hyaluronic acid themselves, in their homes. But there is not the thing. Some of them are asking chatgpt advice to know where to inject, how depth or what materials they should use. We have seen how there is people going to chatgpt instead of the doctor And there are even those who use them to Write medical studiesbut asking him how to fill his lips we didn’t see him come. What’s happening. They tell it in Futurism. In a Reddit community called DIYAESTHETICSusers share their experiences and exchange advice when carrying out medical-aesthetic procedures in their homes. There are a few who support Chatgpt to guide them. This user He used it to know if he should wear gloves while injected. In none of the 16 responses they shave the fact of having asked the AI. In fact, many other threads in this community mention similar things. In the case of This other userafter injecting herself she noticed that the cheek had deformed him and went to Chatgpt, who told him that perhaps a small amount of substance had migrated to that area, but that “it will surely dissolve.” This time there is A user that begs you not to use chatgpt for medical advice. And there is More examples. Doctor Chatgpt, what happens to me? We have already seen that more and more people are going to Chatgpt as if it were a psychologist And there is even chatbots that get through one. If it is happening with mental health, it is not surprising that it is also happening with physical health. There are even A study that affirms that chatgpt responded better for doubts than online care services with real doctors, although This other It concludes that it gives more than 30% wrong results. Anyway, There are more and more people who tell their symptoms to AI In search of a rapid diagnosis and, in many cases, cheaper than going to the doctor (the tendency to inject yourself at home is born precisely from this) AI and health. The irruption of AI has raised numerous ethical debates and that of its health use is one of them. However, there are countless examples in which AI is being a Very powerful tool in the health sector. Recently we have known that China has an AI that helps in the detection of pancreatic cancer. Has also helped Accelerate research in the resistance of some bacteria And there are companies dedicated to APPLICATION IN THE MEDICAL DIAGNOSIS. The AI ​​problem for everything. IA tools can be a great help and make ourselves more efficient, or we can end up using it to do something as risky as botox at home. There are studies that claim that Chatgpt is diminishing our intelligencea historical fear that has emerged with almost every new mass adoption technology. But the problem is not AI, it is How we use itand in areas such as health it is a particularly delicate issue. In summary: AI and health, yes. AI to get Botox at home, not better. Image | Gemini In Xataka | Artificial intelligences are close to overcoming doctors in the most difficult: understand patients

Inject your partner poison

Make up is a risk sport. That they tell the male of the religious mantis who has to feel how His head is devoured by the female While his body, automatically, continues to copulate. This practice is less common than what is thought, since it occurs in just a handful of Mantis speciesbut it is not the only stage of the animal kingdom in which The male is killed for the good of the offspring. And there is A hops They have the same customs. Of course, there is an octopus of a concrete species that has a strategy to fertilize the female and survive the process: poison it. Dimorphism. Something important before entering the case of octopus is that there are many animal species with cases of sexual dimorphism extremely accentuated. This implies a difference in size between the sexes, being the case of the mantis one of them. In mammals, males are usually larger than females, since they are the ones that fight for territories and mating, but it occurs backwards in case of raptors, arthropods, amphibians and reptiles. In the octopus, there are extreme cases in which there are females that are up to ten times larger than males. One of those cases is that of the blue line octopus –Hapalochlaena fasciata-. They are small, but tremendously lethal octopus because they are able to inoculate a very powerful neurotoxin that they share males and females. Contrast with its small size: just bigger than a golf ball. Sex and snack. However, the female is twice as large as the male and mating dynamics is not very healthy to say (for the male, of course): due to that imbalance, the female usually ends the life of her sexual partner during the process. However, in a study published in Science Directa group of researchers from the University of Queensland in Australia has discovered that the male has developed a toxic way of surviving mating, literally. Due to that huge difference in size, males cannot develop tactics that they use in other species of octopus, such as a more elongated reproductive arm to inseminate at a safe distance or even arms – character – with the reproductive load that emerges so that the animal can flee. The only thing left to this species is to bite the female to inject neurotoxin, directly. Here we have a complete half -hour sequence: Poison. As we read in Sciencealertresearchers comment that, probably, this evolution has been “an answer both to the need for reproduction and protection”, and what they do is ‘bite’ the female before trying to copulate. They do it near the aorta, injecting the fair amount of tetrodotoxin to paralyze their partner during the process. To check, the researchers placed six couples in different aquariums and observed this practice in all cases. “The females succumb quickly,” they comment, and it is something they observed because they lost reflexes to light stimuli, paid and the pupils contracted due to the loss of nervous system control. Wait, what happened? They also made more precise observations: while the males went from 20 or 25 contractions per minute at rest at 35 or 45 during the intercourse, the females not only suffered an abrupt fall in their heart rate, but stopped breathing completely after about eight minutes of the bite. They point out that none died, so the amount of neurotoxin they inject is very precise or, evolutionarily, the female has developed countermeasures, but the bite on the back of the head was evident. “Once immobilized, males proceed to intercourse and mating ends when the female regains control of her arms and separates the male,” the researchers point out. In this video we can see how the male approaches while the female remains motionless: Sexual Armament Carrera. The researchers comment that they did not directly measure the levels of neurotoxin, but it is a practice that “suggests an evolutionary armament career among the sexes, in which the cannibalism of large females is counteracted by males through the use of venom.” Fruit of this evolution is that the posterior salivary glands of the males, which is where the symbiotic bacteria that produce toxin accumulate, are three times larger than those of the females. They also comment that they are not the only animals that accumulate that toxin in their bodies and that there are fish, mollusks or amphibians that produce it, so they will continue to investigate to identify whether other animals use it in order to reproduce and leave alive from the process. Ah, and something curious of the experiment: in one of the cases, one of the males bit at a point somewhat away from the aorta and the female took less time than the others to wake up: 35 minutes. Speaking, people understand each other, but when hunger enters during intercourse, it is clear that there are species that fail to suppress those cannibal instincts. By the way, Wen-Sung Chung, one of the main researchers, has shared 15 GB of videos of the octopus copulating using these peculiar strategies. Images and videos | Queensland University In Xataka | A whale toured 13,000 km and three oceans to reproduce. It is a record, and also a bad news

Log In

Forgot password?

Forgot password?

Enter your account data and we will send you a link to reset your password.

Your password reset link appears to be invalid or expired.

Log in

Privacy Policy

Add to Collection

No Collections

Here you'll find all collections you've created before.