We believed that laboratories and millions were needed to build a GPU. A maker is setting one up at home

For years we have assumed that build a GPU It was a field reserved for companies with advanced factories, engineering teams and million-dollar budgets. It wasn’t an absurd idea: just look at the complexity of any modern graphics card to understand why it seemed out of reach for a person. But what he has done Matthias Balwierzknown as Bitluni, forces us to qualify that certainty. It has not replicated a GeForce nor does it intend to compete with NVIDIA, but it does is building from home a graphics machine with thousands of RISC-V microcontrollers. The first phase brings together 8,192 of those microcontrollers, each linked directly to an RGB LED. This decision makes the montage difficult to fit into the usual categories: the design brings together in the same structure the graphic processing and the surface on which the result must appear. In technical terms, it is designed to act as both a graphics card and a screen, without depending on a separate monitor. Of course, the project remains a partial prototype, still far from the scale and capabilities planned for the complete system. A GPU made pixel by pixel That architecture was not defined from the beginning. The maker began thinking about building some type of screen, but when studying the cost and difficulty of the project he ruled out resorting to components Addressable RGBwhich would have made the whole set too expensive. The alternative was more direct: solder an LED to each microcontroller and turn each chip into a visible graphics unit on its own. The decision contained part of the budget, although it multiplied the design, assembly and programming work necessary to coordinate thousands of elements. The scale becomes clearer when we look at the complete objective. A resolution of 1920×1080 would have required more than two million microcontrollers, shooting the cost and complexity far beyond what Bitluni had set itself. The maker then lowered the ambition to 320×200 pixels, a resolution associated with video games of the DOS era, but which still requires 64,000 chips. The components installed so far represent just a first stage of a machine that would multiply its size almost eightfold if it is completed. To organize such a large amount of hardware, Bitluni divided the system into 16×32 “pixel” boards, conceived as independent modules within the set. These are distributed in a circular arrangement that reminds of Cray-1the historic supercomputer of the seventies, although the reference is mainly visual. Internal coordination is also hierarchical: each group of 32 microcontrollers is under the control of a more powerful CH32V unit, in charge of organizing the operation of that section and serving as an intermediate level within the machine. The choice of the QingKe CH570 explains part of the economic logic of the project. It is a microcontroller with a 32-bit RISC-V CPU, a limited instruction set and a frequency of up to 100 MHz. It also integrates a USB controller, a 2.4 GHz transceiver and support for Bluetooth 5.0 LE. Bitluni was able to buy each unit for about $0.13, but the advantage is diluted when multiplied by the entire planned matrix: only the chips necessary to reach 320×200 pixels would exceed $8,000. The problem grows when projecting the power supply of the complete system. It speaks of an estimate of 2,161 W, equivalent to about 655 amps at 3.3Vfor the final planned configuration. The media points out that each microcontroller consumes around 10 mA, although it does not offer a breakdown that allows us to separate the expense of the chips, LEDs and auxiliary electronics. To support such a load, Bitluni has turned to a source Corsair WS3000 and own converters capable of transforming the 12 V output into the required 3.3 V. A big part of the project is also making the infrastructure that allows everything else to work. Bitluni designed the PCBs, power circuits, interface boards and breadboards, tackling a six-layer board for the first time. The complexity of the design ended up pushing him to the limits of the manufacturing service he used. In parallel, he studied an immersion cooling solution and came to the size of the acrylic container he would have needed, although he left that option on hold for economic and environmental reasons. Programming posed another problem of scale: it was not enough to manufacture the boards, the code also had to be loaded into each microcontroller. To avoid doing it by hand, Bitluni 3D printed a small tool with three contacts and attached it to the carriage. a 3D printer. A Python script sent G-code commands to move it to the exact position of each chip and complete the process in a repeatable manner. The printer thus stopped manufacturing parts to become an automated programming machine. This machine does not compete in performance, efficiency or size with a modern graphics card, nor has it yet reached the scale that Bitluni projected. Its value lies in exposing, through separate components, tasks that a commercial solution concentrates or distributes among specialized chips and circuits: calculation, control, power, coordination and visualization. By rebuilding them with low-cost microcontrollers, the maker has turned an unusual idea into a system that can be designed, tested and expanded in stages. It is not a conventional home GPU, but an engineering experiment taken to unusual limits. Images | Bitluni In Xataka | Huawei’s He Tingbo: “This is the first time China has proposed a new principle for the chip industry.” Not everyone is convinced

Anthropic already had Claude writing code. Now he has put it in the laboratories

Anthropic had already placed Claude in one of the most everyday and valuable tasks in the technology industry: writing code. Now he wants to take it to more delicate terrain and with potentially much greater consequences: scientific work within laboratories. The company has introduced Claude Sciencea product designed to help researchers move between literature, data, specialized tools and computing resources. Claude to science. The key to Claude Science is not only that Anthropic has added more tools to Claudebut in the type of problem it is trying to solve. In science, a huge part of the work involves jumping between databases, files, code, figures, citations, and computing resources that rarely talk to each other comfortably. The company wants to integrate all this into a specific application, available from June 30, 2026 in beta for Pro users, MaxTeam and Enterprise on macOS and Linux. A category jump. Anthropic had already begun to bring Claude closer to scientific work last fall, when it launched connectors and functions under the umbrella of Claude for Life Sciences. This helped the model to relate better to software and scientific databases, but it still had a more limited scope. What is happening now goes one step further. Anthropic seems to want science to stop being just a use case and become a product line. Verifiable work. The promise of Claude Science is not limited to helping you write or summarize. Anthropic claims it can analyze scientific literature, execute multi-step investigations, generate figures and manuscripts, and allow the researcher to refine them iteratively. The most important part is how it leaves a trace: each result includes the code, the environment, and the message history that produced it. In addition, a review agent checks quotes and calculations, and can point out untraceable numbers or figures that do not match the code that generated them. Claude Science’s ambition might sound very broad, but his first steps have a fairly recognizable accent. Anthropic has prepared it with more than 60 capabilities and connectors targeting areas such as genomics, proteomics, structural biology, computational chemistry, and single-cell analysis. The computation, within the flow. Many investigations do not stop at reading articles or generating figures: they also require carrying out heavy work on machines prepared for it. Anthropic says Claude Science can help prepare those processes on the researcher’s laptop, on a Linux machine, on an HPC access node via SSH, or with on-demand computing in Modal. The company clarifies that the system writes a plan and asks permission before accessing new resources, so that the researcher can review or revoke decisions. It also states that large or sensitive data can remain in the lab infrastructure, sending Claude only the context necessary for each step of the analysis. Anthropic accompanies the launch with examples. Manifold Bio, dedicated to the design of drugs aimed at specific tissues, used Claude Science to propose targets in its experiments, evaluating surface expression, cell trafficking and safety according to the company’s own criteria. The Allen Institute used it to build a computational review template with about 20 custom skills, capable of reading thousands of articles and organizing findings into an evidence base. And at UCSF, epidemiologist Stephen Francis says the tool sped up glioma analysis to about one-tenth the time before, with results independently validated by his group. Images | Anthropic In Xataka | South Korea has a plan to dominate in memory chips and robotics. One of a billion dollars

the protein that longevity laboratories want to inject in the future

In 1997, the Japanese doctor and researcher Makoto Kuro-o made a mistake in the laboratory where he carried out his experiments. I was trying to create mice with hypertension when the genetic material he manipulated was inserted in the wrong place and altered an unknown gene. The resulting mice aged at an astonishing rate: in just two months they had arteriosclerosis, osteoporosis, cognitive decline and wrinkled skin. The normal thing is for a mouse to live almost three years, but those animals would live much less. After four years of investigating what had gone wrong, Kuro-o identified the gene responsible and published his discovery in Nature. called him klotho in honor of Clotho, the Greek goddess who spins the thread of life. He had discovered, by accident, one of aging suppressants most powerful known. The protein klotho It exists in two versions. One is anchored to the membrane of kidney and brain cells. The other is a fragment that breaks off from the membrane, enters the bloodstream and travels throughout the body acting as a signal of systemic health. The problem is that its levels fall constantly with age in both humans and all primates that have been studied. The interesting thing is that this is not at all a biological coincidence: it is a mechanism that has direct consequences on our aging. A very powerful weapon against aging The most relevant experiment so far He published it in 2025 an international team of researchers from the Institute of Neurosciences of the Autonomous University of Barcelona led by Professor Miguel Chillón. These scientists treated mice with gene therapy in order to get their own cells to produce more klotho. At 24 months (equivalent to about seventy human years) the results were notable: the treated animals lived between 15 and 20% longer with better muscle mass, greater bone density, less fibrosis and better cognitive function. In the hippocampus, the area of ​​the brain where memory resides, the treatment stimulated the generation of new neurons. A 20% longer lifespan in mice is, in aging biology, an extraordinary result. Have klotho in blood is important because this protein acts on several of the most damaging processes derived from aging. In the kidney it regulates how the body manages phosphorus. In fact, without klotho Phosphorus accumulates and accelerates cellular deterioration. The biggest challenge is to find a way to transfer all this knowledge to human beings. And in the rest of the body it reduces oxidative stress, stops chronic inflammation, activates FOXO3A (one of the most studied longevity genes) and inhibits cellular senescence, which is the state in which aged cells stop functioning well but do not die and slowly poison the tissue around them. Be that as it may, the biggest challenge is to find a way to transfer all this knowledge to human beings. In mice, viral vectors were used, injected both into a vein and directly into the brain, a combination that carries significant risks in people. The alternative is administer protein directly as a drug, but finding a system that keeps it stable and delivers it effectively to its target organs (the kidney, brain, muscles and bones) remains an unsolved problem. Still, the longevity biotech industry has decided not to wait. The American startup Minicircle, in which Sam Altman and Peter Thiel have investedbegan a phase 1 clinical trial with 24 participants in October 2025 to test a gene therapy for klotho based on plasmids: DNA fragments that do not integrate into the chromosome and whose effects last approximately one year. This therapy is not approved by the FDA (Food and Drug Administration), so it operates through international clinics. However, the applications pursued by the industry go beyond aging in healthy people. Klotho Neurosciences has programs underway to combat Alzheimer’s, amyotrophic lateral sclerosis and cardiovascular diseases, with phase I and II trials planned between 2027 and 2028. BioVivaon the other hand, has identified improvements in cognitive tests in patients with dementia treated with a combined gene therapy of klotho and telomerase. and the company Avaí Bio works with modified encapsulated cells that overexpress the protein. He plans to have his first results ready for the Second Annual Klotho Conference in September 2026. We have clinical trials, there is private capital moving on a large scale, and there is an annual conference dedicated exclusively to this protein. Everything we have seen in this article looks very good, but we must not overlook that the solid life extension data comes from mice, and the history of the biology of aging is full of spectacular findings in animals that have not been transferred to humans with the same success. Furthermore, several important unanswered questions remain on the table: what effects does overexpression of klotho in the long term, whether the timing of its administration matters in both people and rodents or what happens to phosphorus metabolism and vitamin D after years of treatment. Still, for the first time we have clinical trials, there is private capital moving on a large scale, and there is an annual conference dedicated exclusively to this protein. Klotho is, ultimately, one of the most promising weapons that biology has put in our hands to deal with our aging. Image | Alirio García on Unsplash More information | Nature | UAB In Xataka | Longevity experts are clear: “120 minutes of strength per week is associated with lower mortality”

the animal ‘technology’ that is surpassing laboratories

The story of Mwajuma Abdalla Ngema is that of thousands of people. He went to a clinic in Dar es Sallam (Tanzania) with a persistent cough and the first thing they did was to tuberculosis test which tested negative. After being discharged and a few days had passed, he received a call: the test was positive for tuberculosis, and the result did not come from a laboratory machine, but from the sense of smell of a giant African rat. The method. This scenario, which seems straight out of a science fiction movie, is the core of an innovative program led by the non-profit organization APOPO. In this case, using giant spider rats (Cricetomys ansorgei) have managed to create a tuberculosis detection system that is not only faster and cheaper, but in many cases is proving to be more effective than conventional methods. Tuberculosis. It remains one of the deadliest infectious diseases in the world, causing 1.25 million deaths in 2023. One of the biggest challenges is detection, especially in those countries that have very limited resources to purchase reagents or appropriate machinery. And even if these possibilities are available, sputum analysis has limited sensitivity and some cases with a low bacterial load may occur. This is where the rats come in. APOPO, which initially began training them to detect landmines, discovered that their extremely acute sense of smell could be redirected to identify the specific volatile organic compounds (VOCs) that emits the bacteria Mycobacterium tuberculosis in sputum samples. And the results speak for themselves. Scientific support. A published study in BMC Infectious Diseases reveals the incredible effectiveness of this method. During 2022, the program analyzed 35,766 samples in patients in Tanzania. Of these, local clinics gave a negative result to 33,866 of these samples through classical microscopy or Xpert tests. And this is where the rats came in to re-evaluate the results, offering a shocking fact: the rodents identified 2,029 additional cases of tuberculosis that would otherwise have been missed. This means that rats contributed to 52% of the total tuberculosis cases identified in the program, saving thousands of people from going undiagnosed and untreated. Speed ​​is also a key advantage: a rat can analyze 100 samples in less than 20 minutes, a task that would take a lab technician days. More effective. The true superpower of these “HeroRats,” as APOPO calls them, lies in their ability to detect the undetectable. The study showed that rats are six times more likely to detect tuberculosis in patients with a low bacterial load (“poor” or “1+” categories) compared to standard microscopy in clinics. This sensitivity is especially crucial for children, whose diagnosis of tuberculosis is notoriously difficult due to the low concentration of bacteria and the difficulty in obtaining quality sputum samples. But this is not a problem for rats, which are twice as likely to identify a case of TB in a child than in an adult. The training. Behind each correct diagnosis is a rigorous training process that lasts between nine months and a year at the APOPO center in Morogoro. Trainers socialize the pups from four weeks old to create a trusting rat-researcher bond. Although coexistence is not easy, according to the APOPO coordinator himself, he states that “at first there are trust problems (…) The rat has to trust that I am not a threat, and I have to be sure that it will not bite me.” Once the bond has been created, training is based on positive reinforcement. The rats are presented with several samples and are rewarded with food when they correctly identify a sample that is positive. And logically, before becoming a ‘diagnostic system’ they must have a score of 10/10 by correctly identifying positive samples. Economy. In addition to being effective, it is also a very economical solution. The cost of analyzing a sample with a rat is about 2,600 Tanzanian shillings (about 0.90 euros), while a smear scan costs between 4,700 and 7,000 shillings. And if we talk about a molecular test like PCR, we are going up to 42,000 shillings. This means that after a useful life of seven years, the rats “retire” having saved a lot of money, saving lives and ending his days in the center of Morogoro. Hundreds of thousands of lives. Since its inception, APOPO has analyzed more than 900,000 different samples and detected more than 30,000 cases of tuberculosis that health systems had missed. This is something that has prevented approximately 300,000 new contagion infections, because an untreated person can infect between 10 and 15 people a year. The success in Tanzania and Ethiopia has prompted APOPO to plan to open more laboratories in northern Tanzania and even to transfer the idea to neighboring countries that also have a very high prevalence of this disease. Images | National Institute of Allergy In Xataka | A silent epidemic is killing more and more humans around the planet: fungal infections

A super -governor who will be connected to telescopes and laboratories

Supercomputing has never been just a matter of science. Since its origins, these colossal systems have represented national power, reflecting the technological, scientific and even military capacities of the countries that develop them. Now, The United States has presented His next big bet in this field: Doudna, a superorous who should see the light in 2026 and who promises to be more than ten times more powerful than Perlmutterthe current flagship of the Lawrence Berkeley National Laboratory. A tribute to science that changed biology. The new system has been baptized in honor of Jennifer DoudnaBerkeley’s biochemistry professor and one of the scientists who promoted CRISPR technology, Recognized with the Nobel Prize in Chemistry in 2020. It is not a minor gesture: the choice of the name symbolizes the fusion between biomedical research, artificial intelligence (AI) and computational power. Three axes that, together, aim to define the scientific advances of the next decades. What is exactly Doudna and what will you do. Doudna will be the next super -tider of the National Energy Research Scientific Computing Center (Nersc), a center of the United States Department of Energy located in Berkeley. Its design is in charge of Dell Technologies and will use the new platform Vera Rubin de Nvidiawhich will integrate ARM processors of general purpose. At a technical level, it is designed to execute large -scale hybrid work loads: high fidelity scientific simulations, training models of artificial intelligence, real -time data analysis and quantum algorithms. The machine will not be limited to executing tasks faster: it is designed to integrate into scientific workflows where the data comes from telescopes and laboratories. The objective is clear: to transform the way in which science is done, allowing to adjust experiments almost instantly and accelerate processes that took weeks or months. A project that wants to make a difference. Those responsible for the project are explicit: Doudna is presented as a key piece in the American strategy to lead the development of AI. Chris Wright, Secretary of Energy, It came to compare it with the Manhattan projectensuring that this supercomputer will be fundamental to win the Global AI race. Beyond the headline, the fields of application that are being prepared are ambitious. Nersc has already identified more than twenty scientific teams that are adapting their workflows for this system. The key tools are already on the table: from Frameworks such as Pytorch, Tensorflow and Cuda-Q to the Holoscan development kit, all optimized for the coherent architecture of Rubin and the NVLink interconnection. Why is it important at the national (and world) level. In a context of growing technological competition, especially with China, these types of systems represent more than a scientific resource. They are strategic infrastructure. Japan, with his escape; China, with its most recent Sunway Oceanlite; And now the United States, I already had Frontieramong others, it is reinforcing its muscle in this area with Doudna. The election of Dell against HPE also breaks with the usual dynamics of the great contracts of the Department of Energy, which until now had favored the latter in their three most recent exaescala systems. A jump in energy efficiency. In addition to gross power, one of Doudna’s great achievements will be its efficiency. According to NvidiaThe system will offer between three and five times more perlmutter performance. This is possible thanks to improvements in chips design, dynamic load balancing and new optimizations at the system level. When will it come and what is known about deployment. Douda’s launch is scheduled for 2026. We know that it will be built with servers Poweredge and advanced liquid cooling technologies of Dell, in addition to high -speed connectivity through the network Nvidia Quantum-X800 Infiniband. It will be located at the Berkeley Lab facilities and connected directly to the rest of the Energy Department centers through the scientific network ESNET. What has not been revealed, for now, is the official budget. Unlike the super -terrorist The Captain, which cost 600 million dollarsthe Department of Energy has not advanced any figure on the total investment in Doudna. Nor has it specified how many nodes or how much exact memory the system will have in its final configuration. But it has been made clear that it is designed to climb and adapt over time. Images | Nvidia (1, 2) | Lawrence Berkeley National Laboratory In Xataka | The EU wants to shorten distances in the race for the AI ​​with 750 million euros. And they are good news for Barcelona

Spain was not one of the first to step on Antarctica, but now it has one of the most coveted laboratories on the continent

The Antarctica It is a huge frozen desert, but also one orUnique portunity for research. Spain is one of the more than 30 countries that have Bases in the territory And one of them, Gabriel de Castilla’s, has just been extended to be able to carry out a broader range of projects. The peculiarity is that its construction has been carried out in record time and will allow a boost to the investigation of the Climate change and the Biodiversity With a particularity: Spanish is one of the three clean laboratories on the continent. Only. We have been decades studying Antarctica From the air. Is what is allowing us to know What is it under that layer of icebut we also have been studying at Antarctica from the ground. He Antarctic Treaty of 1959 It is the one that allowed different countries to establish bases on the continent, exclusively for peaceful and scientific purposes. However, before that there were already bases such as Orcadas base from Argentina, which were operating continuously in the field. The reason is that it is a Single scenario For research. Not only for its diversity or for the dry atmosphere that allows to install advanced astronomical observatories, but because we can reconstruct the climate of hundreds of thousands of years thanks to the air bubbles trapped in the ice and, above all, it is a Climate change thermometer. Spanish Antarctica. We owe several findings to the field research, being one of the most notable the discovery of the ozone layer in 1985. As a result of those agreements, Spain could establish Two bases in Antarctica. The most veteran is the Juan Carlos i. It was inaugurated in early 1988 and is operated by the CSIC. It is not busy all year, but maintains automated records when there is no one and supports projects of areas such as biology, geology, weather and glaciology. The other is the Gabriel de Castillaopened a year later and operated by the Army. Its operation area is diverse, with research in the fields of earth sciences (geomagnetism, volcanic surveillance or geomorphology, among others), biological sciences (ecology, ethology or microbiology), environmental sciences (climate change) and disciplines such as physics, mathematics or biochemistry. Gabriel de Castilla. Like Juan Carlos I, this base is not always busy. Spanish work is limited to the months of the Southern summer, which occurs between December and March, and its location is unique because it is next to one of the two active volcanoes of Antarctica. This makes it a unique enclave to study geological processes and extreme ecosystems. But it seems that the base fell short, so a new scientific module has been built. In the upper image we see what the base was like. In the lower one, those small modules have been eliminated to leave the new space. Reform reforms. After an investment of two million euros, the Gabriel de Castilla has been able to expand its surface to about 307 m². Thus, he has been able to improve his equipment thanks to a microscope room, an electricity and electronic space, a sanitary module and a clean laboratory. And we might think that in such an extreme climate the construction would go slow, but no: in 70 days of the plane to having a structure that already expects research equipment. As points The army, 700 panels, 400 profiles, 26 screws and a total of 80 tons of material have been used to create a new module 41 meters long by 7.2 wide and another 7 high. In case you wonder, beyond the heating, the walls have a 50 millimeter polyurethane sandwich -type layer and another 60 millimeter inner layer of rock wool to improve thermal protection. Clean laboratory. But beyond the speed in its construction, the most important thing about the ‘new’ Spanish base in Antarctica is the aforementioned clean laboratory. It is a space designed to minimize external pollution, so research processes can be carried out in a practically aseptic space in which the samples are not contaminated with exterior agents. The protocols are very strict in both cleaning and ventilation and disinfection, and the really important thing is that, of the more than 30 bases present in Antarctica, that of the Gabriel de Castilla is one of the three Clean laboratories from the region. As they detail in This video From El País, it will be shared with Portugal, and one of the objectives will be to analyze pure samples to better understand the human impact on the planet without external interference. Images | Earth Army, Antarctic campaign In Xataka | Some scientists have discovered that Antarctica is raising 5 cm a year. It is not clear if it is a luck or a problem

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