Controlling a video game with your mind seems like an empty advancement. It is the door to treatments for depression or anxiety

Although a good part of the technology industry is focusing on innovations that we are not very clear about how they can help us (there is the waste in AI and humanoid robotics), there are those who are researching something that can open an unthinkable door for thousands of people: brain-computer interfaces. That’s where they come into play brain chips. Neuralink It is the product with the best-known commercial name and the one that seemed to open the way in a more public way, something that China has followed with an important boost in these brain chips. The technology has been tested on humans for years, but there are two problems: it is a very invasive technology and, furthermore, learning to master this computer implanted in the brain It is a complex process that requires training. Yale University, however, is developing another way: an external, non-invasive brain interface that wants to fix these two problems. The problem is that it is not as pretty as it sounds. Work with the brain, not against it A few days ago, researchers at Yale University they published a study in Nature Neuroscience in which they detailed that the idea of ​​this project is to take advantage of the natural geometry of neuronal activity and not fight against it when a user can control software with their mind. The one of the fMRI-based BCIs (brain-computer interfaces) (functional magnetic resonance) is a field that has been explored for some time, but has an efficiency problem. It requires many long training sessions for a user to end up achieving modest results at best. Additionally, up to a third of participants never mastered the software. The twist that the Yale researchers have taken is to use the natural geometry of the brain. That is, taking advantage of the “consolidated pathways” of our brain activity so that technology works in favor of these existing pathways instead of forcing the brain to create completely new pathways. Result? Less friction and faster, more efficient learning. For landing it, we are not talking about a brain chipbut to introduce a person into an MRI machine not to do a standard scan, but so that that person can take advantage of the capabilities of real-time MRIs to move something in software. In this case, an avatar in a video game. That is to say, it does scan, all the time, in fact, while another program reads the data on the fly. To do this, they used a series of their own algorithms to discover the individual geometry of each person and, from that unique “map”, they created a closed system that read the user’s brain scan every two seconds and translated the data into video game movements. They tested three configurations: One based on the most natural pathways used by the brain. Others based on also natural routes, but less dominant. And a third based on pathways that the brain does not produce naturally, but that it builds. According to researchers, it’s like paving a road from scratch. The result was very positive: Participants learned to control the avatar using thought alone in less than an hour when the BCI interface aligned with that more natural brain map. Sometimes even in less time. When the system moved away from natural geometry, participants could control the avatar, but the time spent was much greater. The conclusion is that using this adjustment between the machine and the natural pathways of each individual’s brain, a physical reorganization of the brain has been observed to align with what the interface is demanding. The researchers observed that this reorganization spread even to brain regions that were not being used at the time, demonstrating that there is a kind of domino effect in the brain as it adapts to the changes. It’s very promising, but there is a problem: the necessary equipment. We are talking about that, to achieve these results, users had their heads inside an MRI machine, huge and very expensive equipment which is far from being as practical as brain chips claim to be. That is to say, it is not so much a “street” technology that allows people who need it to find an improvement in their abilities, but that does not mean that it remains a mere discovery. Something like this has interesting implications that can open the door to various applications in fields such as mental health (noting that it can be effective in developing treatments for depression or anxiety), motor and communication disorders or even cognitive improvement. Something more “clinical”, not common at home, although Erica Busch, first author of the study, opens the door to the construction of new generation video game systems controlled directly with the mind. But well, in the end, more than a commercial product, Busch herself points out that This discovery is more useful in the field of research. “We spend a lot of resources trying to become better versions of ourselves through education, practice or therapy. Understanding the structure of our own mind and brain can help us do this much more effectively.” Images | Yale In Xataka | Synchron is Neuralink’s great rival in the race for brain chips. Now you have an ace up your sleeve: ChatGPT

We have a way to improve the effectiveness of treatments such as Ozempic to lose weight: deceive metabolism

Our body did not evolve for the vicissitudes of modern life. During a good part of human existence, staying alive required for example that our body reacts to food shortages to prevent our energy consumption from becoming excessive and drained our reserves. In the world the contemporary world, this strategy has become an inconvenience for many who want to lose weight. A new way. Now this can change thanks to a New discovery. A team of researchers has discovered a mechanism used by the liver in the consumption of sugars and fats. Although the finding is still limited to animal models, the team believes that it shows potential to help improve the effectiveness of weight reduction treatments and even against diabetes. Facing the deficit. Layout seems simple: we just have to spend more calories than we consume. However, this is often complicated, since our body is an expert manager of its energy economy, knows how to react to scarcity. When we see ourselves in a prolonged situation in which we reduce the energy contribution of our body, that is, we ingest less calories, our body reacts reducing our energy consumption. To do this, it has a key tool: slow down metabolism. This implies for example, that after a time of diet, we can see how the weight we lower is reduced. Something that even affects people who resort to drugs such as Ozempic and Wegovy or Zepbound. PLVAP. The team responsible for the finding, They explainHe was studying a gene called Plvap in mice hígados. This is also a gene present in human cells. It was known that people with mutations that eliminated this gene presented problems by metabolizing lipids (fats), which focused group interest. The study of this gene allowed to discover that its function It has to do with metabolic change that occurs when our body goes from consuming sugar to consume fats during fasting. If this gene is not activated, the body continues to burn sugar as if nothing happened. Deceive the body. Controlling this newly discovered mechanism would open the way to improve the treatments present for weight loss. The strategy to achieve this would be to use this gene to “deceive” the liver in its regulation of our metabolism. The details of the study were published In an article In the magazine Cell. Not just a matter of weight. Controlling our weight is something that arouses enormous interest, as the successes of drugs such as those belonging to the Ozempic family have demonstrated. However, those responsible for the study point out that they could also help us treat metabolic diseases. An example is diabetes due to the role of PLVAP protein in the way our body processes sugar. A long road ahead. Transforming the finding into a treatment that can reach people will take years. For now, work has only been carried out in mice, which implies that it must still be demonstrated that the same mechanisms operate in the metabolism of human beings, something predictable but for now without contrast. Designing a drug and getting all common controls, including clinical trials is also something that requires time and, above all effort. The success of the new generation of drugs for weight loss is at least an indication that this type of treatments is on the laboratory agenda, so the effort is. In Xataka | We have been trying to find out why we get fat. Science is increasingly clear Image | Xataka with Gemini / Andres Ayrton

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