Doing more hours of treadmill does not guarantee losing more fat, and the culprit is our metabolism

There is a deep-rooted belief in the world of sports that treats the human body as if it were a simple thermal calculator, which leads us to think that if half an hour of cardio burns 300 calories, a full hour will burn 600. At the end of the day, it all boils down to ‘the more, the better’, but biology and metabolism are much more complex than a linear mathematical equation. It is studied. To get out of this thought that can be logical, an article published this same year made a comparison between the traditional additive model and the “constrained” model of energy expenditure. In this way, when subjecting different individuals to a type of aerobic exercise such as running, the increase in daily energy expenditure was only 30% of what would be expected if the model were completely linear. That is, instead of adding all the calories burned on the treadmill to the total expenditure for the day, the human metabolism implements a partial compensation. Because? This discrepancy occurs because the body, faced with an acute caloric deficit induced by prolonged exercise, activates a series of biological energy-saving mechanisms to protect its energy reserves, still aware of its need for survival. That is, far from burning energy without limit, the body “cuts” spending on other functions. For example, we know that metabolism, when we are on the treadmill, can slow down slightly, reducing the energy it ‘sends’ to non-urgent physiological processes in response to the stress of very aggressive training. There is more. A 2023 review concludes that decreasing unstructured physical activity is an incredibly common coping mechanism. This means that when a very demanding workout begins, people unconsciously tend to move less the rest of the day, which again significantly reduces the total caloric deficit. But when we are persistent in doing intense training, the body ends up adapting and becoming much more efficient, making the neuromuscular and cardiovascular system need less energy to do the same mechanical work. And here again we see that more exercise is not always more expense. Variability. Not all humans are the same, partly due to this great complexity of our organism. We see this in a review which determined that the average energy compensation after the introduction of exercise is around 18%, but warned of strong heterogeneity. The degree to which our body “boycotts” extra caloric expenditure depends strongly on variables such as the duration of exercise, genetics and, above all, the amount of adipose tissue that a person has when starting treatment. Here, a 12-week study in overweight adults pointed to how different groups showed radically different levels of metabolic compensation, registering 35% in one group compared to a massive 63% in the other. But what is clear is that doing more hours on the elliptical or treadmill does not guarantee a parallel increase in the loss of fat mass. Cardio works. Exercise continues to be a non-negotiable pillar due to its profound benefits on cardiometabolic health and continues to contribute to the loss of body fat. What science tells us is that there is a law of diminishing returns that stipulates that, above a certain threshold, adding more training volume generates a decreasing net caloric impact. In Xataka | We were wrong about exercise after 60: why strength training is the true shield against aging

We have a way to improve the effectiveness of treatments such as Ozempic to lose weight: deceive metabolism

Our body did not evolve for the vicissitudes of modern life. During a good part of human existence, staying alive required for example that our body reacts to food shortages to prevent our energy consumption from becoming excessive and drained our reserves. In the world the contemporary world, this strategy has become an inconvenience for many who want to lose weight. A new way. Now this can change thanks to a New discovery. A team of researchers has discovered a mechanism used by the liver in the consumption of sugars and fats. Although the finding is still limited to animal models, the team believes that it shows potential to help improve the effectiveness of weight reduction treatments and even against diabetes. Facing the deficit. Layout seems simple: we just have to spend more calories than we consume. However, this is often complicated, since our body is an expert manager of its energy economy, knows how to react to scarcity. When we see ourselves in a prolonged situation in which we reduce the energy contribution of our body, that is, we ingest less calories, our body reacts reducing our energy consumption. To do this, it has a key tool: slow down metabolism. This implies for example, that after a time of diet, we can see how the weight we lower is reduced. Something that even affects people who resort to drugs such as Ozempic and Wegovy or Zepbound. PLVAP. The team responsible for the finding, They explainHe was studying a gene called Plvap in mice hígados. This is also a gene present in human cells. It was known that people with mutations that eliminated this gene presented problems by metabolizing lipids (fats), which focused group interest. The study of this gene allowed to discover that its function It has to do with metabolic change that occurs when our body goes from consuming sugar to consume fats during fasting. If this gene is not activated, the body continues to burn sugar as if nothing happened. Deceive the body. Controlling this newly discovered mechanism would open the way to improve the treatments present for weight loss. The strategy to achieve this would be to use this gene to “deceive” the liver in its regulation of our metabolism. The details of the study were published In an article In the magazine Cell. Not just a matter of weight. Controlling our weight is something that arouses enormous interest, as the successes of drugs such as those belonging to the Ozempic family have demonstrated. However, those responsible for the study point out that they could also help us treat metabolic diseases. An example is diabetes due to the role of PLVAP protein in the way our body processes sugar. A long road ahead. Transforming the finding into a treatment that can reach people will take years. For now, work has only been carried out in mice, which implies that it must still be demonstrated that the same mechanisms operate in the metabolism of human beings, something predictable but for now without contrast. Designing a drug and getting all common controls, including clinical trials is also something that requires time and, above all effort. The success of the new generation of drugs for weight loss is at least an indication that this type of treatments is on the laboratory agenda, so the effort is. In Xataka | We have been trying to find out why we get fat. Science is increasingly clear Image | Xataka with Gemini / Andres Ayrton

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