“Why the ‘rebound effect’ has become the surgeon’s best ally against Ozempic

In the last two years, the GLP-1 receptor agonists like for example Ozempic either wegovy have gone from being drugs for diabetes to becoming the cultural and medical phenomenon of the decade for fight obesity. And such was its impact, that it was thought that surgery for obesity had come to an end, but the reality has been very different. The premise. The idea is quite clear: if I can take medication twice a month to lose weight… Why would I go into an operating room? A logical idea, especially given the risks that one always has when entering surgery, no matter how well controlled they are. But this enthusiasm of abandon the scalpel It is slowly being diluted, since according to the latest research, bariatric surgery is still superior to GLP-1 agonists and achieves much better results. The devastating fact. The study that has shaken the board comes from NYU Langone where researchers compared patients undergoing interventions such as gastric bypass with those who had taken Ozempic. The result was quite clear. Those who had undergone surgery managed to lose between 24 and 26% of their body weight, while patients on drugs lost an average between 5 and 6%. A result that does not agree with what was expected by pharmaceutical companies with their clinical trials in hand. But the problem is that the variable adherence to treatment It is once again a big problem in medicine. More data. The University Clinic of Navarra He also wanted to investigate in this field, doing a large study with 20,000 patients, concluding exactly the same thing: bariatric surgery surpasses GLP-1 agonists in total weight loss, reduction in BMI and body composition. The human factor. The great failure of a pharmacological treatment is undoubtedly the humans who are going to take it. And it is quite common in medicine for patients to forget to take a dose of their medication or even abandon treatment halfway through without any type of control. But luckily, the big difference between a pill (or injection) and surgery is that the second cannot be “forgotten.” The studies are clear in this sense: between 60% and 70% of patients They abandon GLP-1 treatment before the first year. Something that causes a great rebound effect which makes a patient return to their original weight, especially if they return to the same eating habits as before starting treatment with Ozempic or others. The difference. The reasons for reaching this point in treatment are varied: from persistent gastrointestinal side effects to the high monthly cost of treatment or the shortage. But the thing is that while stopping pricking yourself causes a rebound effect, bariatric surgery, although invasive, offers much more stable long-term results. Although logically he has many other problems behind him. Beyond the scale. The superiority of surgery is not measured only in waist centimeters. Science points through a systematic review published in JAMA Network Open This 2025 suggests that surgery is associated with lower overall mortality and a more drastic reduction in major cardiovascular events compared to drugs. And although GLP-1 has shown great benefits, the truth is that science indicates that surgery is still better in remission of type 2 diabetes with a minimal risk of mortality. Furthermore, despite the initial cost of the operation, in the long term surgery is cheaper for health systems than chronic drug treatment that costs hundreds of euros per month for life. A combined therapy. Despite all this, we are not in a war of one against the other, but the future points to an integration of both elements. In this way, strategies are already being explored where GLP-1 is used before surgery to reduce surgical risk in patients with extreme obesity, or after surgery as a rescue tool if the patient begins to regain weight years later. Even the WHO has begun to include these drugs in its comprehensive treatment guidelines, but emphasizing that they are one more piece of the puzzle, not a universal substitute. Images | David Trinks In Xataka | We have more and more research on the effects of Ozempic. And the problem is that we have more and more doubts

After years of debacle, South Korea has managed to rebound his birth. Now it’s time to find out how the hell has done it

Demographic statistics is nothing more than that: Demographic Statistics. Pure and hard mathematics, with objective and reading data. For years, however, their chronicles in South Korea transmit a dire air, as of announced death. And it’s normal. The country has seen how its birth rate descended to such low dimensions that in 2024 the country had to declare itself in “demographic emergency” and assume officially that it is a “society Super aging“ Now that seems to be changing little by little, which raises two questions: Has Korea achieved out of the demographic hole in which it has been immersed for years? And if so, how? They are key issues for Seoul, but also for other neighboring countries with birth problems, such as China either Japan. What happened? That against all forecast, South Korea Start to get used to to their demographic statistics arrive accompanied by positive signs. That does not mean that they are good at all, the country has managed to stop its demographic bleeding or its fertility rate stands above “Replacement level”; But they are favorable news after all. And that did not happen for a long time. A figure: 20,717. The latest data published by Statistics Korea show that in April they were born in the country 20,717 babies8.7% more than 19,059 counted during the same month of 2024. The data is interesting because it leaves several positive readings. The first is that three years ago the number of monthly lights remained below the 20,000 barrier. The second is that this 8.7% growth shows the highest year -on -year increase in the last three and a half decades. You have to go back to 1991 to find another similar percentage. More babies, more weddings. There are not only more babies. There are also more couples giving the ‘yes I want’. The data Statistics Korea show that in April 18,921 marriages in the country were formalized, which leaves an interannual increase of 4.9%. The data invites optimism for another reason: it is the thirteenth consecutive month in which this indicator is green. It may seem a minor issue, but in the South Korean society couple and birth They go hand in. There are studies that calculate that less than 5% From babies they are born out of marriage. Coincidence or trend? That is the question that surveys the birth data of Korea. Especially since the last years have been marked by the shadow of the pandemic, which modes to take many couples to postpone their wedding plans or even the decision to become parents. In his favor the country has to They are not the first in positive. Seoul already said goodbye to 2024 with a positive birth rate (the number of births 3.6% increased), something that had not happened for a decade. Looking for the causes. At this point, the question is obvious: beyond the influence of the pandemic, is there any factor that explains the rebound in birth in the country? The question is interesting for South Korea, but also for other nations that have been dealing with demographic challenges, such as Japan, China, Russia or many European nations, including Spainwhich in recent years has gained population thanks basically to foreigners. “The increase in births seems to be influenced by the increase in marriages since last year, the growth of the population of women between 30 and 39 years and various birth promotion policies by central and local governments,” Clarify Statistics Korea to the Yonhap News agency. In summary, after the birth rebound in Korea there would be three major factors: more weddings, the effect of the ‘ProbebĂ©’ policies and that in the country there are more women in the first section of the thirties. A concept: echo boombe. At least part of the demographic change would therefore be explained thanks to demography itself. And the key is in a certain group of the cohort of the echo boomers. The Guardian remember That the population born between 1991 and 1995 begins to reach the “ideal” age to marry and have children and that group has grown sensitively. If in 2020 there were about 1.51 million women between 30 and 34 years old, now there are already 1.65 million. To its possible effect, the wide range of policies that for years have deployed the South Korean authorities (both regional and state) to encourage the formation of couples and birth rate are added. And that includes from the delivery of generous ‘Baby checks’ to the application of Fiscal incentives, parental permitsinitiatives for Improve food of mothers or even appointment programs (with prize included) to form new couples. Well but not perfect. The latest data from Statistics Korea are good, but they are far from being perfect and of course they do not allow South Korea to launch the bells on the flight. On the contrary. Although birth is emerging, the country’s fertility rate remains at 0.79far from the replacement level that the country needs to keep its population stable without depending on immigration. In addition, although the number of births with respect to 2024 has increased, they remain clearly insufficient to stop the fall of the national census. The reason? Babies are born, but in the increasingly aging Korean society there are also more deaths. The deaths grew 0.8% year -on -year in April until adding 28,785. Images | Nathan Q (UNSPLASH) and Tommao Wang (UNSPLASH) In Xataka | Throughout Europe, birth rate collapses as soon as women begin to earn more money. Except in Sweden

A rebound in historical heritage

After a week chaining Falls in stock markets around the world, before the uncertainty created For the announcement of the US tariff policy, stock markets lived a historical day marked by the increases. The turning point was marked by the publication of a statement in Donald Trump’s profile in his social network in which he announced the 90 -day postponement For your tariffs. The rally after the pause of tariffs. The unexpected Trump ad Not only relieved stock pressure on The main technology companiesbut also unleashed an unprecedented rebound in the quotes. Investors who bet on the market at their lowest time, saw how their portfolios fired marking a 9.5% rise in S&P 500, the fourth largest increase in this index since you have records. According to data of Financial Timesthis rally contributed about 4.3 billion dollars to the market of the S&P 500 and the Dow Jones won almost 8%. According to The published by Business Insiderwith this sudden climb the 10 main millionaires from the Forbes list increased their assets by about 107,000 million dollars. As May water for technology. Technology companies were the ones that best recovered after the collapse of the last days. The Nasdaq 100 rose 12%, so companies such as Microsoft, Apple, Tesla, Amazon or goal recovered more than 1.5 billion dollars in market value in a matter of few hours. The recovery of these companies in turn had an impact on the revaluation of the fortunes of its founders and main shareholders. According to estimates of Business InsiderElon Musk, CEO of Tesla, led the profits by recovering $ 35.9 billion to its assets in a single day. Jeff Bezos and Mark Zuckerberg were not far behind, increasing their balance sheets by 18,500 million. Although this rally was celebrated by most investors such as May water, there is still a lot of room to compensate for the accumulated losses For these millionaires in recent weeks. It is estimated that they amounted to more than 244,360 million dollars. In the right place, at the right time. Trump’s announcement not only benefited the billionaires, but also those investors who knew how to take advantage of the trend of previous market fall. In Words by Warren Buffett: “A simple rule dictates my way of buying: being afraid when others are greedy and being greedy when others are afraid.” The investors who followed these words and bought more actions during their fall, with the rebound obtained a millionaire benefit almost immediately. Suspicions about market manipulation. Such and as he published The Guardianthe rapid rebound in the bags has sown the doubt between analysts, about whether Trump’s maneuver could be a Deliberate manipulation form to favor certain economic groups. Three hours before the advertisement advertisement of tariffs, Trump He published a message In his profile in his social network inviting to buy shares, while the stock market was still in free fall. Representatives of the Democratic Party, as the senator for Massachusetts Elisabeth Warren, already have requested an investigation To clarify if there was manipulation of markets To benefit your donors. While that request was taken, an euphoric Donald Trump joked with his collaborators and members of his presidential cabinet about how much money each one had earned with the rebound of the values. In Xataka | Trump has become one of the most valuable crypto overnight. The problem is who is enriched: Trump In Xataka | Cryptocurrencies were supposed to “become” independent “from the power of states. The US has just killed him Image | Flickr (The White House), Unspash (Rafael As Martins)

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