The first hard drives in history were gigantic. Then a miracle happened: miniaturization

Nowadays it is normal to have 32 or 64 GB of capacity on our mobile devices, and that capacity is usually multiplied by several orders of magnitude on our PCs and laptops. Storage technology has advanced incredibly in all these years, and to appreciate this evolution it is not a bad idea to take a short trip to the past and see how decades ago hard drives were heavy and cumbersome monstrosities that also had very limited capacity and features. The first example of that evolution we have it in the IBM RAMAC 305a monster that appeared in 1956 and was capable of storing 5 MB thanks to a system with 50 24-inch “platters”. That device rotated at a speed of 600 revolutions per minute and generated such a quantity of heat that it was necessary to enclose it in a large “refrigerator” with two cooling systems. Another curious fact about this product is that IBM already thought about a subscription model to make it profitable: clients who wanted to use this product had to pay $3,200 per month at the time, which would be equivalent to almost $30,000 today with inflation. Miniaturization would still take years to reach an industry that was trying to advance especially in the area of ​​storage capacity: customers demanded more capacity, and those 24 inch plates wereAs seen in the image, huge. In this case these models reached 10 MB capacity per disk. The giant of the time, IBM, dominated the sector for years, and in 1962 the company created the first “removable” drives. The IBM 1311 Disk Storage Drive made use of IBM 1316 “disk packs” that allowed the company’s customers to expand their needs to suit. From the 24 inches of the previous disks it went to 14 inches, with 2 Mbytes for each “pack”. The path to smallness Another of those storage devices It was UniDisc.a storage expansion that appeared in 1962 for the Univac 1004/1005 computers. That “flexible” disk similar to those used by IBM had a diameter of 14 inches and was capable of holding 2 Mbytes of information. The drive the disk was inserted into was about the size of a washing machine. At that time, several manufacturers tried to be leaders in a promising sector, and among them was Burroughs, a mainframe manufacturer that, for example, launched this unit of 250 MB in 1979. A true marvel that used, pay attention, regenerative braking: when it was turned off, the motor became a magnetic brake: otherwise the discs continued spinning for an average of 4 hours. A few years earlier IBM had already launched its new hard drive technology, the so-called “winchester“. The IBM 3340 drive had a smaller, lighter read/write head that had a design that allowed it to move across that surface at a tiny distance. Things would advance from that moment even more rapidly, especially in the field of miniaturization (more or less) and the capacity of units that, for example, in 1980 already reached the gigabyte with the IBM 3380 unit. From that year 1980 is also the Memorex Mark XIV “disk pack” in the header image that was advertised as an “error-free” system. It had a capacity of 80 MB and was intended for Memorex disk drives that were again the size of a washing machine. 5¼ units would soon give way to 3.5-inch oneswhich would arrive first from the Rodime company (with former Burroughs employees, by the way). Their devices were capable of storing 6.38 and 12.75 Mbytes and would start a real trend in the PC and laptop market. User needs continued to dictate smaller formats, and this led to 2.5-inch drives that are currently especially widespread due to their use in the solid state drive segment. The rest, as they say, is history: 3.5-inch drives are still widely used today, but that revolution would be followed a few years ago by that of solid state drives or SSD (especially in M.2 format) that have allowed us to achieve reading and writing speeds that were unthinkable just a decade ago. In the area of ​​capacity and cost per gigabyte, yes, those traditional hard drives continue to be (for now) the kings of the market, but if we want examples of miniaturization, the 1 TB drives that SanDisk presented at CES seven years ago made things even better. And what remains. In Xataka | Sandisk has risen 1,000% in the stock market since the summer. Its advantage is called Kioxia In Xataka | The computers of the future have found an unexpected ally to store information: fungi

Germany is experiencing a new “industrial miracle” that it already experienced 90 years ago: that of weapons

Germany has been living a transformation silent but very deep. The country that saw the birth of the industrial miracle of the automobile is seeing something similar again, but from a perspective completely different: rearmament, which until recently was a political taboo and a social discomfort, has become a great industrial and labor accelerator. War as a driving force. The country, pushed by the russian invasion of Ukraine and the feeling that the American umbrella is already It’s not so automatic As before, it has been shifting its center of gravity towards defense with a mix of strategic urgency and productive ambition. And that mutation is measured in something very specific: employment, factories, supply chains and a demand that is no longer described as temporary, but as a new normal that promises to last for years, with orders that come in like a wave and companies that prepare to produce at scale, with war economy rhythms without the need to call it that. Mass hiring. German defense contractors have entered into a veritable hiring feverincreasing its workforce by nearly a third in just four years. The data provided by a representative group of large companies and start-ups shows a jump from around 63,000 workers in 2021 to almost 83,000 today Within its defense-focused divisions, a 30% growth which reflects the extent to which the industry is expanding at real speed. I remembered the financial times that, although these figures do not cover the entire sector and there are large companies that did not participate, the portrait is enough to understand the direction of the country: Germany not only buys more weapons, but is rearming its industrial muscle to manufacture, sustain and modernize them, with a labor market that is beginning to reorganize itself around this new priority. Rheinmetall Panther KF51 The budget turn. The great fuel for this expansion is public money converted into contracts. Since 2022, the German Ministry of Defense has signed arms deals worth of 207,000 million eurosand last year alone it concentrated 83,000 million, a figure that contrasts with the 23,000 million in 2021 and that summarizes the break with the previous stage. The most significant thing is that the trend does not aim to stop: Chancellor Merz, in office since May, has relaxed the strict debt rules to allow the level of spending needed in defense, a message that, beyond politics, works as an industrial signal: there will be stable demand, continuity and visibility, just what companies need to invest, expand capacity, hire and plan for the long term without fear that everything will freeze with the next electoral cycle. The real size of the sector. Even with this boom, the German defense industry remains a relatively modest player in terms of employment when compared to the country’s historical giant: the automobile. The Ministry of Economy itself cited around 105,000 jobs direct in defense in 2022, and although the figure will have risen since then, it remains far from the approximately 700,000 workers in the automotive sector, today hit by layoffscompetitive pressure and technological transition. This comparison is important because it cuts to the root a repeated idea: that rearmament can “replace” the car as a great work cushion. Defense can grow a lot, even draw on industry and attract talent, but due to volume it does not seem capable of absorbing the size in the short term. of the engine crisisat least not quickly or massively. Airbus and Reinmetall. Within the employment map, Airbus stands out as the largest employer, with around 38,000 people working in defense worldwide and just over half in Germany, manufacturing key pieces of European military architecture such as the Eurofighter Typhoon and the transport plane A400M. right behind Rheinmetall appearswhich has become the most visible symbol of the boom: the producer of tanks, artillery and ammunition has grown from about 15,400 employees in 2021 at 23,500 todaythe greatest absolute leap among the companies analyzed, and its CEO, Armin Papperger, has even projected a target of 70,000 employees in three years. In parallel, Rheinmetall has begun to experience something that in Germany is a cultural indicator: social attractiveness. He speaks of hundreds of thousands of applications in a single year, as if defense had stopped being a dark or secondary sector to suddenly become a bet for the future for engineers, technicians and industrial profiles. Military startups. The big relative surprise is in the new scene of military start-upsyoung companies focused on surveillance systems or weapons not always publicly detailed, that are raising hundreds of millions in financing and growing at a rate almost unthinkable a decade ago. The most striking case It’s Helsing.which makes armed drones and whose workforce has grown 18-fold in four years after evolving from an artificial intelligence software approach to hardware productiona leap that involves going from selling algorithms to build real objects with parts, assembly lines, logistics and maintenance. This movement is, in itself, a statement: European defense no longer wants to depend only on digital innovation, it wants to convert innovation in physical and deployable systemsand for that you need companies capable of manufacturing and scaling, not just programming. The State accelerates. From within the sector, the discourse is one of sustained takeoff. The BDSV employers’ association, in the voice of Hans Christoph Atzpodien, insists that growth will accelerate because Germany has streamlined processes purchase and has given more visibility on future demand, which allows capacity planning with less uncertainty. The phrase is almost industrially literal: now everything is placed so that large orders “arrive at the doors” of manufacturers. If you want and how do we countthe scenario describes a change of era: for years Europe talked about spending more on defense, but it did so with administrative slowness, political doubts and eternal programs; now the feeling is that the system is being reconfigured to buy and produce urgently, because the threat is perceived to be close and the margin for improvisation has been exhausted. The great temptation: “steal” the car. … Read more

the “miracle” of Namibia to fill Europe’s supermarkets with grapes

The country of ‘Namibia’ may a priori be truly unknown to many people, but the reality is that many of the grapes we buy in the EU come from here. a country practically desert that has been achieved and that a priori is not ready to host cultivation, but that has achieved something unusual: converting one of the most arid landscapes on the planet into a large grape plantation that compete in the most demanding markets. An evolution. In this way, what three decades ago was a silent, sun-battered valley on the banks of the Orange River, Today it is the epicenter of the billion-dollar grape industry.. The Aussenkehr region has not only “greened” the desert, it has redefined the global table grape calendar. The origin. The industry was born from the vision of Dusan Vasiljevican entrepreneur who in 1988 identified Aussenkehr’s hidden potential. The challenge was monumental: an environment with less than 50 liters of annual rainfall, a total lack of infrastructure and no previous experience in growing grapes in the area. A priori, only a madman could build a grape plantation here, since it seemed like a guaranteed waste of money. But in the end it was quite the opposite. Overcoming critical financial obstacles, Vasiljevic planted the first 150 hectares, achieving an initial harvest of 1,000 tons in 1991. Since then, expansion has been constant. Collaboration between the private sector and entities such as the Namibia Grape Company (NGC) and the national government has allowed cultivation to be extended to more than 700 additional hectares, turning the valley into an engine of development that currently exports to a good part of the planet. great growth. Namibia’s quantitative leap in recent decades is an economic case study without a doubt. The country’s ability to take advantage of its ideal climate for early harvests allows it to enter the European market before its competitors, obtaining very good prices. This way, exports have passed from 1,917 tons in 1997 to having 7.5 billion cartons ready to ship this season. All this with a value that in 2023 reached 84.2 billion dollars. Your logistics. Namibian success does not depend only on production, but on robust logistics. Right now the main market for this production company is in the European Union, which absorbs 75% of the production, followed by the United Kingdom and emerging markets in Asia. That is why the company’s focus has been on high-value varieties such as Arra Honey Pop and Arra Fire Crunch that offer greater flavor and, above all, more resistance in transportation. Regarding its exit routes to other countries, the strategic ports of Walvis Bay and Cape Town stand out above all, which guarantee the necessary freshness for European shelves. satellite images. But words can sometimes create confusion or even give rise to the idea that we are completely exaggerating. But the reality is that the satellite images do not deceive, and reveal a great contrast between the bright green of the plantations in contrast with the ocher sand of the Namib. View from Google Earth of the grape plantation in Namibia It is also fantastic for lovers of geometric shapes, since in the images you can clearly see different almost perfect green squares in the middle of an arid background. And the truth is that it seems a miracle that it has been possible to revitalize this land that now supplies the European market with a large quantity of grapes. This is something that in 2010 was the focus of NASA that used he Advanced Land Imager and gave recent scientific studies, like those from WaterWatchwhich highlight that Namibia has achieved these yields with exceptional water efficiency, using precision irrigation systems that minimize waste of water from the Orange River. Socioeconomic impact. Beyond foreign currency, grapes have become the livelihood of thousands of families in this area. Right now, the industry supports 3,500 permanent workers and 7,000 temporary employees during harvest peaks. Furthermore, this model has been praised in international forums such as Davos, where it was presented as an example of how irrigated agriculture can be sustainable and profitable in arid regions of sub-Saharan Africa. In Xataka | In the midst of desertification, Australia has had an idea as strange as it is effective to retain water: covering the land with wool

It’s tempting to start a “miracle diet” against the clock to get to Christmas. The experts have something to say

We have reached December and, with it, Christmas lights turn on and also a silent race that repeats itself every year. While company dinners, meetings with friends and family gatherings accumulate, thousands of people begin what we could call “the last sprint”: losing weight quickly before sitting down at the table at Christmas. But behind this sprint There is a much more complex phenomenon. One that has social, emotional and biological roots, and that hides a perverse effect. Express diets teach the body to be more efficient in saving energy, which ends up causing us to regain it and sometimes even more after losing weight quickly. The pre-Christmas sprint. Every December, an almost automatic reflex is activated, the feeling of having to “get there safely” to the holidays. The psychologist specialized in Eating Disorders (ED), Sara Bolo, He explained to us in Xataka that this phenomenon is not coincidental, but a pattern that repeats itself year after year. “Christmas is a special time, where we see family or friends again that we don’t see every day. And with that, comments about the body reappear: ‘I look thinner at you’, ‘you’ve gained weight’…” This dynamic, as common as it is harmful, multiplies aesthetic pressure and turns coexistence into a silent body examination. Another ingredient is added to this context, the purposes that were not fulfilled. “We arrived in December with the idea of New Year, New Me that we announced in January – says Bolo – and the urgency appears to show that we have achieved something.” That mixture of self-demand and closure of the cycle pushes many people to make drastic decisions in a very short time. One more factor. And it’s not just aesthetic pressure or frustration, there’s also anticipatory fear. According to Bolo, it is common for some people to restrict their diet in the weeks before, thinking that this way they “compensate” for Christmas meals in advance. “It becomes a defensive preparation. I don’t want them to tell me anything, I don’t want to feel guilty, so I start restricting before,” he details. This urgency is exactly what dietitian-nutritionist Laura Jorge also observes, director of the centers that bear her name. Since your consultation, December always has the same profile, more requests for “quick fixes”, more promises of express weight loss and more anxiety. “Every year we see an increase in people looking to lose X kilos ‘before the holidays’. It is a very clear pattern,” he explained to us in an interview. Three elements are repeated: urgency, guilt and dichotomous thinking – “now I restrict myself, and at Christmas I will eat” -. What starts as a sprintBoth experts agree, it usually ends up being an emotional and metabolic trap. The hidden enemy. Science explains it bluntly, when we subject the body to extreme and sudden caloric restriction, the body activates survival mechanisms, not weight loss. As Jorge details, the metabolism slows down, hunger increases, satiety decreases and the body begins to use muscle mass as a source of energy. This not only makes it difficult to maintain weight loss, but also reduces basal metabolic expenditure, making it easier for us to gain weight later. Scientific research supports these observations. A study of New England Journal of Medicine showed thatafter losing weight, leptin—the satiety hormone—was still low and ghrelin—the hunger hormone—was still elevated even 12 months later, even though the person had already recovered part of their eating routine. The authors conclude that these adaptations create “a physiological environment that favors the recovery of what was lost.” In addition, the factor of genetics must be taken into account. A study from 2024 published in International Journal of Obesity points out that not everyone responds the same; some people, after repeated cycles, develop a greater risk of insulin resistance or visceral adiposity. The other side. Rapid weight loss has an immediate emotional effect and makes it seem like a success. “You get on the scale, you see fewer kilos and you feel immediate euphoria,” admits Sara Bolo. But it is a mirage. When the weight returns – as it usually does – the emotional collapse appears: guilt, frustration, shame, absolute thoughts (“I am a failure”, “I have no willpower”). Furthermore, the environment reinforces this dynamic because thinness is praised and gain is censored, even with “innocent” comments. This back and forth deteriorates self-esteem and fuels restrictive behaviors that, far from solving the problem, intensify it. A door that is better not to open. “The restrictive diet is the first step of any eating disorder,” he says. the psychologist Rigid control, obsessive calorie counting, avoiding social meals, or classifying foods as good or bad are early signs. And Christmas is one of the moments where they manifest themselves the most. Laura Jorge agrees: “In these weeks we see people who begin to talk obsessively about compensating, skipping meals or doing compulsive exercise. These are signs that should not be ignored.” The combination of aesthetic pressure, abundance of stimuli and comments can activate a latent ED or aggravate an existing one. When the comment is “innocent”, it is not. Social responsibility is evident. The experts remember that comments as common as: “Oops, are you repeating yourself already?” “That’s good, you’re thinner.” “After these meals, tomorrow on a diet.” Behind all these phrases, a thin laugh follows that for many sounds like a roar. And as experts say, they are not only unnecessary, but potentially harmful. “You have to take care of your language,” summarizes the nutritionist. “Do not congratulate people for losing weight, do not comment on their own or other people’s bodies, do not pressure them to eat or stop eating.” Aesthetic pressure often begins with a comment that seemed harmless. So how can we accompany? For those who live Christmas meals with fear of losing control, the key is not in the plate, but in the environment. The psychologist Sara Bolo insists that accompany It does not mean guarding, but offering a safe space. His advice … Read more

That Napoleon’s jewels were stolen from the Louvre in seven minutes is not a miracle. It is something much worse for France

You have hardly been able to escape to the news of the weekend. It happened when the morning of Paris had not yet acquired the pulse of tourism. Then, a four-man gang climbed the facade of the Louvre as if the very principle of deterrence did not exist. Everything was surprising: there was no night, no disguise of technological ingenuity, no escape into an interior labyrinth. Thus, in the seven minutes it took us humans to have a coffee, the group removed from the heart of the museum the most sensitive remains of the French imperial lineage. The most guarded museum in the world could be crossed like if it were a decoration. The material blow. He told in a detailed report this morning Le Monde that the command arrived on the side of the Seine taking advantage a context of works and the functional anonymity of an urban furniture-mountain. They forced a porte-fenêtre towards the Galerie d’Apollon (the room that condenses the mythology of state sovereignty: joyaux de la CouronneNapoleonic inheritances, diadems and colliers that condense continuity of power) and broke two high security display cases in seconds, collecting eight pieces of heritage value not translatable to the market. The operation lasted around seven minutes. The withdrawal was done along the same vertical axis with the support of two large displacement scooters. In the rush of escape, the criminals dropped the Eugenie’s crownlater recovered damaged. What they took and what they didn’t. The theft affected pieces of the corpus Marie-Amélie/Hortense (including sapphire colliers, earrings and tiaras) and jewelry linked to Marie-Louise. They were unable to extract the diamant-régent (one of the three canonical diamonds of the French canon) nor, as we said, preserve Eugénie’s crown in the flight. What is stolen is, strictly speaking, unmarketable as an entire heritage object, but its dismantling (gold, diamonds, sapphires separately) suppresses cultural and biographical traceability, which is where the irreparable lies. Structural failure. They count national media that the gap was not the cunning of others but the internal predictability: five agents for a room thermodynamically saturated with risk, a relay that reduces to four personnel in the exact strip in which the coup is carried out, a security architecture whose modernization was postponed, and a prioritization curve that armored the Joconde but it decompensated the surrounding heritage periphery. In fact, the runion and staff action (boos to management, demand for an independent audit, denunciation of years of unattended alerts) indicates that the failure was not only big, it was known and was never corrected. Political responses. The assault detonated a immediate response of Macron, of the Interior and of the judiciary, with the affirmation that the authors were going to be captured and the pieces recovered. For its part, the opposition transferred the episode to a frame of state decay: If the Louvre (symbol of the nation’s continuous narrative) is permeable during opening hours, the crack is more than museum-like. In other words, from that prism, public humiliation then operates in two planes: exterior (Country-image) and interior (delegitimization of the chain of command over heritage). The crown of Empress Eugenia de Montijo Criminal logic. We said it at the beginning. The pieces, en bloc, do not circulate. Its economic power lies rather in its deconstruction. The likely incentive is not conventional private collecting (impossible to display) but the supply on demand (unknown contractor, including state or quasi-state) or the cannibalized high margin industrial bulk. According to Le Mondehe recent pattern (Cognacq-Jay, Museum of Nature History, Limoges) shows a vector of criminal professionalization with a logistical window close to civil works, rapid emergence, cold extraction, brief departure and, sometimes, exogenous assignment. The discarding of an item in the flight suggests, perhaps, operational friction, but not global improvisation. Precedents. There is no doubt, France knows famous robberies (1911 the Joconde1976 sword of Charles, 1998 the Corot) but the qualitative leap lies in the practical deactivation of the Louvre taboo during visiting hours. The museum was closed to preserve vestiges and the criminal investigation is open with focus on escape routeabandoned equipment, construction perimeters and cameras. In fact, the hypothesis of a foreign commission is not ruled out, nor is the performance of a cell trained in high-density urban theater patterns. Hunting status. From what is known, the investigation focuses in four authorsscooters and routes already mapped, with cameras analyzed and forensic material in progress. One damaged piece was recovered, but eight remain missing. Plus: the probability of intact recovery decreases with time because the thief’s rational incentive is, a priori, to disassemble, volatilize and recombine. The cultural loss is absolute if the components are assembled in another vector or if the metal is melted and sold through other channels. What the robbery reveals. The reputational implosion now forces us to accelerate what years of internal warnings They did not move: comprehensive shielding, redistribution of personnel due to real risk and not due to tradition, closing of logistical windows associated with civil works, and a redefinition of the security perimeter by layers, not only by a single idol (the Joconde-Gioconda). The only “advantage” of an open-hour robbery with global symbolic production is that it makes it politically unaffordable to return to the previous status quo. If you also want, the episode, rather than pointing out an unusual criminal genius, points to the country itself. The escape in seven minutes did not measure the capacity of the thieves, but rather the exact time in which the State left open the possibility that the largest museum in the world could be treated like the entrance to a bathroom in full public service. Image | Tore Sætre, Alexandre-Gabriel Lemonnier In Xataka | Everyone wants to see the Mona Lisa, a problem that the Louvre is going to solve drastically: by hiding it In Xataka | A Saudi prince paid $450 million for a Da Vinci painting. The problem is that it may not be by Da Vinci

Only “a miracle” can save the company that launched Yuri Gagarin

What until now were rumors and suspicions It has become the harsh reality confirmed from within. And in the most brutally possible way possible. The legendary RSC Energy, the pillar on which the entire Soviet and Russian space program was built, is in a “critical situation”, on the verge of bankruptcy. It does not say a western analyst, but the general director of the Russian company, Igor Maltsev, in an internal statement that contradicts the Kremlin propaganda. “We have to stop lying.” Far from the usual fanfare, the message published on the occasion of the 79th anniversary of RSC Energia lacks euphemisms. “Multimillionaire debts, loan interests that eat the entire budget, ineffective processes and a significant part of the team that has lost motivation and the sense of shared responsibility,” writes Maltsev. Filtered by The Russian medium Gazeta.ru And confirmed by multiple sources, the message is a low blow for Russian space propaganda. Maltsev was appointed director just three months ago and has needed little time to understand the magnitude of the disaster. In his letter, he affirms that the legacy of geniuses like Serguéi Koroliov “has been exhausted” and that, in recent years, “all important projects and all deadlines have been breached.” On the verge of bankruptcy. In a desperate cry, Maltsev warns their thousands of employees that the future might not be the “flourishing of RSC Energy”, but the “closing of the corporation and the impossibility of functioning normally, paying salaries and creating new products.” The conclusion of your message, Full -widespread in Telegram channelsIt is almost a plea to heaven: to get the company forward is a task “of the kingdom of miracles”. It is a radical change against the usual rhetoric of Roscosmos, which usually focuses on past glories and Grandilocuent future projects But with little financing. As Eric Berger points out in Ars TechnicaThe reality is that the Russian space program is deeply definanced, a situation that has been especially aggravated by the war in Ukraine. With interest rates in 18%, capital is increasingly scarce and debts become unpayable. The end of the Russian monopoly in the ISS. The RSC Energia crisis, manufacturer of the created Soyuz ships and the progress cargo ships coincides with the moment when its role in the International Space Station has ceased to be indispensable. For decades, Russia has been in charge of raising the orbit of the station to counteract atmospheric decay, a task that performs with the engines of the Zvezda module or the progress ships coupled to the ISS. However, his monopoly is already history. NASA, concerned about Russian threats to leave the stationit has been looking for alternatives for years. And he has already found them. As Daniel Marín details in EurekaSpacex’s new CRON-33 ship has been equipped with a specific propulsion system to raise the ISS orbit regularly. This capacity makes the Dragon a robust and reliable alternative to Russian progress, eliminating the main pressure lever that Roscosmos had left at the station. A minimum diplomacy. Ironically, this unprecedented internal crisis coincides with a shy diplomatic thaw. As We counted in XatakaNASA and Roscosmos bosses gathered in August for the first time in almost eight years. On the table, they agreed to maintain cooperation in the ISS until 2028 and collaborate in their future exorbitation. This approach, more than a sign of strength, seems like a pure need maneuver. The space station agrees by leaps and bounds, with the Russian module Zvezda as the main concern for its persistent air leaks. The Maltsev action call is the most obvious symptom that the Russian space program faces a systemic collapse. The loss of its technical monopoly in the ISS, combined with an internal economic bleeding, Leave Roscosmos in its weakest position in decades. The “miracle” requested by the director of Energy is not only to save a historical company, but to prevent one of the great legacies of space exploration from becoming a museum piece. Image | ROSCOSMOS In Xataka | The Marian Rover of ESA is definitely damn: the exomars mission accumulates 20 years of calvary and bad luck

Minoxidil looked like the great miracle medication against baldness. A pharmaceutical company financed by Google has just overcome it

The fight against alopecia is A thriving market. The first laboratory to achieve the “miracle treatment” that manages to avoid or reverse androgenic alopecia (conventional hair loss associated with age) could take a lucrative prize comparable with the success of formulas such as Ozempic. One of the best positioned laboratories in this race seems to be Pelage Pharmaceuticals. Preliminary results. A few days ago, the Pelage Pharmaceuticals laboratory announced “positive” preliminary results in the second phase of its clinical trials of the compound PP405. According to its announcement, the formula showed a quick and statistically significant response in these trials. PP405. The compound developed by this company, pp405, is designed for topical application and with the aim of reactivating latent follicular stem cells (HFSC), thus allowing the restoration of hair growth. According to Explain the laboratorythese cells usually alternate latency and activity cycles when they work conventionally. However, with age or in response to certain external or internal stimuli, these cells can be “blocked” in the sleeping phase of this oscillation. As highlighted, this state of latency does not imply its disappearance or loss of viability. Test treatment seeks to “restore the regenerative capacity” of these follicles, which entails the recovery of capillary growth. 78 participants. Preliminary results published by the company They belong to phase 2a of clinical trials of the compound. It is a randomized and controlled study in which 78 participants, men and women with androgenic alopecia have taken part. The participants were divided between the experimental group and control group or placebo: the participants of the experimental group applied the compound in their scalp for four weeks; while the control group received a placebo. After four weeks of application, a 12 weeks were monitored to check the effects on the participants. Results. The results now presented do not correspond to those obtained after the essay but to their eighth week (after four weeks of treatment and four subsequent monitoring). The responsible team observed that among men with more advanced baldness, 31% Of these they showed a 20% increase in capillary density. They stood out for this reason the speed of the response to treatment, at least in principle faster than that observed in contemporary treatments. A crucial difference. However, the key to this treatment was in its effect on inactive follicles. The experiment showed regenerative potential both in the areas of weak growth and in the areas where the hair was no longer growing. The treatments we have in the present are useful when reinforcing growth in weakened but active follicles, not those that have already fallen in a state of latency. “These early clinical results reinforce the potential of our approach to go beyond the slowdown of the hair loss process and directly attack the hair follicle tegeneration,” pointed in a press release Christina Weng, medical director of Pelage Pharmaceuticals. A long way to go. The results are preliminary and correspond to a study conducted in a limited sample, so we will have to wait for the company to give new data on the drug evaluation process. According to the laboratorythe last stage of this process, phase 3 of clinical trials, could begin in 2026. The support of a giant. The origin of the project is in the work carried out in the last decade by researchers at the University of California Los Angeles and other institutions. According to the company, the development achieved the support of investors led by Google Ventures. In Xataka | The hair industry in Türkiye has a new enemy: a protein that protects us from baldness Image | Donald Teel

We have been talking about the ‘Miracle Inditex’ for years to explain its growth. That phenomenon is coming to an end

Inditex has just confirmed what many feared: it is no longer the unstoppable growth machine we knew and faces a more mature stage, without the double digit that until very recently was the custom. Why is it important. The first quarter marks a turning point in the history of the Galician giant. Sales grow just 1.5% compared to 7.1% of the previous year, and the benefit stagnates at 0.8%. They are figures of any European textile company, not the empire that used to other numbers. In figures. The numbers are devastating: 8,274 million in sales … … When analysts expected 8,380 million. Is The weakest growth since 2018excluding pandemia. The stock market does not forgive: the shares collapse more than 4% and touch the 46 euros in intradic minimums. The context. Three factors explain this unexpected normalization. The strong euro devours international sales with an impact of 3% that the company did not know how to foresee. Torrential rains in Spain (15% of global sales) have stopped spring clothes purchases. Operating costs grow above income for the first time in years. Between the lines. The data of the balance They show something more worrying: Inditex is losing efficiency. Stocks rise 6.3% when the company is proud to maintain Stocks minima. The net financial position falls by 7.3%. They are symptoms of a company that can no longer control all variables as well as before. Now it remains to see if it is something temporary or goes further. Yes, but. The second quarter offers a respite: sales are growing 6% between May and June. Even so, it is half of the 12% registered a year ago in the same period. The improvement exists, but it is still that of a normal company, not that of a phenomenon as it was so far. The latest. The Jose Arnau exitvice president and right hand of Amancio Ortega for 24 years, symbolizes the end of an era. Your substitute, Roberto Cibeirainherits a prosperous but mortal company. The transformation is complete: Inditex has gone from being a business unicorn to a solid, but predictable multinational. The miracle is over and gives way to the era of maturity. Outstanding image | Inditex In Xataka | Amancio Ortega: the billionaire who lives as one more neighbor (except for private jets and superyates)

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