They have found a bacteria capable of increasing your risk

We often think of the health of our mouth as something completely isolated that has no more significance than the odious cavities that we get. forced to go to the dentist or the bad breath. However, science has been warning for years that the mouth is the gateway to much more complex systems, such as the possibility that a bacteria from our gums travel to the breast tissue and may accelerate tumor growth. An unwanted traveler. The protagonist of this new discovery is the bacteria Fusobacterium nucleatum, an old acquaintance of dentists. We are talking about an opportunistic bacteria that thrives in dental plaque and is one of the main culprits of periodontitis, which is undoubtedly one of the most recognized gum diseases. What the team led by Dipalo Sharma has recently demonstrated is that this bacteria does not stay still on the gumsbut it has the ability to travel through the body to the breast tissue or even also is already linked to colon cancer. Its effect. The study In this case, he used mice to simulate two different scenarios in order to see how this very common bacteria behaved. The first of them was to inject the bacteria into the breasts of healthy mice, where precancerous inflammatory lesions began to be seen. In the case of injecting into existing tumors is where the alarms go off, since in these mice the presence of the bacteria tripled the size of the cancer and caused lung metastases in 100% of the cases observed. How he does it. It’s the million-dollar question: how does a bacteria from the mouth know that it has to go to the chest and how does it manage to do so much damage? Science has found an explanation at a molecular level that begins with inflammation of the gums in periodontal disease, since this causes the bacteria to enter the bloodstream. Once in the stream, the bacteria begins to travel and takes advantage of a very specific protein, called Fap2, which acts like a key that searches for a specific lock: a sugar called Gal-GalNAc, which turns out to be very abundant on the surface of breast cancer cells. Creating a shield. Once the bacteria adheres to the tissue thanks to this specificity, it begins to colonize, but it also has the ability to suppress the cells in charge of our defense. And specifically those that defend us from cancer cells that bypass the body’s checkpoints. Furthermore, it induces direct DNA damage and preferentially colonizes cells that have mutations in the BRCA1 gene, exacerbating the risk in genetically predisposed people. Dental hygiene. The result of this research leads us to a very clear question: does not brushing your teeth cause cancer? Logically not. In the field of health, causality is not as simple as ‘do this and that happens’, but rather it works as an accumulation of risks that increase the chances of generating a problem such as cancer. A risk factor. In this case, science suggests that having periodontitis, due to poor hygiene sustained over time, is associated with an increase of around 22% in the risk of suffering from breast cancer. And it is not the first time that dental disease is a risk factor of this type. A well documented case is in the relationship between deep dental caries and bacterial endocarditisan infection of the inner lining of the heart. That is why the recommendation here is always to maintain good oral hygiene and always treat cavities as soon as possible when they appear. Images | Caroline L.M. In Xataka | AI is no longer a promise in breast cancer: the largest clinical trial confirms that it detects more and reduces the burden on the radiologist

Colon cancers are increasing alarmingly among young people. We have a suspect: sedentary lifestyle

colon cancer It is one of the tumors that has increased its incidence the most in young adults over the last few decades, a trend that is very worrying because has made science need to answer why. One of the most important points are the factors that are influencing more and more young people to begin to have tumors in their digestive system. A big problem. Colon cancer is undoubtedly one of the most aggressive diseases that we endure, and also really frequent among the population, with a really aggressive treatment with surgeries that can mean the removal of part of the colonbut also with a high mortality behind them. Its early diagnosis is so relevant that in Spain there are many autonomous communities that have screening programs either screening (although sometimes they fail like in Andalusia) to begin treatment in the case of positive cases, as soon as possible to increase their chances of survival. The problem is that this horrible disease is becoming increasingly prevalent, and science is seeing many factors that are important to take into account to try to reduce the chances of suffering from it. Quantified. This trend has been reflected in a published study in Annals of Internal Medicine which has detected that in many countries the number of cases among those under fifty years of age has grown up to four times faster than in older people. In the end, it is a phenomenon that has revived the debate about the causes and future strategies that must be taken in prevention and early detection. This is extremely important, since a timely diagnosis can mean a big difference in life expectancy who has a patient. The reasons. As stated in the Institute for Cancer Research, London After studying forty-two different countries, two main explanations have been identified. The first is the screening that is done among adults. Although it is very positive to do screening among the population for this disease, the reality is that there is an age limit from which these tests are carried out. This does not occur among the younger population who do not receive this type of screening tests on a regular basis, which may explain the accelerated growth in this group, since cancers are not diagnosed in the early stages. The second reason given is obesity. In this case It is considered a very important risk factor which drives the increased probability of suffering from colon cancer in young people and adults of all ages. Although it remains to be seen if there is an increase in its relationship with the younger population. Environmental factors. In addition to these two causes, the research led by the CNIO Digital Genomics Group in Spain provides new evidence about why this may occur. In his published study In Nature, the influence of the intestinal microbiota, particularly certain strains of E.coli intestinal, producers of the toxin colibactin. As we already sawthis can cause great genetic damage to colon cells that can accelerate tumor development. But other factors associated with the patients’ lifestyle are also being considered. In this case, the increase in type 2 diabetesespecially when there is a sedentary habit and unhealthy diets that seem to increase the risk of having this type of cancer. A Swedish study with a national cohort showed that people with diabetes reach an equivalent risk of colorectal cancer at younger ages than those who do not suffer from it, requiring prevention and monitoring before the standard screening age in the general population. But ultra-processed diets also come in here, excessive consumption of alcohol or even sugary drinkswhich can be an important risk factor. Prevention. Experts agree that there is no single and definitive cause, but rather a combination of genetic, biological, environmental and social factors. While research continues, it is proposed to implement comprehensive prevention policies that adapt to these realities. To do this, they aim to apply personalized screening that includes risk factors such as obesity, diabetes or family history. But we must also focus on research into how our microbiota can have an important implication in this. This forces us to have to take great care of what we eat and maintain adequate intestinal health. But the most relevant thing is to adapt the recommendations for starting screening for high-risk groups, such as young people who have diabetes or a family history so that they begin surveillance at age 40. Images | Ramon Inciarte Julia Koblitz In Xataka | Until now, different types of cancer required different types of treatment. A new vaccine wants to change that

The chaos of streaming is causing a phenomenon that we thought was in recession: downloads are increasing

The market fragmentationhe price increase of subscriptions and a user experience increasingly less friendly are the main factors pointing to an uptick in unauthorized downloads. Since Netflix began raising rates and banning shared accounts, customers have raised the threat of a return to downloading. Now, for the first time in years, the numbers seem to back them up. Temporary drop. The emergence of services streaming like Netflix devoured unauthorized downloads. With the promise of a wide and accessible catalog for a fixed rate, the platforms significantly reduced the consumption of movies and series outside of conventional channels. However, the utopia of that completely legal market subject to companies has faded. Recent reports show an uptick in access to this type of content, reversing the trend of the previous decade. The data. According to the Observatory of Piracy and Consumer Habits of Digital Content of 2024, digital piracy in Spain increased by 9% last year, reaching a record figure of 42,782 million euros in value of content defrauded through 7,330 million illegal accesses. In addition, the study indicates that for the first time access to platforms has been recorded through apps, social networks and decoders, growing the aggregate figure even more (an additional 14% compared to the previous year).​ Because? As we pointed out, this rebound is due to a series of circumstances that have changed the outlook for the streaming: Streaming is no longer convenient. Although perhaps the main reason for the public’s disenchantment with the streaming is that the supply is increasingly dispersed– To access all relevant content, the user must subscribe to multiple services. The exclusivity strategy that studios use to attract and retain subscribers has broken that ideal convenience of accessing content legally thanks to the streaming. To watch a series with multiple seasons, the user may need to subscribe to different platforms or wait months for the service to change. This dynamic clashes head-on with the immediacy that consumers expect from digital content. All of this is made worse by the licensing war: each studio wants its own titles on its platform exclusively, and leads to the need to subscribe to very specific platforms to access such popular franchises as Marvel, Star Wars or Stranger Things, for example. Technically poorer service. In addition to price and fragmentation, the service offered by some platforms has also worsened, further eroding user loyalty. Many services They have reduced the bitrate in their transmissions to save costs, leading to worse image quality. This loss of quality is often a trigger for users to search for an illegal version that offers a better viewing experience, which makes no theoretical sense: an unauthorized copy of a film often looks and sounds much better than the one available online. streaming. lUnauthorized downloads have evolved. But in addition, traditional downloads by torrent consumption on websites is now added streaming built outside of unofficial platforms, unauthorized IPTV services and the distribution of content through social networks like Telegram and WhatsApp. 96% of movie and series consumption in 2023 was done through streaming Unauthorized: you no longer have to download anything, which reduces the risks. It is a very tempting panorama. Gabe already said it. Specifically in 2011, Gabe Newell said that “Piracy is not a price problem, it is a service problem“. Faced with a legal market that is expensive, fragmented and inconvenient, users see unauthorized downloads as a kind of alternative “service” that offers all the content with better quality and for free. It can be said that it is a problem that the industry itself has partly created. In Xataka | Spaniards “torrenteros” around the world: when you go to live in Germany and discover that you can’t download anything

an increasing problem for the wine industry

In early February, The Civil Guard dismantled An international network dedicated to illegal wine from La Rioja. That is, a network dedicated to falsifying wine bottles and selling them in Vietnam and China. The funny thing is that they have operated for years and only the alarm has jumped because a Spanish tourist saw a suspicious bottle in a gourmet store in Vietnam and bought it to bring it to the country and analyze it. A problem that does not stop growing. For years, illicit trade and fraud in the wine sector and spirits keep growing. In 2023, Spanish customs and police authorities seized Almost 15 million liters of illegal drinks. Globally, although there are those who estimate that up to fifth of the wine that is sold could be false, more conservative estimates They say that annual losses in drinks of this type amount to 1,300 million euros. Of course, it is something that worries (and much) the most important wineries who see not only how they lose income, but how the low quality of falsifications affects their brand image. In fact, there are lawsuits specialized in intellectual property that They offer service to the wineries throughout Europe to monitor the market (ON and Offline) and detect this type of falsification. What exactly is that is falsified? To start the same wine. There is Fine fakes that combine lower quality wines To try to pass them through higher bottles, but normally it is about replacing. But there is much beyond the “dilution” and “replacement of ingredients”, there is a lot explained in the Spanish A few years ago Fabián Torres, Director of Business Development of SICPA Spain. Complex. Be that as it may, counterfeiters play with one thing: the world of tastings is a complicated world. Although it seems that it is true that There are supercatters capable of overcoming the most difficult teststhe truth is that for most human beings there are no major differences between wines. Not enough, at least, to detect a falsification achieved. And this has more crumb than it seems. Because many people have begun to ask that why pay a disproportionate amount of money for a flavor profile that, in short, can be achieved “falsified” at a much lower price. The best example is the case of Rudy Kurniawan, perhaps the most famous counterfeit in recent years. After leaving prison in 2021 he has set up a business in which FALSIFY VINES ‘ON DEMAND’. In your case, organize tastings to buy exclusive broths with your own falsifications. Normally, they win their wines. Of “falsified wine” to “duplicate wine”. It is a phenomenon very similar to the calls’duplicated perfumes‘(legal fragrances designed to smell like other design perfumes): we have seen it in supermarkets with Cheap versions of the most popular wines of the moment, like Verdejo frizzante. However, The potential of this type of products It is much greater. After all, we live in a world in which LOS DUPLAS WITHOUT ALCOHOL No They stop growing. We have gone from an industry in which the flavor was inseparable to the historical manufacturing process to a flavor profiles laboratory. And, in Spain, one of the world’s world leaders, this revolution will make the foundations vibrate of the industry. Image | Kelsey Knight | Klara Kulikova In Xataka | If the question is what is the future of wine, more and more Bordeaux wineries are clear: the without alcohol

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