We have been heating water to make coffee for a century. It wasn’t necessary: ​​just ultrasounds

For many people, making coffee is practically as important a ritual as drinking it. Because by the way: anyone can make coffee, but not everyone does it well. Following scrupulously the Specialty Coffee Association recipe, To make the canonical espresso you need 7 to 9 grams of coffee and force the passage of water at 90.5 – 96.1ºC at 9 – 10 atmospheres of pressure. The coffee grind should be such that the extraction time is 20 to 30 seconds. That’s what any barista or super-automatic machine should aspire to. Next to nothing. Although the coffee maker is not on the list of appliances that increase the electricity bill at home the most, on an industrial scale things change: this process of bringing the water to those temperature and pressure conditions represents a significant energy cost. So an Australian research team has found another way to do it without the need for heat: ultrasound. The invention. To make coffee with ultrasound and without heat, the first thing you need is a filter holder tuned in an ultrasonic reactor where high-frequency sound waves induce acoustic cavitation. It sounds backwards, but in practice the ultrasonic coffee maker that the University of New South Wales has patented looks like a normal coffee maker with a small accessory. Let’s go back to the acoustic cavitation. Roughly speaking, the waves create thousands of tiny bubbles within the water that, when collapsing with the ground coffee, act as if they were a hammer: they break the surface of the heat and release what is inside, that is, flavors, oils, aromas and caffeine. The result is an espresso with a concentration equivalent to conventional espresso in less than three minutes. Why is it important. Because you can make coffee consuming much less: for the same amount of drink, this ultrasonic system consumes only 24.3% of the energy required by a conventional espresso machine. On a domestic scale the savings are small, but for a factory that 75% saving is significant. And it has another win-win for the industry: the coffee obtained comes out cold and concentrated, so there is no need to wait for it to cool (or chill it), it is ready to be mixed directly with milk or water in a factory, which saves time, energy and money. Context. Although it sounds exotic, ultrasounds are not new in the food industry. Without going any further, They have been used for decades for the processing of juices, oils or dairy products. In fact, its application to coffee is not new either: at least two manufacturers have brought similar infusion devices to the marketbut they didn’t go that far: the UNSW project goes one step further. Thus, it is the first that has achieved an espresso (not a diluted cold brew, your previous job) that passes for a conventional espresso in a sensory tasting with 100 participants. In detail. The study analyzed the influence of variables such as grind size, extraction ratio and duration of ultrasonic treatment. And he came to the conclusions that a finer grind managed to extract the flavor more efficiently and an infusion time of between 2.5 and 3 minutes gave the best results. For sensory tasting, the team conducted random blind tests with four beverages: traditional espresso, ultrasonic espresso, traditional filter coffee, and ultrasonic filter coffee. In the case of espresso, those who participated were unable to clearly distinguish which had been prepared traditionally and which had been prepared ultrasonically as there were no significant differences in aroma, flavor, bitterness or overall rating. Curiously, for filter coffee the ultrasonic version was preferred. Yes, but. The first limitation of this peculiar way of making coffee is time: compared to less than half a minute, with ultrasound the process lasts up to three minutes. A time that can be interesting (due to energy savings) on an industrial scale, but not for hospitality and homes. On the other hand, and although it comes out with flying colors in the blind tastings, they have not analyzed the presence of healthy compounds in coffee, such as polyphenols or antioxidants, nor their proportion. Drinking coffee is a pleasure that also has health benefits. Finally, the ultrasonic coffee maker is currently a prototype: the enormous leap from the laboratory to the industrial scale remains to be made. In Xataka | Coffee doesn’t just wake you up: science now suggests that it also improves your mood (even decaffeinated) In Xataka | Drinking coffee is not harmful, but for science there is a very clear limit that should not be exceeded

30% of depressions do not respond to pills or psychotherapy. A psychiatrist’s idea: treat them with ultrasounds

Depression is a truly complex disorder, which in 30% of cases do not respond to treatment conventional. Neither pharmacotherapy nor psychotherapynor the transcranial magnetic stimulation (used to treat OCD) appear to offer lasting relief to those who become trapped in the more resistant states of the disease. And although at first they can be ‘given up as lost’, the Argentine psychiatrist Salvador Guinjoan He is already working on another avenue of treatment. The idea. The psychiatrist, researcher Laureate Institute for Brain Research from Oklahoma, is working on an alternative that uses more physics than psychiatry for these patients who a priori had no other type of solution. This is based on the low intensity focused ultrasound, what is known as LIFU (Low-Intensity Focused Ultrasound). During the recent Conference on Updates on Neuromodulation held in Seville by the Spanish Society of Clinical Psychiatry, Guinjoan explained that the objective is quite ambitious: to modify the electrical activity of the brain circuits involved in psychiatric symptoms without the need to open the skull or implant an electrode as he explained. in an interview to El País. What is LIFU. This technology uses mechanical energy instead of electrical or chemical energy. Its transducer generates ultrasonic waves that are capable of passing through the skull and concentrating the energy at a very specific point in the brain, subtly modulating the mechanosensitive ion channels of the neurons. In practice, this alters neural communication in regions that are involved in emotion, motivation, or decision-making. But the important thing in this case is that unlike traditional deep stimulation (DBS), which requires surgery and permanent implants, LIFU allows completely reversible interventions with high anatomical precision. According to Guinjoan, the method opens the possibility of observing, for the first time, causal relationships between a specific brain circuit and a clinical symptom: “If modifying a circuit changes the symptom, we can begin to understand the cause,” he points out. The bibliography supports it in these cases, since previous research, such as those carried out in the Massachusetts General Hospital and published in Nature Neuroscience (2024), had already shown how LIFU can influence deep regions such as the amygdala or thalamus without visible tissue damage. Now, the challenge is to transfer that precision to the psychiatric field. Key points. Guinjoan and his team focus their trials on two key markers of resistant depression: anhedonia (inability to experience pleasure) and the persistence of negative thoughts. Both phenomena seem to be related to connection circuits between the prefrontal cortex and the basal ganglia. And it is precisely in this circuit where the psychiatrist wants to intervene with LIFU. The researcher suggests that modulating the subcircuits that connect the prefrontal cortex and the basal ganglia with ultrasound can alleviate these characteristic symptoms without resorting to surgical interventions and perhaps without more medication in the future. And although at the moment there is still a long way to go, pilot studies in the United States point to sustained symptomatic improvements after several sessions, with mild side effects such as temporary headaches. The ethics. The ability to literally reprogram the brain without invading it opens up questions that go beyond medicine. Guinjoan agrees with neuroscientist Rafael Yuste, promoter of the neurorightsin which it is urgent to regulate the non-therapeutic use of these technologies. Although the border between treating a disease and enhancing mental performance is increasingly blurred. Unlike other home neuromodulation tools, such as transcranial electrical stimulation (tDCS) devices that They are already sold for personal useLIFU requires high-precision neuronavigators and a specialized clinical environment. Guinjoan does not believe that it will become a domestic technology, but he does imagine a future where each patient receives a personalized neuromodulation treatment, adjusted to their specific neural map. The future. If ongoing trials confirm efficacy, focused ultrasound could be incorporated in the next decade into the arsenal we have in the treatment of resistant depression, anxiety or even schizophrenia. All this without having to enter an operating room. Something that could also represent a new leap in psychiatry as we know it and a paradigm shift in the therapeutic approach to this type of pathology. Images | Fernando @cferdophotography Robina Weermeijer In Xataka | There are people eating carrots like rabbits because they think it will make them tan. There’s just one little problem

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