Science explains why the cure can be worse than the disease

At the time of want to lose a few kilos The truth is that many different strategies emerge, such as eliminate sweetsstart exercising more or eat much more protein. But, on the other hand, there are strategies that are really extravagant and that are spread by influencers of our society that do not have any solid foundation. The last one arrives from actor Matt Damon who claims to have lost a few kilos thanks to leaving gluten out of his diet. A discrepancy. And the reality is that science has a lot to say about this decision. Since the ‘gluten-free’ foods that now flood supermarkets were born as a medical necessity for 1% of the population. But now it has become a holy grail of weight loss following the following logic: ‘if I cut out bread and pasta, I lose weight. Ergo, gluten makes you fat.’ There is no evidence. Nutritional science has bad news for these peopleincluding the actor, since eliminating gluten does not have a specific slimming effect. In fact, if you do not have celiac disease or gluten sensitivity diagnosed, eliminating it can even be counterproductive for cardiovascular and metabolic health. It’s a calorie deficit. The first myth to debunk is that gluten, per sebe a metabolic villain that makes us accumulate fat. According to a systematic review published in International Journal of Cardiovascular Sciencesgluten-free diets are not associated with greater weight loss compared to normal gluten-containing diets in healthy adults. So… why do some people swear they lost weight by giving up gluten? The answer lies in the changes that accompany this diet, but not in gluten. And when you give up gluten, you automatically stop eating calorie-dense ultra-processed foods such as industrial pastries, cookies, refined pasta… In this way, you eat fewer total calories and this is what causes you to lose weight and not the absence of gluten. The effect of water. In addition to this caloric deficit, a pilot study in athletes noted that the rapid weight loss after six weeks without gluten was primarily due to loss of fluid and glycogen stores, not an actual metabolic advantage. Fewer refined carbohydrates mean less water retention. But if there was any doubt, another clinical trial in patients with a metabolic problem in their history detected reductions in waist circumference and triglyceridesbut without changes in weight. In this way, the researchers suggest that this is due more to better food selection and glycemic control than to a “fat-removing effect” of gluten. A flat stomach. Another of the great thoughts that can be heard in this sense is that people who do not eat wheat feel much less bloated. And this is real, but the culprit is not gluten, but from the fructans of wheatwhich is basically a type of fermentable carbohydrate that produces a lot of gas and bloating. In this way, the abdomen looks much flatter, but not because of a loss of fat. The cardiovascular paradox. But although gluten is seen as a demon, the reality is that it has several intrinsically good things. For example, gluten is often accompanied by whole grains, and whole grains are cardioprotective. This is evidenced in a study published in the BMJ with more than 100,000 participants who were followed for 26 years. This concludes that gluten consumption does not increase the risk of coronary heart disease. What’s more, when the data was adjusted, a higher gluten intake was associated with a lower risk of coronary heart disease. That is why the authors warned: promoting gluten-free diets in healthy people can reduce the consumption of whole grains and, therefore, negatively affect cardiovascular health. And in diabetes. In this case they were three large studies that showed an inverse relationship: Those who ate the most gluten had a 13% lower risk of developing type 2 diabetes compared to those who ate the least. The why? Again, the fiber and micronutrients associated with the cereal that contains gluten. The problem of the accused. When we see that something is ‘gluten free’ we may think that we are looking at something much healthier. But the reality is that sometimes, to compensate for the lack of elasticity and texture that gluten provides, The food industry often reformulates products by adding more saturated fat, more sugar and reducing the protein it contains. Furthermore, gluten-free diets in non-celiac people have also been associated with a lower intake of fiber, B vitamins and a worse long-term cardiometabolic profile. Who should give up gluten? Science is quite clear in this case: who needs it, that is, the 1% of the population with celiac disease. And logically also people with non-celiac gluten sensitivity who may have major digestive problems. For the rest of the population, eliminating gluten offers no clear nutritional benefits. On the contrary: there is a risk of spending more money on products with a worse nutritional profile, reducing the consumption of cardioprotective fiber and attributing to gluten a success that, in reality, simply belongs to eating less ultra-processed foods. Images | Wesual Click Towfiqu barbhuiya In Xataka | Food has been filled with contradictory messages: a sports nutritionist helps us understand what’s behind it

Working in a nuclear power plant is not the best way to avoid cancer. Now it turns out that its waste also serves to cure it

If there is a terrifying and mainstream disease, it is cancer: after all, according to the WHOone in five people will develop it at some point in their life. Although in some cases the risk factors vary depending on the type of cancer, working in a nuclear power plant poses some riskas long as there is greater exposure to ionizing radiation, even if there are no accidents or more intense exposure through maintenance work. Paradoxically, the activity of nuclear power plants, which can cause cancer, also serves to generate the basis of the medicine to cure it. And we are not talking about a potentially distant study, but rather something that can already be materialized. In fact, the United Kingdom has already taken a step forward to transform some of its radioactive waste into anti-cancer medication. The world’s first lead-212 radiopharmaceutical ecosystem. Because in the UK they have closed an agreement between the public body Nuclear Decommissioning Authority and the biotechnology company Bicycle Therapeutics for which the latter will have 400 tons of reprocessed uranium to extract the valuable (for the medical industry) lead – 212 for 15 years. Behind Bicycle is Sir Greg Winter, co-founder of the company and winner of the Nobel Prize in Chemistry in 2018. This will provide them with the infrastructure to create the world’s first end-to-end lead-212 radiopharmaceutical ecosystem, from discovery to commercial supply. So explains it Mike Hannay, Chief Product and Supply Chain Officer at Bicycle Therapeutics. The benefits of lead – 212. Lead – 212 is an isotope used in therapeutic contexts thanks to its particular decay properties, so that it emits both alpha and beta particles. While the former provide high-energy, short-range cytotoxicity, the latter have a more extended range, targeting micro-metastasis. In a simplified way, this medically applicable isotope is essential for precision treatments against tumors resistant to other therapies. Thus, it carries radiation and acts directly on cancer cells to destroy tumors, minimizing the damage to the surrounding healthy tissue. This type of technique offers promising results in prostate cancers and neuroendocrine tumors of organs such as the intestine or pancreas. Extracting lead-212 is an arduous task. Converting the waste from nuclear power plants into cancer treatments seems like a fantastic idea for two reasons: because of the cure for cancer itself and the problem of dealing with radioactive waste, one of the great challenges faced by these energy industries, which have also explored other avenues such as take advantage of the remaining energy. But getting here has not been easy: the extraction process of this isotope has been carried out by the United Kingdom National Nuclear Laboratory (UKNNL) with a complex chemical process that requires the isolation of scandalously small quantities of the precursor material from the used nuclear fuel. Thus, first the Thorium-228 is extracted from the reprocessed uranium to later process it into Radium-224. It is then loaded into a lead-212 generator that has been custom-made for Bicycle Therapeutics’ needs by US company SpectronRx. This is a continuous regeneration, producing enough lead-212 to deliver tens of thousands of doses of precision therapy per year. The laboratory explains that the critical part is in the beginning: “The initial precursor material extracted is comparable to finding a single drop of water in an Olympic swimming pool.” From that minute amount, an even smaller fraction of lead-212 is separated. First discover the universe, then cure cancer. In addition to this unexpected use of nuclear power plant waste, in recent weeks a group of researchers from the University of York have evidenced in a study that the intense radiation captured in the beam absorbers of particle accelerators could be reused to produce materials used in cancer therapies. Those particle accelerators They are used, among other things, in experiments to discover the matter of which the universe is composed. In Xataka | The rarest element on Earth aims to cure cancer. And Europe is already accelerating its production In Xataka | We have been believing that bacteria are a weapon against tumors for 150 years. And finally we have discovered how Cover | Jakub Zerdzicki and Ivan S

In 1962, a remote village in Tanzania suffered an epidemic of laughter. To this day we still have not been able to cure it.

If you are one of those who are easily infected by other people’s laughter, you probably would not have survived what happened to a town of Tanganyika on January 30, 1962. This is what two doctors say who compiled the facts: at a girls’ missionary school in the town of Kashasha, on the coast of what we currently know as Lake Victoria (Tanzania), three students began to joke. His laugh mutated from normal to nervous, ceasing to be both a manifestation of humor and something more disturbing. The girls couldn’t stop laughing hysterically. Laughter, that traditional escape valve, was now a terrifying reaction. Without knowing very well how, the rest of the school began to be infected with this effect, and within a few hours 95 of the 159 attendees at school were also laughing for hours, 16 hours in a row in the most serious cases. These were the facts that caught the attention of the doctors: on the one hand, the Kashasha school also operated as a residence. The girls slept in communal rooms, dividing themselves into rooms with girls of various ages. Those affected were not located in specific points of the residence, there were no rooms where everyone suffered from hysteria at the same time, but instead They were distributed throughout the center. None of the two Europeans and three Africans who worked as teachers suffered any uncontrollable panic attacks. Trying to put a stop to the phenomenon, the residence and school were closed for a month. The girls went home, but instead of stopping it, they extended it much further: after ten days, cases of uncontrollable laughter were observed 80 kilometers from the school. Five months later the final count in this area of ​​10,000 people was 217 people treated and around 1,000 affected. Boys and girls suffered from it indiscriminately, children but also some young people, and mostly illiterate kids with modest finances. Each patient’s attacks lasted an average of four to eight hours, with a known case of 16 consecutive daysand after the attack subsided they usually suffered one or two more. No one had more than four attacks. Although we imagine these abductions as something comical, comedy was the last of the predominant feelings during those episodes: to the laughter was added crying, respiratory problems, a general restlessness of the subject, manifestation of violence towards others and, in some specific cases, paranoia, with girls commenting that there were demonic subjects chasing them. Would the corn flour have been contaminated? Maybe a new virus? Maybe a supernatural curse? The blood samples that were sent to the laboratories came back with a NAD, “Nothing Abnormal Detected”. There are even those who suspected that everything could have been distorted or invented. This hypothesis lost strength over the years. For a very simple reason: because other outbreaks of sudden, very strange social epidemics were observed. The dance, the fainting, the dream In 1983in the area of ​​the West Bank occupied by the Israeli army, it was seen that at least 400 Arab girls and a teacher had spontaneously suffered nausea, nervousness and dizziness, ending in fainting and loss of consciousness. Over time, some Israeli female soldiers would also disappear. In Virginia, United States, some high school students suffered a mass hysteria of laughter equal to that of Tanganyika in the 60s. Any new drugs? Anyone put laughing gas through the vents? “The school is still safe”said the authorities, who at the end of the cycle attributed the circumstance to a “unusual stress” that students might be suffering. In 2017 a strange local Swedish phenomenon was published in the press for the first time that has been going on for decades. There have not been many cases between the 90s and 2010, but only between 2015 and 2016 there were almost 200 cases at once. Only the children of refugees who have requested asylum suffer from it. As soon as the parents know that permission has been denied, some of these children enter a kind of coma: they remain completely passive, do not speak, eat or drink, lose control of their sphincters and do not know how to react to pain. Swedish doctors say they do not know what to do, since the investigation of the event causes the epidemic to spread with new cases. They do not doubt the veracity of the phenomenon: although attempts at fraud have been discovered, with parents simulating the effect on their children to stay longer in the host country, most cases have been authenticated. Psychologists have named the ailment as Resignation Syndromealthough the hypothesis of studying it as another case of “epidemic hysteria” was considered. The academic term for epidemic hysteria is “mass psychogenic illness”or MPI, as it appears abbreviated in psychiatry manuals. To say that there are few certainties is to exceed the medical achievements achieved to determine what these attacks consist of. They are episodes so specific and so little controllable that, as they come, they go. Among the common aspects that have been seen are: a) that there is no plausible organic basis; b) that there is previously excessive anxiety in the affected group; and c) that spreads through sight, sound or oral communication. Although the effects are physical, it seems that it is a disease closely linked to the psychological. Although it has not been possible to study it correctly due to its lack of data, some historical cases of hysteria have subsequently been read as examples of the MPI. There they were dance epidemics in medieval Europein which the local population danced or held obscene orgies for hours or days, leading some to death. In search of answers The priests who were going to exorcise the novices of the cloistered convents Sometimes they noted that several of these newcomers suffered from it at the same time. Perhaps in response to the excessive discipline and poverty of the lives that awaited them, many of them began to meow, insult and seduce their companions. Although it … Read more

The rarest element on Earth aims to cure cancer. And Europe is already accelerating its production

In the fight against cancer there are many ‘weapons’ that we have at our disposalsuch as chemotherapy or radiotherapy. The problem is that these are assimilated like bombing a city to destroy a single house: it is achieved, but with a lot of collateral damage. But this can be solved if We attack only what interests usin this case a tumor cell, and science points to one of the rarest elements on the planet as a candidate to achieve this. Where are we now. The goal of science is to find the most specific therapies possible so that they attack a tumor cell and not a healthy cell with the aim of reducing the adverse effects of the treatment and also being more effective. For this there are different options such as immunotherapy or the use of very specific antibodies, but there is still a long way to go. A particle. He astatinewhose name comes from the Greek astats (“unstable”), lives up to its name. It is the rarest natural element on Earth and disappears almost as soon as it is formed and that is very interesting to us. Especially a ‘version’ of this element which is At-211 which has a half-life of only 7.2 hours. But this instability is part of its magic. At-211 is what Texas A&M scientists call a “Goldilocks” isotope: perfect for the job. Its advantages. Currently, heto traditional radiation used in cancer treatments have a great impact on the body when traveling over long distances. But At-211 emits alpha particles, which is a heavy, slow-moving helium nucleus, which when emitted releases an enormous amount of energy, but can only travel a tiny distance, just the thickness of a few cells. This is crucial. Targeted Alpha Therapy involves “gluing” an atom of At-211 to a molecule (such as an antibody) designed to specifically seek out and bind to cancer cells. At-211 travels through the body, ignoring healthy cells, and when it finds its target, it anchors to the tumor and releases its alpha particle. The result is a localized and devastating explosion of energy, which irreversibly destroys the DNA of the cancer cell. But since the particle cannot travel any further, the healthy cell next to it will not be affected, making this an almost perfect killer. Your problem. At first glance everything seems great, but… Why don’t we use it? The answer lies in its availability, since it is impossible to mine astatine, since with a life of 7.2 hours the clock is running against it. The only way to obtain it is to create it artificially in a cyclotron, a particle accelerator. The process basically involves firing a beam of alpha particles at a Bismuth-209 target. Now the advance that has been achieved is to create a fully automated system to produce and ship the AT-211 as quickly as possible so that it can be used. In Europe. With this advance, which has been made in Texas, processing time is reduced and the safety of technicians who do not have to handle this substance increases. And while Texas A&M resolves supply in the US, Europe is making a move. The project Accelerate.EUfunded by the European Union, was launched at the end of 2024 with a clear objective: to create a robust and sustainable manufacturing and treatment infrastructure for At-211 throughout Europe. The project focuses on especially difficult-to-treat cancers, such as pancreas, breast and brain tumors (glioblastomas), demonstrating that this therapy is a global strategic priority. The future therefore lies in the possibility of using one isotope to illuminate the tumor and then using another to kill it, inaugurating authentic personalized nuclear medicine. Images | freepik In Xataka | The most unexpected treatment against cancer is LED light, and it is giving good results

We have been looking for the definitive cure of allergies for years and we have not yet solved the big problem: understand them

The end of the rains and the arrival of good weather have, for many, a dark back: The allergies. Spring, and especially the months of May and June, brings us the pollen proliferationone of the most important allergens, the main cause of sneezing at this time of year. The most common way of treating this type of allergies is through antihistaminesdrugs aimed at blocking the effects of histaminea neurotransmitter that also plays an important role in immune system. Recall that allergies are nothing other than a reaction of our immune system to external substances that understands as dangerous and that are not really, allergens. Antihistamines are very useful when treating allergic symptoms. But one thing is that, and another thing is to definitively cure these disorders. Today we do not have A cure for allergiesbut at least there are some routes open to hope. So close we are to achieve it. Perhaps one of the first treatments that come to mind when talking about healing the allergy are vaccines. What we understand today as vaccines against allergy are immunotherapy -based injections, and its logic is not far from conventional vaccines: it is about administering a small amount of what causes us allergy capable of alerting the immune system without unleashing an allergic reaction. While they are a useful treatment in many cases, they do not finish solving the problem, so we will need periodic injections that will improve the response capacity of our immune system. What ways are there open? Almost ten years ago, We commented on some of the open research lines in the search for a cure for allergies. These ways included, for example, the “biological therapies.” These are therapies that focus on antibodiesthe proteins that our body produces when it detects substances that it understands as harmful. This type of treatments They are still One of our great hopes. An example of this is omalizumab, a drug in principle aimed at combating asthma and approved two decades ago in the United States. In recent years, science has been validating this therapeutua option. A recent example is in A study Posted in 2022 in the magazine Clinical and Translational Allergy. In this analysis, the team observed that the drug was effective when preventing spring allergic rhinitis. Understand the problem To understand how our knowledge has evolved in recent years, we must first understand why it is so difficult to find a definitive cure. The background problem is simple: We do not understand the allergies well enough to find a solution. We still do not understand why certain people suffer from a certain allergy while others suffer from another type of reaction, at the same time that others do not seem to have such problems. We don’t know either Why allergies are permanent despite the fact that the antibody that we generally associate with them does not usually remain in our body for long periods of time. Two studies Published last year in the magazine Translational Medicine Science They can help us understand this situation a little better, explaining at least this last point. The answer could be in an antibody that we usually do not associate with allergies, immunoglobulin G (IgG), and the cells that produce it. What the teams responsible for these studies discovered is that some cells responsible for producing IgG produce immunoglobulin E, which is associated with allergies, when they run into an allergen. The key to allergic “memory” could therefore be in these cells. Before going better, everything seems to indicate that the allergies problem will go worse. And is that every time More people suffer This type of disorders. There are several factors that could be, independently or together, behind rapid ascent in the number of allergic people in the world. One of these hypotheses is that of hygiene. Since our immune system is “trains” through exposure to external agents, the absence of these agents in early stages can imply that our system does not perceive them as normal and, exposed in later stages, ends up reacting disproportionately. s From the environmental point of view, we must also consider the presence of pollutants in the atmospherelike particular matter. These pollutants can also affect our airways, combining their effect with that of conventional allergens and aggravating the situation. In Xataka | The time of the year in Japan has arrived where everyone has a mask. The fault is World War II Image | Cottonbro Studio

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