the most disruptive technology for treating patients in the ICU turns out to be an MP3 file

When we think about the advances in hospitals to improve survival or recovery of patientswe can come to think of better respirators, monitors that offer thousands of data or new drugs that are almost miraculous. However, science has given us a blow of reality by demonstrating that accompanying families during hospital stays offers great results. This is something that has been seen directly in a hospital’s ICU itself, where patients are between life and death. That is why a study decided to use something as ‘low-tech’ as It is a voice recording of a family member to see the real impact it could have on his recovery. And the truth is that we have been underestimating the usefulness of this clinical tool. The problem. One of the big problems faced by patients entering the ICU is the ‘delirium’. A state of great confusion resulting from an acute failure of the nervous system that affects up to 80% of patients that have mechanical ventilation. And this is something terrible within these units. Not because it is annoying for the patient to be in a great state of confusion, but because it has been seen that mortality, hospital stay and all this increase. leads to higher costs for the healthcare system. Something that has been calculated and that points to an expense of between 6,000 and 20,000 million dollars annually. And the worst thing: current drugs (sedatives, antipsychotics) are often part of the problem or are not entirely effective in preventing it. The solution. Once we had the problem, Cindy Munro proposed a simple but powerful hypothesis to solve it: if the brain “disconnects” from reality due to isolation and sedation, can we use a familiar voice to bring it back? The test. In order to see if this was possible or not, a study was carried out that included 178 patients from two large hospitals in Florida and which had the collaboration of five large universities. The goal was clear: treat sound almost as if it were medicine. To do this, a protocol was created to play the audio so that it was not simply connecting the radio or mobile phone and allowing the patient to listen. The standard was to use common audio players, with two-minute clips recording the families and a playback that would be done twice a day: at 9 in the morning and at 4 in the afternoon. The time was not chosen at random, but was designed to ‘hack’ the circadian rhythm. Listening to familiar voices during the day helps the brain orient itself temporally, reinforcing the difference between day and night, something that is completely lost under the artificial lights of an ICU. The result. In addition to offering a positive result to the patients’ condition, it was also seen to have a dose-dependent effect like medications. That is, the more messages patients received, the greater the reduction in delirium in the ICU. Why this matters. Today the industry does not cease its attempts to search for complex molecules to protect the brain, regenerate cells and countless other techniques. But the reality is that the solution seems to lie in our evolutionary biology (or at least a little help): reacting to the voices of our ‘tribe’. Images | Stephen Andrews In Xataka | Science wants to put ‘microrobots’ into our bodies to medicate us. They have already given good results

We have been detecting a relationship between Herpes and Alzheimer’s years. Now we are discovering that treating one helps with the other

A few years ago the scientists detected A strange coincidencea relationship between herpes virus and a neurodegenerative and noncommissible disease: Alzheimer’s. What at the time seemed a spurious and casual relationship, it seems more and more proven and proven. Adding tests. Now a new study He has obtained evidence of this relationship. However, perhaps the most important fact that we can extract from the new analysis has to do with vaccines against infection. According to the study, antiviral treatments against herpes are related to a 17% lower risk of suffering from Alzheimer’s, suggesting that treatment against this virus can protect us against the appearance of this form of dementia. HSV-1. In study he linked again the infection by the Herpes simplex virus Type 1 (HSV-1) with the appearance of Alzheimer’s disease, a form of dementia that is characterized by accumulation in the brain of beta-amyloid plates. Today we do not have a clear idea of ​​how this relationship occurs “(Some) studies have indicated that inflammatory alterations in the brain caused by HSV infection are central to the development of (the disease),” Explain the team Resposable study. “It is pointed out that peptides (beta-amyloids (Aβ)) are deposited in response to HSV infection and protect host cells (…). Consistently, they threw antimicrobial properties against several pathogens, including HSV-1,” they detail. 344,628 matches. In his study, the team He turned to 344,628 participants with Alzheimer who were paired with two participants without diagnosis but with similar characteristics. They observed that among people with Alzheimer’s 0.44% had been previously diagnosed with HSV-1, while only 0.25% of the control group had the same previous diagnosis. The analysis indicates that, taking into account other relevant factors, the probability of finding a previous HSV-1 diagnosis was 80% higher among people with Alzheimer’s than in people without the disease. The details of the study were published In an article In the magazine BMJ Open. Not only HSV-1. The study focused on a variant of the herpes virus but also paid attention to other pathogens of the “family”, such as the HSV-2, Varicela Zoster, or Citomegalovirus. They found a relationship between two of them (HSV-2 and Vicela Zoster) and a greater risk of Alzheimer’s. Understanding the causes. New studies will still be necessary that Explain biochemical mechanisms that explain this type of relationship between infectious processes and noncommunicable diseases. Only in this way can we establish the underlying causal relationships and, hopefully, to find more effective treatments in the fight against disorders as serious as cancer and Alzheimer’s. “Although there is a lot of research ahead to find out the reasons and mechanisms that lead from infection to a process of dementia that manifests many years later, the accumulation of the evidence suggests that the management of these infections, with treatments that are effective for all herpes, or with vaccines such as herpes zoster, is an interesting tool to reduce the risk or delay dementia” explained to SMC María Jesús Bullido Gómez-Heres, head of the Research Group Pathogenic mechanisms of Alzheimer’s disease, who was not involved in the study. Not so non -transmissible diseases. This is not the only example of a noncommissible disease to which we have found a surprising relationship with past infections. A recent example We find it in colorectal cancer and its possible link with infections caused by bacteria Escherichia coli. In Xataka | We are getting closer to ahead of the arrival of Alzheimer’s. Knowing it can reassure us, but maybe too much Image | Matteo Vistocco / CDC/DR. Erskine Palmer

Log In

Forgot password?

Forgot password?

Enter your account data and we will send you a link to reset your password.

Your password reset link appears to be invalid or expired.

Log in

Privacy Policy

Add to Collection

No Collections

Here you'll find all collections you've created before.