In the last 20 years, colorectal cancer has doubled among young people and we didn’t know why. Now we have a track

In the last 20 years, the incidence of colorectal cancer has doubled in young adults and that has fired all alarms. Above all, because while this type of tumor shoots, we have no idea why. Now, a study headed by Spanish researchers has found a suspect: it is called colibactin and a bacterial toxin produced by some strains of Escherichia coli. The colorectal epidemic. The term is “epidemic”, yes. As Manuel Anse explainedthe alarm jumped in the US in the late 2000s: while colorectal cancer decreased in people over 70, growth rates in children under 50 grew at a rate of 1.5%. In Europe, the data suggests that it has arrived to grow to the rhythm of 8% Between twenty -year -old. It was a huge public health problem. But, above all, it was a mystery. What could be behind all this? The first track. In 2020, a research team from the Netherlands discovered that certain strains of Escherichia coli They produced colibactin and that toxin could produce cancer mutations In the children’s DNA. It was an interesting, promising way; But there were too many conditional in the idea. Those conditionals are those who have tried to eliminate the investigation that It has just been published in Nature. What have they done? They have analyzed the DNA of almost a thousand tumors of this type of 11 different countries (and three continents). Not only that: they have examined varieties, typologies and demographic features. And what they have found is more than interesting. To begin with, there are two genetic brands related to the toxin in question that are 3.3 times more common in tumors of young people (compared to those of people over 70 years old). To continue, “they are especially prevalent in countries with a high incidence of colorectal cancer in young people.” What does this mean? “Mutational firms are a kind of historical record in the genome; they point out that exposure to colibactin in early stages of life promotes colorectal cancer of early appearance,” Ludmil Alexandrov explainedfrom the University of California in San Diego. Everything seems to indicate that the harmful effects of this toxin begin soon (in the first 10 years of life). That is, “if someone acquires one of these driving mutations at 10 years, decades could be advanced in the development of colorectal cancer and suffering from age 40 instead of 60, “explained Alexandrov. It is great news. No, it’s excellent news. Insufficient, preliminary and still precarious: but if we are clear, it is that to contain the epidemic we must understand where it comes from. And, for now, it seems that it comes from the modern world. “In the most industrialized countries there is an increase in cases of infection with this strain of Escherichia coliwhich leads us to think about changes in lifestyle “, Díaz Gay says in the country. How can we use it in our favor? We do not know, but we will discover it. Image | JC Gellidon | National Cancer Institute In Xataka | We have found a cure for more aggressive colon cancer: this is how the drug is referred to

The Curiosity Rover has found its best track so far that Mars was a habitable planet

NASA’s indefatigable Curiosity Rover has found one of the most forceful evidence until the date of the past habitability of Mars. But also of the fragility of this habitable ecosystem. The finding. Curiosity arrived in Mars on August 6, 2012. Covered with dust and with deteriorated wheelscontinues to put the Gale crater in which he landed. In a stretch of 89 meters of rocky strata, on the slopes of Mount Sharp, a discovery has caught the attention of scientists. According to a study Published in Science magazineX -ray crystallography instruments and Curiosity gas analysis have detected large amounts of siderita, an iron carbonate ore, between sulfate rich rocks. Why it is important. Although I know They had detected carbonates on Marsthis discovery is exceptional for several reasons. First, the abundance of Siderita: it reaches between 4.8 and 10.5% of the weight of three perforated samples, which have been baptized as Tapo Caparo, Ubajara and Sequoia. Second, the purity of the siderita. It is almost pure feco3, with very little magnesium or calcium, which contrasts with other Martian carbonates. Third, its coexistence with highly soluble salts in water: calcium sulfates and magnesium sulfates. All this fits with an ancient evaporation process. What tells us about the old Mars. The formation of this siderite implies that the Martian atmosphere contained sufficient carbon dioxide to dissolve in water and react with the rocks. When precipitating as mineral, the CO2 was kidnapped In the rocks. The Gale crater was a lake that gradually dry out over time, leaving behind these layers of different salts or minerals. The study estimates that recent samples could house between 2.6 and 36 millibars of atmospheric CO2, up to six times the current CO2 pressure on Mars, confirming that There was once an important carbon deposit interacting with surface water, a key requirement for habitability. An incomplete cycle. But the story does not end there. The team found evidence that part of the siderite that formed was subsequently destroyed. A close sample (nicknamed Canaima) lacked a siderite, but contained abundant iron oxyhydroxides. Samples with siderita (tapo caparo, ubajara, sequoia) also contained these oxides in variable quantities. Researchers believe that it is due to a diagenesis process. Subsequent fluids interacted with the rocks, partially dissolving the siderite. This destruction oxidized the iron forming oxihydroxides, and released part of the CO2 previously kidnapped again to the atmosphere. This training cycle (CO2 kidnapping) and partial destruction (CO2 release) constitutes the best evidence so far of a Old carbon cycle on Mars. However, Siderita’s persistence indicates that it was a partial and incomplete cycle: more carbon was kidnapped than was subsequently released, unlike the carbon cycle of planet Earth, which has maintained a greater balance over geological time. A fragile habitability. The discovery reinforces the idea of ​​a habitable primitive Mars with liquid water interacting with a CO2 rich atmosphere until The warm and wet days are over. He tells us that the planet was habitable, but also that habitability is something very fragile. Perhaps a lesson about the climatic stability of our own planet in the face of climate change. Mars, once again, serves as a planetary laboratory to understand the evolution and fragility of the habitable worlds. Image | POT In Xataka | NASA’s Curiosity robot has opened a rock on Mars by accident. A yellow treasure has just revealed

We have been looking for the mysterious ancestor town of the Indo -Europeans. We have a new track in DNA

We know that Latin languages ​​have their common origin in Latin peoples such as the one that ended up forging the Roman Empire. We know that Germanic languages ​​had their origin in the Germanic tribes that at that same time inhabited northern Europe. But these two language families have a common trunk that goes back to prehistory, the language protoindoeuropeo. Now, who spoke this language? CLV. A new study He has discoveredthrough a genetic analysis in several archaeological sites in Europe, a new prehistoric group, an archaic society that they have called people of the Caucasus-Bajo Volga or CLV (Caucasus-Lower Volga). As the study concludes, this town could be linked to the protoindo -European language and with Its expansion. The protoindoeuropeo. The protoindoeuropeo (foot) language is the “common ancestor” of numerous contemporary languages, including Spanish and the rest of languages ​​spoken in the Peninsula (except Basque). A list that includes from English to Persian, through Russian and Greek. It is estimated that about half of the world population speaks languages ​​with this origin. This language would have been the speech of one or more prehistoric peoples of the border region between Europe and Asia. The migrations starring this group would have given rise to the speakers of this language ending their linguistic imprint in much of Eurasia. And more than linguistics, also genetics. From Yamnaya to Clv. Genetics had already given us important clues about these peoples, allowing us The so -called Yamnaya culturea population that would have inhabited the steppes north of the Caspian between the years 3,300 and 2,600 before our era. These analyzes had focused on this culture as probable vector of Indo -European expansion around the year 3,100 aec But there was a problem with its own name: the Anatolias languages, a group of languages ​​already extinct among which was included, for example, the hitita. These languages ​​would have been the first to break down from the common Indo -European trunk, before acquiring “steppe features.” This implied that this separation would have occurred before the arrival of Yamnaya culture and that there should be a protoindo -European group prior to this from which both anatolias languages ​​arose and those that would later derive in the Greek, Latin or Celta. Now, the new Study points to the people of the CLV as possible common ancestors of both. More than 4,000 years ago. All thanks to genetics. The new work studied the DNA of 435 individuals found in various archaeological sites in Eurasia, covering a period between the years6,400 and 2,000 AEC the details of the study were broken down In an article Posted in the magazine Nature. Missing link. Genetic analysis pointed out that Yamnaya’s group would have inherited about 80% of its ancestry of the CLV population, which in turn would have legacked about 10% of its ancestry to the anatolians. This makes this mysterious group the common ancestors of the populations that initiated the expansion of Indo -European languages ​​during the Copper Age. In Xataka | Looking for money, they found gold: this was Dmanisisis Gora, the megafortiness of the Caucasus built 3,000 years ago Image | XVODOLAZX / Denis Vitchenko

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