intestines

We have long realized that we are surrounded by microplastics, both in the water which we take as in food or even the air that we breathe, causing them to appear even in the human placenta. However, there are still many questions about the consequences of having these microplastics in the body, although science continues to take steps to give us an answer about them. how it can alter our general healthand the last thing we know is related to the effect on our digestive system. Ground zero. Something that is already known by almost everyone is that the intestine is full of billions of microorganisms which are essential for our immunity and also for metabolism, making its alteration related even to issues in the central nervous system. But now, science suggests that microplastics can drastically alter the composition and diversity of this ecosystem by destroying some of the bacteria that we harbor inside us to create a completely different environment that can affect our digestion, but also other parts of the body. How it has been seen. To understand how this happens in real time, CSIC researchers developed a sophisticated patented digestion simulation system known as SIMGI. This is mainly based on introducing artificial particles formed by the typical plastic of water bottles into the stomach and colon and observing how it affected bacterial diversity. From here, different investigations have seen that families of beneficial bacteriaas Lachnospiraceae, Oscillospiraceae and Ruminococcaceaeplummet, while the growth of groups that can generate disease is favored. And we must understand that ‘good’ bacteria occupy a space in our intestine so that nothing else can ‘germinate’ there. But logically, if they disappear, they leave their ‘hole’ for other bacteria to pass through. It goes further. But beyond a bacterial imbalance, there is different research that already points to how microplastics destroy the physical barrier we have in our intestine. In this way, scientists have detected that these tiny fragments cause the generation of oxidative stress and, therefore, the overproduction of reactive oxygen species, which only generates great damage to the tissues. But this chemical attack also adds to mechanical damage, which some experts categorize as ‘sandpaper’, since together they manage to reduce the expression of proteins that are key to maintaining the union structure that characterizes the cells that exist in our intestinal wall. The result. If we destroy the scaffolding that maintains the ‘walls’ of our digestive system, the only thing that will be achieved is that increase intestinal permeabilityso any toxin or bacterial molecule will be able to pass from the intestine to the bloodstream, since there is no ‘wall’ that blocks the access of agents that are not wanted in our body. Logically, the passage of toxins without the control of this intestinal barrier activates our immune system defenses, which results in inflammation maintained over time that favors the destruction of tissues and also progresses in important chronic diseases. There is more. As if that were not enough, it is known that microplastics are excellent transport vehicles, since when they come into contact with our biological fluids they become covered with a “protein crown”. This is something really important, since this layer literally camouflages the microplastic and makes it easier for it to adhere to our living cells. But added to all this, we also see that they can act as the perfect support for bacteria and form what is known as biofilms. In this way, microplastic can be seen as a vehicle for external and potentially dangerous microbial communities directly to our tissues. Where are they going? If microplastics alter our barriers, logically the plastic has a free way and that is why it is capable of traveling to different organs such as, for example, the liver, kidneys or brain. And once here, research already indicates that its accumulation is related to DNA damage, deregulation of the immune system or alterations in our entire hormonal system that can lead to chronic diseases. Images | rimufilms on Freepik In Xataka | Researchers analyzed 280 samples of bottled water. Only one of the brands was free of microplastics