The rarest element on Earth aims to cure cancer. And Europe is already accelerating its production

In the fight against cancer there are many ‘weapons’ that we have at our disposalsuch as chemotherapy or radiotherapy. The problem is that these are assimilated like bombing a city to destroy a single house: it is achieved, but with a lot of collateral damage. But this can be solved if We attack only what interests usin this case a tumor cell, and science points to one of the rarest elements on the planet as a candidate to achieve this. Where are we now. The goal of science is to find the most specific therapies possible so that they attack a tumor cell and not a healthy cell with the aim of reducing the adverse effects of the treatment and also being more effective. For this there are different options such as immunotherapy or the use of very specific antibodies, but there is still a long way to go. A particle. He astatinewhose name comes from the Greek astats (“unstable”), lives up to its name. It is the rarest natural element on Earth and disappears almost as soon as it is formed and that is very interesting to us. Especially a ‘version’ of this element which is At-211 which has a half-life of only 7.2 hours. But this instability is part of its magic. At-211 is what Texas A&M scientists call a “Goldilocks” isotope: perfect for the job. Its advantages. Currently, heto traditional radiation used in cancer treatments have a great impact on the body when traveling over long distances. But At-211 emits alpha particles, which is a heavy, slow-moving helium nucleus, which when emitted releases an enormous amount of energy, but can only travel a tiny distance, just the thickness of a few cells. This is crucial. Targeted Alpha Therapy involves “gluing” an atom of At-211 to a molecule (such as an antibody) designed to specifically seek out and bind to cancer cells. At-211 travels through the body, ignoring healthy cells, and when it finds its target, it anchors to the tumor and releases its alpha particle. The result is a localized and devastating explosion of energy, which irreversibly destroys the DNA of the cancer cell. But since the particle cannot travel any further, the healthy cell next to it will not be affected, making this an almost perfect killer. Your problem. At first glance everything seems great, but… Why don’t we use it? The answer lies in its availability, since it is impossible to mine astatine, since with a life of 7.2 hours the clock is running against it. The only way to obtain it is to create it artificially in a cyclotron, a particle accelerator. The process basically involves firing a beam of alpha particles at a Bismuth-209 target. Now the advance that has been achieved is to create a fully automated system to produce and ship the AT-211 as quickly as possible so that it can be used. In Europe. With this advance, which has been made in Texas, processing time is reduced and the safety of technicians who do not have to handle this substance increases. And while Texas A&M resolves supply in the US, Europe is making a move. The project Accelerate.EUfunded by the European Union, was launched at the end of 2024 with a clear objective: to create a robust and sustainable manufacturing and treatment infrastructure for At-211 throughout Europe. The project focuses on especially difficult-to-treat cancers, such as pancreas, breast and brain tumors (glioblastomas), demonstrating that this therapy is a global strategic priority. The future therefore lies in the possibility of using one isotope to illuminate the tumor and then using another to kill it, inaugurating authentic personalized nuclear medicine. Images | freepik In Xataka | The most unexpected treatment against cancer is LED light, and it is giving good results

The aging of its population is about to leave Japan without a key element for the nation: pants

Japan has entered a unprecedented demographic phase for an advanced economy: retirement mass of the generation that supported its industry coincides with a young one that is too small (and unwilling) to occupy the jobs that this economy requires to continue functioning. On paper, global demand for certain domestically manufactured goods has never been higher, but in the engine room, those who know how to produce them are aging without substitutes. Fabric turned into luxury. He japanese denimslowly woven, dense and dyed with natural indigo in repeated cycles, enjoys a moment of consecration worldwide: Dior, Balenciaga and other luxury houses incorporate it, celebrities exhibit it, the market projects grow more than 85% until 2035 and tourism (supported by a weak yen) triple sales in Kojima’s “Jeans Street.” For an industry that had been hollowed out by decades of cheap imports, the return of demand is not marginal but cultural: the value resides in the texturethe way indigo ages and in that kind of aura of exclusivity that results from real and not cosmetic scarcity. In fact, brands with Japanese only website and without direct export they increase that breath of rarity and price. Without a job when it is most demanded. The apogee has arrived when the productive base collapses: There are barely fifty artisans left in the founding heart of the japanese selvedgethe average age is close to seventy, and apprentices last months before giving up due to noise, heat, grease, discipline and slowness. Bloomberg counted that the skill curve is not linear: it takes six months to five years to operate the loom and up to a decade to maintain and repair it. With the master generation entering retirement and entrepreneurs without time to transmit the trade, continuity is broken by calendar, not by market. Ancient technology. The shuttle looms of the early 20th century (now relics) allow continuous edging what gives the “selvedge” and the density of the weave that produces an unmistakable drape, feel and aging in the fabric. Japan came to have 300,000 machines of this type. The problem? Today there are less than 400 operationsa lower third a single signature. To maintain them you have to remove pieces of other machines already stopped and work at a pace that doesn’t fit with today’s industry. They cannot be replaced by automation without losing exactly what the customer pays for: a finish that only time gives on a slow-made fabric. What is authentic is paid for. Plus: the one who pays For this denim you are not looking just for the feel, but for a product that takes time to make, that ages well and does not depend on the rapid rotation of fashion. In other words, this preference fits with the rejection of fast-fashion and a turn towards objects designed to last. The signs are many and clear: Levi’s sells “Blue Tab” lines for twice the price of a normal 501, Capital places jeans worth several hundred or thousands of dollars, and funds linked to the almighty LVMH they invest in Kojima brands. The problem of aging. Japan is getting older faster than there is time to teach the trade. The factories have plenty of orders, but they cannot get hire or train substitutes. The owners travel and manage, but they do not have hours to teach, and the machines will be lost due to lack of parts and hands that know how to maintain them. If the drift continues like this, the problem will not be a lack of demand but capacity: in about ten years (according to own manufacturers) this type of product will no longer be able to be made because neither the technicians nor the machines will be able to work. There are no shortcuts. The final paradox is that the boom of the sector It doesn’t seem like it’s going to save the job, rather it accelerate towards the limit: The more demand grows, the more it squeezes the few remaining hands and the less time there is to teach others. Thus, the world Japanese denim is faced with a disturbing choice: slow down the pace to transmit the trade (even if that means losing sales in the short term) or exploit the latest generation until it is exhausted, knowing that this would leave a product that will possibly disappear, not due to lack of market, but because no one will be able to do it anymore. Image | PxHere, Liface In Xataka | That Japan has 100,000 people over 100 years old explains a problem: they are literally running out of drivers. In Xataka | Japan’s aging has hit rock bottom with a devastating fact: more and more elderly people want to live in prison

Ode to rounded corners, the visual element that has proven Steve Jobs right once again

Let’s pay a small tribute to a visual element that we almost never pay attention to, but that is already an integral part of our lives. Let’s talk about rounded corners. They are everywhere and have taken over technology. We love them. We are full of devices and interfaces dominated by rectangles and squares with rounded corners. They are more elegant, softer to look at, much less aggressive and strident. But there is a true psychology behind that way of designing objects and interfaces. For example: since we were little we always knew that sharp corners were dangerous – today corner protectors for children are a big deal. These elements facilitate visual perception, and their introduction into the technological world deserves to be remembered. Steve Jobs was right (again) Andy Hertzfeld was one of the team members who developed the Apple Macintosh. In May 1981 he shared a curious story, now recovered by the Computer History Museum. Lisa OS 1.0. Look at the edges of the calculator app. They are rounded! The protagonist of that story is Bill Atkinson, legendary Apple engineer and Hertzfeld’s partner on that project. At that time Atkinson was working on the development of his QuickDraw application – then called LisaGraf – and although he usually worked from home, if he made any significant progress he would quickly go to the office to show off the improvement. That’s what happened that spring. Atkinson approached Apple’s offices in mythical “Texaco Towers” Cupertino campus and showed how he had added code to be able to draw circles and ovals very easily. Programming that was much more complicated than it seems because square roots were usually involved to achieve it and the Motorola 68000 of the Lisa and the Macintosh did not support floating point operations. Atkinson managed to solve it with calculations that only used addition and subtraction—he was probably inspired by the Bresenham algorithm—and began to fill the screen with circles and ovals while his companions probably smiled in astonishment and satisfaction. But there was someone who was neither too amazed nor too pleased. That someone was Steve Jobs. Upon seeing the demonstration, Jobs said —Okay, circles and ovals are fine, but How about drawing rectangles with rounded corners? Can we do that too? —No, there is no way to do it. “It would actually be really difficult to do, and I don’t really think we need it,” Atkinson replied, probably annoyed that Jobs hadn’t been too impressed with his method for creating circles and ovals. —Rectangles with corners are everywhere! Look around this room! Hello, Mac OS X with rounded corners (2001). Sure enough, the room had objects like whiteboards and tables with rounded corners, and Jobs insisted that they were everywhere and that he only had to look out the window to notice. He ended up convincing Atkinson to take him around the block and point out all the rectangles with rounded corners they saw. After seeing a no parking sign that was rectangular with rounded edges, he said: —Okay, I give up. I’ll see if it’s as difficult as I thought. And he went home to work on the problem. The next afternoon he returned to the office with a huge smile: his new demo I didn’t just draw rectangles with rounded cornersbut it did it almost as fast as it did drawing rectangles with corners. He added that code and called that primitive “RoundRects”. In our pockets we usually carry a device that makes good use of these rectangles with rounded corners. The iPhone, of course, does it. That design element soon became an integral and indispensable part of the Macintosh operating system interface. And it also ended up being part of the hardware (hello, mobile phones with rounded corners) and software design at both Apple and many other technology companies. Source: Freepik. The Cupertino firm also fully integrated it into its iPhones starting in 2013, when iOS 7 and its “squircle” arrivedan even more subtle type of rectangle with rounded corners that he ended up using, for example, in his icons. It was one more example of the particular relevance of a design element that has ended up completely taking over our screens and the technological world. Long live the rounded corners. In Xataka | Many young people already see and hear everything at 1.5x. They didn’t get there by chance: there was a lot of money at stake

A very rare element of the periodic table is unleashing a new geopolitical battle with China: Germanio

China has been weaving, little by little, a network of power around critical minerals: first Rare earthsafter Copper And now Germanio. Although its name barely says anything to the general public, this metal is essential for the defense industry – from the night vision systems of the fighters to the satellites – and for the optical fibers that support the Internet. Today there is almost no market, its price has been quintupled in two years and the origin of the collapse has a clear name: Beijing. The origin of the crisis. Two years ago, China announced controls At the exit of Germanio, Gallium and Antimony in response to the restrictions of the United States and the Netherlands on advanced semiconductors. However, the real blow arrived at the end of 2024: Germanio’s exports collapsed, leaving merchants without supply. Terence Bell, from Strategic Metal Investments, I recognized Financial Times That had been able to buy a gram six months. “The situation is desperate,” he said. Aaron Jerome, from Lipmann Walton & Co, described a devastated market: “Before we could buy 100 kilos; now we are lucky if we got 10, and the triple price.” And Christian Hell, from the Tradition Commercial House, added to the same medium that the demand was “for the clouds” and that he received desperate consultations of companies from the United States and Europe. The figures confirm the collapse. According to a Policy Accelator Silverado analysis cited by Financial Timesbetween January and July of this year, Germanio imports to the United States from China fell 40%. The result has been an unprecedented price escalation: just $ 1,000 in 2023 to almost $ 5,000 in September this year. This is the highest level registered since 2011. A strategic role. The importance of Germanio is not in its geological rarity, but that it is very difficult to extract, since it is obtained as a zinc and coal byproduct. In addition, its use in defense is irreplaceable for thermal image systems in fighters, drones and satellites. In the civil sector, it is used in optical fiber, solar panels and chips. “Finding substitute materials is complicated, because it would imply a complete redesign and a loss of unacceptable precision in military applications,” explained the analyst Caroline Messecar in Financial Times. For these reasons, According to estimates from the Fastmarkets agencyworld demand is around 180-200 tons per year of Germanio. One more piece of a much wider board. In Beijing they have converted critical minerals into geopolitical weapons. At the end of 2024, They prohibited export from Gallium, Antimony and Germanio to the United States, and shortly after added Scandio and Disposioessential in chips, telecommunications and storage. The strategy behind the Asian giant is to monopolize the control of the entire chain. To name a few examples, China has 4% of world copper reserves, but controls 49% of the global refining. “More than accumulating raw materials, China is building an intentional bottleneck in the supply chain,” My partner has detailed in Xataka. The same goes for the Tungsten, where it controls 83% of the world supply and tightened the export controls in February 2025, What fired prices 55%. In simple words: Beijing seeks to be essential. It controls the most valuable link – the defendant – and with it conditions global access to strategic metals of the 21st century. However, its power is not absolute: it depends on importing concentrates from countries such as Chile, Peru or Mexico. If any of those partners change position – Mexico, for example, 50% tariffs have already imposed Chinese products in 2025-, Beijing risks a cut of vital supplies. In addition, this control strategy has a price: Chinese copper foundations work with negative margins and some have had to close. A movement to counterreloj. Before the blockade, Germanio’s great consumers try to move quickly. On the one hand, in the United States, defense giant Larkheed Martin signed in August a direct agreement with the South Korea Zinc to ensure supply, something unpublished so far. Lightpath Technologies, with government support, works in optical alternatives, although its director Sam Rubin warns in ft: “No one is going to redesign an existing system until it is inevitable.” On the other hand, the options are scarce. Umicore in Belgium and Teck Resources in Canada produce some Germanio, but insufficient. Germany He already warns thatif the crisis lasts, its automotive industry could stop part of the production in a matter of weeks. The European Chamber of Commerce has even asked Beijin to release supplies for chips factories. The historical supplier, Russia, has also been out of the board. For years it was one of Germanio’s main sources for the West, thanks to its production associated with zinc and coal mining. However, international sanctions for the Ukraine War cut that flow almost completely. Moscow continues to produce, but its exports are now directed to China and countries that do not participate in the sanctions, According to FT. For the United States and Europe, that means having lost another supply route in the worst possible time, which has further reinforced Beijing’s domain. Looking to the future. In Germany, a group of researchers from the Technical University of Freiberg Work in a method surprising: extract Germanio from plants after fermentation processes for biogas. At the moment, they only achieve some milligrams per liter, but they aspire to reach a gram, which would open the door to a sustainable and local production. From anonymity to key element. Germanio has become a symbol of a new era: that of minerals as strategic weapons. As Financial Times has pointed outdemand does not stop growing while the offer narrows. And the lesson is clear: in an electrified and militarized world, who controls critical minerals will control power. Image | Freepik and Unspash Xataka | Nickel’s paradox: West needs it more than ever for electrification, but China and Indonesia have market dominance

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