altering

‘Toxic’ people can be anywhere, such as the office, school or even in one’s own homewith an effect that quickly depletes our energy when dealing with them. In psychology, these types of people are beginning to be called ‘hasslers‘ and are defined as people who complicate life, whether they are family members, work colleagues or even partners. The problem is that they can even affect physical and mental health. They make us old. That a toxic person can damage our mental health It is something that we have already internalized enough from our own experiences, but now the PNAS magazine has confirmed that chronic stress derived from these relationships has an impact on the “biological clock”, causing our cells to age much faster. How it looked. To reach this conclusion, the researchers analyzed to more than 2,000 adults from the state of Indiana in the United States for almost 20 years. But here they did not limit themselves to asking them about their stress levels in a survey, but rather they cross-referenced the data with different biological markers from their saliva. From here, scientists used epigenetic clocks as algorithms that do not measure how old we are on the DNI, but rather different key points in our DNA that indicate how aged our cells are. Among these points, for example, stands out the methylation of DNA or some very specific chemical marks. The results. This is where it was seen that indeed people who were in relationships with very conflictive people in their immediate environment had an accelerated aging rate of an extra 1.5%. This means that biological age increases by an average of nine months. Because? That something that seems purely psychological affects on a physical level seems like something that has little to do with it, but the reality is that interacting with these people constantly increases the levels of cortisol in the blood, which is the stress hormone. And having a lot of cortisol is not recommended at all, since it is related to an increase in oxidative stress that damages cells. But in addition, the study observed that this process inhibits a key enzyme in cells such as telomerase. And it is key because its function is to protect DNA to prevent it from shortening at an accelerated rate to the point where the cell has to be destroyed. Something that also favors cellular aging. Not everyone suffers the same. Here women, smokers and people with low social support show greater vulnerability to this accelerated aging by being with the wrong people. Furthermore, the study identified that family members and work colleagues have a greater weight in this wear and tear than friends, probably due to the difficulty of “escape” from those ties easily, while with a colleague you have to put up with it no matter what. It can be fixed. Until now we are quite clear that having a toxic relationship gives us more misfortunes than joys, but the question is obligatory: can we go back? Here science suggests that we are facing a partially reversible process, meaning that with psychological therapy, the establishment of clear limits in the social sphere or even physical distancing from that toxic person, the clock can be “slowed down.” Images | Italy Gariev In Xataka | The science of being single: a macro study warns that well-being plummets if you have not had a partner by 25