One of the wishes of many people is to live forever and they may have in mind ending up with their head stuck in a jar like in the Futurama series or becoming cryogenized for an eternity until the key to eternal life is found. But we are still quite far from that, although right now science has been able to recover the activity of a brain after ‘killing’ it.
Far from the resurrection. In recent days we have been sold the idea that we are facing a new way of ‘resurrecting’ the dead or achieving the wish of eternal life, but the reality is that the latest thing science has done is recover short-term functional activity in mouse brain tissue after subjecting it to vitrification.
What was done. Historically, the great enemy of cryopreservation of human tissue have been ice crystals. This is because when we freeze tissue, the water in the cells expands and crystallizes, perforating the cell membranes and destroying the structure from within, making it impossible for that tissue to come back to life. Something that generates a lot of damage and that goes against the famous cryogenization cabins that promise to wake us up in the future when science has advanced a lot.
But now, instead of traditional freezing, the latest experiment used powerful cryoprotectants and took mouse brain tissue to -150ºC. This process transforms the liquids into a glass-like state, preventing the formation of these crystals, and when they wanted to ‘awaken’ the tissue again, ultra-rapid reheating was simply done to prevent crystallization from destroying the samples.
What was achieved. The original article shows extraordinary results, since the amount of neuronal properties that survived were many by ensuring that the cells did not collapse and the tissue returned to consuming energy normally. In addition, the neurons maintained their ability to fire signals and also the possibility of creating new connection networks, which is essential for learning and memory.
Why does it matter? As he warns Nature Newsthese results must be read with caution, since it is mouse tissue, not a complete human brain. And recovering electrical activity in a cut of the hippocampus is not equivalent to restoring the consciousness, identity or life of an entire animal, much less a person.
But even if they do not manage to pause our definitive death, the reality is that this can be crucial in the field of research by facilitating the transport and storage of brain samples for study in other places. But it will also allow drugs to be tested on actual brain tissue that has been preserved, perhaps reducing the need to sacrifice so many experimental animals.
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