“Words are insufficient when trying to describe this disease. As for his suffering, it seemed almost beyond what is humanly bearable.” Although the news about the hantavirus They make it sound even scarier, that commentIn reality, it is more than 2,000 years old. The chronicler Thucydides wrote it in his ‘History of the Peloponnesian War’ to give an idea of the terrible plague that devastated Athens around 430 BC, an ailment that he himself suffered and took the lives of some 75,000 people.
For centuries that epidemic has been remembered as the ‘plague of Athens’although we don’t actually know exactly what caused it. Now a group of Greek researchers have shed some more light on that dark episode.
Epidemic detectives. In a hyperconnected world, in which people are capable of traveling thousands of kilometers in a few hours and it comes with blocking a remote strait of the Middle East to put the world economy in check, the specter of pandemics seems more present, but the truth is that humanity takes centuries dealing with him. Before the COVID pandemic, we had, for example, the 1918 flu or the disastrous Black Deathwhich devastated Europe between 1346 and 1353 and (by some estimates) reached 60% case fatality rates in some regions.
Long before any of them, in the times of Classical Greece, another equally devastating epidemic was recorded: the plague of Athens. Thanks to authors like Thucydideswho in addition to being a chronicler suffered it himself, today we can learn in detail how that outbreak developed and experienced, which left tens of thousands of dead.
The episode was important not only because of its death toll: between 75,000 and 100,000 in the four years that elapsed from 430 to 426 BC One of the deceased was Periclesa historical leader of Athens. In fact, experts usually agree that the plague precipitated the decline of the Athenian Golden Age and its death toll facilitated its final defeat in the war against Sparta.
The great unknown. Despite this historical value, the Athenian plague remains shrouded in unknowns. We know when it developed, we know where it developed and there is even evidence suggesting that the initial outbreak occurred in sub-Saharan Africa, spread to Egypt and Libya and then passed to Athens via Piraeus. What is not clear is what exactly caused the plague and why it was so disastrous. And Thucydides was in charge of describing all its symptoms.
Now a team from the University of Athens (NKUA) have wanted to clear up this mystery by analyzing the symptoms described by the chronicler and comparing it with that of known ailments. The result they have published it in the magazine AMHA.
A pulse on history. If it is difficult to track a viral outbreak in 2026, the task becomes daunting when we are talking about one of the first known epidemics in human history. To face such a challenge, Dr. Dimosthenis Papadimitrakis and his colleagues had an idea: they looked at the symptoms described by Thucydides and other sources, They selected 17 diseases known that more or less fit that symptomatology and created a “metric system” with different scores to determine which of them best fit the epidemic that hit Athens 2,400 years ago.
“The most terrible thing, despair”. Whether due to his zeal as a chronicler or because he himself suffered from the disease, Thucydides detailed the symptoms suffered by those who contracted the Athenian plague: migraines, high fever, redness and inflammation of the eyes, bad breath, sneezing, cough and profound gastrointestinal discomfort, such as nausea, vomiting, spasms and painful diarrhea.
Over time, rashes, pustules and ulcers appeared on the patient’s skin, especially in the abdomen area. Those who could not stand the disease died after seven or nine days, after experiencing intense burning that led them to take off their clothes or even immerse themselves in cold water. “Gangrene of the extremities and eyes was common among both survivors and victims,” detail experts, who remember that it was not unusual for patients who survived the plague to do so with amnesia.
“The most terrible thing was the despair into which people fell when they realized that they had contracted the plague. They immediately adopted an attitude of absolute hopelessness and, by giving in in this way, they lost their capacity for resistance,” Thucydides reflects. “Words are insufficient when trying to give a general image of the illness.”
Ruling out candidates. With that starting point, Papadimitrakis and his colleagues developed a list of diseases that the Athenians of 2,400 years ago could have contracted and that coincided to a greater or lesser extent with the symptoms described by Thucydides. They came up with 17 potential ‘candidates’, including cholera, measles, scarlet fever, tuberculosis, Ebola, malaria, smallpox, bubonic plague, ergotism or Lassa fever.
Then with that chart on the table, two questions were asked: Which of those diseases caused rashes and gangrene? How many are transmitted between humans? And what historical evidence is there for each of these ailments? Thanks to this analysis they reached a series of conclusions, although the team warns that they are only hypotheses based on probability, not firm and unquestionable truths.
“The plague of Athens presents difficulties in identifying the causal agent due to several factors. The main source of information is the accounts of Thucydides, but his lack of medical knowledge and the lapse of up to 20 years between the events and their documentation can lead to erroneous interpretations,” the authors explain. “Furthermore, the inability to isolate or culture the responsible microorganism poses a major obstacle. Even if preserved bodies of plague victims were discovered, the microbes would have decomposed over time.”
And what is the conclusion? That of the diseases analyzed, the one with the most votes is typhoid fever. “It appears to meet most of the criteria, so it is considered the most likely agent,” summary the researchers. Furthermore, in a necropolis from the time of the epidemic, remains of the bacteria that trigger this disease were detected. Does that mean we’ve solved the mystery? Not necessarily. Among other reasons because it casts doubt on how the disease could have been transmitted in Athens more than 2,400 years ago.
More open windows. The researchers recognize that both measles and meningococcal disease have quite a few advantages as well and conform to certain data provided by Thucydides. Two other diseases with a considerable (although somewhat lower) level of overlap are epidemic typhus, tuberculosis, and scarlet fever.
Beyond the 17 diseases analyzed by scientists, there would still be two other possibilities. The first is that the plague of Athens did not respond to just one ailment, but rather that the city was shaken at the same time by two or even three pathogens, such as typhus and dysentery. Another “plausible scenario”, experts admitis that the outbreak was triggered by an unknown and now extinct disease, such as an arenavirus similar to the Lassa fever virus.
There is still a long way to go, but what is undeniable is that science is one step closer to solving one of the great enigmas of Classical Antiquity.
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