We have been obsessed with Japan for decades to understand people who live over 100 years. The key was in Brazil

For decades, when science was searching for secrets of aginghe always looked in the same places: Japan’s “Blue Zones”Sardinia or the icy and homogeneous populations of northern Europe. However, researchers have pointed out that all this time we have been ignoring a biological gold mine: Brazil.

The study. Understanding why there are people who live to be over one hundred years of age is undoubtedly an objective of science to to be able to unlock possible therapies in the future that will extend our lives much longer. Since it is curious that in specific areas such as Japan the population ages far beyond the normal average, being a mystery to science (although the reasons are already gone).

The latest research on the matterpublished on January 6 in Genomic Psychiatry, has identified a genetic mix in the South American country that could contain protective variants invisible in more uniform populations.

The Brazilian superhumans. The study, led by geneticists Mayana Zats and Mateus Vidigal de Castro, is based on the analysis of a group of more than 160 centenarians and at least 20 supercentenarians, who They are those people who are over 110 years old.

Among these people, some quite relevant figures stand out, such as Sister Inah, who reached the age of 116, and several of the oldest men in the world, according to the LongeviQuest Atlas. But what really makes this group of people who have been analyzed by researchers special is not their age, but their biological resilience.

Its biological resistance. The researchers’ main thesis is that the intense Brazilian miscegenation, fruit of centuries of interaction between indigenous populationsPortuguese colonizers, enslaved people of African origin and European and Japanese immigrants, has created a unique genomic diversity.

By analyzing this genetic “breeding ground”, scientists have identified millions of variants that do not appear in large international biobanks. The hypothesis suggests that this mixture allows protective variants to emerge that are practically invisible in homogeneous populations. It is, in essence, a search for the genes of resilience in an environment of maximum diversity.

COVID resistance. Without a doubt, it is one of the most fascinating examples of this history, since before the arrival of vaccines, three supercentenarians of the study they managed to survive the disease. By analyzing their immune response, the researchers found a concentration of cells related to innate defense that was very efficient.

In this way, it was seen that individuals not only live longer, but also have a defense system capable of neutralizing threats that are lethal to people decades younger. Something that seems to be related to an increase in biological processes related to autophagy, that is, the ability of some cells to literally clean the body of harmful components.

What was already known. This paradigm shift connects with previous works such as those done by researcher Manel Esteller on the epigenetic profile of the Spanish María Branyasthe oldest Spanish person of all time. In this case, what was done was to understand the “biological clock” of longevity in Europe.

Now, the Brazilian project expands the map into the unknown. By sequencing entire genomes in this mixed-race population, scientists have discovered some eight billion undescribed variants, many of which could have a functional impact on how we age and how our cells withstand the test of time.

Towards the future. The study of Brazilian supercentenarians is not only a matter of biographical curiosity about who holds the age record, but a critical step towards genomic medicine of the future. By understanding how the mixture of ancestors can concentrate protective factors against degenerative or infectious diseases, science is getting closer to discovering whether there is a biological “formula” for longevity that can be translated into therapies for the rest of the population.

Brazil, with its genetic mosaic, is demonstrating that the most complex answers to our survival could be written in the genes of those who, against all odds, have seen more than a century of history pass by.

Images | Unsplash

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