superfungi

When we talk about the antibiotic resistancemany people are already aware of the great problem that not having medications against superbacteria poses for public health, since today there are many antibiotics that have no effect on bacteria. But the WHO launch an alert very important to expand our field of vision also to the “super mushrooms“. Growing danger. If there is a protagonist in this new threat, it is Candida auris, precisely because, unlike other fungi that have been with us for centuries, this one has recently emerged as a global public health problem by causing serious infections, especially in people who are admitted to hospitals or nursing homes, who already have other associated diseases. A genomic macro-study in which the Carlos III Health Institute has participated analyzing more than 300 isolates from patients in 19 countries, has drawn the map of the evolution of this multi-resistant fungus. And the reality we face is that it is capable of spreading rapidly among fragile patients, and worst of all, it is very resistant to the anti-fungal drugs that we use on a daily basis. It is very complete. As experts point out, the enormous expansion of C. Auris is not only focused on the ability to evade the first-line antifungals that we have, but also on its ability to form biofilms on hospital surfaces or medical devices. This causes an object used by several patients to become ‘infected’ and spread the infection among them. It was suddenly. The reality is that today there are many fungi from the Candida family that coexist with us by being on our skin naturally, and without causing problems. The trigger comes when our defenses fall because we are sick, immunosuppressed due to a transplant or naturally because we are older. And this is where this fungus goes from being a being that lives with us ‘in peace’ to completely invading us and causing disease. The culprit. Paradoxically, our efforts to kill bacteria have part of the blamesince here the experts point to a structural problem of abuse of broad-spectrum antibiotics that “sweeps away” the natural bacterial flora of our body. In this way, if bacteria that colonize our digestive system are destroyed, for example, it creates free ‘holes’ that can be used by fungi without control. Added to this is a serious pharmacological problem, since right now we do not have many medications to fight fungi. And the problem is that its structure is quite similar to the surfaces of our own cells as it contains cholesterol in many cases. This means that drugs that destroy the fungus without producing a toxic effect on the patient are not very abundant. There is more. Although we focus on C. auris, there are other threats in this same kingdom, such as Scedosporium prolificansa multiresistant fungus that, through unique evasion mechanisms, causes very high mortality rates in immunosuppressed patients. The solution. Right now, science indicates that we cannot address the crisis of superfungi and superbacteria with patches, but rather we must create a unitary strategy that encompasses human, animal and ecosystem health. And right now the massive use of fungicides in agriculture causes the fungi in the environment to resist our medications that we use in the most serious patients. Images | Adrian Lange In Xataka | Faced with the need to look for weapons against superbacteria, science has opted to send viruses into space