taking Ozempic to lose weight is a thing of the past, Wegovy is already in pills

The fight against obesity has just crossed a border that many were waiting for: that of comfort. Until now there are several medications approved to treat obesityas is the case with the famous Ozempicbut they had a problem: they were injections that had to be injected repeatedly. Now a big step has been taken by having a pill version of one of these options: wegovy. In the United States. The FDA, the drug regulatory agency in the United States, has given the green light to the oral version of Wegovy. Something that makes it the first drug in the GLP-1 family that does not require a weekly injection, but rather a simple daily intake of 25 mg. This move by Novo Nordisk is not only a change in the way of administration; It is a coup in a market valued in billions of dollars that until now relied on prefilled syringes and more complex cold chain logistics. The same results. The data supporting the approval of this new drug is actually quite good. Specifically, This new pill has been tested for 64 weeksseeing that those patients treated with this system strictly achieved a natural weight loss of 16.6%. This is something that is consistent with effectiveness in “real life”, where weight loss ranges between 13.6 and 14% The data being very similar to that obtained with the injectable version. And even other effects are also achieved, such as the reduction of major adverse cardiovascular events. Why has it taken? A priori, the logical thing is that these medications would have emerged as a simple pill that is taken daily, instead of an uncomfortable injection that also requires cold to be preserved. The problem in this case is that semaglutide (the component of the drug) it is a protein that the digestive system tends to destroy with its acids before reaching the bloodstream. This meant that it had to be administered directly into the blood to avoid this problem. Now, the Novo Nordisk company has managed to protect the molecule from gastric acids, although without reducing the classic side effects. In this case, patients have reported diarrhea and vomiting when taking this medication, as was already the case with the injection. Price and availability. The announcement has had a great impact, making the pharmaceutical company’s shares will shoot up more than 7%and much more that will surely do so when it is launched in the United States starting in January 2026. For the rest of the countries like Spain, it depends on the approval of local regulatory agencies that must verify the studies that support this pill to check if its effects are real. But the most disruptive may be the price. Novo Nordisk has suggested a starting dose of 1.5 mg at a cost of $149 per month. This is a considerably lower figure than current injectables, probably due to logistical savings, since manufacturing an injection is not the same as manufacturing a blister of pills. Its importance. With this pill, the barrier to entry that many patients had was eliminated: needle phobia. Although there is still the price issue ahead. In addition, it simplifies distribution and storage, alleviating supply problems that have been a major drawback in recent years. We are at the beginning of the “oral era” of GLP-1, where the competition (such as Eli Lilly) is already working on their own versions. For now, Novo Nordisk has taken the lead in the race to conquer the medicine cabinets of millions of people with obesity. It’s still not a miracle. Like the injection, this pill does not make you lose weight by ‘the grace of God’, but rather requires a very important personal process. The tablet can make us eat less, but if you stop the treatment we return to the beginning, little will have been done during the journey in which you have been medicated. Images | Haberdoedas danilo.alvesd In Xataka | For many people, food is a source of intrusive thoughts. Ozempic is able to “silence” them

30% of depressions do not respond to pills or psychotherapy. A psychiatrist’s idea: treat them with ultrasounds

Depression is a truly complex disorder, which in 30% of cases do not respond to treatment conventional. Neither pharmacotherapy nor psychotherapynor the transcranial magnetic stimulation (used to treat OCD) appear to offer lasting relief to those who become trapped in the more resistant states of the disease. And although at first they can be ‘given up as lost’, the Argentine psychiatrist Salvador Guinjoan He is already working on another avenue of treatment. The idea. The psychiatrist, researcher Laureate Institute for Brain Research from Oklahoma, is working on an alternative that uses more physics than psychiatry for these patients who a priori had no other type of solution. This is based on the low intensity focused ultrasound, what is known as LIFU (Low-Intensity Focused Ultrasound). During the recent Conference on Updates on Neuromodulation held in Seville by the Spanish Society of Clinical Psychiatry, Guinjoan explained that the objective is quite ambitious: to modify the electrical activity of the brain circuits involved in psychiatric symptoms without the need to open the skull or implant an electrode as he explained. in an interview to El País. What is LIFU. This technology uses mechanical energy instead of electrical or chemical energy. Its transducer generates ultrasonic waves that are capable of passing through the skull and concentrating the energy at a very specific point in the brain, subtly modulating the mechanosensitive ion channels of the neurons. In practice, this alters neural communication in regions that are involved in emotion, motivation, or decision-making. But the important thing in this case is that unlike traditional deep stimulation (DBS), which requires surgery and permanent implants, LIFU allows completely reversible interventions with high anatomical precision. According to Guinjoan, the method opens the possibility of observing, for the first time, causal relationships between a specific brain circuit and a clinical symptom: “If modifying a circuit changes the symptom, we can begin to understand the cause,” he points out. The bibliography supports it in these cases, since previous research, such as those carried out in the Massachusetts General Hospital and published in Nature Neuroscience (2024), had already shown how LIFU can influence deep regions such as the amygdala or thalamus without visible tissue damage. Now, the challenge is to transfer that precision to the psychiatric field. Key points. Guinjoan and his team focus their trials on two key markers of resistant depression: anhedonia (inability to experience pleasure) and the persistence of negative thoughts. Both phenomena seem to be related to connection circuits between the prefrontal cortex and the basal ganglia. And it is precisely in this circuit where the psychiatrist wants to intervene with LIFU. The researcher suggests that modulating the subcircuits that connect the prefrontal cortex and the basal ganglia with ultrasound can alleviate these characteristic symptoms without resorting to surgical interventions and perhaps without more medication in the future. And although at the moment there is still a long way to go, pilot studies in the United States point to sustained symptomatic improvements after several sessions, with mild side effects such as temporary headaches. The ethics. The ability to literally reprogram the brain without invading it opens up questions that go beyond medicine. Guinjoan agrees with neuroscientist Rafael Yuste, promoter of the neurorightsin which it is urgent to regulate the non-therapeutic use of these technologies. Although the border between treating a disease and enhancing mental performance is increasingly blurred. Unlike other home neuromodulation tools, such as transcranial electrical stimulation (tDCS) devices that They are already sold for personal useLIFU requires high-precision neuronavigators and a specialized clinical environment. Guinjoan does not believe that it will become a domestic technology, but he does imagine a future where each patient receives a personalized neuromodulation treatment, adjusted to their specific neural map. The future. If ongoing trials confirm efficacy, focused ultrasound could be incorporated in the next decade into the arsenal we have in the treatment of resistant depression, anxiety or even schizophrenia. All this without having to enter an operating room. Something that could also represent a new leap in psychiatry as we know it and a paradigm shift in the therapeutic approach to this type of pathology. Images | Fernando @cferdophotography Robina Weermeijer In Xataka | There are people eating carrots like rabbits because they think it will make them tan. There’s just one little problem

Federal authorities confiscate machinery that processs 160,000 daily fentanyl pills

Machinery for processing 160,000 daily fentanyl pills is part of the smuggling merchandise seized in the Los Angeles/Long Beach port complex. Next to the Los Angeles Maritime Museum, the interim federal prosecutor of the Department of Justice, Joseph T. McNally announced the arrest of eight individuals: four of Chinese origin and four Latinos who were part of a sophisticated network of smugglers. The main leader is a fugitive and is speculated that he hides in China. The specific figures associated with the alleged criminals were: $ 130 million in smuggling seized and $ 200 million in smuggling goods attributed to the defendants, including counterfeit goods and chemical precursors to produce narcotics and machinery to produce fentanyl pills. At present, the authorities have seized more than $ 1.3 billion in counterfeit products associated with this type of smuggling and other similar schemes of stamps. Container surveillance is extreme in the Los Angeles/Long Beach port complex. Credit: Jorge Luis Macías | IMPREMEDIA Cloned seal The criminal plan fell apart in 2023 when a Customs Agriculture and Border Protection (CBP) specialist in a routine review detected that the seal of a container had been cloned. This prevented the detection of smuggling merchandise from the containers arriving at the ports of Los Angeles and Long Beach. The original seal was found within the container that the worker was inspecting. “This case attests to its unwavering surveillance, maximum professionalism and great focus on protecting the integrity of legal trade, a key component of our critical national security mission,” said Cheryl Davies, director of Customs field operations and border protection of USA. Davies informed that, among the smuggling seized were substances, controlled, chemical precursors, weapons, spare parts for weapons, false postcards, currency and falsified consumption products, drug paraphernalia and more than 220 tons of prohibited plant and animal products. Customs Office and Border Protection staff were present.Credit: Jorge Luis Macías | IMPREMEDIA Shipments also contained several capsules filling machines, which can be used in the production of illicit chemicals. “To import a machine for encapsulating pills, a permission from the US drug administration (DEA) is needed,” Jaime Ruiz, Customs spokesman and border protection of the United States (CBP) told La Opinion. “They are large, automatic and similar machines; When they are smuggled, they have a potential capacity to produce between 160,000 and 190,000 fentanyl pills daily. ” Order forces also intercepted around 50 falsified stamps and made 204 seizures, including controlled substances and prohibited items. The band of alleged criminals hired $ 300 or up to $ 10,000 to truck drivers to transport smuggling items. Thus, the investigations will be extended to the drivers of tractocamiones that were probably involved in the distribution of merchandise. There could be more arrests. “The message for these people who abuse their position of trust and for truckers in the port, is that if they participate in this behavior (to get involved in smuggling), they could go to a federal prison,” said prosecutor Joseph T . “There are real consequences for them if they participate in smuggling and for those who organize fraud,” he added. “We will detect this behavior, we will process them and face important sanctions in the federal judicial system.” Jaime Ruiz is a spokesman for the Office of Customs and Border Protection (CBP).Credit: Jorge Luis Macíás | IMPREMEDIA McNally said that truckers will not be able to argue that they did not know that the load they transported was not illegal. “The truckers were not innocent. The accusation alleges that these individuals participated consciously and voluntarily in the plan. ” In the investigation that began since 2023, in addition to the Federal Prosecutor of the United States of Los Angeles, agents of National Security Investigations (HSI), Customs and Border Protection of the United States (CBP), and the investigation services of investigation of The Coast Guard. The investigation began since 2023 The joint operation of order forces is part of an operation of the anti -drug work group against organized crime (OECTF). Federal Prison If they are convicted of all charges, those accused of a federal large jury would face a maximum legal sentence of five years in federal prison for each position of conspiracy, up to 10 years in federal prison for each charge of breaking customs stamps and up to 20 years Prison for each smuggling position. Seven defendants were arrested on Friday, an eighth was arrested on Saturday night and a defendant is fugitive. Seven of those arrested have already been prosecuted in the United States District Court. Each of them declared innocent of the charges against him and for March 18 the date of the trial is scheduled. If they are convicted of all charges, the defendants would face a maximum legal sentence of five years in federal prison for each conspiracy charge, up to 10 years in federal prison for each charge of breaking customs seals and up to 20 years in prison for each smuggling . Change of stamps According to the accusation, Weijun Zheng, Hexi Wang, Jin “Mark” Liu and others maintained and operated stores to store, hide and sell large amounts of smuggling goods that were illegally imported to the United States from China. When smuggling containers were selected by the United States Customs and Border Protection Office (CBP) for inspection, the defendants hired commercial truck drivers to transport containers from the port of Los Angeles to private warehouses controlled by conspirators , including stores in the city of Industry that were controlled or managed by Zheng, Wang and others. In these places, the accomplices broke the safety stamps of the shipping containers and took the smuggling from the interior. Then, they placed false security stamps on the containers to hide that they had removed the load of them. Subsequently, Zheng, Wang and others ordered their accomplices to transport the containers (after emptying them from much of their original load and securing them with false seals) to places authorized by the CBP so that the rest of the … Read more

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