In 1888 an English doctor dissected a corpse down to its nerves. And illuminated forensic science along the way

If you stop by the bookstore of the Faculty of Medicine of the Drexel Universityin Philadelphia, you’re most likely in for a scare. Fright that will be followed by an uncomfortable gesture. Discomfort from which you will jump to surprise. And surprise that will give way to absolute fascination. There, locked in a glass display case located in the Student Activities Center of the faculty, received visitors until at least a couple of years ago, a dissected human body, tall, well bleached and with bulbous eyes with an expression of superlative and perennial surprise. The most curious thing is that the corpse does not preserve the skin. Not even the muscles. Not even the veins. Not even cartilage. Not even the bones. The corpse, baptized “Harriet”, is pure nerve. And it is in the most literal and full sense of the word. “Harriet” is the result of the surgical virguería of the late 19th century, the result of meticulous and pioneering work – it had so much of both that there were those who believed it impossible – prepared more than 130 years ago by the Dr. Rufus B. Weavera former professor of Hahnemann Medical Collegenow known as Drexel College. Maybe in the era of 3D printing Harriet’s vision is less moving than in 1900, when medical students observed her; but the effect revives when you know two things. One, that Harriet are the remains of a real person, a former employee of the center who died at the age of 35; two, that to give it shape Weaver had to arm himself with patience and separate, filament by filament, the entire nervous system. The process took five to six months. and it only failed in the intercostal area. This is your story. With the eye of an anatomist and the pulse of a seamstress By the late 1880s Dr. Weaver was a well-established and respected professional. He was almost 50, had made a name for himself by identifying and removing bodies from fallen soldiers at Gettysburg and had been working for some time as a professor of Anatomy at the Hahnemann Medical College. In mind, however, Weaver had a project that would allow him to gain fame in the United States and abroad: completing a total dissection of the cerebrospinal system. During his travels through Europe he had seen partial works, but none that showed a complete “x-ray”. Help for his task came, it is believed, from where he least expected: from Harriet Cole, a young African American who was dedicated to cleaning the anatomy laboratory. Although he was only 35 years old, Cole’s health was very delicate. He suffered tuberculosis and his forces were greatly undermined. Before he died in 1888, however, he decided to donate his body to science and offer Dr. Weaver the opportunity he was looking for for his ambitious nervous system project. Over the next six months, Professor Weaver, armed with patience, eyesight and a seamstress’s hand, set about extracting the entire cerebrospinal nervous system. It takes a look at the result to understand that the work was anything but simple. Only the base of the skull required two weeks of dedicationalmost half a month during which he cut the bones piece by piece to keep the dura mater intact and that the eyes remained attached to the optic nerves. With the help of a very fine needle he separated the cranial nerves, the spinal cord and its nerves. Then he used bandages, gauze and pads soaked in alcohol and applied white lead-based paint and shellac to preserve them. Extracting and preserving the intricate system of filaments that shaped Harriet Cole’s system was only part of the challenge. To shape the composition that still today, 13 decades later, continues to amaze Drexel medical students, he had to suspend the mass of fibers from a special board with thousands of pins. The result, named “Harriet” in a nod to the donor, was used by Weaver for his anatomy classes at Hahnemann Medical College; but his virguería soon transcended the walls of the laboratory and even the limits of Philadelphia. In 1839, about three years after the professor’s death, the board was presented and achieved distinction in the famous Word’s Columbian Exhibition. Since then, Harriet’s image has been reproduced in books, articles… Even today, more than 130 years later, the Legacy Center in Drexel University welcomes applications of teachers who want to use their images for their classes at universities or secondary schools. Who was Harriet? As time has passed, the focus has also been placed on Cole herself. Years ago precisely the Legacy Center decided to go beyond inherited history since the end of the 19th century and delve into the figure of the former Hahnemann cleaner. Specifically, he asked himself some questions: Did Harriet really exist? And if it was so, who was it? Why did he donate his body? Under what circumstances did you decide it? Did she know what Professor Weaver would use her corpse for? During their investigation they found many clues and circumstantial evidence, but no conclusive data. The Legacy Center located an 1870 census entry referring to an African-American woman named Harriet Cole who worked as a domestic servant and lived in Philadelphia, right in the same district where Hahnemann College was located; also a death certificate with his name signed in March 1888 and which attributes the cause of death to tuberculosis. What’s more, the center dedicated to medical study is designated as the “place of burial.” Does that mean that Harriet is the same person that, stripped of muscles, veins, bones and cartilage, we continue to see pinned at Drexel University? The institution recognizes that it is very difficult to know. The gaps in the center’s records between 1869 and 1900 make it difficult to go further. In any case, slip that it is not crazy think that Harriet Cole was a poor woman who, faced with the prospect of imminent death, decided to bequeath her … Read more

It’s not just “nerves”, it’s sabotage to the cells

Without a doubt, it is one of the phrases that we have heard ad nauseam: stress makes us hair falls out. And if this occurs in autumnthe increase is much greater. The problem is that science had not found a clear correlation to be able to say that this was 100% true. What we knew was that stress raised the cortisol and that this altered the growth cycles, but we lacked the ‘how’. Something that we have already managed to solve. A path for treatments. Without a doubt in the aesthetic world there is a great demand for treatments that solve baldness problems how are shampoos, vitamin supplements and without a doubt the option of hair follicle transplant They are on the order of the day. That is why understanding exactly why hair falls out in certain situations can end up helping to develop a greater number of medications. The study. The good news we have on the table comes from a study published in the magazine cell supported by previous research that has found the missing link regarding stress and hair loss. A priori it could be thought that cortisol, the so-called ‘stress hormone‘ could be responsible for this loss. But science has taken a turn of the helm by pointing to an electrical overload of the nervous system that would literally be frying the hair cells. The fighting system. Our nervous system has two very clear parts. One we call ‘parasympathetic‘which is the body’s brake and is active when we are most relaxed. But, on the other hand, we have the ‘sympathetic’ that is activated in times of stress, to increase heart rate or tension. It is precisely this system that causes this undesirable effect, especially because when activated it produces epinephrine or norepinephrinewhich is a powerful vasoconstrictor that causes the muscle to have more blood, tension to increase or the heart rate to skyrocket. And this is precisely the substance that travels to the hair follicles, being almost like a poison for the stem cells that are responsible for regenerating hair. As. All the cells in our body need energy to function, as if they were a small factory. Energy is ‘generated’ in what we call mitochondriawhich literally take oxygen from the blood to produce a reaction that releases the energy that the cell will use to do all its tasks such as synthesizing the necessary elements that our hair has. The problem is that with the arrival of norepinephrine to the cells, these mitochondria die, and a production system without energy is condemned to die. And this is precisely what happens to the cells of the hair follicle, causing the system to collapse and accompanied by hair loss. This is something that has been demonstrated in mice, where by blocking the entry gates of norepinephrine to the hair follicle cell, hair loss was blocked. The immune system. Beyond the effect of norepinephrine, we also find the effect of our own defenses. And there are many factors that can activate the immune system around the follicle, which explains why stress is such a common trigger of alopecia areatawhich is an autoimmune disease where the body itself attacks its own follicles as if they were something foreign when it is its own thing. The future of baldness. As we mentioned before with this door open, pharmacology can now do its job by looking for ways to block the effect of norepinephrine in these cells without affecting the rest of the body (where it is very necessary). Although not stressing and having a calm life, the truth is that it can be the best possible treatment for both baldness and other diseases, although in today’s society it is undoubtedly a great challenge. Images | Gustavo Sanchez In Xataka | Minoxidil seemed like the great miracle drug against baldness. A Google-funded pharmaceutical company has just surpassed it

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