Science had been looking for an alternative to laboratory mice for years without success. Until he found the moths

In the world of science, the mouse has been for decades the undisputed king of the laboratory. However, it is an expensive, slow and, above all, ethically complex reign. That is why we have been looking for alternatives for years, and the answer may not be in a silicon chipbut an insect that you have probably seen eating the wax of a beehive. The advance. This is what researchers at the University of Exeter have arrived at, who have achieved a milestone that promises to change the rules of the game in the fight against superbacteria: They have genetically “hacked” dinner moth larvae to function as real-time biological indicators. The most impressive thing is that they even have a very visual indicator: they shine when you get sick and go off when the medicine is working correctly. The biological traffic light. The study, published this week in Naturedetails how the research team has achieved what seemed impossible: applying tools of genetic editing advanced these moths with unprecedented precision. And I know this is very important, since using insects to model human diseases had limitations, but this team has combined two key techniques. The techniques. The first of them is the system PiggyBac to be able to insert genes that produce fluorescent proteins into these moths, so they have basically gone from having larvae to biological “neon lights.” In this way, if bacteria or fungi are injected, fluorescence makes it possible to monitor the infection in vivo under the microscope. In addition, the famous technique was also included CRISPR-Cas9 to deactivate specific genes in the insect’s body. This is a tremendously positive thing, as it allows scientists to manipulate the larva’s immune system to see how it reacts to different pathogens, mimicking complex human conditions. The key data. The bottom line is that the modified larvae allow us to see if an antibiotic is working in real time. The indicator we have is fluorescence, which if it decreases indicates that the bacteria is dying from the antibiotic and the larva is surviving. All this in a visual, fast and cheap way. Why the moth. It may sound strange to compare a moth with a mammal such as the mouse, which may be more like us, but the Galleria mellonella He has an ace up his sleeve: your body temperature. Unlike the fruit fly, these larvae can breed and survive comfortably at 37°C, the average human body temperature, which is crucial because many human pathogens only activate their virulence genes at that temperature. Furthermore, their innate immune system is surprisingly similar to that of mammals in terms of structure and function of phagocytes, the cells that literally ‘eat’ pathogens that enter the body. Furthermore, with this animal model the use of 10,000 mice per year in the United Kingdom alone can be avoided. Against the clock of the resistance. The context of this advance is not trivial, since we are facing a race against the resistance of bacteria to our antibiotics. We need at this moment test thousands of new compounds fastand doing it in mice is a brutal bottleneck both because of the time it takes and the ethical questions that arise. On the other hand, these transgenic larvae allow for massive screening. Instead of waiting weeks to see results in mice, scientists here can test hundreds of compounds in larvae and get immediate visual readings on toxicity and efficacy. Images | Wikipedia Kalyan Sak In Xataka | Researchers removed Instagram and TikTok from 300 young people to see if their anxiety decreased. The results speak for themselves

If there is something that biologists did not expect to discover is that billions of moths look at the stars to orient

Imagine having to travel a thousand kilometers to a place where you have never been. Now imagine you have to do it at night, without GPS, or maps of any kind. To finish curling the curl, imagine that you only have one chance in your life to do so. You don’t have to imagine it because we are not talking about a person, but of moths. The annual pilgrimage of the Bogong moths. This is the feat that billions of Bogong moths (Infusa agrotis) They perform every year in Australia. And scientists have just discovered that they are oriented looking at the stars. This discovery, Posted in Nature magazineconverts the Bogong moth in the first insect of which you have a record that uses a stellar compass for long -distance navigation, a skill that until now was believed reserved for animals such as some night migratory birds. The trip of a life. Each southern spring, these moths undertake one of up to a thousand kiometers. They hatch in the warm plains of southeastern Australia and fly towards a handful of cold caves in the Australian Alps to spend the summer (a process called Estivation). When the fall arrives, those same moths undertake the trip back to their breeding areas to reproduce and, finally, die. The big question that has fascinated biologists for years is how they do it. No one teaches them the way. It is a round trip that each individual performs only once. A team of researchers, led by David Dreyer from the University of Lund, had already demonstrated in 2018 that the moths were sensitive to the magnetic field of the earth, Like other animalsbut they suspected there was something else. They had their eyes on the sky. A planetarium for moths. To confirm your hypothesis, The team designed an ingenious experiment. They captured migration during their migration and introduced them into a flight simulator. This device, similar to a small planetarium, held the moth allowing him to beat the wings and turn freely, while a sensor recorded his flight address. The team did several tests: They canceled the magnetic field: using a coil system, they created an environment without magnetic clues. Thus they made sure that any correct orientation was due to visual signals. They projected a natural starry sky: under an artificial night sky, identical to the one they would see in the time of migration, the moths were oriented persistently in their correct migratory direction: to the south in spring and north in autumn. They turned the sky 180 degrees: In the final test, the researchers rotated the projection of the starry sky 180 degrees. The response of the moths was immediate and amazing: they invested their flight direction almost exactly 180 degrees. They project random stars: to make sure they did not respond simply to the light, they projected an image with the same amount of stars and brightness, but randomly distributed, without forming recognizable patterns. In this situation, the moths flew disoriented, without a clear direction. Unexpected. These results demonstrated without a doubt that the moths not only see the stars, but use them as a true compass to maintain a specific geographical direction for thousands of kilometers. It was already known that other insects, such as players, use the Milky Way to orient. However, they do it to move in a straight line and quickly move away from a lot of manure, a short -term orientation and without a fixed destination. The achievement of the Bogong moth is much more complex. Use the stars to “discern specific geographical directions” and sail towards a “distant objective”, something radically different and much more sophisticated. A brain connected to the stars. The researchers did not stop in behavior. They also analyzed the brain of the moths and discovered visual neurons that responded specifically to the rotation of the starry sky. Interestingly, these neurons showed their maximum activity when the moth was heading south, regardless of whether it was spring or autumn, which suggests that they have a wiring neuronal system to detect a fundamental light blue orientation. This does not invalidate its magnetic compass. In another experiment, the scientists observed that on completely cloudy nights, when the stars were invisible, the moths were still oriented correctly. The conclusion is that the Bogong moth has an incredibly robust and redundant navigation system. It uses both the Earth’s magnetic field and a stellar compass, probably using a system to calibrate the other or to take over when one of the two fails. There are still mysteries to solve, such as what stars or exact constellations use or how they compensate for the rotation of the earth throughout the night. But what is clear is that not only the ancient sailors looked at the stars to find their way. A tiny insect, on his only trip, also does. Image | Pexels In Xataka | If the question is whether there is an “invasion” of moths in Murcia, the answer is that of every year by these dates

Murcia has filled with moths. There is nothing weird in this invasion

Temperatures in Spain rise. The State Meteorology Agency has already launched the first notice that We will touch the 40º this final stretch of May. The first half of June is expected to be more dry and warm than usualand with that increase in temperatures, in recent weeks there is something that has proliferated: bugs. The mosquitoes returnbut in some areas of Murcia there is another type of invasion: that of The moths. There is already talk of “plague”, but it is neither a plague nor it is weird that there are more moths in Murcia. Alert! “Matcia moths” is already a trend In networks like Tiktokwhere we talk about an authentic invasion, but there are users from other parts of the country who are reporting an increase in the population of these insects. Many of the videos begin with a “what is happening with the moths.” And the answer is that nothing is happening out of the ordinary. As we read in The truththe neighbors complain that the number increases at night and this is also completely normal. In fact, last year, attention began to be attracted to a moths The first week of June. Usual suspects. Every year at this time, the Spanish Levante, as well as a large part of the Peninsula, report an increase in the presence of these lepidoptera, especially at nightfall. The reason is that they are attracted to artificial lighting, which is why it is easier to see them in cities, but as we say, it is cyclical and that nothing has to do with an invasion or something exotic. The Limero Little There are two suspicious species. On the one hand, the Prays Citrior “Limero moth.” It is a lepidopter that has a clear objective: citrus. It has a size of about 10 millimeters and is a species that experiences population peaks in spring and summer. In some citrus producing regions in Murcia they are seeing these daysand these moths are only one of the insect species that You have to fight so that they do not affect the harvest. And the Gamma Autograph On the other hand, we have the Autographa gammaa larger moth (which can reach 45 millimeters and that is the most stir can be causing these days. It is a night moth that lives in the Iberian Peninsula and in North Africa that, in addition, is migratory. temperature increasepopulations shoot and undertake their way to regions in which they cannot survive in winter, such as northern Europe. Of plague, nothing. Taking advantage of fast air currents, Autographa gamma He undertakes his journey from South to the north on these dates, the opposite occurring in autumn, when they return from the north to the Mediterranean and Africa breeding areas. This means that When the heat beginsThey spend a few days in the Spanish Levante while they travel the area to the north. The Zoonosis Service of the City of Murcia has confirmed the newspaper The opinion that these days have received several calls from neighbors alerting about this fact, but that is nothing out of the ordinary. They also clarify that they are not clothes moths, do not transmit diseases and are not a danger. And from Sanimura Murcian company of pest control, have confirmed our partners of Straight to the palate that “you can have them or not, but it is no plague. It is not true.” Every time … before? This year’s problem is that the cycles of these species seem to have been advanced. It has been A especially rainy springso that increase in humidity and vegetation causes more insects than, with the arrival of higher temperatures, resulting in a population explosion. It does not mean that there are more than usual, but that they have arrived before. José Luis Viejo Montesinos is a professor of Zoology and a member of the Spanish Society of Entomology and comments on ABC That he is surprised that he talks about “plague” and recommends something as simple as “if you find one of these moths, give them a snack if they bother you and nothing more.” Images | Ben comes out, Carlos Delgado, Donald Hobern In Xataka | The United States prepares for the invasion of creatures in an event that nobody had seen since 1803

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