Only “a miracle” can save the company that launched Yuri Gagarin

What until now were rumors and suspicions It has become the harsh reality confirmed from within. And in the most brutally possible way possible. The legendary RSC Energy, the pillar on which the entire Soviet and Russian space program was built, is in a “critical situation”, on the verge of bankruptcy. It does not say a western analyst, but the general director of the Russian company, Igor Maltsev, in an internal statement that contradicts the Kremlin propaganda. “We have to stop lying.” Far from the usual fanfare, the message published on the occasion of the 79th anniversary of RSC Energia lacks euphemisms. “Multimillionaire debts, loan interests that eat the entire budget, ineffective processes and a significant part of the team that has lost motivation and the sense of shared responsibility,” writes Maltsev. Filtered by The Russian medium Gazeta.ru And confirmed by multiple sources, the message is a low blow for Russian space propaganda. Maltsev was appointed director just three months ago and has needed little time to understand the magnitude of the disaster. In his letter, he affirms that the legacy of geniuses like Serguéi Koroliov “has been exhausted” and that, in recent years, “all important projects and all deadlines have been breached.” On the verge of bankruptcy. In a desperate cry, Maltsev warns their thousands of employees that the future might not be the “flourishing of RSC Energy”, but the “closing of the corporation and the impossibility of functioning normally, paying salaries and creating new products.” The conclusion of your message, Full -widespread in Telegram channelsIt is almost a plea to heaven: to get the company forward is a task “of the kingdom of miracles”. It is a radical change against the usual rhetoric of Roscosmos, which usually focuses on past glories and Grandilocuent future projects But with little financing. As Eric Berger points out in Ars TechnicaThe reality is that the Russian space program is deeply definanced, a situation that has been especially aggravated by the war in Ukraine. With interest rates in 18%, capital is increasingly scarce and debts become unpayable. The end of the Russian monopoly in the ISS. The RSC Energia crisis, manufacturer of the created Soyuz ships and the progress cargo ships coincides with the moment when its role in the International Space Station has ceased to be indispensable. For decades, Russia has been in charge of raising the orbit of the station to counteract atmospheric decay, a task that performs with the engines of the Zvezda module or the progress ships coupled to the ISS. However, his monopoly is already history. NASA, concerned about Russian threats to leave the stationit has been looking for alternatives for years. And he has already found them. As Daniel Marín details in EurekaSpacex’s new CRON-33 ship has been equipped with a specific propulsion system to raise the ISS orbit regularly. This capacity makes the Dragon a robust and reliable alternative to Russian progress, eliminating the main pressure lever that Roscosmos had left at the station. A minimum diplomacy. Ironically, this unprecedented internal crisis coincides with a shy diplomatic thaw. As We counted in XatakaNASA and Roscosmos bosses gathered in August for the first time in almost eight years. On the table, they agreed to maintain cooperation in the ISS until 2028 and collaborate in their future exorbitation. This approach, more than a sign of strength, seems like a pure need maneuver. The space station agrees by leaps and bounds, with the Russian module Zvezda as the main concern for its persistent air leaks. The Maltsev action call is the most obvious symptom that the Russian space program faces a systemic collapse. The loss of its technical monopoly in the ISS, combined with an internal economic bleeding, Leave Roscosmos in its weakest position in decades. The “miracle” requested by the director of Energy is not only to save a historical company, but to prevent one of the great legacies of space exploration from becoming a museum piece. Image | ROSCOSMOS In Xataka | The Marian Rover of ESA is definitely damn: the exomars mission accumulates 20 years of calvary and bad luck

Minoxidil looked like the great miracle medication against baldness. A pharmaceutical company financed by Google has just overcome it

The fight against alopecia is A thriving market. The first laboratory to achieve the “miracle treatment” that manages to avoid or reverse androgenic alopecia (conventional hair loss associated with age) could take a lucrative prize comparable with the success of formulas such as Ozempic. One of the best positioned laboratories in this race seems to be Pelage Pharmaceuticals. Preliminary results. A few days ago, the Pelage Pharmaceuticals laboratory announced “positive” preliminary results in the second phase of its clinical trials of the compound PP405. According to its announcement, the formula showed a quick and statistically significant response in these trials. PP405. The compound developed by this company, pp405, is designed for topical application and with the aim of reactivating latent follicular stem cells (HFSC), thus allowing the restoration of hair growth. According to Explain the laboratorythese cells usually alternate latency and activity cycles when they work conventionally. However, with age or in response to certain external or internal stimuli, these cells can be “blocked” in the sleeping phase of this oscillation. As highlighted, this state of latency does not imply its disappearance or loss of viability. Test treatment seeks to “restore the regenerative capacity” of these follicles, which entails the recovery of capillary growth. 78 participants. Preliminary results published by the company They belong to phase 2a of clinical trials of the compound. It is a randomized and controlled study in which 78 participants, men and women with androgenic alopecia have taken part. The participants were divided between the experimental group and control group or placebo: the participants of the experimental group applied the compound in their scalp for four weeks; while the control group received a placebo. After four weeks of application, a 12 weeks were monitored to check the effects on the participants. Results. The results now presented do not correspond to those obtained after the essay but to their eighth week (after four weeks of treatment and four subsequent monitoring). The responsible team observed that among men with more advanced baldness, 31% Of these they showed a 20% increase in capillary density. They stood out for this reason the speed of the response to treatment, at least in principle faster than that observed in contemporary treatments. A crucial difference. However, the key to this treatment was in its effect on inactive follicles. The experiment showed regenerative potential both in the areas of weak growth and in the areas where the hair was no longer growing. The treatments we have in the present are useful when reinforcing growth in weakened but active follicles, not those that have already fallen in a state of latency. “These early clinical results reinforce the potential of our approach to go beyond the slowdown of the hair loss process and directly attack the hair follicle tegeneration,” pointed in a press release Christina Weng, medical director of Pelage Pharmaceuticals. A long way to go. The results are preliminary and correspond to a study conducted in a limited sample, so we will have to wait for the company to give new data on the drug evaluation process. According to the laboratorythe last stage of this process, phase 3 of clinical trials, could begin in 2026. The support of a giant. The origin of the project is in the work carried out in the last decade by researchers at the University of California Los Angeles and other institutions. According to the company, the development achieved the support of investors led by Google Ventures. In Xataka | The hair industry in Türkiye has a new enemy: a protein that protects us from baldness Image | Donald Teel

We have been talking about the ‘Miracle Inditex’ for years to explain its growth. That phenomenon is coming to an end

Inditex has just confirmed what many feared: it is no longer the unstoppable growth machine we knew and faces a more mature stage, without the double digit that until very recently was the custom. Why is it important. The first quarter marks a turning point in the history of the Galician giant. Sales grow just 1.5% compared to 7.1% of the previous year, and the benefit stagnates at 0.8%. They are figures of any European textile company, not the empire that used to other numbers. In figures. The numbers are devastating: 8,274 million in sales … … When analysts expected 8,380 million. Is The weakest growth since 2018excluding pandemia. The stock market does not forgive: the shares collapse more than 4% and touch the 46 euros in intradic minimums. The context. Three factors explain this unexpected normalization. The strong euro devours international sales with an impact of 3% that the company did not know how to foresee. Torrential rains in Spain (15% of global sales) have stopped spring clothes purchases. Operating costs grow above income for the first time in years. Between the lines. The data of the balance They show something more worrying: Inditex is losing efficiency. Stocks rise 6.3% when the company is proud to maintain Stocks minima. The net financial position falls by 7.3%. They are symptoms of a company that can no longer control all variables as well as before. Now it remains to see if it is something temporary or goes further. Yes, but. The second quarter offers a respite: sales are growing 6% between May and June. Even so, it is half of the 12% registered a year ago in the same period. The improvement exists, but it is still that of a normal company, not that of a phenomenon as it was so far. The latest. The Jose Arnau exitvice president and right hand of Amancio Ortega for 24 years, symbolizes the end of an era. Your substitute, Roberto Cibeirainherits a prosperous but mortal company. The transformation is complete: Inditex has gone from being a business unicorn to a solid, but predictable multinational. The miracle is over and gives way to the era of maturity. Outstanding image | Inditex In Xataka | Amancio Ortega: the billionaire who lives as one more neighbor (except for private jets and superyates)

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