In the midst of a race towards immortality, China believes it has found a way for us to live 150 years: with grapes
Aging is the objective that a good part of society has right now with different diets to look younger, ‘anti-aging’ treatments or even cocktails that promise this (although our biology has a fairly clear limit). Now, China is targeting a biotechnology company that affirms be developing a pill capable of prolonging human life to 150 years. A simple grape. A priori it seems that it has nothing to do with human aging, but we are quite wrong. The Shenzhen biotechnology company claims to have identified in its seeds a compound called procyyanidin C1 (PCC1) which achieves the effect that many want and has a great antioxidant effect. Zombie cells. To understand how this supposed miracle compound works, we must first talk about the enemy of aging: senescence cellular. As time goes by, some of our cells stop dividing, but they do not die. They remain in a state of limbo, accumulating in the tissues and secreting inflammatory substances that damage neighboring cells that are not so lazy and continue dividing. These cells that do not want to die is what known as ‘zombie cells’ because in the end there are quite a few parallels. As. Once taken into account, this is where PCC1 comes into play, which is nothing more than a natural flavonoid. Where the interesting begins is in a key study published in Nature Metabolism where it is pointed out that PCC1 acts as a senolytic agent. This means that it has a fairly important selective capacity to act on the cells that are bothering us the most. Specifically, at low doses, PCC1 inhibits the toxic substances emitted by zombie cells, but at high doses it kills them without harming healthy cells. And up to this point everything is quite solid, since it has been scientifically proven. There are ‘buts’. The scientific basis that the Chinese laboratory uses for its claims comes almost exclusively from animal models to whom this substance was applied. In this way, the researchers achieved several things by applying PCC1 on old mice: Reduce the load of senescent cells in vital organs. Reverse motor dysfunctions, making the mouse have more strength and better balance. Increase life expectancy between 9 and 60%. The big ‘but’ we found is that it has only been tested on mice and not on humans. And given this we can ask ourselves something quite simple: why are we skeptical about the claim of 150 years in humans? There are several reasons to be so. The first of them is that saying that because a mouse lives 60% longer, a human will live 60% longer is also a biological fallacy. The metabolism of mice and humans is not similar at all, and that is why there are drugs that, although they have worked in a mouse, have failed in humans. we are not equal with the mice. That’s why we don’t age in the same way. Although it is true that humans have senescent cells that are related to aging, we are much more complex. Aging involves genomic instability, telomere shortening, mitochondrial dysfunction, and stem cell exhaustion. That is why cleaning the ‘zombie cells’ could improve health in old agebut it is unlikely that on its own it will make us exceed the current biological limit of our species. This is also added to the fact that to date there are no published clinical trials that support the safety and effectiveness of using this compound in the human body. That is why, in conclusion, we can conclude that PCC1 is a very important finding to identify a door to therapies that make us age better. But talking about extending life to 150 years undoubtedly presents many doubts, since surely this ‘Chinese pill’ will not make us immortal overnight. Images | Maja Petric Daniel Franco In Xataka | Not all brain cells age at the same time: we have found a “hot spot” of aging
