We thought Ozempic was only for weight loss. Science is seeing that it can end alcoholism

The famous Ozempic has been revolutionizing the treatment of type 2 diabetes for years and also has an important effect on obesity when it comes to helping patients lose weight by causing a greater satiety. However, the scientific community had long suspected that its effects went far beyond weight control and now, science has an idea that it may have an effect on alcohol. New advances. A new study published earlier this month in The Lancet ha proven that these drugs are capable of significantly reducing the days of excessive alcohol consumption in patients who have an alcoholism problem. Something that is a great milestone, since until now the evidence on the use of these drugs to treat addictions was based on small studies, but now a big change has been made by designing a trial with the maximum guarantees to find a clear relationship between taking Ozempic and the control of addiction. How it was done. For 26 weeks, researchers followed 108 adult patients who had both obesity and an alcohol use disorder. From this sample, the group treated with semaglutide once a week experienced a 41% reduction in days of heavy drinking, compared to 26% in the placebo group not taking the treatment. In addition, patients on medication consumed an average of 1,026 grams of alcohol per month, which is a significantly lower figure considering that the control group drank 1,550 grams of alcohol. And they both thought they were taking the same treatment, although that was not the case. It’s not magic. To understand why this happens, we have to go to 2023, where a study showed that semaglutide, which is the active ingredient in Ozempic, binds directly to the nucleus accumbens of mice. By doing so, it suppresses the release of dopamine induced by alcohol consumption, suppressing the reward circuit that generates satisfaction when you drink a little alcohol and that is the effect that addicts seek. In this way, if alcohol does not generate that chemical “high”, the desire to consume it disappears. The limitations. Despite the enthusiasm that this may generate for having a new treatment against alcoholism, which is an addiction that has great negative effects, we must put the brakes on a little. At a technical level, we must keep in mind that 108 people is still a relatively small group to extrapolate the results to the entire population. Furthermore, all patients who participated in the study were obese and white, which limits the generalizability of the results to patients of normal weight or other ethnicities. And as if those were not enough limitations, it should be noted that the trial was funded by the drug manufacturers and does not have follow-up data beyond week 26. Images | freepik freepic.diller on Magnific In Xataka | We thought that quenching hunger with Ozempic was the definitive remedy against obesity. Until we look at the muscle

In 1914 Russia decided to prohibit vodka to stop alcoholism. It was a disastrous decision

Exists A legend (not confirmed) that said that, when the final surrender of Nazi Germany was known in World War II, the jubilation with which it was held in the Soviet Union is counted as one of the drunkenness more epic in the history of ethyl celebrations. The myth did not stay there, since the story said the Victory Day It led to the closest to a “national alcoholic blackout”, leaving the nation Without vodka in just 24 hours. The truth is that, whether or not, it makes all the meaning of the world. They came from a prohibition that had resulted. An ancestral relationship. Counted in an extensive Report The Atlantic that the Russian inclination towards alcohol has religious and political roots. In 988, the Prince Vladimir chose orthodox Christianity in part for not prohibiting Alcohol consumption, unlike Islam. During the 16th century, Ivan the terrible established the first state taverns (the calls Kabaks) that they became Fiscal monopolies. In less than a century, a third of Russian men I was indebted With these drink houses. Already in the 18th century, Pedro the Great consolidated that institutional dependence: not only tolerated the alcoholism of his subjects, but punished wives They tried to get their husbands out of the taverns, and recruited ethyl debtors for the army. Arrived at the nineteenth century, the State obtained almost half of its income from the sale of vodka. Far from being an externality of the system, alcohol would be said that it became its collection engine. In this context, the Tsar was going to make a decision of Ajundia. Imperial abstinence. According to Timethe history of the Russian prohibition not only precedes the famous Dry American Lawbut it constitutes one of the most transcendental (and fatal) decisions of the Tsar Nicolás II. It happened in September 1914, when a few days after the death in combat of his cousin, the prince Oleg Romanovthe Tsar sent a telegram to his uncle Konstantin Konstantinovich announcing the definitive suppression of the state sale of vodka in Russia. That gesture, which apparently responded to a moral conviction and a personal loss, dismantled one of the pillars Economics of the Empire: For centuries, the State had maintained a lucrative monopoly on alcohol, generating up to a third of its income thanks to sales to the peasantry. When renouncing that source of financing just at the threshold of World War I, Nicolás not only unleashed a deep fiscal crisis, but also fragile social contract between the throne and its people. Nicolás II Catastrophic consequences. The problem was not only economic. The measure was adopted at a time when the empire tried Revict your prestige After the defeat in the Russian-Japanese war of 1905, where alcoholism among soldiers was indicated as a decisive factor of military collapse. Collective drunkenness during mobilizations and the front had been so notorious that even the Káiser Guillermo II He came to declare that in the next conflict he would win the nation that he least drank. Under that impulse, the ban seemed a strategic decision, aimed at disciplining the army and facilitating mobilization. And, indeed, Russia initially deploy troops quickly and obtain some early victories. However, the price was elevated: by suddenly depriving millions of people of their usual consumption in full war and without social compensation mechanisms, a deep resentment Between peasants, workers and soldiers, amplifying the distance between imperial power and masses. Logistic collapse The Tsar appointed the reformist Peter Bark as Minister of Finance with the difficult task of disconnecting the treasury of alcohol, but the budget vacuum became unsustainable. Given the loss of hundreds of millions of rubles, the solution was the most precarious: Print moneyaccelerating hyperinflation and eroding even more the economy of war. The fiction that national productivity had improved without vodka was sustained with falsified reports and grandiloquent statements, while citizens suffered the consequences of shortage and monetary depreciation. At the logistics level, chaos was equally shocking: the wagons that had to transport grain and supplies to the front were occupied by Aristocratic distillators That, prevented from selling within the country, tried to export their vodka to France, Japan or any port available, saturating the already weak Russian rail networks. From Tsarism to Bolshevism. Paradoxically, the prohibitionist policyborn within the Tsarist conservative regime, was one of the few who survived the tumultuous change of governments that Russia shook Between 1917 and 1924. Neither the provisional government nor Lenin’s Bolsheviks revoked the measure. The communist leader, in fact, defended it as a Ethical and ideological principlewarning that a socialism based on the sale of alcohol was a betrayal of the revolutionary ideal. During the civil war, discipline, sobriety and consumption control were seen as essential components of the new order. Of course, after Lenin’s deaththe logic of state benefit imposed once again: Stalin The monopoly reestablished of vodka (now decorated with the Hoz and the hammer), restoring the practices of the old empire under a new clothing ideological. In terms of fiscal consumption and profitability, the prohibitionist stage It was erased almost completely. Moral experiment. That’s how it ended A movement That did not go as expected, much less. Beyond its symbolism, the Russian prohibition embodies a singular case where a moral decision, taken from power, precipitated the collapse of a regime whole. Time told That, in the context of a devastating war, a broken economy and a desperate population, the elimination of one of the few social exhaust valves ended up exacerbating all the latent tensions of the system. The Zar tried to save the soul of the Russian people removing alcohol, but ended up losing the throne. Thus, the vodka veto not only marked the start of the end of The Romanovbut left a enduring lesson about the risks of moralizing governance in times of crisis. Now, that legend of the end of World War II and the greater ethyl celebration It charges all the meaning of the world, because, sometimes, drunkenness can be more … Read more

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